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The map label for this gene is alr

Identifier: 218927526

GI number: 218927526

Start: 328000

End: 329079

Strand: Direct

Name: alr

Synonym: YPO0321

Alternate gene names: 218927526

Gene position: 328000-329079 (Clockwise)

Preceding gene: 218927525

Following gene: 218927527

Centisome position: 7.05

GC content: 54.63

Gene sequence:

>1080_bases
ATGAAAGCGGCAACAGCAGTCATCGACCGCCATGCTCTGCGACATAACTTACAACAAATTCGGCGTCTGGCACCGCAAAG
CCGGTTGGTGGCTGTTGTGAAAGCAAATGCTTATGGCCACGGGTTATTAGCCGCAGCACACACATTACAGGATGCTGATT
GTTATGGCGTGGCCCGTATTAGCGAGGCGCTGATGTTGCGAGCGGGTGGAATAGTTAAACCTATTTTGCTGCTGGAAGGG
TTCTTTGATGCAGAAGACCTGCCGGTATTGGTGGCTAACCACATTGAAACCGCCGTTCACAGCCTGGAACAGCTCGTGGC
ATTGGAAGCGGCTACGCTTTCTGCGCCGATTAATGTCTGGATGAAATTGGATACAGGGATGCACCGCCTGGGGGTTCGCC
CAGATCAGGCCGAAGCGTTTTATCAGCGTTTGAGCGCATGCCGTAACGTCATCCAGCCGGTCAATATCATGAGTCACTTT
AGCCGTGCCGATGAACCTGAAGTGGCGGCCACGCAACAGCAACTGGCGTGTTTTGATGCGTTTGCTGCAGGTAAACCTGG
GAAACAATCTATCGCTGCTTCGGGCGGTATTCTGCGGTGGCCACAAGCGCACCGTGATTGGGTGCGCCCAGGGATTGTGC
TGTATGGGGTTTCGCCGTTTGATGCGCCCTATGGCCGTGATTTCGGTTTATTGCCCGCCATGACCCTGAAATCCAGTCTG
ATCGCGGTGCGTGAACATAAAGCCGGTGAATCGGTCGGGTATGGCGGCACCTGGGTCAGTGAGCGCGATACGCGTTTAGG
TGTGATCGCGATAGGCTATGGTGATGGCTACCCACGTAGCGCCCCGTCAGGGACACCGGTATGGCTTAATGGCCGTGAAG
TGAGCATCGTTGGCCGGGTATCGATGGACATGATCTCCATTGATCTTGGCCCGGAAAGTACAGATAAGGTGGGCGATGAA
GCCCTGATGTGGGGAGCCGAATTACCGGTTGAACGCGTGGCTGCCTGCACCGGTATCAGCGCGTATGAATTGATCACTAA
TCTGACCTCCCGCGTAGCGATGGAATATCTAGGGGAATAA

Upstream 100 bases:

>100_bases
GTAGTGAATAGCCTCTTGGTATTTGATACTGCCGAGGTGAGCACGGACTACCTGCAACGCCAATCATGTTGGGAATAATA
TCAATTATTAAGGATAAGCA

Downstream 100 bases:

>100_bases
GGTAAGCTGCAAGAGCGACCCATTTCCATATACCCGCCATATTTCAAATTGCAGGCGTGCTGGCTGTCTGCGTCCCCCTT
GGTCACTTACTCATGTAAGC

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MKAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARISEALMLRAGGIVKPILLLEG
FFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINVWMKLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHF
SRADEPEVAATQQQLACFDAFAAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPFDAPYGRDFGLLPAMTLKSSL
IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRVSMDMISIDLGPESTDKVGDE
ALMWGAELPVERVAACTGISAYELITNLTSRVAMEYLGE

Sequences:

>Translated_359_residues
MKAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARISEALMLRAGGIVKPILLLEG
FFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINVWMKLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHF
SRADEPEVAATQQQLACFDAFAAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPFDAPYGRDFGLLPAMTLKSSL
IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRVSMDMISIDLGPESTDKVGDE
ALMWGAELPVERVAACTGISAYELITNLTSRVAMEYLGE
>Mature_359_residues
MKAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARISEALMLRAGGIVKPILLLEG
FFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINVWMKLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHF
SRADEPEVAATQQQLACFDAFAAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPFDAPYGRDFGLLPAMTLKSSL
IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRVSMDMISIDLGPESTDKVGDE
ALMWGAELPVERVAACTGISAYELITNLTSRVAMEYLGE

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1790487, Length=358, Percent_Identity=72.0670391061452, Blast_Score=541, Evalue=1e-155,
Organism=Escherichia coli, GI1787439, Length=350, Percent_Identity=42.5714285714286, Blast_Score=275, Evalue=4e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR1_YERPE (Q8ZJ10)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AC0040
- RefSeq:   NP_667915.1
- RefSeq:   NP_991869.1
- RefSeq:   YP_002345401.1
- ProteinModelPortal:   Q8ZJ10
- SMR:   Q8ZJ10
- IntAct:   Q8ZJ10
- GeneID:   1145525
- GeneID:   1173165
- GeneID:   2766961
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO0321
- KEGG:   ypk:y0578
- KEGG:   ypm:YP_0476
- HOGENOM:   HBG712172
- OMA:   TRKEDAN
- ProtClustDB:   PRK00053
- BioCyc:   YPES187410:Y0578-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 38732; Mature: 38732

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 34-34 ACT_SITE 254-254

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARI
CCHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
SEALMLRAGGIVKPILLLEGFFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINVW
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
MKLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHFSRADEPEVAATQQQLACFDA
EEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FAAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPFDAPYGRDFGLLPAMTLKSSL
HHCCCCCCHHHHCCCCEEECCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRV
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCEEEEEEEE
SMDMISIDLGPESTDKVGDEALMWGAELPVERVAACTGISAYELITNLTSRVAMEYLGE
EEEEEEEECCCCCCHHCCCHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKAATAVIDRHALRHNLQQIRRLAPQSRLVAVVKANAYGHGLLAAAHTLQDADCYGVARI
CCHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEEECCCCCHHHHHHHHHCCCCHHHHHHH
SEALMLRAGGIVKPILLLEGFFDAEDLPVLVANHIETAVHSLEQLVALEAATLSAPINVW
HHHHHHHCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEE
MKLDTGMHRLGVRPDQAEAFYQRLSACRNVIQPVNIMSHFSRADEPEVAATQQQLACFDA
EEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
FAAGKPGKQSIAASGGILRWPQAHRDWVRPGIVLYGVSPFDAPYGRDFGLLPAMTLKSSL
HHCCCCCCHHHHCCCCEEECCHHHHHHCCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHH
IAVREHKAGESVGYGGTWVSERDTRLGVIAIGYGDGYPRSAPSGTPVWLNGREVSIVGRV
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCCCEEEECCCEEEEEEEE
SMDMISIDLGPESTDKVGDEALMWGAELPVERVAACTGISAYELITNLTSRVAMEYLGE
EEEEEEEECCCCCCHHCCCHHHHCCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430