Click here to switch to the map view.

The map label for this gene is pyrD

Identifier: 218905014

GI number: 218905014

Start: 3735583

End: 3736512

Strand: Reverse

Name: pyrD

Synonym: BCAH820_3898

Alternate gene names: 218905014

Gene position: 3736512-3735583 (Counterclockwise)

Preceding gene: 218905015

Following gene: 218905013

Centisome position: 70.46

GC content: 40.11

Gene sequence:

>930_bases
ATGAACAGATTGCAAGTTGAATTACCAGGATTGTCATTAAAAAATCCAATTATACCGGCATCTGGATGCTTTGGATTTGG
TCGTGAATATGCACAGTTTTACGATTTAAGTGTACTAGGATCAATCATGATTAAAGCGACGACAGAACAACCACGCTATG
GAAATCCTACGCCTCGTGTTGCTGAAACACCGGGCGGCATGTTAAATGCAATCGGACTTCAAAACCCAGGATTAGAAAAA
GTAATGAATTCTGAATTACCATGGTTAGAACAATTTGATCTTCCAATCATTGCGAACGTTGCAGGCTCACAAGCTGAAGA
TTACGTAGCGGTTGCAAAGGAAATTTCTAAAGCGCCTAATGTTCATGCACTAGAATTAAACATTTCTTGTCCAAACGTAA
AAACAGGTGGTATCGCCTTTGGTACAAATCCTGAAATTGCTGCTGATTTAACGAAGCGAGTAAAAGAGGTTTCTGAAGTA
CCTGTATACGTGAAATTGTCACCGAACGTGGCAAACATTGTGGAAATTGCAAAAGCGATTGAAAATGCAGGTGCAGATGG
TTTAACGATGATTAATACATTGCTTGGTATGCGTCTAGATTTAAAAACAGCTAAACCAATTTTAGCAAACCGTACAGGCG
GATTATCAGGTCCTGCAATTAAGCCAGTAGCAATTCGTATGGTACATGAAGTAAGCCAAGCGGTTAACATTCCAATTATC
GGAATGGGTGGTATTGAAACAGCGGAAGATGTAATTGAATTCTTCTACGCTGGTGCAAGCGCAGTTGCAGTAGGTACAGC
GAATTTTATCGATCCGTTCGTATGTCCGACAATTATTGAGGAGTTACCAGCATTACTAGATGAATTAGGATTTGATCACA
TTTCGGAATGTCAAGGAAGGAGCTGGAAGCAAACATGTCACAGTCGTTAA

Upstream 100 bases:

>100_bases
GTTTCGCATGTGTATGCCACTTACAAGAAGATCCAAGTGGACATTCTTACAAGAAGGTGTGTAGCGACGGACCAGTATTT
CCAATCGGGGAGGTTGTACT

Downstream 100 bases:

>100_bases
TCGTTGCACTAGATTTCCCAGGGAAACAAGATGTAGAACAATTCTTGCGCCACTTTGAAGGGGAAGAGTTATTTGTCAAA
GTTGGTATGGAGTTATTTTA

Product: dihydroorotate dehydrogenase 1B

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRVAETPGGMLNAIGLQNPGLEK
VMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPNVHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEV
PVYVKLSPNVANIVEIAKAIENAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPII
GMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGRSWKQTCHSR

Sequences:

>Translated_309_residues
MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRVAETPGGMLNAIGLQNPGLEK
VMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPNVHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEV
PVYVKLSPNVANIVEIAKAIENAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPII
GMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGRSWKQTCHSR
>Mature_309_residues
MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRVAETPGGMLNAIGLQNPGLEK
VMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPNVHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEV
PVYVKLSPNVANIVEIAKAIENAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPII
GMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGRSWKQTCHSR

Specific function: Unknown

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Homo sapiens, GI119943098, Length=344, Percent_Identity=30.2325581395349, Blast_Score=121, Evalue=8e-28,
Organism=Homo sapiens, GI45006951, Length=327, Percent_Identity=29.6636085626911, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI87082059, Length=317, Percent_Identity=28.7066246056782, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1787177, Length=295, Percent_Identity=27.7966101694915, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71984108, Length=210, Percent_Identity=34.2857142857143, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17509475, Length=327, Percent_Identity=28.4403669724771, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6322633, Length=305, Percent_Identity=27.5409836065574, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24640763, Length=222, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI18858217, Length=222, Percent_Identity=33.3333333333333, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI281361352, Length=324, Percent_Identity=29.320987654321, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17137316, Length=324, Percent_Identity=29.320987654321, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRD_BACAA (C3P654)

Other databases:

- EMBL:   CP001598
- RefSeq:   YP_002868120.1
- ProteinModelPortal:   C3P654
- SMR:   C3P654
- EnsemblBacteria:   EBBACT00000127844
- GeneID:   7848750
- GenomeReviews:   CP001598_GR
- KEGG:   bai:BAA_4046
- GeneTree:   EBGT00050000001544
- ProtClustDB:   PRK07259
- GO:   GO:0005737
- HAMAP:   MF_00224_B
- InterPro:   IPR013785
- InterPro:   IPR005720
- InterPro:   IPR012135
- InterPro:   IPR001295
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000164
- TIGRFAMs:   TIGR01037

Pfam domain/function: PF01180 DHO_dh

EC number: =1.3.3.1

Molecular weight: Translated: 32990; Mature: 32990

Theoretical pI: Translated: 4.79; Mature: 4.79

Prosite motif: PS00911 DHODEHASE_1; PS00912 DHODEHASE_2

Important sites: ACT_SITE 130-130

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRV
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC
AETPGGMLNAIGLQNPGLEKVMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPN
CCCCCCCEEECCCCCCCHHHHHCCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCC
VHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEVPVYVKLSPNVANIVEIAKAI
EEEEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
ENAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPII
HHCCCCHHHHHHHHHCCEECCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
GMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGR
ECCCCCHHHHHHHHHHCCCHHEEECCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
SWKQTCHSR
CHHHHHCCC
>Mature Secondary Structure
MNRLQVELPGLSLKNPIIPASGCFGFGREYAQFYDLSVLGSIMIKATTEQPRYGNPTPRV
CCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC
AETPGGMLNAIGLQNPGLEKVMNSELPWLEQFDLPIIANVAGSQAEDYVAVAKEISKAPN
CCCCCCCEEECCCCCCCHHHHHCCCCCCHHHCCCCEEEECCCCCHHHHHHHHHHHHCCCC
VHALELNISCPNVKTGGIAFGTNPEIAADLTKRVKEVSEVPVYVKLSPNVANIVEIAKAI
EEEEEEEEECCCCCCCCEEECCCCHHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHH
ENAGADGLTMINTLLGMRLDLKTAKPILANRTGGLSGPAIKPVAIRMVHEVSQAVNIPII
HHCCCCHHHHHHHHHCCEECCCCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCEE
GMGGIETAEDVIEFFYAGASAVAVGTANFIDPFVCPTIIEELPALLDELGFDHISECQGR
ECCCCCHHHHHHHHHHCCCHHEEECCHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHCCC
SWKQTCHSR
CHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA