Click here to switch to the map view.

The map label for this gene is mutH [H]

Identifier: 218927969

GI number: 218927969

Start: 864925

End: 865611

Strand: Direct

Name: mutH [H]

Synonym: YPO0789

Alternate gene names: 218927969

Gene position: 864925-865611 (Clockwise)

Preceding gene: 218927950

Following gene: 218927970

Centisome position: 18.59

GC content: 52.98

Gene sequence:

>687_bases
ATGTCTGTTTACTCTTTGCCTCCTGCTCCCCCCAGTGATGAACATCAACTTTTTCAACGTGCACAGGCATTGTCTGGTTT
TACCCTGGGTGAATTAGCAACACGTGCCCAGTGGGTCATCCCCGCAGACCTAAAACGCGTAAAAGGTTGGGTTGGGATGC
TGTTGGAGTTCTATCTAGGCGCCAGTGCTGGCAGTAAACCAGAGCAGGATTTCGCCGATATCGGCATCGAGCTGAAAACC
ATCCCGATCAGTGCACAAGGAAAACCACTGGAAACGACATTCGTCTGCGTGGCACCACTCACCGGGAATAGCGGTGTCAC
CTGGGAAAGTAGCCATGTGCGTCATAAGCTTGCCAGAGTGTTATGGGTGCCCGTCGAAGGCGAACGGCATATTCCGTTAG
CAGAACGCCGAGTCGGTGCTCCGCTGCTGTGGAGCCCTAATGTAGAAGAAGAAGAGTTACTGCGCCGCGATTGGGAAGAA
CTCATGGATCTGATTGTTTTGGGTAAAGTCGAAAGCATCACGGCTCGCCATGGTCAGGTGTTACAGTTGCGCCCCAAAGC
AGCCAATAGCCGGGCATTAACAGAAGCCATCGGCGAATTTGGGCAGCCTATCATGACCTTGCCACGTGGCTTTTATCTGA
AGAAGACACTGACCGCGCCGATGCTGGCTCGCCACTTTTTGCTGTAG

Upstream 100 bases:

>100_bases
AATCATGCTATTATTGCTGTCCGTTTCACTGGATTATAATGCTTGAGCGGTCATTTTTATTTGAGCTTATTTTTTAACCA
CTTTTAGCGAGTTTTTCCGA

Downstream 100 bases:

>100_bases
CCCAGTCATTCCGATTATGATCATCAATTCATTACATTATCTGATGTGTTAATGATGACTAATACGGTAATAGTGATTAA
TTAAAGCGGGATGTTCTCTA

Product: DNA mismatch repair protein

Products: NA

Alternate protein names: Methyl-directed mismatch repair protein [H]

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSVYSLPPAPPSDEHQLFQRAQALSGFTLGELATRAQWVIPADLKRVKGWVGMLLEFYLGASAGSKPEQDFADIGIELKT
IPISAQGKPLETTFVCVAPLTGNSGVTWESSHVRHKLARVLWVPVEGERHIPLAERRVGAPLLWSPNVEEEELLRRDWEE
LMDLIVLGKVESITARHGQVLQLRPKAANSRALTEAIGEFGQPIMTLPRGFYLKKTLTAPMLARHFLL

Sequences:

>Translated_228_residues
MSVYSLPPAPPSDEHQLFQRAQALSGFTLGELATRAQWVIPADLKRVKGWVGMLLEFYLGASAGSKPEQDFADIGIELKT
IPISAQGKPLETTFVCVAPLTGNSGVTWESSHVRHKLARVLWVPVEGERHIPLAERRVGAPLLWSPNVEEEELLRRDWEE
LMDLIVLGKVESITARHGQVLQLRPKAANSRALTEAIGEFGQPIMTLPRGFYLKKTLTAPMLARHFLL
>Mature_227_residues
SVYSLPPAPPSDEHQLFQRAQALSGFTLGELATRAQWVIPADLKRVKGWVGMLLEFYLGASAGSKPEQDFADIGIELKTI
PISAQGKPLETTFVCVAPLTGNSGVTWESSHVRHKLARVLWVPVEGERHIPLAERRVGAPLLWSPNVEEEELLRRDWEEL
MDLIVLGKVESITARHGQVLQLRPKAANSRALTEAIGEFGQPIMTLPRGFYLKKTLTAPMLARHFLL

Specific function: Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair [H]

COG id: COG3066

COG function: function code L; DNA mismatch repair protein

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mutH family [H]

Homologues:

Organism=Escherichia coli, GI1789196, Length=220, Percent_Identity=72.7272727272727, Blast_Score=335, Evalue=1e-93,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004230
- InterPro:   IPR011337
- InterPro:   IPR011335 [H]

Pfam domain/function: PF02976 MutH [H]

EC number: NA

Molecular weight: Translated: 25333; Mature: 25202

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVYSLPPAPPSDEHQLFQRAQALSGFTLGELATRAQWVIPADLKRVKGWVGMLLEFYLG
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHC
ASAGSKPEQDFADIGIELKTIPISAQGKPLETTFVCVAPLTGNSGVTWESSHVRHKLARV
CCCCCCCCHHHHHCCEEEEEEEECCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHH
LWVPVEGERHIPLAERRVGAPLLWSPNVEEEELLRRDWEELMDLIVLGKVESITARHGQV
EEEECCCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCE
LQLRPKAANSRALTEAIGEFGQPIMTLPRGFYLKKTLTAPMLARHFLL
EEECCCCCCHHHHHHHHHHHCCCHHHCCCCEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVYSLPPAPPSDEHQLFQRAQALSGFTLGELATRAQWVIPADLKRVKGWVGMLLEFYLG
CCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHC
ASAGSKPEQDFADIGIELKTIPISAQGKPLETTFVCVAPLTGNSGVTWESSHVRHKLARV
CCCCCCCCHHHHHCCEEEEEEEECCCCCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHH
LWVPVEGERHIPLAERRVGAPLLWSPNVEEEELLRRDWEELMDLIVLGKVESITARHGQV
EEEECCCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCE
LQLRPKAANSRALTEAIGEFGQPIMTLPRGFYLKKTLTAPMLARHFLL
EEECCCCCCHHHHHHHHHHHCCCHHHCCCCEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA