BacMap

Definition	Desulfurococcus kamchatkensis 1221n chromosome, complete genome.
Accession	NC_011766
Length	1,365,223

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The map label for this gene is psmB1

Identifier: 218884589

GI number: 218884589

Start: 1199017

End: 1199625

Strand: Direct

Name: psmB1

Synonym: DKAM_1278

Alternate gene names: 218884589

Gene position: 1199017-1199625 (Clockwise)

Preceding gene: 218884588

Following gene: 218884595

Centisome position: 87.83

GC content: 47.29

Gene sequence:

>609_bases
ATGGGTGAAGTTGTTTTACCTGGCACAGCAATAGGGTTAAAAACCAGTGAGGGAGTAGTGTTAGCCAGCGAGAAAAGGCT
GACGTATGACGGATTCGTGCTAAGTAGGAACGCTAGGAAAATTCATATGATAACTAACCATATAGGAGTGGGCTTCGCCG
GGTTAATGGGCGATGTAAACTTCCTGGTTAAGGTTTTAAGGCTCGAGGCCAAGAACTACGAGCTTCAACATGGAAGGGAG
ATTAAAACCAGGAGCCTGGCGAAGCTTCTCTCAGTGATCCTTTACAGTTACAAGCTTGCACCCATGCTCACAGAGGTTGT
TGTAGGAGGATATGATGAGGAGGGACCCTCATTATATATCCTAGACCCTGTTGGAAGCGTGATAGAGGAGAAATACGTGG
CAGTGGGCTCGGGTGCTCAACTAGCACTAGGCTACATAGAGCCAAGATACAATCCAGGCCTCGGCCTCAAGGAGGCTGAG
GAGCTAGCGGTGAACGCTGTGAAAACGGTGATAGAGAGAGATGTACTATCTGGGGACGGGATAGATCTAGTAGTAATAGA
TAAGAACGGCTATCAGTCAAAGGAAATCATATTCAAGATGACGGGTTAG

Upstream 100 bases:

>100_bases
CATACCGAGGCGGTTGCGGGTTCTGACTAATTTATAATCCAGGTATCTCTTTAAGATATAGTTAGGTTTCAAATCAAGAG
AGCACATGGGAGTGAGCACA

Downstream 100 bases:

>100_bases
AAATTTTATTATTCCAACCAAGGTAAATACAAACCTGGATAAAGGGCCCGTCGCCTAGCCAGGATAGGGCGCCGGCCTGC
GGAGCCGGAGGCCCCGGGTT

Product: Proteasome subunit

Products: NA

Alternate protein names: 20S proteasome beta subunit 1; Proteasome core protein PsmB 1

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MGEVVLPGTAIGLKTSEGVVLASEKRLTYDGFVLSRNARKIHMITNHIGVGFAGLMGDVNFLVKVLRLEAKNYELQHGRE
IKTRSLAKLLSVILYSYKLAPMLTEVVVGGYDEEGPSLYILDPVGSVIEEKYVAVGSGAQLALGYIEPRYNPGLGLKEAE
ELAVNAVKTVIERDVLSGDGIDLVVIDKNGYQSKEIIFKMTG

Sequences:

>Translated_202_residues
MGEVVLPGTAIGLKTSEGVVLASEKRLTYDGFVLSRNARKIHMITNHIGVGFAGLMGDVNFLVKVLRLEAKNYELQHGRE
IKTRSLAKLLSVILYSYKLAPMLTEVVVGGYDEEGPSLYILDPVGSVIEEKYVAVGSGAQLALGYIEPRYNPGLGLKEAE
ELAVNAVKTVIERDVLSGDGIDLVVIDKNGYQSKEIIFKMTG
>Mature_201_residues
GEVVLPGTAIGLKTSEGVVLASEKRLTYDGFVLSRNARKIHMITNHIGVGFAGLMGDVNFLVKVLRLEAKNYELQHGREI
KTRSLAKLLSVILYSYKLAPMLTEVVVGGYDEEGPSLYILDPVGSVIEEKYVAVGSGAQLALGYIEPRYNPGLGLKEAEE
LAVNAVKTVIERDVLSGDGIDLVVIDKNGYQSKEIIFKMTG

Specific function: Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation

COG id: COG0638

COG function: function code O; 20S proteasome, alpha and beta subunits

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase T1B family

Homologues:

Organism=Homo sapiens, GI4506191, Length=201, Percent_Identity=32.3383084577114, Blast_Score=99, Evalue=3e-21,
Organism=Homo sapiens, GI4506201, Length=183, Percent_Identity=28.4153005464481, Blast_Score=93, Evalue=1e-19,
Organism=Homo sapiens, GI4506193, Length=207, Percent_Identity=28.0193236714976, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI4506203, Length=183, Percent_Identity=32.2404371584699, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI23110942, Length=192, Percent_Identity=29.6875, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI22538465, Length=196, Percent_Identity=25.5102040816327, Blast_Score=87, Evalue=7e-18,
Organism=Homo sapiens, GI73747875, Length=183, Percent_Identity=25.1366120218579, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI4758970, Length=183, Percent_Identity=25.1366120218579, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI4506181, Length=190, Percent_Identity=28.4210526315789, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI195539356, Length=139, Percent_Identity=30.2158273381295, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI153791216, Length=184, Percent_Identity=26.6304347826087, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI68303563, Length=198, Percent_Identity=24.7474747474747, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI156713442, Length=190, Percent_Identity=26.8421052631579, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI4506185, Length=190, Percent_Identity=26.8421052631579, Blast_Score=65, Evalue=3e-11,
Organism=Homo sapiens, GI23110925, Length=193, Percent_Identity=22.7979274611399, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17508493, Length=191, Percent_Identity=34.0314136125654, Blast_Score=98, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17535357, Length=195, Percent_Identity=27.1794871794872, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17541700, Length=185, Percent_Identity=27.5675675675676, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17508499, Length=169, Percent_Identity=27.2189349112426, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17554384, Length=190, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562790, Length=190, Percent_Identity=26.8421052631579, Blast_Score=74, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17508495, Length=182, Percent_Identity=25.8241758241758, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17508491, Length=160, Percent_Identity=29.375, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25143215, Length=194, Percent_Identity=26.2886597938144, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562788, Length=189, Percent_Identity=26.984126984127, Blast_Score=66, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17562792, Length=182, Percent_Identity=26.3736263736264, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321574, Length=199, Percent_Identity=28.643216080402, Blast_Score=84, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6325360, Length=184, Percent_Identity=26.0869565217391, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6323547, Length=188, Percent_Identity=31.3829787234043, Blast_Score=80, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319430, Length=202, Percent_Identity=26.2376237623762, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324731, Length=179, Percent_Identity=27.9329608938547, Blast_Score=76, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321692, Length=200, Percent_Identity=27, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324938, Length=158, Percent_Identity=33.5443037974684, Blast_Score=71, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320941, Length=185, Percent_Identity=26.4864864864865, Blast_Score=68, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6320849, Length=184, Percent_Identity=23.9130434782609, Blast_Score=62, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24664391, Length=178, Percent_Identity=29.7752808988764, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24639979, Length=184, Percent_Identity=30.9782608695652, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24654391, Length=196, Percent_Identity=29.0816326530612, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24654389, Length=196, Percent_Identity=29.0816326530612, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355573, Length=183, Percent_Identity=31.1475409836066, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24652553, Length=183, Percent_Identity=31.1475409836066, Blast_Score=87, Evalue=8e-18,
Organism=Drosophila melanogaster, GI17737927, Length=187, Percent_Identity=28.3422459893048, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI281360341, Length=186, Percent_Identity=28.494623655914, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586406, Length=186, Percent_Identity=28.494623655914, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586400, Length=186, Percent_Identity=28.494623655914, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24586402, Length=186, Percent_Identity=28.494623655914, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130281, Length=185, Percent_Identity=27.5675675675676, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24584895, Length=185, Percent_Identity=29.1891891891892, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI19921232, Length=203, Percent_Identity=30.0492610837438, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28573221, Length=179, Percent_Identity=26.2569832402235, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355629, Length=196, Percent_Identity=22.4489795918367, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17737605, Length=204, Percent_Identity=22.5490196078431, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI19922898, Length=184, Percent_Identity=28.2608695652174, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24652204, Length=140, Percent_Identity=34.2857142857143, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737405, Length=163, Percent_Identity=31.2883435582822, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24581176, Length=189, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PSB1_DESK1 (B8D673)

Other databases:

- EMBL:   CP001140
- RefSeq:   YP_002428971.1
- GeneID:   7171339
- GenomeReviews:   CP001140_GR
- KEGG:   dka:DKAM_1278
- HOGENOM:   HBG499923
- OMA:   EKRVSYG
- ProtClustDB:   CLSK2399615
- GO:   GO:0005737
- HAMAP:   MF_02113_A
- InterPro:   IPR019983
- InterPro:   IPR000243
- InterPro:   IPR001353
- PRINTS:   PR00141
- TIGRFAMs:   TIGR03634

Pfam domain/function: PF00227 Proteasome

EC number: =3.4.25.1

Molecular weight: Translated: 21928; Mature: 21797

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00854 PROTEASOME_B_1; PS51476 PROTEASOME_B_2

Important sites: ACT_SITE 9-9

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEVVLPGTAIGLKTSEGVVLASEKRLTYDGFVLSRNARKIHMITNHIGVGFAGLMGDVN
CCCEECCCCEEEEECCCCEEEECCCCEEECCEEEECCCCEEEEEECCCCCCHHHHHHHHH
FLVKVLRLEAKNYELQHGREIKTRSLAKLLSVILYSYKLAPMLTEVVVGGYDEEGPSLYI
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LDPVGSVIEEKYVAVGSGAQLALGYIEPRYNPGLGLKEAEELAVNAVKTVIERDVLSGDG
ECCHHHHHHHHEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
IDLVVIDKNGYQSKEIIFKMTG
EEEEEECCCCCCCCEEEEEECC
>Mature Secondary Structure 
GEVVLPGTAIGLKTSEGVVLASEKRLTYDGFVLSRNARKIHMITNHIGVGFAGLMGDVN
CCEECCCCEEEEECCCCEEEECCCCEEECCEEEECCCCEEEEEECCCCCCHHHHHHHHH
FLVKVLRLEAKNYELQHGREIKTRSLAKLLSVILYSYKLAPMLTEVVVGGYDEEGPSLYI
HHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEE
LDPVGSVIEEKYVAVGSGAQLALGYIEPRYNPGLGLKEAEELAVNAVKTVIERDVLSGDG
ECCHHHHHHHHEEEECCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCC
IDLVVIDKNGYQSKEIIFKMTG
EEEEEECCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA