Click here to switch to the map view.

The map label for this gene is parF [H]

Identifier: 218927865

GI number: 218927865

Start: 733354

End: 734085

Strand: Direct

Name: parF [H]

Synonym: YPO0672

Alternate gene names: 218927865

Gene position: 733354-734085 (Clockwise)

Preceding gene: 218927864

Following gene: 218927866

Centisome position: 15.76

GC content: 47.54

Gene sequence:

>732_bases
ATGCTATTAATTTTGCGCACGGTTCTGGCTGTTTTATATTGTTTTCTAGTGTGTGTGTTTGGTTCGATTTATTGCCTGTT
CAGCCCGCGAAATCCTCGCCATGTGGCAACATTTTCGCATCTGTTTGGCCGGATGTCCGTGTTGTTTGGCATTACGATTG
AGCAGCGTATTCCCGCAGAAGCGGCTAAATACGGTAACTGTATTTATATTGCTAACCACCAAAATAATTACGATATGGTC
ACCATGTCGAATGTGGTTCAGCCCGGTACCGTGACCGTGGGCAAAAAGAGCCTGCTGTGGGTACCCTTATTTGGCCCGCT
CTATTGGTTGACGGGTAACCTGCTTATTGATCGTGACAACCGTGCCAAGGCTCACAGCACCATTGCTCAGGTGGTTGAAC
AGGTGCAAAAAAGAAACATCTCTATTTGGATGTTCCCAGAAGGCACACGCAGCCGTGGCCGTGGTTTATTGCCGTTTAAG
ACTGGCGCGTTCCATGCGGCGATTGCTGCAGGTGTTCCTATCGTACCGATCTGCGTTTCTAGCACTAATGGTATCAAGTT
AAATCGTTGGTCGAACGGTAAAGTGATTATTGAGATGTTACCGCCCATTGACACCTCCGGGTACACTAAAGAGCGCGTTC
GTGAGCTGTCTGAGCATTGCCGCAATTTGATGCTGGCTAAAATTGAGCAGTTAGATGCCGAAGTGGCTCAACAGTCCGTT
GCTAAAAAATAA

Upstream 100 bases:

>100_bases
TTGCAAGTAAACAGTATTTCTCAAGTAAACAGTATTTTGCGAGTAAACCGTTATACTAGCGTCGGTTGTCTATTTAAGGG
TGAGTATTTAAGAGGCGGTT

Downstream 100 bases:

>100_bases
TGTATTTGTTTTTGCGGTGCAGGCTATCGCGGCCCCGCGCGGCGGTTATATTTATCGCCACAAATTTTAGATGTTGATTT
AAGCGACTCTGGTCGTGAGC

Product: putative acyltransferase

Products: NA

Alternate protein names: 1-AGP acyltransferase; 1-AGPAT; Lysophosphatidic acid acyltransferase; LPAAT; Phosphatidic acid synthase; PA synthase [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MLLILRTVLAVLYCFLVCVFGSIYCLFSPRNPRHVATFSHLFGRMSVLFGITIEQRIPAEAAKYGNCIYIANHQNNYDMV
TMSNVVQPGTVTVGKKSLLWVPLFGPLYWLTGNLLIDRDNRAKAHSTIAQVVEQVQKRNISIWMFPEGTRSRGRGLLPFK
TGAFHAAIAAGVPIVPICVSSTNGIKLNRWSNGKVIIEMLPPIDTSGYTKERVRELSEHCRNLMLAKIEQLDAEVAQQSV
AKK

Sequences:

>Translated_243_residues
MLLILRTVLAVLYCFLVCVFGSIYCLFSPRNPRHVATFSHLFGRMSVLFGITIEQRIPAEAAKYGNCIYIANHQNNYDMV
TMSNVVQPGTVTVGKKSLLWVPLFGPLYWLTGNLLIDRDNRAKAHSTIAQVVEQVQKRNISIWMFPEGTRSRGRGLLPFK
TGAFHAAIAAGVPIVPICVSSTNGIKLNRWSNGKVIIEMLPPIDTSGYTKERVRELSEHCRNLMLAKIEQLDAEVAQQSV
AKK
>Mature_243_residues
MLLILRTVLAVLYCFLVCVFGSIYCLFSPRNPRHVATFSHLFGRMSVLFGITIEQRIPAEAAKYGNCIYIANHQNNYDMV
TMSNVVQPGTVTVGKKSLLWVPLFGPLYWLTGNLLIDRDNRAKAHSTIAQVVEQVQKRNISIWMFPEGTRSRGRGLLPFK
TGAFHAAIAAGVPIVPICVSSTNGIKLNRWSNGKVIIEMLPPIDTSGYTKERVRELSEHCRNLMLAKIEQLDAEVAQQSV
AKK

