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The map label for this gene is tyrB [H]

Identifier: 218927527

GI number: 218927527

Start: 329265

End: 330458

Strand: Direct

Name: tyrB [H]

Synonym: YPO0322

Alternate gene names: 218927527

Gene position: 329265-330458 (Clockwise)

Preceding gene: 218927526

Following gene: 218927528

Centisome position: 7.08

GC content: 50.5

Gene sequence:

>1194_bases
GTGTTCCAGAATGTTGACGCCTACGCAGGTGACCCCATCCTTTCACTGATGGAAAGTTTTAAAGCCGATAACCGGGCACA
TAAGGTGAATCTGAGTATTGGGCTTTATTACAATGAACAAGGTGAAATCCCGCAAATGCAGGCTGTGGATGCTGCCGAAG
CGCAATTGAGTACTCAACCTCATGGGACACCGGTTTATTTACCGATGGAAGGTCTGCAATCTTACCGTACTGCTATCCAG
CAATTATTATTTGGTCACGACCATCCAATGCTGGTTCAGCAACGGGTGGCGACAATACAGACGGTGGGCGGTTCTGGTGC
GTTGAAAGTCGGGGCTGATTTCCTTAATCACTATTTCCCTGATTCACAGGTGTGGGTCAGCGATCCTACCTGGGAAAACC
ACGTGGCTATTTTTAGCGGCGCAGGTTTTAAAGTGAACACCTATCCGTATTTCGACAATGATAAGCTGGCGGTGAAGTTT
GACCCGATGCTGGCAACCTTGCAGCAATTGCCCGCCAGAAGCATCGTGTTGTTACATCCTTGCTGCCACAATCCAACCGG
TTCTGATCTGACCAATGCCCAATGGGATCGCCTCATTGATGTGGTAAAAGAGCGTGAACTGATCCCGTTCCTGGATATAG
CGTACCAAGGCTTTGGGGCAGGGCTGAATGAAGATGCTTATGCTATCCGCGCTATGGCCGCAGTTGGATTGCCATGCCTC
ATCAGCAACTCCTTCTCAAAAATCTTCTCGCTCTATAACGAGCGGGTCGGTGGTTTATCTGTGGTGTGTGAAAGTGACGA
GGCCGCAGGGCGTGTATTGGGCCAATTGAAAGCGACAGTGCGCCGTAACTATTCCAGCCCGCCAAACTTTGGTGCGCAGG
TCGTTTCGAAAGTCCTAAATGATACGGTATTGCGCGCGCAATGGCAGGCAGAGGTGGAACAGATGCGCCTACGGATCCTT
GATATGCGCCACACGCTGGTGGAAGCCTTAAAAGCCTCGTTACCAGAGCGCAATTTTGATTATCTGTTGCAACAACGCGG
CATGTTCAGCTACACCGGCTTTAGTGAGGCACAGGTAGAGAGCTTACGTGAAGAGTTTGGTGTGTATCTGATTGCGAGCG
GAAGAATGTGTATGGCGGGAGTCAATCACCAGAATGTTGAGCAGGTTGCGGTCGCTTTTGCGGCGGTACAGTAA

Upstream 100 bases:

>100_bases
CTTACTCATGTAAGCCCTAGGAGGGCCGCTCCGTTGCCGCCTTTCTGCAATTCGGATGATTGCAGGTATAGAATTATTAT
CAATTTAGGAGAGCAGCACC

Downstream 100 bases:

>100_bases
TGTTCAGCCTTTAACCACGAGCAAACGGGTGGCCACAATAAAATAAGCAGGCAGTAAAATATTGATATCGCCCATGGAAG
GGCCGCTATATTTTTACGGC

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: ARAT; AROAT [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQPHGTPVYLPMEGLQSYRTAIQ
QLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYFPDSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKF
DPMLATLQQLPARSIVLLHPCCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAVGLPCL
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLNDTVLRAQWQAEVEQMRLRIL
DMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVESLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ

Sequences:

>Translated_397_residues
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQPHGTPVYLPMEGLQSYRTAIQ
QLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYFPDSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKF
DPMLATLQQLPARSIVLLHPCCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAVGLPCL
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLNDTVLRAQWQAEVEQMRLRIL
DMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVESLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ
>Mature_397_residues
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQPHGTPVYLPMEGLQSYRTAIQ
QLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYFPDSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKF
DPMLATLQQLPARSIVLLHPCCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAVGLPCL
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLNDTVLRAQWQAEVEQMRLRIL
DMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVESLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=388, Percent_Identity=39.1752577319588, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI4504067, Length=387, Percent_Identity=39.7932816537468, Blast_Score=289, Evalue=3e-78,
Organism=Homo sapiens, GI117414139, Length=378, Percent_Identity=28.042328042328, Blast_Score=175, Evalue=8e-44,
Organism=Escherichia coli, GI1790488, Length=396, Percent_Identity=75.7575757575758, Blast_Score=634, Evalue=0.0,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=42.6767676767677, Blast_Score=346, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI71981858, Length=396, Percent_Identity=37.3737373737374, Blast_Score=298, Evalue=5e-81,
Organism=Caenorhabditis elegans, GI25147133, Length=387, Percent_Identity=38.7596899224806, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17569539, Length=368, Percent_Identity=39.1304347826087, Blast_Score=275, Evalue=3e-74,
Organism=Caenorhabditis elegans, GI17569537, Length=391, Percent_Identity=30.690537084399, Blast_Score=194, Evalue=7e-50,
Organism=Caenorhabditis elegans, GI17550384, Length=264, Percent_Identity=35.6060606060606, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI25147136, Length=212, Percent_Identity=35.377358490566, Blast_Score=147, Evalue=7e-36,
Organism=Saccharomyces cerevisiae, GI6323055, Length=405, Percent_Identity=36.5432098765432, Blast_Score=279, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6322743, Length=424, Percent_Identity=33.9622641509434, Blast_Score=233, Evalue=5e-62,
Organism=Drosophila melanogaster, GI19922362, Length=385, Percent_Identity=40.2597402597403, Blast_Score=302, Evalue=2e-82,
Organism=Drosophila melanogaster, GI24654046, Length=385, Percent_Identity=40.2597402597403, Blast_Score=302, Evalue=3e-82,
Organism=Drosophila melanogaster, GI24580972, Length=397, Percent_Identity=37.7833753148615, Blast_Score=288, Evalue=6e-78,
Organism=Drosophila melanogaster, GI19920542, Length=388, Percent_Identity=38.1443298969072, Blast_Score=287, Evalue=7e-78,
Organism=Drosophila melanogaster, GI24580970, Length=397, Percent_Identity=37.7833753148615, Blast_Score=287, Evalue=7e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.57 [H]

Molecular weight: Translated: 44033; Mature: 44033

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQP
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHCCHHHHHHCCCC
HGTPVYLPMEGLQSYRTAIQQLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYFP
CCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
DSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKFDPMLATLQQLPARSIVLLHP
CCCEEECCCCCCCCEEEEECCCEEEECCCEECCCEEEEEECHHHHHHHHCCCCCEEEEEC
CCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAVGLPCL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHH
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLN
HHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
DTVLRAQWQAEVEQMRLRILDMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
SLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ
HHHHHCCEEEEECCCEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MFQNVDAYAGDPILSLMESFKADNRAHKVNLSIGLYYNEQGEIPQMQAVDAAEAQLSTQP
CCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHCCHHHHHHCCCC
HGTPVYLPMEGLQSYRTAIQQLLFGHDHPMLVQQRVATIQTVGGSGALKVGADFLNHYFP
CCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCC
DSQVWVSDPTWENHVAIFSGAGFKVNTYPYFDNDKLAVKFDPMLATLQQLPARSIVLLHP
CCCEEECCCCCCCCEEEEECCCEEEECCCEECCCEEEEEECHHHHHHHHCCCCCEEEEEC
CCHNPTGSDLTNAQWDRLIDVVKERELIPFLDIAYQGFGAGLNEDAYAIRAMAAVGLPCL
CCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHH
ISNSFSKIFSLYNERVGGLSVVCESDEAAGRVLGQLKATVRRNYSSPPNFGAQVVSKVLN
HHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
DTVLRAQWQAEVEQMRLRILDMRHTLVEALKASLPERNFDYLLQQRGMFSYTGFSEAQVE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEECCCCHHHHH
SLREEFGVYLIASGRMCMAGVNHQNVEQVAVAFAAVQ
HHHHHCCEEEEECCCEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3521591; 3907634; 8265357; 9278503; 3308851; 10417420 [H]