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The map label for this gene is rseP

Identifier: 218928219

GI number: 218928219

Start: 1191980

End: 1193335

Strand: Direct

Name: rseP

Synonym: YPO1051

Alternate gene names: 218928219

Gene position: 1191980-1193335 (Clockwise)

Preceding gene: 218928218

Following gene: 218928220

Centisome position: 25.61

GC content: 47.35

Gene sequence:

>1356_bases
ATGATGAGCATACTCTGGAGCCTGGCTGCGTTTATTGTCGCACTGGGGATCTTAATTACAGTGCATGAGTTTGGTCACTT
TTGGGTGGCACGGCGCTGTGGTGTCCGTGTAGAGCGTTTTTCAATTGGTTTTGGTAAAGCGTTATGGCGCCGTACTGATC
GTCAGGGAACCGAGTATGTTATCGCCCTTATCCCACTGGGCGGTTACGTTAAAATGTTAGATGAGCGTGTAGAGGCTGTT
GCGCCAGAATTACGCCATCAATCATTCAACAATAAAACTGTTTTACAACGTGCGGCAATCGTCAGCGCGGGTCCTATTGC
TAACTTCCTTTTTGCCATCGTCGCTTACTGGCTGGTGTTTATCATCGGCGTGCCAAGTGTCCGTCCGGTCATTGGTGATA
TTTCGCCACAATCTATTGCTGCGCAAGCCAATATTTCTTCAGGAATGGAACTTAAGTCTGTTGATGGCATCGAAACGCCT
GATTGGGATTCTGTTCGTTTGGCGTTGATCAGCCGAATTGGCGATAAGCAAATGCAAGTGGGGGTCGCTCCATTTGGTTC
CGACAATGTGGTAGAGAAAACTCTGGATTTACGCCAGTGGCAATTTGAACCCGATAAACAAGATCCAGTTGTAGCACTCG
GTATTATCCCACGTGGTCCGCAGATTGAATCTGTCTTGGCTGAAGTTCAGCCAGGGTCAGCGGCACAAAAGGCGGGTTTA
CAAGCAGGGGATAGGATCGTTAAAGTTAATGGTCAATTATTGGATCGTTGGCAGACATTTGTGTTACAGGTCCGTGATAA
TCCCGGCCAGCCGCTGGTATTAGATATTGAAAGGGAGAGTACCCCCTTGTCTTTAACCTTGATACCAGATACAAAATCGG
TTGGAGAAAACCGTAGTGAAGGTTTTGCGGGTGTAGTGCCGAAAGTGATACCACTTCCGGATGAATATAAAACAATTCGC
CAATATGGGCCGTTTACGGCAGTCTATCAAGCTGGGGATAAAACCTGGCAGTTGATGCGGTTGACGGTAAGCATGTTGGG
TAAACTGATTACTGGTGATGTTAAGCTGAATAACCTAAGTGGCCCGATATCTATTGCGCAAGGCGCTGGGCTTTCAGCTG
AGTACGGATTGGTGTACTACCTGATGTTTTTGGCGCTAATCAGCGTCAACTTGGGCATTATCAATTTGTTCCCATTACCA
GTATTAGATGGTGGACATCTGCTCTTCCTGGCGATAGAAAAGCTGAAGGGTGGGCCGGTTTCTGAGCGAGTGCAGGACTT
CAGTTATCGCATCGGCTCGATTTTGCTGGTGCTATTAATGGGGCTTGCACTTTTCAATGATTTCTCCCGTCTTTAA

Upstream 100 bases:

>100_bases
ATACTGGATCGTATCGATAGCCTGACCGCAGCTGTGCCGGTATTTGCCTGCTTAATGCTGTTAGTGTTTTAATCCGTCAC
TGACGGGGAGTTTAGGGATT

Downstream 100 bases:

