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The map label for this gene is manD [H]

Identifier: 218928014

GI number: 218928014

Start: 917421

End: 918587

Strand: Direct

Name: manD [H]

Synonym: YPO0838

Alternate gene names: 218928014

Gene position: 917421-918587 (Clockwise)

Preceding gene: 218928013

Following gene: 218928015

Centisome position: 19.71

GC content: 56.56

Gene sequence:

>1167_bases
ATGCGTACTGCCTATCTCGCTGATCGCACTTTTACTCCGCAAGGCATTGAAACCGGCGTCGCGGTTATCGTCGAGCAAGG
CGAGATTGTGGCAGTAACACGCGAGCTGCCAGCGGATGCAGAAATTGTGCATCTGACAGGGAAAACCCTGATCCCAGGTC
TGATCGACATTCATATTCATGGTCGCCAGGGGGCGGATGTCATGGATGCCTCTGCGGAGGCATTACGCACCATTGCCCGT
GCCCTACCCCAAACCGGGGTTGTTGCCTGGGTCGGCACCACCGTCAGTGCGCCGATACAGGATATCTTTGCGGCTCTGGC
GCAGGTGCGTGATTTTATTGCAGACCCGGATAACGCACGTGATACCCGCACCGCAACCCTGCTCGGCAGTTTTCTGGAGG
GGCCATATTTCACCGCGCCTTTCCGGGGTTCACACCCAGAAAAGTATCTGACGACACCAACACCACAAGAGCTGGAGCAA
TTACGGCATTCGGCGGGTAACACCTTGTTGCGTGCAGCTATCGCACCTGAGTCACCCGAGGCTTTGGCCGCGATCCGCTG
GCTGGTGAATCACGGGATCAAAACCTCTGTGGCGCACACTGCGGCTAATTTTGAGCAAGTGACGGCGGCCTATCAGCAAG
GTGCGGATTGCGGCGTACATTTGTATAACGGCATGTCAGGGTTGCATCACCGTGAACCGGGCTGCTGTGGTGCCGTGTTG
TATCACGACATGCTGGCAGAGCTGATTGCCGATGGCATTCATGTGCATCCGGTGATGATGAATCTGGCGTATCGCATGAA
AGGTTATCGCCGCATTGCACTGATCACCGACTGCATGCGCGCAGGGGGGCTGGGTGAGGGGCGTTATTTACTCGGCGCAC
AGCATATCACGGTACGTCAGGGGGAAGCGCGCACCGATGATGGTTCACTGGCAGGCAGTACTTGTAGCTTGGATCAGGCG
CTGCGTAACATGATCCAACATGCGCAAGTCCCCGAGTGGGAAGCTGTACAAATGGCCAGCGCAGTACCCGCCGCTTATCT
GGGATTAGCGTCAACACTGGGTTCGATCCAGATGGGTGCACAAGCCAGCATGGTGGTGATGGAGAGTGACTTTACCGTTG
CCGCAACCCTGATTAAAGGTGAATGGGCTTATCGCCACTCAGCCTAA

Upstream 100 bases:

>100_bases
TACTGATGGATATTGGCGCGTCCAGTGTACAGAACCTACGGGCTGAGCTGGACACCGCTCTGGTTACTGATAGCGGCGAA
AACGAGGATGGGCTCTAATT

Downstream 100 bases:

>100_bases
GTGCCGTGCTGCTCACGGCCGGGATCCTCTGCCGATCGCTTCACTGACATAACGCCTTTTATGCTTATTTACACCTCATA
GATTTCAGAATGTAGTCAAC

Product: putative acetylglucosamine-6-phosphate deacetylase

Products: NA

Alternate protein names: GlcNAc 6-P deacetylase [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MRTAYLADRTFTPQGIETGVAVIVEQGEIVAVTRELPADAEIVHLTGKTLIPGLIDIHIHGRQGADVMDASAEALRTIAR
ALPQTGVVAWVGTTVSAPIQDIFAALAQVRDFIADPDNARDTRTATLLGSFLEGPYFTAPFRGSHPEKYLTTPTPQELEQ
LRHSAGNTLLRAAIAPESPEALAAIRWLVNHGIKTSVAHTAANFEQVTAAYQQGADCGVHLYNGMSGLHHREPGCCGAVL
YHDMLAELIADGIHVHPVMMNLAYRMKGYRRIALITDCMRAGGLGEGRYLLGAQHITVRQGEARTDDGSLAGSTCSLDQA
LRNMIQHAQVPEWEAVQMASAVPAAYLGLASTLGSIQMGAQASMVVMESDFTVAATLIKGEWAYRHSA

Sequences:

>Translated_388_residues
MRTAYLADRTFTPQGIETGVAVIVEQGEIVAVTRELPADAEIVHLTGKTLIPGLIDIHIHGRQGADVMDASAEALRTIAR
ALPQTGVVAWVGTTVSAPIQDIFAALAQVRDFIADPDNARDTRTATLLGSFLEGPYFTAPFRGSHPEKYLTTPTPQELEQ
LRHSAGNTLLRAAIAPESPEALAAIRWLVNHGIKTSVAHTAANFEQVTAAYQQGADCGVHLYNGMSGLHHREPGCCGAVL
YHDMLAELIADGIHVHPVMMNLAYRMKGYRRIALITDCMRAGGLGEGRYLLGAQHITVRQGEARTDDGSLAGSTCSLDQA
LRNMIQHAQVPEWEAVQMASAVPAAYLGLASTLGSIQMGAQASMVVMESDFTVAATLIKGEWAYRHSA
>Mature_388_residues
MRTAYLADRTFTPQGIETGVAVIVEQGEIVAVTRELPADAEIVHLTGKTLIPGLIDIHIHGRQGADVMDASAEALRTIAR
ALPQTGVVAWVGTTVSAPIQDIFAALAQVRDFIADPDNARDTRTATLLGSFLEGPYFTAPFRGSHPEKYLTTPTPQELEQ
LRHSAGNTLLRAAIAPESPEALAAIRWLVNHGIKTSVAHTAANFEQVTAAYQQGADCGVHLYNGMSGLHHREPGCCGAVL
YHDMLAELIADGIHVHPVMMNLAYRMKGYRRIALITDCMRAGGLGEGRYLLGAQHITVRQGEARTDDGSLAGSTCSLDQA
LRNMIQHAQVPEWEAVQMASAVPAAYLGLASTLGSIQMGAQASMVVMESDFTVAATLIKGEWAYRHSA

Specific function: N-acetylglucosamine utilization. [C]

COG id: COG1820

COG function: function code G; N-acetylglucosamine-6-phosphate deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nagA family [H]

Homologues:

Organism=Homo sapiens, GI21361513, Length=385, Percent_Identity=29.3506493506493, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI224922791, Length=391, Percent_Identity=28.9002557544757, Blast_Score=136, Evalue=3e-32,
Organism=Escherichia coli, GI1786892, Length=381, Percent_Identity=28.3464566929134, Blast_Score=161, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI17553768, Length=363, Percent_Identity=30.8539944903581, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI19920392, Length=353, Percent_Identity=29.7450424929178, Blast_Score=141, Evalue=9e-34,
Organism=Drosophila melanogaster, GI281361140, Length=366, Percent_Identity=28.9617486338798, Blast_Score=138, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR003764
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.1.25 [H]

Molecular weight: Translated: 41596; Mature: 41596

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTAYLADRTFTPQGIETGVAVIVEQGEIVAVTRELPADAEIVHLTGKTLIPGLIDIHIH
CCCEEECCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCEEEEECCCCCCCCEEEEEEE
GRQGADVMDASAEALRTIARALPQTGVVAWVGTTVSAPIQDIFAALAQVRDFIADPDNAR
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
DTRTATLLGSFLEGPYFTAPFRGSHPEKYLTTPTPQELEQLRHSAGNTLLRAAIAPESPE
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHH
ALAAIRWLVNHGIKTSVAHTAANFEQVTAAYQQGADCGVHLYNGMSGLHHREPGCCGAVL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHH
YHDMLAELIADGIHVHPVMMNLAYRMKGYRRIALITDCMRAGGLGEGRYLLGAQHITVRQ
HHHHHHHHHHCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCEEEEEC
GEARTDDGSLAGSTCSLDQALRNMIQHAQVPEWEAVQMASAVPAAYLGLASTLGSIQMGA
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QASMVVMESDFTVAATLIKGEWAYRHSA
CEEEEEEECCCEEEEEEEECCCCCCCCC
>Mature Secondary Structure
MRTAYLADRTFTPQGIETGVAVIVEQGEIVAVTRELPADAEIVHLTGKTLIPGLIDIHIH
CCCEEECCCCCCCCCCCCCEEEEEECCCEEEEEECCCCCCEEEEECCCCCCCCEEEEEEE
GRQGADVMDASAEALRTIARALPQTGVVAWVGTTVSAPIQDIFAALAQVRDFIADPDNAR
CCCCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCCC
DTRTATLLGSFLEGPYFTAPFRGSHPEKYLTTPTPQELEQLRHSAGNTLLRAAIAPESPE
HHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCHH
ALAAIRWLVNHGIKTSVAHTAANFEQVTAAYQQGADCGVHLYNGMSGLHHREPGCCGAVL
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCHHHHHH
YHDMLAELIADGIHVHPVMMNLAYRMKGYRRIALITDCMRAGGLGEGRYLLGAQHITVRQ
HHHHHHHHHHCCCEEHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCEEEECCEEEEEC
GEARTDDGSLAGSTCSLDQALRNMIQHAQVPEWEAVQMASAVPAAYLGLASTLGSIQMGA
CCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QASMVVMESDFTVAATLIKGEWAYRHSA
CEEEEEEECCCEEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969210 [H]