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The map label for this gene is nhaA [H]

Identifier: 218927667

GI number: 218927667

Start: 500743

End: 501927

Strand: Direct

Name: nhaA [H]

Synonym: YPO0470

Alternate gene names: 218927667

Gene position: 500743-501927 (Clockwise)

Preceding gene: 218927666

Following gene: 218927668

Centisome position: 10.76

GC content: 47.51

Gene sequence:

>1185_bases
GTGACAAATATCATTCGTCAATTTTTACGCCAAGAGGCCGCAGGTGGCCTGATTCTGATTATTGCTGCCGCTATCGCCTT
GTTGATGGCGAACAGCGCCCTACAAGGGGTTTATCAATCATTTCTTGATATACCAGTCTCGATAAAAATAGCTTCGCTGG
ATATCAGTAAACCGTTATTACTGTGGATTAACGATGGTCTAATGGCGGTGTTTTTCCTGATGATCGGGCTGGAAGTTAAA
CGTGAGTTGATGGAAGGCTCTTTGGCGGGCCGCGATAAAGCAGTTTTCCCCGCGATTGCGGCATTGGGGGGGATGTTAGC
CCCAGCGCTGATTTACTTACTGTTCAATGGTGCTGATGAGGTGACCCGCCAAGGGTGGGCGATCCCGGCAGCGACTGACA
TTGCGTTTGCCTTGGGAGTGATGGCGCTATTAGGTAACCGGGTACCCACCGGGCTGAAGGTCTTTTTACTGGCATTAGCC
ATTATCGATGACCTTGGTGTCATTATTATTATTGCGTTGTTCTATACCCAGCAGGTTTCATTACAATCTTTGGGTATTGC
TGCGGCTGCTATTGCTTTACTGGCGTATATGAACTGGCGTGGTGTAGGGAAAACATCAGCTTATCTGCTGGTCGGCTTGG
TTTTGTGGGTCTGTATTCTTAAATCGGGTGTACATGCGACTTTGGCTGGGGTGATTGTTGGCTTTATGATCCCGCTGCAT
ACCCAAGACCAACGCTCTCCTTCTGAATCGCTGGAGCATGGTTTACATCCGTGGGTTGCCTATTTAATTTTGCCATTGTT
TGCTTTTGCCAATGCGGGGGTCTCTTTACAAGGCGTTTCTCTTTCAGGGCTGACGTCACTACTGCCAATGGGGATTGCAA
CCGGTCTGTTTATCGGTAAACCGTTGGGAATTTTCACTTTTAGTTGGCTCGCGGTTAAGTTAGGTATTGCTAAACTACCC
GACGCAATAAATTTTAAGCAAATTTTTGCAGTTTCAGTGTTGTGTGGGATCGGCTTTACTATGTCGATATTTATCGCATC
ACTGGCATTTGAAGGCACAGATATCGCTCTGACGACCTATTCCAAACTAGGGATATTGCTAGGCTCTACCACAGCGGCTG
TTGTGGGTTACAGCTTACTGCGTTTGGTTTTACCCGCTCGGCGGAAGGCTGTTAACGTAAGGTAA

Upstream 100 bases:

>100_bases
GTGATAAAAATGAATTTTTTTCGATCTGATAATTATCTTAAAATTCGTGACTTGATTTGCCGAGCAACCGCTTTCTGTCC
GATGTAAGGAGTTATTCATT

Downstream 100 bases:

>100_bases
TGTACCATCACGTTATTGATTCAGCATTGCTGCCCAAGCGCAGGCAGCAATGCTTGGTGGAATTTAAAGATGGTTTGTCG
TGCATGAGGCCATGTATCTG

Product: pH-dependent sodium/proton antiporter

Products: Na (I) [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: Sodium/proton antiporter nhaA [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGVYQSFLDIPVSIKIASLDISKPLLLWINDGLMAVFFLMIGLEVK
RELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALA
IIDDLGVIIIIALFYTQQVSLQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLH
TQDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGKPLGIFTFSWLAVKLGIAKLP
DAINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTYSKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR

Sequences:

>Translated_394_residues
MTNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGVYQSFLDIPVSIKIASLDISKPLLLWINDGLMAVFFLMIGLEVK
RELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALA
IIDDLGVIIIIALFYTQQVSLQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLH
TQDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGKPLGIFTFSWLAVKLGIAKLP
DAINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTYSKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR
>Mature_393_residues
TNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGVYQSFLDIPVSIKIASLDISKPLLLWINDGLMAVFFLMIGLEVKR
ELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADEVTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALAI
IDDLGVIIIIALFYTQQVSLQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLHT
QDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGKPLGIFTFSWLAVKLGIAKLPD
AINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTYSKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR

Specific function: Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons [H]

COG id: COG3004

COG function: function code P; Na+/H+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nhaA Na(+)/H(+) (TC 2.A.33) antiporter family [H]

Homologues:

Organism=Escherichia coli, GI1786201, Length=381, Percent_Identity=65.8792650918635, Blast_Score=461, Evalue=1e-131,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023171
- InterPro:   IPR004670 [H]

Pfam domain/function: PF06965 Na_H_antiport_1 [H]

EC number: NA

Molecular weight: Translated: 41719; Mature: 41587

Theoretical pI: Translated: 9.69; Mature: 9.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGVYQSFLDIPVSIKIASLDISKPLL
CCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEE
LWINDGLMAVFFLMIGLEVKRELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADE
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
VTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALAIIDDLGVIIIIALFYTQQVS
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
TQDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGK
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCC
PLGIFTFSWLAVKLGIAKLPDAINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTY
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEH
SKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TNIIRQFLRQEAAGGLILIIAAAIALLMANSALQGVYQSFLDIPVSIKIASLDISKPLL
CHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEE
LWINDGLMAVFFLMIGLEVKRELMEGSLAGRDKAVFPAIAALGGMLAPALIYLLFNGADE
EEECCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHH
VTRQGWAIPAATDIAFALGVMALLGNRVPTGLKVFLLALAIIDDLGVIIIIALFYTQQVS
HHHCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQSLGIAAAAIALLAYMNWRGVGKTSAYLLVGLVLWVCILKSGVHATLAGVIVGFMIPLH
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCC
TQDQRSPSESLEHGLHPWVAYLILPLFAFANAGVSLQGVSLSGLTSLLPMGIATGLFIGK
CCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHCC
PLGIFTFSWLAVKLGIAKLPDAINFKQIFAVSVLCGIGFTMSIFIASLAFEGTDIALTTY
CHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEH
SKLGILLGSTTAAVVGYSLLRLVLPARRKAVNVR
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: Na (I) [Cytoplasm] + 2 Proton [Periplasm] = Na (I) [Periplasm] + 2 Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA