| Definition | Yersinia pestis CO92 chromosome, complete genome. |
|---|---|
| Accession | NC_003143 |
| Length | 4,653,728 |
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The map label for this gene is thrA [H]
Identifier: 218927656
GI number: 218927656
Start: 483395
End: 485854
Strand: Direct
Name: thrA [H]
Synonym: YPO0459
Alternate gene names: 218927656
Gene position: 483395-485854 (Clockwise)
Preceding gene: 218927654
Following gene: 218927657
Centisome position: 10.39
GC content: 49.88
Gene sequence:
>2460_bases ATGCGAGTGCTGAAATTTGGCGGGACATCAGTGGCAAATGCCGAGCGCTTTATGCGTGTTGCCGATATCATCGAAAGTAA TGCGCGTCAGGGACAAGTGGCTACGGTGTTATCCGCTCCCGCGAAGATAACGAACCATCTCGTTGCCATGATCGATAAAA TGGTCGCAGGGCAAGATATCTCCCCGAACATCAGCGATGCTGAGCGGATTTTTGCTGAGTTATTGCGTGGATTAGCTGAT ACTCAGCCAGGCTTTGATTATGATCGCCTAAAAGCCTTGGTCGGCCATGAGTTTGCGCAACTCAAACACCTGCTACACGG TATTTCGTTGTTGGGGCAGTGCCCAGACAGCATTAATGCCTCAATTATCTGCCGTGGCGAAAAACTCTCCATCGCCATTA TGGAGGCGTTATTTCAGGCTAAGGGTTATCACGTTACGGTGATTAATCCAGTCGAAAAATTGTTGGCGCAGGGCCATTAT CTCGAATCCACTGTTGATATCACGGAGTCTACCCGCCGTATCGGTGCCAGCGGTATTCCATCTGATCACATCATCCTGAT GGCTGGTTTTACTGCGGGTAATGATAAAGGTGAATTGGTGGTGTTGGGGCGTAATGGCTCTGATTATTCCGCTGCCGTGC TGGCTGCTTGCTTACGGGCAGATTGTTGTGAGATTTGGACCGATGTCGACGGGGTCTATACTTGTGACCCGCGTACCGTT CCAGATGCCAGATTACTGAAATCGATGTCATACCAAGAGGCAATGGAGCTTTCCTATTTTGGTGCTAAAGTTCTTCACCC TCGCACTATCGCTCCTATTGCCCGCTTCCAAATTCCTTGTCTGATAAAAAACACCTCTAACCCGCAAGCCCCCGGTACCT TGATTGGTGGTGAAAGCATTGATGAGGATTCTCCGGTCAAAGGCATTACCAACCTGAATAATATGGCGATGATTAATGTT TCAGGGCCAGGAATGAAAGGGATGGTCGGTATGGCTGCCCGCGTCTTTGCGGTGATGTCGCGCAGCGGTATTTCAGTGGT GCTAATCACTCAGTCCTCTTCTGAATACAGCATCAGTTTTTGTGTGCCGCAAGGTGAGTTATTGCGCGCCCGCCGAGCGC TGGAAGATGAGTTTTATCTGGAGTTGAAAGACGGTGTCTTGGATCCTCTGGATGTGATGGAACATCTGGCAATTATCTCT GTGGTCGGTGACGGTATGCGCACCCTGCGCGGTATTTCTGCCCGTTTCTTCTCGGCTCTGGCGCGCGCCAACATCAATAT TATTGCTATCGCTCAAGGCTCGTCTGAGCGCTCTATTTCTGTGGTTGTCAATAATGATGCGGTCACTACCGGGGTGCGAG TTTGCCACCAGATGCTGTTTAACACGGATCAAGTCATTGAGGTGTTTGTCATTGGCGTGGGTGGTGTGGGGGGCGCATTA ATCGAACAAATCTATCGCCAGCAACCGTGGTTGAAACAGCGTCATATTGATTTACGTGTTTGTGGTATCGCGAATTCCAA AGCCATGTTGACCAACGTGCATGGCATTGCATTAGATAACTGGCGTCAGGAACTGGCTGAAGTTCAGGAGCCGTTTAACC TGAGCCGCTTGATCCGTCTGGTTAAAGAGTATCACTTACTGAACCCGGTCATTGTTGACTGTACCTCAAGCCAGGCGGTT GCTGATCAATATGCTGATTTCCTGACCGATGGCTTCCATGTGGTGACGCCAAACAAGAAAGCCAACACTTCATCAATGAA TTATTACCGCCAAATGCGTGCCGCTGCGACGAAATCGTGCCGTAAATTCTTGTATGACACAAACGTTGGGGCGGGGCTAC CGGTGATCGAGAACTTACAGAACCTGCTCAATGCGGGTGATGAACTGATGCGCTTCACCGGTATTCTGTCCGGTTCACTT TCCTTCATCTTCGGTAAGCTAGATGAGGGGATGTCATTGTCAGAGGCAACACGGCAAGCTAAGGCGTTGGGGTATACCGA ACCCGATCCACGTGATGATCTCTCTGGGATGGATGTTGCCCGTAAATTGTTGATTTTGGCCCGTGAAGCAGGGTACAAAC TTGAGTTGGCTGATATCGAGGTTGAGTCCGTCTTACCAGCAAGCTTTGATGCTTCAGGTGATGTGGATACTTTCCTGGCG CGCCTGCCATCATTGGATGCTGAATTTACCCGCTTGGTAGCGAATGCTGCGGAGCAGGGCAAAGTGCTACGTTATGTCGG AGTGATTGAAGACGGGCGTTGTAAAGTGCGGATGGAGGCAGTTGACGGTAACGACCCGTTGTATAAAGTTAAGAATGGCG AGAATGCGTTGGCTTTCTATACCCGCTATTATCAGCCAATTCCGTTGGTGCTACGCGGTTATGGCGCAGGCAATGATGTG ACTGCCGCTGGGGTGTTTGCCGATCTTTTACGCACATTATCATGGAAGTTGGGAGTTTAA
Upstream 100 bases:
>100_bases GAAAAAAGCCCGCACCTAGACAGTGCGGGCTTTTTTTTTCAATCAAATCTTTGCAAAAAAAGTTTGCGATAAAAAGCGCG AAAGCGGGAGAGAATCAGAA
Downstream 100 bases:
>100_bases ATATGGTTAAAATCTATGCTCCGGCATCAATTGGCAATGTCAGCGTCGGCTTCGATGTATTAGGTGCGGCGGTCTCGCCA ATAGATGGCACATTGCTCGG
Product: bifunctional aspartokinase I/homoserine dehydrogenase I
Products: NA
Alternate protein names: Aspartokinase I/homoserine dehydrogenase I; AKI-HDI; Aspartokinase; Homoserine dehydrogenase [H]
Number of amino acids: Translated: 819; Mature: 819
Protein sequence:
>819_residues MRVLKFGGTSVANAERFMRVADIIESNARQGQVATVLSAPAKITNHLVAMIDKMVAGQDISPNISDAERIFAELLRGLAD TQPGFDYDRLKALVGHEFAQLKHLLHGISLLGQCPDSINASIICRGEKLSIAIMEALFQAKGYHVTVINPVEKLLAQGHY LESTVDITESTRRIGASGIPSDHIILMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIARFQIPCLIKNTSNPQAPGTLIGGESIDEDSPVKGITNLNNMAMINV SGPGMKGMVGMAARVFAVMSRSGISVVLITQSSSEYSISFCVPQGELLRARRALEDEFYLELKDGVLDPLDVMEHLAIIS VVGDGMRTLRGISARFFSALARANINIIAIAQGSSERSISVVVNNDAVTTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL IEQIYRQQPWLKQRHIDLRVCGIANSKAMLTNVHGIALDNWRQELAEVQEPFNLSRLIRLVKEYHLLNPVIVDCTSSQAV ADQYADFLTDGFHVVTPNKKANTSSMNYYRQMRAAATKSCRKFLYDTNVGAGLPVIENLQNLLNAGDELMRFTGILSGSL SFIFGKLDEGMSLSEATRQAKALGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPASFDASGDVDTFLA RLPSLDAEFTRLVANAAEQGKVLRYVGVIEDGRCKVRMEAVDGNDPLYKVKNGENALAFYTRYYQPIPLVLRGYGAGNDV TAAGVFADLLRTLSWKLGV
Sequences:
>Translated_819_residues MRVLKFGGTSVANAERFMRVADIIESNARQGQVATVLSAPAKITNHLVAMIDKMVAGQDISPNISDAERIFAELLRGLAD TQPGFDYDRLKALVGHEFAQLKHLLHGISLLGQCPDSINASIICRGEKLSIAIMEALFQAKGYHVTVINPVEKLLAQGHY LESTVDITESTRRIGASGIPSDHIILMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIARFQIPCLIKNTSNPQAPGTLIGGESIDEDSPVKGITNLNNMAMINV SGPGMKGMVGMAARVFAVMSRSGISVVLITQSSSEYSISFCVPQGELLRARRALEDEFYLELKDGVLDPLDVMEHLAIIS VVGDGMRTLRGISARFFSALARANINIIAIAQGSSERSISVVVNNDAVTTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL IEQIYRQQPWLKQRHIDLRVCGIANSKAMLTNVHGIALDNWRQELAEVQEPFNLSRLIRLVKEYHLLNPVIVDCTSSQAV ADQYADFLTDGFHVVTPNKKANTSSMNYYRQMRAAATKSCRKFLYDTNVGAGLPVIENLQNLLNAGDELMRFTGILSGSL SFIFGKLDEGMSLSEATRQAKALGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPASFDASGDVDTFLA RLPSLDAEFTRLVANAAEQGKVLRYVGVIEDGRCKVRMEAVDGNDPLYKVKNGENALAFYTRYYQPIPLVLRGYGAGNDV TAAGVFADLLRTLSWKLGV >Mature_819_residues MRVLKFGGTSVANAERFMRVADIIESNARQGQVATVLSAPAKITNHLVAMIDKMVAGQDISPNISDAERIFAELLRGLAD TQPGFDYDRLKALVGHEFAQLKHLLHGISLLGQCPDSINASIICRGEKLSIAIMEALFQAKGYHVTVINPVEKLLAQGHY LESTVDITESTRRIGASGIPSDHIILMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIARFQIPCLIKNTSNPQAPGTLIGGESIDEDSPVKGITNLNNMAMINV SGPGMKGMVGMAARVFAVMSRSGISVVLITQSSSEYSISFCVPQGELLRARRALEDEFYLELKDGVLDPLDVMEHLAIIS VVGDGMRTLRGISARFFSALARANINIIAIAQGSSERSISVVVNNDAVTTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL IEQIYRQQPWLKQRHIDLRVCGIANSKAMLTNVHGIALDNWRQELAEVQEPFNLSRLIRLVKEYHLLNPVIVDCTSSQAV ADQYADFLTDGFHVVTPNKKANTSSMNYYRQMRAAATKSCRKFLYDTNVGAGLPVIENLQNLLNAGDELMRFTGILSGSL SFIFGKLDEGMSLSEATRQAKALGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPASFDASGDVDTFLA RLPSLDAEFTRLVANAAEQGKVLRYVGVIEDGRCKVRMEAVDGNDPLYKVKNGENALAFYTRYYQPIPLVLRGYGAGNDV TAAGVFADLLRTLSWKLGV
Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]
COG id: COG0527
COG function: function code E; Aspartokinases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 2 ACT domains [H]
Homologues:
Organism=Escherichia coli, GI1786183, Length=820, Percent_Identity=81.9512195121951, Blast_Score=1373, Evalue=0.0, Organism=Escherichia coli, GI1790376, Length=821, Percent_Identity=30.816077953715, Blast_Score=346, Evalue=4e-96, Organism=Escherichia coli, GI1790455, Length=479, Percent_Identity=27.7661795407098, Blast_Score=160, Evalue=2e-40, Organism=Saccharomyces cerevisiae, GI6322599, Length=338, Percent_Identity=33.7278106508876, Blast_Score=173, Evalue=8e-44, Organism=Saccharomyces cerevisiae, GI6320893, Length=497, Percent_Identity=27.364185110664, Blast_Score=168, Evalue=3e-42,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR001048 - InterPro: IPR005106 - InterPro: IPR001341 - InterPro: IPR018042 - InterPro: IPR011147 - InterPro: IPR001342 - InterPro: IPR019811 - InterPro: IPR016040 [H]
Pfam domain/function: PF00696 AA_kinase; PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]
EC number: =2.7.2.4; =1.1.1.3 [H]
Molecular weight: Translated: 89112; Mature: 89112
Theoretical pI: Translated: 5.94; Mature: 5.94
Prosite motif: PS01042 HOMOSER_DHGENASE ; PS00324 ASPARTOKINASE
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.6 %Cys (Translated Protein) 2.9 %Met (Translated Protein) 4.5 %Cys+Met (Translated Protein) 1.6 %Cys (Mature Protein) 2.9 %Met (Mature Protein) 4.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRVLKFGGTSVANAERFMRVADIIESNARQGQVATVLSAPAKITNHLVAMIDKMVAGQDI CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCHHHHHHHHHHHHHHHCCCCC SPNISDAERIFAELLRGLADTQPGFDYDRLKALVGHEFAQLKHLLHGISLLGQCPDSINA CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC SIICRGEKLSIAIMEALFQAKGYHVTVINPVEKLLAQGHYLESTVDITESTRRIGASGIP EEEEECCCHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC SDHIILMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV CCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIARFQIPCLIKNTSNPQAPGTLIGGESI CHHHHHHHCCHHHHHHHHHHCHHHCCCCHHCCHHHEECCEEEECCCCCCCCCEEECCCCC DEDSPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRSGISVVLITQSSSEYSISF CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEE CVPQGELLRARRALEDEFYLELKDGVLDPLDVMEHLAIISVVGDGMRTLRGISARFFSAL ECCCHHHHHHHHHCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ARANINIIAIAQGSSERSISVVVNNDAVTTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL HHCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCHHHEEEEEEEECCCCCHHH IEQIYRQQPWLKQRHIDLRVCGIANSKAMLTNVHGIALDNWRQELAEVQEPFNLSRLIRL HHHHHHCCCCHHHCCCCEEEEECCCCCEEEEECCCEEHHHHHHHHHHHHCCCCHHHHHHH VKEYHLLNPVIVDCTSSQAVADQYADFLTDGFHVVTPNKKANTSSMNYYRQMRAAATKSC HHHHHHCCCEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH RKFLYDTNVGAGLPVIENLQNLLNAGDELMRFTGILSGSLSFIFGKLDEGMSLSEATRQA HHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHH KALGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPASFDASGDVDTFLA HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECEEHHHCCCCCCCCCCCHHHHHH RLPSLDAEFTRLVANAAEQGKVLRYVGVIEDGRCKVRMEAVDGNDPLYKVKNGENALAFY HCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEEEECCCCCEEEECCCCCEEEEH TRYYQPIPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV HHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC >Mature Secondary Structure MRVLKFGGTSVANAERFMRVADIIESNARQGQVATVLSAPAKITNHLVAMIDKMVAGQDI CEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCEEHHHHCCHHHHHHHHHHHHHHHCCCCC SPNISDAERIFAELLRGLADTQPGFDYDRLKALVGHEFAQLKHLLHGISLLGQCPDSINA CCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC SIICRGEKLSIAIMEALFQAKGYHVTVINPVEKLLAQGHYLESTVDITESTRRIGASGIP EEEEECCCHHHHHHHHHHHCCCCEEEEECHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC SDHIILMAGFTAGNDKGELVVLGRNGSDYSAAVLAACLRADCCEIWTDVDGVYTCDPRTV CCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCC PDARLLKSMSYQEAMELSYFGAKVLHPRTIAPIARFQIPCLIKNTSNPQAPGTLIGGESI CHHHHHHHCCHHHHHHHHHHCHHHCCCCHHCCHHHEECCEEEECCCCCCCCCEEECCCCC DEDSPVKGITNLNNMAMINVSGPGMKGMVGMAARVFAVMSRSGISVVLITQSSSEYSISF CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEE CVPQGELLRARRALEDEFYLELKDGVLDPLDVMEHLAIISVVGDGMRTLRGISARFFSAL ECCCHHHHHHHHHCCHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ARANINIIAIAQGSSERSISVVVNNDAVTTGVRVCHQMLFNTDQVIEVFVIGVGGVGGAL HHCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHHHHCHHHEEEEEEEECCCCCHHH IEQIYRQQPWLKQRHIDLRVCGIANSKAMLTNVHGIALDNWRQELAEVQEPFNLSRLIRL HHHHHHCCCCHHHCCCCEEEEECCCCCEEEEECCCEEHHHHHHHHHHHHCCCCHHHHHHH VKEYHLLNPVIVDCTSSQAVADQYADFLTDGFHVVTPNKKANTSSMNYYRQMRAAATKSC HHHHHHCCCEEEECCCCHHHHHHHHHHHHCCEEEECCCCCCCCHHHHHHHHHHHHHHHHH RKFLYDTNVGAGLPVIENLQNLLNAGDELMRFTGILSGSLSFIFGKLDEGMSLSEATRQA HHHHHCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHH KALGYTEPDPRDDLSGMDVARKLLILAREAGYKLELADIEVESVLPASFDASGDVDTFLA HHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECEEHHHCCCCCCCCCCCHHHHHH RLPSLDAEFTRLVANAAEQGKVLRYVGVIEDGRCKVRMEAVDGNDPLYKVKNGENALAFY HCCCCCHHHHHHHHHHHHCCCEEEEEEEEECCCEEEEEEEECCCCCEEEECCCCCEEEEH TRYYQPIPLVLRGYGAGNDVTAAGVFADLLRTLSWKLGV HHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8423151 [H]