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The map label for this gene is mltA [H]

Identifier: 218928193

GI number: 218928193

Start: 1165302

End: 1166474

Strand: Direct

Name: mltA [H]

Synonym: YPO1025

Alternate gene names: 218928193

Gene position: 1165302-1166474 (Clockwise)

Preceding gene: 218928192

Following gene: 218928194

Centisome position: 25.04

GC content: 48.17

Gene sequence:

>1173_bases
ATGACAAGTCGTTGGGGCAAATACCTACTGAGTGGAATAATGATTGCTGTTCTGGCCGGTTGCCAATCACGGCCAACCGA
TCGTGGGCAACAATATAAGGATGGTCGCCTGGAGCAATCACTGGAACTGGTGAACGAACCCAATGCGGCAGGTAAGCCAG
TCAACGCCAAAGATTATTCTGATCAGGTGAAAGTGATTAATCAGTCTTCACCGGGTCTGTATAACCGCAACAGCGATACA
TTCAATGCGGTACAAAACTGGATGCTGGCCGGTGCTGATACCAGTAAGTTGAGCTTGTTTGGTTTGAATGCTTATCAGAT
GGAAGGTGTCGATAACTTCGGTAACGTACAATTTACTGGTTACTACACTCCTGTGCTTCAGGCCCGCTACACGCCACAAG
GCGAATTTCGTCATCCACTGTATCGTATGCCTGCTAAAGGAAAACGCCGTTTACCGGATCGGGCGGCAATTTATGCGGGT
GCGCTGGATAACCGTAATTTAATCATCGCGTATACCAATTCGCTGGTAGACAATTTCATGATGGAAGTTCAGGGCAGCGG
CTATGTTGATTATGGTGATGGGCGGCCTCTAACATTCTTCGGGTACGCGGGTAAAAATGGTCACGCTTACCGCAGCATCG
GTAAAGTACTTATTGATCGCGGTGAAGTCGCAAGGGCTGATATGTCGATGCAGGCTATCCGTCAATGGGCTGAAAACCAC
AGTGAAGCTGAAGTCAGGGAGTTGTTGGAGCAGAATCCCTCTTTCGTTTTCTTTAAACCGGTAATGTATGCGCCAGTTAA
AGGGGCCAGTGCGGTCCCATTGATTGCTAAAGCCTCTGTGGCATCAGACAAATCTCTGATTCCGCCGGGTACCACCCTGT
TGGCAGAAGTGCCTTTACTTGATGACCAAGGGAAATTTACCGGCAAATATCAAATGCGTCTGATGGTGGCATTGGATGTT
GGGGGCGCAATAAAAGGCCAACATTTTGATATTTATCAAGGGATTGGTCATGAGGCAGGTCAGGCTGCTGGGTTCTACAA
CCATTATGGCCGGGTCTGGGTACTGAAAAATGCACAAAGCAGTGGTCCGTTGTTCACTGCTTATAAAGGTGGCACGCAGA
GCGAGCCTACCAGTAATGATTCGTCATTACTGGTGAATAATCAGGATCGATAA

Upstream 100 bases:

>100_bases
TAACCGTCATCGAGATTTTTTTCTGCCTGCTGATTCCTTTATCCATAGGCGTTTGTTATCGTTCGCCGGTAGATAAAATG
AGTCAAAGAGAAGGCGTGAA

Downstream 100 bases:

>100_bases
GTCAGCGGATGTGCAGGGTAAACATTTGTTTTGATTAAGCGGCCAGTTGGCCGCTTTTGCATGAGTACTTAGAATCTTAT
TGAGTACGAAGCGTCTTTTT

Product: murein transglycosylase A

Products: Muramic Acid Residue [C]

Alternate protein names: Mlt38; Murein hydrolase A [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MTSRWGKYLLSGIMIAVLAGCQSRPTDRGQQYKDGRLEQSLELVNEPNAAGKPVNAKDYSDQVKVINQSSPGLYNRNSDT
FNAVQNWMLAGADTSKLSLFGLNAYQMEGVDNFGNVQFTGYYTPVLQARYTPQGEFRHPLYRMPAKGKRRLPDRAAIYAG
ALDNRNLIIAYTNSLVDNFMMEVQGSGYVDYGDGRPLTFFGYAGKNGHAYRSIGKVLIDRGEVARADMSMQAIRQWAENH
SEAEVRELLEQNPSFVFFKPVMYAPVKGASAVPLIAKASVASDKSLIPPGTTLLAEVPLLDDQGKFTGKYQMRLMVALDV
GGAIKGQHFDIYQGIGHEAGQAAGFYNHYGRVWVLKNAQSSGPLFTAYKGGTQSEPTSNDSSLLVNNQDR

Sequences:

>Translated_390_residues
MTSRWGKYLLSGIMIAVLAGCQSRPTDRGQQYKDGRLEQSLELVNEPNAAGKPVNAKDYSDQVKVINQSSPGLYNRNSDT
FNAVQNWMLAGADTSKLSLFGLNAYQMEGVDNFGNVQFTGYYTPVLQARYTPQGEFRHPLYRMPAKGKRRLPDRAAIYAG
ALDNRNLIIAYTNSLVDNFMMEVQGSGYVDYGDGRPLTFFGYAGKNGHAYRSIGKVLIDRGEVARADMSMQAIRQWAENH
SEAEVRELLEQNPSFVFFKPVMYAPVKGASAVPLIAKASVASDKSLIPPGTTLLAEVPLLDDQGKFTGKYQMRLMVALDV
GGAIKGQHFDIYQGIGHEAGQAAGFYNHYGRVWVLKNAQSSGPLFTAYKGGTQSEPTSNDSSLLVNNQDR
>Mature_389_residues
TSRWGKYLLSGIMIAVLAGCQSRPTDRGQQYKDGRLEQSLELVNEPNAAGKPVNAKDYSDQVKVINQSSPGLYNRNSDTF
NAVQNWMLAGADTSKLSLFGLNAYQMEGVDNFGNVQFTGYYTPVLQARYTPQGEFRHPLYRMPAKGKRRLPDRAAIYAGA
LDNRNLIIAYTNSLVDNFMMEVQGSGYVDYGDGRPLTFFGYAGKNGHAYRSIGKVLIDRGEVARADMSMQAIRQWAENHS
EAEVRELLEQNPSFVFFKPVMYAPVKGASAVPLIAKASVASDKSLIPPGTTLLAEVPLLDDQGKFTGKYQMRLMVALDVG
GAIKGQHFDIYQGIGHEAGQAAGFYNHYGRVWVLKNAQSSGPLFTAYKGGTQSEPTSNDSSLLVNNQDR

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi [H]

COG id: COG2821

COG function: function code M; Membrane-bound lytic murein transglycosylase

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1789179, Length=366, Percent_Identity=69.9453551912568, Blast_Score=546, Evalue=1e-157,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010611
- InterPro:   IPR014733
- InterPro:   IPR005300 [H]

Pfam domain/function: PF06725 3D; PF03562 MltA [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 42915; Mature: 42784

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRWGKYLLSGIMIAVLAGCQSRPTDRGQQYKDGRLEQSLELVNEPNAAGKPVNAKDYS
CCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
DQVKVINQSSPGLYNRNSDTFNAVQNWMLAGADTSKLSLFGLNAYQMEGVDNFGNVQFTG
CCEEEEECCCCCCCCCCCCHHHHHHHHEEECCCCCEEEEEECCEEEECCCCCCCCEEEEE
YYTPVLQARYTPQGEFRHPLYRMPAKGKRRLPDRAAIYAGALDNRNLIIAYTNSLVDNFM
EECCEEEEECCCCCCCCCCHHCCCCCCCCCCCCHHEEEEECCCCCCEEEEEHHHHHHHHH
MEVQGSGYVDYGDGRPLTFFGYAGKNGHAYRSIGKVLIDRGEVARADMSMQAIRQWAENH
HEECCCCEEECCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
SEAEVRELLEQNPSFVFFKPVMYAPVKGASAVPLIAKASVASDKSLIPPGTTLLAEVPLL
CHHHHHHHHHCCCCEEEECCEEECCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCC
DDQGKFTGKYQMRLMVALDVGGAIKGQHFDIYQGIGHEAGQAAGFYNHYGRVWVLKNAQS
CCCCCCCEEEEEEEEEEEECCCCCCCCCEEHHHCCCCCCCCCCCHHHCCCEEEEEECCCC
SGPLFTAYKGGTQSEPTSNDSSLLVNNQDR
CCCEEEEECCCCCCCCCCCCCEEEEECCCC
>Mature Secondary Structure 
TSRWGKYLLSGIMIAVLAGCQSRPTDRGQQYKDGRLEQSLELVNEPNAAGKPVNAKDYS
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
DQVKVINQSSPGLYNRNSDTFNAVQNWMLAGADTSKLSLFGLNAYQMEGVDNFGNVQFTG
CCEEEEECCCCCCCCCCCCHHHHHHHHEEECCCCCEEEEEECCEEEECCCCCCCCEEEEE
YYTPVLQARYTPQGEFRHPLYRMPAKGKRRLPDRAAIYAGALDNRNLIIAYTNSLVDNFM
EECCEEEEECCCCCCCCCCHHCCCCCCCCCCCCHHEEEEECCCCCCEEEEEHHHHHHHHH
MEVQGSGYVDYGDGRPLTFFGYAGKNGHAYRSIGKVLIDRGEVARADMSMQAIRQWAENH
HEECCCCEEECCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
SEAEVRELLEQNPSFVFFKPVMYAPVKGASAVPLIAKASVASDKSLIPPGTTLLAEVPLL
CHHHHHHHHHCCCCEEEECCEEECCCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCC
DDQGKFTGKYQMRLMVALDVGGAIKGQHFDIYQGIGHEAGQAAGFYNHYGRVWVLKNAQS
CCCCCCCEEEEEEEEEEEECCCCCCCCCEEHHHCCCCCCCCCCCHHHCCCEEEEEECCCC
SGPLFTAYKGGTQSEPTSNDSSLLVNNQDR
CCCEEEEECCCCCCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid Residue (N-Acetylmuramic Acid And N-Acetylglucosamine Residues) [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic [C]

General reaction: Cleavage Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]