>100_bases
CGGCAGGGGATAGGTTAGGAAGAACGCATAACAACGATGGCGATGAAAAAGTTGCTCATAGCGTCGCTGCTGTTTGGCAG
CGCCACCGTATACGGTGCAG

Product: zinc metallopeptidase RseP

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MMSILWSLAAFIVALGILITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDRQGTEYVIALIPLGGYVKMLDERVEAV
APELRHQSFNNKTVLQRAAIVSAGPIANFLFAIVAYWLVFIIGVPSVRPVIGDISPQSIAAQANISSGMELKSVDGIETP
DWDSVRLALISRIGDKQMQVGVAPFGSDNVVEKTLDLRQWQFEPDKQDPVVALGIIPRGPQIESVLAEVQPGSAAQKAGL
QAGDRIVKVNGQLLDRWQTFVLQVRDNPGQPLVLDIERESTPLSLTLIPDTKSVGENRSEGFAGVVPKVIPLPDEYKTIR
QYGPFTAVYQAGDKTWQLMRLTVSMLGKLITGDVKLNNLSGPISIAQGAGLSAEYGLVYYLMFLALISVNLGIINLFPLP
VLDGGHLLFLAIEKLKGGPVSERVQDFSYRIGSILLVLLMGLALFNDFSRL

Sequences:

>Translated_451_residues
MMSILWSLAAFIVALGILITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDRQGTEYVIALIPLGGYVKMLDERVEAV
APELRHQSFNNKTVLQRAAIVSAGPIANFLFAIVAYWLVFIIGVPSVRPVIGDISPQSIAAQANISSGMELKSVDGIETP
DWDSVRLALISRIGDKQMQVGVAPFGSDNVVEKTLDLRQWQFEPDKQDPVVALGIIPRGPQIESVLAEVQPGSAAQKAGL
QAGDRIVKVNGQLLDRWQTFVLQVRDNPGQPLVLDIERESTPLSLTLIPDTKSVGENRSEGFAGVVPKVIPLPDEYKTIR
QYGPFTAVYQAGDKTWQLMRLTVSMLGKLITGDVKLNNLSGPISIAQGAGLSAEYGLVYYLMFLALISVNLGIINLFPLP
VLDGGHLLFLAIEKLKGGPVSERVQDFSYRIGSILLVLLMGLALFNDFSRL
>Mature_451_residues
MMSILWSLAAFIVALGILITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDRQGTEYVIALIPLGGYVKMLDERVEAV
APELRHQSFNNKTVLQRAAIVSAGPIANFLFAIVAYWLVFIIGVPSVRPVIGDISPQSIAAQANISSGMELKSVDGIETP
DWDSVRLALISRIGDKQMQVGVAPFGSDNVVEKTLDLRQWQFEPDKQDPVVALGIIPRGPQIESVLAEVQPGSAAQKAGL
QAGDRIVKVNGQLLDRWQTFVLQVRDNPGQPLVLDIERESTPLSLTLIPDTKSVGENRSEGFAGVVPKVIPLPDEYKTIR
QYGPFTAVYQAGDKTWQLMRLTVSMLGKLITGDVKLNNLSGPISIAQGAGLSAEYGLVYYLMFLALISVNLGIINLFPLP
VLDGGHLLFLAIEKLKGGPVSERVQDFSYRIGSILLVLLMGLALFNDFSRL

Specific function: Degrades both heat shock sigma factors rpoE and rpoH

COG id: COG0750

COG function: function code M; Predicted membrane-associated Zn-dependent proteases 1

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain

Homologues:

Organism=Escherichia coli, GI1786373, Length=451, Percent_Identity=77.6053215077605, Blast_Score=699, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RSEP_YERPE (Q8ZH59)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0129
- RefSeq:   NP_670427.1
- RefSeq:   NP_994106.1
- RefSeq:   YP_002346094.1
- ProteinModelPortal:   Q8ZH59
- SMR:   Q8ZH59
- MEROPS:   M50.004
- GeneID:   1148075
- GeneID:   1173891
- GeneID:   2765887
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO1051
- KEGG:   ypk:y3128
- KEGG:   ypm:YP_2799
- HOGENOM:   HBG664087
- OMA:   HGTEFVV
- ProtClustDB:   PRK10779
- BioCyc:   YPES187410:Y3128-MONOMER
- BioCyc:   YPES214092:YPO1051-MONOMER
- GO:   GO:0006508
- InterPro:   IPR001478
- InterPro:   IPR004387
- InterPro:   IPR008915
- SMART:   SM00228
- TIGRFAMs:   TIGR00054

Pfam domain/function: PF00595 PDZ; PF02163 Peptidase_M50; SSF50156 PDZ

EC number: NA

Molecular weight: Translated: 49429; Mature: 49429

Theoretical pI: Translated: 7.65; Mature: 7.65

Prosite motif: PS50106 PDZ; PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 23-23

Signals:

None

Transmembrane regions:

HASH(0xc29e648)-; HASH(0xce46748)-; HASH(0xc593a88)-;

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSILWSLAAFIVALGILITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDRQGTEYV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCEEE
IALIPLGGYVKMLDERVEAVAPELRHQSFNNKTVLQRAAIVSAGPIANFLFAIVAYWLVF
EEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IIGVPSVRPVIGDISPQSIAAQANISSGMELKSVDGIETPDWDSVRLALISRIGDKQMQV
HHCCCCCCHHHCCCCCHHHEECCCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCEEE
GVAPFGSDNVVEKTLDLRQWQFEPDKQDPVVALGIIPRGPQIESVLAEVQPGSAAQKAGL
EECCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCC
QAGDRIVKVNGQLLDRWQTFVLQVRDNPGQPLVLDIERESTPLSLTLIPDTKSVGENRSE
CCCCEEEEECHHHHHHHHHEEEEEECCCCCCEEEEEECCCCCEEEEECCCCHHHCCCCCC
GFAGVVPKVIPLPDEYKTIRQYGPFTAVYQAGDKTWQLMRLTVSMLGKLITGDVKLNNLS
CCCCCCCCCCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCC
GPISIAQGAGLSAEYGLVYYLMFLALISVNLGIINLFPLPVLDGGHLLFLAIEKLKGGPV
CCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCEEEEEEEHHCCCCH
SERVQDFSYRIGSILLVLLMGLALFNDFSRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure
MMSILWSLAAFIVALGILITVHEFGHFWVARRCGVRVERFSIGFGKALWRRTDRQGTEYV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCCCEEE
IALIPLGGYVKMLDERVEAVAPELRHQSFNNKTVLQRAAIVSAGPIANFLFAIVAYWLVF
EEEEECCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
IIGVPSVRPVIGDISPQSIAAQANISSGMELKSVDGIETPDWDSVRLALISRIGDKQMQV
HHCCCCCCHHHCCCCCHHHEECCCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCEEE
GVAPFGSDNVVEKTLDLRQWQFEPDKQDPVVALGIIPRGPQIESVLAEVQPGSAAQKAGL
EECCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHCCCCCHHHHCCC
QAGDRIVKVNGQLLDRWQTFVLQVRDNPGQPLVLDIERESTPLSLTLIPDTKSVGENRSE
CCCCEEEEECHHHHHHHHHEEEEEECCCCCCEEEEEECCCCCEEEEECCCCHHHCCCCCC
GFAGVVPKVIPLPDEYKTIRQYGPFTAVYQAGDKTWQLMRLTVSMLGKLITGDVKLNNLS
CCCCCCCCCCCCCHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCEEEECCC
GPISIAQGAGLSAEYGLVYYLMFLALISVNLGIINLFPLPVLDGGHLLFLAIEKLKGGPV
CCEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCEECCCCEEEEEEEHHCCCCH
SERVQDFSYRIGSILLVLLMGLALFNDFSRL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430