Specific function: Converts lysophosphatidic acid (LPA) into phosphatidic acid by incorporating an acyl moiety at the 2 position. This enzyme can utilize either acyl-CoA or acyl-ACP as the fatty acyl donor [H]

COG id: COG0204

COG function: function code I; 1-acyl-sn-glycerol-3-phosphate acyltransferase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI5453718, Length=225, Percent_Identity=30.6666666666667, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI15100175, Length=225, Percent_Identity=30.6666666666667, Blast_Score=129, Evalue=3e-30,
Organism=Homo sapiens, GI6041665, Length=224, Percent_Identity=30.3571428571429, Blast_Score=120, Evalue=2e-27,
Organism=Escherichia coli, GI1789395, Length=244, Percent_Identity=71.7213114754098, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17564032, Length=183, Percent_Identity=34.4262295081967, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17568319, Length=217, Percent_Identity=34.5622119815668, Blast_Score=117, Evalue=7e-27,
Organism=Saccharomyces cerevisiae, GI6320151, Length=241, Percent_Identity=34.0248962655602, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24641614, Length=244, Percent_Identity=34.0163934426229, Blast_Score=130, Evalue=8e-31,
Organism=Drosophila melanogaster, GI24641612, Length=244, Percent_Identity=34.0163934426229, Blast_Score=130, Evalue=8e-31,
Organism=Drosophila melanogaster, GI281364648, Length=216, Percent_Identity=31.4814814814815, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24582856, Length=216, Percent_Identity=31.4814814814815, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24582854, Length=216, Percent_Identity=31.4814814814815, Blast_Score=123, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR004552 [H]

Pfam domain/function: PF01553 Acyltransferase [H]

EC number: =2.3.1.51 [H]

Molecular weight: Translated: 27146; Mature: 27146

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLILRTVLAVLYCFLVCVFGSIYCLFSPRNPRHVATFSHLFGRMSVLFGITIEQRIPAE
CEEHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEHHCCCHH
AAKYGNCIYIANHQNNYDMVTMSNVVQPGTVTVGKKSLLWVPLFGPLYWLTGNLLIDRDN
HHHCCCEEEEEECCCCCCEEEECCCCCCCEEEECCCEEEEEECHHHHHHHCCCEEEECCC
RAKAHSTIAQVVEQVQKRNISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIVPICVS
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEC
STNGIKLNRWSNGKVIIEMLPPIDTSGYTKERVRELSEHCRNLMLAKIEQLDAEVAQQSV
CCCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKK
CCC
>Mature Secondary Structure
MLLILRTVLAVLYCFLVCVFGSIYCLFSPRNPRHVATFSHLFGRMSVLFGITIEQRIPAE
CEEHHHHHHHHHHHHHHHHHHCEEEEECCCCCCHHHHHHHHHHHHHHHHEEEEHHCCCHH
AAKYGNCIYIANHQNNYDMVTMSNVVQPGTVTVGKKSLLWVPLFGPLYWLTGNLLIDRDN
HHHCCCEEEEEECCCCCCEEEECCCCCCCEEEECCCEEEEEECHHHHHHHCCCEEEECCC
RAKAHSTIAQVVEQVQKRNISIWMFPEGTRSRGRGLLPFKTGAFHAAIAAGVPIVPICVS
CHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHCCCCEEEEEEC
STNGIKLNRWSNGKVIIEMLPPIDTSGYTKERVRELSEHCRNLMLAKIEQLDAEVAQQSV
CCCCEEEEEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKK
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1557036; 9278503 [H]