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The map label for this gene is glsA1

Identifier: 218928120

GI number: 218928120

Start: 1048155

End: 1049081

Strand: Reverse

Name: glsA1

Synonym: YPO0949

Alternate gene names: 218928120

Gene position: 1049081-1048155 (Counterclockwise)

Preceding gene: 218928121

Following gene: 218928119

Centisome position: 22.54

GC content: 48.76

Gene sequence:

>927_bases
GTGGTAACAACGTTAGATAATGCCTTACTAAACGATATATTACAGCAGGTCCGCCCGTTGATTGGTCAGGGTAAAGTCGC
TGATTATATTCCCGCACTGGCGGAGGTTCCGGCCAATAAGCTGGGAATTGCCGTTTGTACACTGGATGGTCAGATATTTC
AGGCAGGGGATGCCGATGAACGCTTCTCTATCCAATCGATTTCTAAAGTATTAAGTCTGACGCTGGCCTTATCCCGTTAC
AGTGAGCAAGATATTTGGCAGCGGGTGGGTAAAGAGCCTTCTGGCCAGCCATTCAACTCATTGGTTCAGTTGGAGTTAGA
AAAGGGAAAACCCCGTAACCCATTTATTAATCTAGGGGCGCTGGTGGTCTGCGATATGTTGCAAAGCCGCCTGAGTGCCC
CAAAACAACGTCTGTTGGAAGTTGTACGCCAGTTAGTGAAGGATGACAGCATCAGTTACGATCCTCGTGTGGCGCGTTCC
GAATTTGAGCATTCAGATCGCAATGCGGCTATTGCTTATCTAATGAAGTCTTTTGGTAATTTCGATAACGACGTATTGAC
GGTATTGCAGACCTATTTCCACTACTGTGCGATGCGTATGAGCTGTGTCGAGTTGGCCCGTTGCTTTGTTTATCTGGCGA
ATCAGGGGCGCAGCATCAGTGGCTCCGAGTCTTTAATTACCCCCATGCAGGCGCGGCAAATTAATGCTCTGATGATCACT
AGCGGCATGTATGATGGTGCAGGGGAGTTTGCCTTCCGAGTCGGGATGCCGGGTAAATCGGGGGTTGGTGGTGGTATTAT
TGCCATTGTTCCGGATGAGTTCTGTATTGCCGTTTGGTCACCTGAATTGGATCATGCAGGGAACTCATTGGCGGGTACCG
CTGCCTTAGAGAGATTGGCGCAACAAATGGGTCGTTCTATCTTTTAA

Upstream 100 bases:

>100_bases
TAACGGCTGATCATTAAACAGGGCGCCCTAACCGGCGCCTTTGTTTTTACTGGCTGTAATTAGTGGAAATTGTTAGCGGG
TTTTTATTGGGAGCCTTGTA

Downstream 100 bases:

>100_bases
GACAGCTCTTCTTCTGCTTAAAGATAAGTTCTGGCAGAGTATAGAGATAGACCAAAGTACTCGAGGTTGCAGTCAGGCAG
CAATCGAATGGCACAATTTT

Product: glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MVTTLDNALLNDILQQVRPLIGQGKVADYIPALAEVPANKLGIAVCTLDGQIFQAGDADERFSIQSISKVLSLTLALSRY
SEQDIWQRVGKEPSGQPFNSLVQLELEKGKPRNPFINLGALVVCDMLQSRLSAPKQRLLEVVRQLVKDDSISYDPRVARS
EFEHSDRNAAIAYLMKSFGNFDNDVLTVLQTYFHYCAMRMSCVELARCFVYLANQGRSISGSESLITPMQARQINALMIT
SGMYDGAGEFAFRVGMPGKSGVGGGIIAIVPDEFCIAVWSPELDHAGNSLAGTAALERLAQQMGRSIF

Sequences:

>Translated_308_residues
MVTTLDNALLNDILQQVRPLIGQGKVADYIPALAEVPANKLGIAVCTLDGQIFQAGDADERFSIQSISKVLSLTLALSRY
SEQDIWQRVGKEPSGQPFNSLVQLELEKGKPRNPFINLGALVVCDMLQSRLSAPKQRLLEVVRQLVKDDSISYDPRVARS
EFEHSDRNAAIAYLMKSFGNFDNDVLTVLQTYFHYCAMRMSCVELARCFVYLANQGRSISGSESLITPMQARQINALMIT
SGMYDGAGEFAFRVGMPGKSGVGGGIIAIVPDEFCIAVWSPELDHAGNSLAGTAALERLAQQMGRSIF
>Mature_308_residues
MVTTLDNALLNDILQQVRPLIGQGKVADYIPALAEVPANKLGIAVCTLDGQIFQAGDADERFSIQSISKVLSLTLALSRY
SEQDIWQRVGKEPSGQPFNSLVQLELEKGKPRNPFINLGALVVCDMLQSRLSAPKQRLLEVVRQLVKDDSISYDPRVARS
EFEHSDRNAAIAYLMKSFGNFDNDVLTVLQTYFHYCAMRMSCVELARCFVYLANQGRSISGSESLITPMQARQINALMIT
SGMYDGAGEFAFRVGMPGKSGVGGGIIAIVPDEFCIAVWSPELDHAGNSLAGTAALERLAQQMGRSIF

