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The map label for this gene is parC [H]

Identifier: 218927864

GI number: 218927864

Start: 730792

End: 733065

Strand: Direct

Name: parC [H]

Synonym: YPO0671

Alternate gene names: 218927864

Gene position: 730792-733065 (Clockwise)

Preceding gene: 218927862

Following gene: 218927865

Centisome position: 15.7

GC content: 51.19

Gene sequence:

>2274_bases
ATGAGTGACTTGACTCATGACGGTGCAGAACGCCTACCGCTGCACACCTTTACTGAAAACGCCTATCTGAACTATTCCAT
GTACGTCATCATGGATCGGGCGTTGCCGTTTATCGGCGATGGTTTAAAGCCGGTACAGCGTCGCATTGTCTACGCGATGT
CCGAACTGGGGTTGAATAACAGCGCTAAATTCAAAAAATCAGCCCGTACCGTGGGTGACGTGCTGGGTAAATATCATCCG
CACGGCGACAGTGCTTGCTATGAAGCGATGGTATTGATGGCACAGCCTTTTTCTTATCGCTACCCACTGGTTGATGGGCA
GGGGAACTGGGGTGCACCGGATGATCCTAAATCCTTTGCGGCGATGCGTTATACCGAATCTCGTTTATCCAAATATGCGG
AAGTGTTATTGGGTGAGCTGGCCCAAGGCACGGTAGATTGGGTGCCAAACTTTGATGGCACCATGCAGGAGCCGAAAATG
CTCCCTGCGCGCCTGCCAAATATCTTGCTGAACGGTACAACCGGTATTGCTGTGGGCATGGCGACGGATATCCCGCCACA
CAACGTGCGCGAAATTGCGCAGGCAGTGCTGGCGCTGATCGATAAACCCACGACGTCGCTCGACGAGTTGCTGGAGTTTG
TACAAGGGCCGGATTTCCCGACTGAAGCAGAAATTATCACTCCGCGTGATGATATTCGCAAAATTTACCAGAATGGTCGT
GGCTCCGTCCGTATGAGGGCGGTGTGGAAAAAAGAAGATGGCAGCGCCGTGATCACGGCGTTACCACATCAGGTTTCCGG
CGCGAAAGTACTGGAACAGATTGCCAACCAGATGCGCGCTAAGAAATTGCCTATGGTTGAAGATTTACGTGATGAATCTG
ACCATGAGAACCCTACTCGCCTGGTAATTGTTCCGCGCACCAATCGGGTCGATCTGGATCAAGTGATGAGCCACCTGTTC
GCCACGACTGATTTGGAAAGAAGTTATCGCATCAATATGAATATGATCGGTTTGGATAACCGCCCATCAGTCAAAGGGTT
GTTAGAGATCCTGACTGAGTGGTTGGTCTTCCGCCGCCAAACTGTGCGCAATCGCCTGAATTTCCGCTTGGAAAAGGTAT
TGAAGCGCCTGCATATTTTAGAAGGTTTATTAATTGCCTTCCTGAATATTGATGAAGTTATTCATATCATCCGCACCGAA
GATGATCCTAAACCGCTACTGATGCAGCGTTTTTCCATTTCGGAAACGCAGGCTGAGGCGATCCTCGAACTGAAACTCCG
CCACTTAGCCAAGCTGGAAGAGGTGAAAATCCGGGGTGAGCAGGATGAGTTAGCGAAAGAACGCGATCAGCTACAGGCAC
TGCTGGCGTCTGAACGTAAACTTAACACCCTGATCAAGAAAGAAATTCAAGCCGATGCTGCTGCTTATGGTGATGACCGC
CGTTCACCGCTAACTGAACGTGGTGAAGCCAAAGCCATGAGCGAGCATGATATTGTGCCTTCTGAACCGGTAACCATTGT
GTTGTCTGAAATGGGCTGGGTTCGTAGTGCGAAAGGCCATGATATCGATCCAAGCGGATTAAGCTATAAAGCGGGTGACA
GCTTCCGTGCCGCCGCGCGGGGCATGAGCAATCAACCGGTGGTATTTATCGACTCAACGGGGCGCAGTTACGCATTAGAT
CCGCTCACGCTGCCTTCTGCCCGTGGCCAAGGGGAGCCGCTGACCGGCAAACTGACGCCACCGCCGGGGGCGACCATTGA
ACATGTCTTAATGGCACCGGATTCGCAGAAATTACTGATGGCATCAGATGCAGGTTATGGCTTTGTCTGTACTTTTAATG
ATTTGGTCGCCAAGAACCGCGCTGGCAAGACGATGATCACATTGCCAGAAAATGCCAAAGTCTTGCCGCCACTGGAAATT
TATGGCCCGGATGACATGCTGCTATCCATCACTGCGGTTGGCCGGATGTTGATGTTCCCGGTTGCTGATCTCCCTGAGCT
TTCAAAAGGTAAAGGCAACAAAATTGTCTCTATCCCCGCAGCACAAGCGGCGGCAGGTGAAGATCGCTTAGCATGGCTGT
TTGTCCTGCCTCCGCAAACCTCGATTACCCTTCATTTTGGTAAACGTAAACTCACGCTACGGCCTGAAGATTTGCAAAAA
TTCCGTGCTGAGCGAGGTCGTAAAGGTTCGCCATTACCACGTGGTTTACAACGCATTGATCGGATTGATGTCGATGCACC
GCCACGGGCAATAGCCACCGAGAGCGAAGAGTAA

Upstream 100 bases:

>100_bases
TAGATGAGGTACTATCGCGGGCAGAAATTGACAATGAACTTGCGGTGCCGATCCGCTGACGCCAGTGATCGTCATTCCAG
AGTCTGAGGATAATTGAGTA

Downstream 100 bases:

>100_bases
AAATAAGGAAACCAGCCACCACCATGGCGGAAATGGCTGTGGTGGTGATTGAGGCGTTCGTCAAACATGACCCTGTTAAT
ATGGCATACGGCAGGTATAA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 757; Mature: 756

Protein sequence:

>757_residues
MSDLTHDGAERLPLHTFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNNSAKFKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAEVLLGELAQGTVDWVPNFDGTMQEPKM
LPARLPNILLNGTTGIAVGMATDIPPHNVREIAQAVLALIDKPTTSLDELLEFVQGPDFPTEAEIITPRDDIRKIYQNGR
GSVRMRAVWKKEDGSAVITALPHQVSGAKVLEQIANQMRAKKLPMVEDLRDESDHENPTRLVIVPRTNRVDLDQVMSHLF
ATTDLERSYRINMNMIGLDNRPSVKGLLEILTEWLVFRRQTVRNRLNFRLEKVLKRLHILEGLLIAFLNIDEVIHIIRTE
DDPKPLLMQRFSISETQAEAILELKLRHLAKLEEVKIRGEQDELAKERDQLQALLASERKLNTLIKKEIQADAAAYGDDR
RSPLTERGEAKAMSEHDIVPSEPVTIVLSEMGWVRSAKGHDIDPSGLSYKAGDSFRAAARGMSNQPVVFIDSTGRSYALD
PLTLPSARGQGEPLTGKLTPPPGATIEHVLMAPDSQKLLMASDAGYGFVCTFNDLVAKNRAGKTMITLPENAKVLPPLEI
YGPDDMLLSITAVGRMLMFPVADLPELSKGKGNKIVSIPAAQAAAGEDRLAWLFVLPPQTSITLHFGKRKLTLRPEDLQK
FRAERGRKGSPLPRGLQRIDRIDVDAPPRAIATESEE

Sequences:

>Translated_757_residues
MSDLTHDGAERLPLHTFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNNSAKFKKSARTVGDVLGKYHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAEVLLGELAQGTVDWVPNFDGTMQEPKM
LPARLPNILLNGTTGIAVGMATDIPPHNVREIAQAVLALIDKPTTSLDELLEFVQGPDFPTEAEIITPRDDIRKIYQNGR
GSVRMRAVWKKEDGSAVITALPHQVSGAKVLEQIANQMRAKKLPMVEDLRDESDHENPTRLVIVPRTNRVDLDQVMSHLF
ATTDLERSYRINMNMIGLDNRPSVKGLLEILTEWLVFRRQTVRNRLNFRLEKVLKRLHILEGLLIAFLNIDEVIHIIRTE
DDPKPLLMQRFSISETQAEAILELKLRHLAKLEEVKIRGEQDELAKERDQLQALLASERKLNTLIKKEIQADAAAYGDDR
RSPLTERGEAKAMSEHDIVPSEPVTIVLSEMGWVRSAKGHDIDPSGLSYKAGDSFRAAARGMSNQPVVFIDSTGRSYALD
PLTLPSARGQGEPLTGKLTPPPGATIEHVLMAPDSQKLLMASDAGYGFVCTFNDLVAKNRAGKTMITLPENAKVLPPLEI
YGPDDMLLSITAVGRMLMFPVADLPELSKGKGNKIVSIPAAQAAAGEDRLAWLFVLPPQTSITLHFGKRKLTLRPEDLQK
FRAERGRKGSPLPRGLQRIDRIDVDAPPRAIATESEE
>Mature_756_residues
SDLTHDGAERLPLHTFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNNSAKFKKSARTVGDVLGKYHPH
GDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKYAEVLLGELAQGTVDWVPNFDGTMQEPKML
PARLPNILLNGTTGIAVGMATDIPPHNVREIAQAVLALIDKPTTSLDELLEFVQGPDFPTEAEIITPRDDIRKIYQNGRG
SVRMRAVWKKEDGSAVITALPHQVSGAKVLEQIANQMRAKKLPMVEDLRDESDHENPTRLVIVPRTNRVDLDQVMSHLFA
TTDLERSYRINMNMIGLDNRPSVKGLLEILTEWLVFRRQTVRNRLNFRLEKVLKRLHILEGLLIAFLNIDEVIHIIRTED
DPKPLLMQRFSISETQAEAILELKLRHLAKLEEVKIRGEQDELAKERDQLQALLASERKLNTLIKKEIQADAAAYGDDRR
SPLTERGEAKAMSEHDIVPSEPVTIVLSEMGWVRSAKGHDIDPSGLSYKAGDSFRAAARGMSNQPVVFIDSTGRSYALDP
LTLPSARGQGEPLTGKLTPPPGATIEHVLMAPDSQKLLMASDAGYGFVCTFNDLVAKNRAGKTMITLPENAKVLPPLEIY
GPDDMLLSITAVGRMLMFPVADLPELSKGKGNKIVSIPAAQAAAGEDRLAWLFVLPPQTSITLHFGKRKLTLRPEDLQKF
RAERGRKGSPLPRGLQRIDRIDVDAPPRAIATESEE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=192, Percent_Identity=27.6041666666667, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1789396, Length=751, Percent_Identity=82.2902796271638, Blast_Score=1300, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=750, Percent_Identity=34.8, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI212645845, Length=402, Percent_Identity=26.1194029850746, Blast_Score=75, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=358, Percent_Identity=24.0223463687151, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84240; Mature: 84109

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLTHDGAERLPLHTFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNN
CCCCCCCCHHCCCCEEECCCCEEEEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCCC
SAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHH
AMRYTESRLSKYAEVLLGELAQGTVDWVPNFDGTMQEPKMLPARLPNILLNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEE
ATDIPPHNVREIAQAVLALIDKPTTSLDELLEFVQGPDFPTEAEIITPRDDIRKIYQNGR
ECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCCC
GSVRMRAVWKKEDGSAVITALPHQVSGAKVLEQIANQMRAKKLPMVEDLRDESDHENPTR
CCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCE
LVIVPRTNRVDLDQVMSHLFATTDLERSYRINMNMIGLDNRPSVKGLLEILTEWLVFRRQ
EEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TVRNRLNFRLEKVLKRLHILEGLLIAFLNIDEVIHIIRTEDDPKPLLMQRFSISETQAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHH
ILELKLRHLAKLEEVKIRGEQDELAKERDQLQALLASERKLNTLIKKEIQADAAAYGDDR
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RSPLTERGEAKAMSEHDIVPSEPVTIVLSEMGWVRSAKGHDIDPSGLSYKAGDSFRAAAR
CCCCCCCCCHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHC
GMSNQPVVFIDSTGRSYALDPLTLPSARGQGEPLTGKLTPPPGATIEHVLMAPDSQKLLM
CCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCEEE
ASDAGYGFVCTFNDLVAKNRAGKTMITLPENAKVLPPLEIYGPDDMLLSITAVGRMLMFP
EECCCCEEEEEHHHHHHCCCCCCEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHC
VADLPELSKGKGNKIVSIPAAQAAAGEDRLAWLFVLPPQTSITLHFGKRKLTLRPEDLQK
CCCCCCCCCCCCCEEEECCCHHHCCCCCCEEEEEEECCCCEEEEEECCEEEEECHHHHHH
FRAERGRKGSPLPRGLQRIDRIDVDAPPRAIATESEE
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SDLTHDGAERLPLHTFTENAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNN
CCCCCCCHHCCCCEEECCCCEEEEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHHCCCC
SAKFKKSARTVGDVLGKYHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHH
AMRYTESRLSKYAEVLLGELAQGTVDWVPNFDGTMQEPKMLPARLPNILLNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCEEEECCCCEEEEE
ATDIPPHNVREIAQAVLALIDKPTTSLDELLEFVQGPDFPTEAEIITPRDDIRKIYQNGR
ECCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCEEECCHHHHHHHHHCCC
GSVRMRAVWKKEDGSAVITALPHQVSGAKVLEQIANQMRAKKLPMVEDLRDESDHENPTR
CCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCCCCE
LVIVPRTNRVDLDQVMSHLFATTDLERSYRINMNMIGLDNRPSVKGLLEILTEWLVFRRQ
EEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHH
TVRNRLNFRLEKVLKRLHILEGLLIAFLNIDEVIHIIRTEDDPKPLLMQRFSISETQAEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCHHHHHHHCCCHHHHHH
ILELKLRHLAKLEEVKIRGEQDELAKERDQLQALLASERKLNTLIKKEIQADAAAYGDDR
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
RSPLTERGEAKAMSEHDIVPSEPVTIVLSEMGWVRSAKGHDIDPSGLSYKAGDSFRAAAR
CCCCCCCCCHHCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCHHHHHC
GMSNQPVVFIDSTGRSYALDPLTLPSARGQGEPLTGKLTPPPGATIEHVLMAPDSQKLLM
CCCCCCEEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEECCCCCCEEE
ASDAGYGFVCTFNDLVAKNRAGKTMITLPENAKVLPPLEIYGPDDMLLSITAVGRMLMFP
EECCCCEEEEEHHHHHHCCCCCCEEEECCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHC
VADLPELSKGKGNKIVSIPAAQAAAGEDRLAWLFVLPPQTSITLHFGKRKLTLRPEDLQK
CCCCCCCCCCCCCEEEECCCHHHCCCCCCEEEEEEECCCCEEEEEECCEEEEECHHHHHH
FRAERGRKGSPLPRGLQRIDRIDVDAPPRAIATESEE
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]