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family

Homologues:

Organism=Homo sapiens, GI156104878, Length=273, Percent_Identity=36.6300366300366, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI20336214, Length=294, Percent_Identity=34.3537414965986, Blast_Score=167, Evalue=1e-41,
Organism=Escherichia coli, GI1787804, Length=308, Percent_Identity=74.6753246753247, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1786693, Length=286, Percent_Identity=37.7622377622378, Blast_Score=201, Evalue=4e-53,
Organism=Caenorhabditis elegans, GI17507019, Length=297, Percent_Identity=36.3636363636364, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17532727, Length=298, Percent_Identity=34.2281879194631, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI193204073, Length=287, Percent_Identity=35.8885017421603, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI193204075, Length=289, Percent_Identity=35.6401384083045, Blast_Score=174, Evalue=5e-44,
Organism=Drosophila melanogaster, GI281363239, Length=285, Percent_Identity=37.1929824561403, Blast_Score=191, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24653162, Length=285, Percent_Identity=37.1929824561403, Blast_Score=190, Evalue=9e-49,
Organism=Drosophila melanogaster, GI281363241, Length=285, Percent_Identity=37.1929824561403, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24653158, Length=285, Percent_Identity=37.1929824561403, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24653164, Length=285, Percent_Identity=37.1929824561403, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24653156, Length=285, Percent_Identity=37.1929824561403, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI116008307, Length=285, Percent_Identity=37.1929824561403, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24653166, Length=285, Percent_Identity=37.1929824561403, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLSA1_YERPE (Q8ZHF1)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AE0116
- RefSeq:   NP_670635.1
- RefSeq:   NP_994770.1
- RefSeq:   YP_002345995.1
- ProteinModelPortal:   Q8ZHF1
- SMR:   Q8ZHF1
- IntAct:   Q8ZHF1
- GeneID:   1148283
- GeneID:   1173785
- GeneID:   2765271
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO0949
- KEGG:   ypk:y3336
- KEGG:   ypm:YP_3492
- HOGENOM:   HBG512335
- OMA:   AGDWEVP
- ProtClustDB:   PRK00971
- BioCyc:   YPES187410:Y3336-MONOMER
- BioCyc:   YPES214092:YPO0949-MONOMER
- BRENDA:   3.5.1.2
- HAMAP:   MF_00313
- InterPro:   IPR012338
- InterPro:   IPR015868
- Gene3D:   G3DSA:3.40.710.20
- PANTHER:   PTHR12544
- TIGRFAMs:   TIGR03814

Pfam domain/function: PF04960 Glutaminase; SSF56601 PBP_transp_fold

EC number: =3.5.1.2

Molecular weight: Translated: 33700; Mature: 33700

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVTTLDNALLNDILQQVRPLIGQGKVADYIPALAEVPANKLGIAVCTLDGQIFQAGDADE
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHEEEEEEECCCEEECCCCCC
RFSIQSISKVLSLTLALSRYSEQDIWQRVGKEPSGQPFNSLVQLELEKGKPRNPFINLGA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHEEEEECCCCCCCCCCHHHH
LVVCDMLQSRLSAPKQRLLEVVRQLVKDDSISYDPRVARSEFEHSDRNAAIAYLMKSFGN
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCC
FDNDVLTVLQTYFHYCAMRMSCVELARCFVYLANQGRSISGSESLITPMQARQINALMIT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHCCEEEEE
SGMYDGAGEFAFRVGMPGKSGVGGGIIAIVPDEFCIAVWSPELDHAGNSLAGTAALERLA
CCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCHHHCCCCHHHHHHHHHHH
QQMGRSIF
HHHCCCCC
>Mature Secondary Structure
MVTTLDNALLNDILQQVRPLIGQGKVADYIPALAEVPANKLGIAVCTLDGQIFQAGDADE
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHEEEEEEECCCEEECCCCCC
RFSIQSISKVLSLTLALSRYSEQDIWQRVGKEPSGQPFNSLVQLELEKGKPRNPFINLGA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHEEEEECCCCCCCCCCHHHH
LVVCDMLQSRLSAPKQRLLEVVRQLVKDDSISYDPRVARSEFEHSDRNAAIAYLMKSFGN
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCC
FDNDVLTVLQTYFHYCAMRMSCVELARCFVYLANQGRSISGSESLITPMQARQINALMIT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCHHHHHCCEEEEE
SGMYDGAGEFAFRVGMPGKSGVGGGIIAIVPDEFCIAVWSPELDHAGNSLAGTAALERLA
CCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCHHHCCCCHHHHHHHHHHH
QQMGRSIF
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430