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The map label for this gene is ahcY [H]

Identifier: 218884566

GI number: 218884566

Start: 1174292

End: 1175563

Strand: Direct

Name: ahcY [H]

Synonym: DKAM_1255

Alternate gene names: 218884566

Gene position: 1174292-1175563 (Clockwise)

Preceding gene: 218884563

Following gene: 218884567

Centisome position: 86.01

GC content: 47.09

Gene sequence:

>1272_bases
GTGAGGGTGGATTATATGGAGTATAAGGTTAAAGATCTCGCTCTAGCTCCACAGGGGAATGCGAAGATCTCCTGGGCTGA
GCAAAACATGCCGGTATTGATGCTGCTGAGGAAACGGCACAGTGCTTTAAAACCCCTTAAAGGAGTTAGGGTTGGCGCCG
TCCTTCATGTAACCAAGGAGACGGCTGTATTAATGAAGGCATTCGTTGATGCGGGGGCAGAGGTCGTGTTAGCTGGAAGT
AATCCGCTTTCAACACAGGACGATATAGCGGCTGCCCTAGTCGAATACGGTGTACACGTGTATGCCTGGAGAGGGCAGTC
CTCCAGTGAATACTACTGGTGCCTTGAGAAAATAATTGAGTGGAGGCCGCAAATAGTATTGGATGATGGTGCTGATCTCC
ACGCCTTAATACATGAGAAACACCTAGACCTTGCTGAACAAATAATCGGTGGTACAGAGGAGACTACTACAGGGGTTATA
AGGCTTAAAGCCTTGGAGAGAGAAGGGCTACTTAAATACCCTGTGATAGCCGTGAATAATGCCTATACAAAGCACATGTT
CGACAATAGGTATGGAACCGGGCAGAGCACCTTCGATGGAATACTTAGAGCCACCAACATCCTTATAGCTGGAAAAATAG
TTGTAGTAGCTGGTTATGGCTGGGTTGGTAAAGGCATAGCGATGAGAGCCAGGGGTCTTGGAGCCAGAAGAGTCATAGTC
ACAGAGGTCAATCCCATAAGGGCTCTTGAAGCAATATATGATGGCTTCGAGGTAATGCCCATGAGTGAAGCCGCTGAGAT
AGGCGATATATTCATAACTGCAACCGGTAATAAAGCTGTTATAAGGAGGGAGCACTTCGAGAAAATGAAGAATGGGGCTA
TCTTGGCTAATGCTGGACATTTCAATGTAGAGGTATGGATACCGGATCTAGAGGAGTTAGCAAGGTCTAAGAGACATGTG
CTACCATATGTTACAGAGTATGAGTTAAGGGATGGGAGAAAGATATATCTACTGGCTGAGGGGAGACTCGTAAACCTCGT
GGCAGCCGAGGGGCATCCAAGTGAGGTCATGGATATGAGCTTTGCCAACCAGTTCTTAGCCTCACTATACCTTATGGATA
ACAAGGGTAAGCTGCCCTTAAGGGTCATGAATCCACCGCTTGAGCTAGATGAAATGGTTGCATCGCTGAAACTGGAGTCG
ATGAGTGTGAGAATAGACTCGATGACGCGTGAGCAGGAGGAGTATGTTAAATCATGGAGGCATGGAACTTGA

Upstream 100 bases:

>100_bases
GTATGTGCTGATGAAGCGTCTGCGTTTCCCTGCTTGCTTCAACCTGGTTGAGATAAACCTCATATTTAAAGCGATACATG
GATTCTAAACTATTATAGCC

Downstream 100 bases:

>100_bases
CCACCTGGTGTACTCTATGGGCTTCATTAAGCGTAAACCCAGCGATAGGGAGCTAGATGAGTTAAGATGGATCGCTAAAA
TACAGTTCGGCGTAGGCAGA

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MRVDYMEYKVKDLALAPQGNAKISWAEQNMPVLMLLRKRHSALKPLKGVRVGAVLHVTKETAVLMKAFVDAGAEVVLAGS
NPLSTQDDIAAALVEYGVHVYAWRGQSSSEYYWCLEKIIEWRPQIVLDDGADLHALIHEKHLDLAEQIIGGTEETTTGVI
RLKALEREGLLKYPVIAVNNAYTKHMFDNRYGTGQSTFDGILRATNILIAGKIVVVAGYGWVGKGIAMRARGLGARRVIV
TEVNPIRALEAIYDGFEVMPMSEAAEIGDIFITATGNKAVIRREHFEKMKNGAILANAGHFNVEVWIPDLEELARSKRHV
LPYVTEYELRDGRKIYLLAEGRLVNLVAAEGHPSEVMDMSFANQFLASLYLMDNKGKLPLRVMNPPLELDEMVASLKLES
MSVRIDSMTREQEEYVKSWRHGT

Sequences:

>Translated_423_residues
MRVDYMEYKVKDLALAPQGNAKISWAEQNMPVLMLLRKRHSALKPLKGVRVGAVLHVTKETAVLMKAFVDAGAEVVLAGS
NPLSTQDDIAAALVEYGVHVYAWRGQSSSEYYWCLEKIIEWRPQIVLDDGADLHALIHEKHLDLAEQIIGGTEETTTGVI
RLKALEREGLLKYPVIAVNNAYTKHMFDNRYGTGQSTFDGILRATNILIAGKIVVVAGYGWVGKGIAMRARGLGARRVIV
TEVNPIRALEAIYDGFEVMPMSEAAEIGDIFITATGNKAVIRREHFEKMKNGAILANAGHFNVEVWIPDLEELARSKRHV
LPYVTEYELRDGRKIYLLAEGRLVNLVAAEGHPSEVMDMSFANQFLASLYLMDNKGKLPLRVMNPPLELDEMVASLKLES
MSVRIDSMTREQEEYVKSWRHGT
>Mature_423_residues
MRVDYMEYKVKDLALAPQGNAKISWAEQNMPVLMLLRKRHSALKPLKGVRVGAVLHVTKETAVLMKAFVDAGAEVVLAGS
NPLSTQDDIAAALVEYGVHVYAWRGQSSSEYYWCLEKIIEWRPQIVLDDGADLHALIHEKHLDLAEQIIGGTEETTTGVI
RLKALEREGLLKYPVIAVNNAYTKHMFDNRYGTGQSTFDGILRATNILIAGKIVVVAGYGWVGKGIAMRARGLGARRVIV
TEVNPIRALEAIYDGFEVMPMSEAAEIGDIFITATGNKAVIRREHFEKMKNGAILANAGHFNVEVWIPDLEELARSKRHV
LPYVTEYELRDGRKIYLLAEGRLVNLVAAEGHPSEVMDMSFANQFLASLYLMDNKGKLPLRVMNPPLELDEMVASLKLES
MSVRIDSMTREQEEYVKSWRHGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=416, Percent_Identity=48.3173076923077, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI239937451, Length=390, Percent_Identity=48.974358974359, Blast_Score=355, Evalue=3e-98,
Organism=Homo sapiens, GI298286489, Length=420, Percent_Identity=39.2857142857143, Blast_Score=301, Evalue=8e-82,
Organism=Homo sapiens, GI195539349, Length=420, Percent_Identity=39.2857142857143, Blast_Score=301, Evalue=1e-81,
Organism=Homo sapiens, GI195539337, Length=420, Percent_Identity=39.2857142857143, Blast_Score=300, Evalue=1e-81,
Organism=Homo sapiens, GI24308043, Length=420, Percent_Identity=39.2857142857143, Blast_Score=300, Evalue=2e-81,
Organism=Homo sapiens, GI21361647, Length=419, Percent_Identity=38.4248210023866, Blast_Score=278, Evalue=5e-75,
Organism=Caenorhabditis elegans, GI17506425, Length=418, Percent_Identity=45.4545454545455, Blast_Score=342, Evalue=2e-94,
Organism=Saccharomyces cerevisiae, GI6320882, Length=435, Percent_Identity=43.448275862069, Blast_Score=347, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24642172, Length=413, Percent_Identity=46.7312348668281, Blast_Score=352, Evalue=2e-97,
Organism=Drosophila melanogaster, GI24656245, Length=402, Percent_Identity=39.3034825870647, Blast_Score=285, Evalue=3e-77,
Organism=Drosophila melanogaster, GI45553385, Length=413, Percent_Identity=40.9200968523002, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45553387, Length=413, Percent_Identity=40.9200968523002, Blast_Score=279, Evalue=2e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 47274; Mature: 47274

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRVDYMEYKVKDLALAPQGNAKISWAEQNMPVLMLLRKRHSALKPLKGVRVGAVLHVTKE
CCCCHHHEEEEHEEECCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEHHH
TAVLMKAFVDAGAEVVLAGSNPLSTQDDIAAALVEYGVHVYAWRGQSSSEYYWCLEKIIE
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
WRPQIVLDDGADLHALIHEKHLDLAEQIIGGTEETTTGVIRLKALEREGLLKYPVIAVNN
CCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEECCEEEECC
AYTKHMFDNRYGTGQSTFDGILRATNILIAGKIVVVAGYGWVGKGIAMRARGLGARRVIV
CHHHHHCCCCCCCCCHHHHHHHHHHHEEEEEEEEEEEECCCCCCCHHHHCCCCCCCEEEE
TEVNPIRALEAIYDGFEVMPMSEAAEIGDIFITATGNKAVIRREHFEKMKNGAILANAGH
EECCHHHHHHHHHCCCEEEECHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCE
FNVEVWIPDLEELARSKRHVLPYVTEYELRDGRKIYLLAEGRLVNLVAAEGHPSEVMDMS
EEEEEECCCHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCCHHHHHHH
FANQFLASLYLMDNKGKLPLRVMNPPLELDEMVASLKLESMSVRIDSMTREQEEYVKSWR
HHHHHHHHEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHC
HGT
CCC
>Mature Secondary Structure
MRVDYMEYKVKDLALAPQGNAKISWAEQNMPVLMLLRKRHSALKPLKGVRVGAVLHVTKE
CCCCHHHEEEEHEEECCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEEEHHH
TAVLMKAFVDAGAEVVLAGSNPLSTQDDIAAALVEYGVHVYAWRGQSSSEYYWCLEKIIE
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHH
WRPQIVLDDGADLHALIHEKHLDLAEQIIGGTEETTTGVIRLKALEREGLLKYPVIAVNN
CCCCEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCEECCEEEECC
AYTKHMFDNRYGTGQSTFDGILRATNILIAGKIVVVAGYGWVGKGIAMRARGLGARRVIV
CHHHHHCCCCCCCCCHHHHHHHHHHHEEEEEEEEEEEECCCCCCCHHHHCCCCCCCEEEE
TEVNPIRALEAIYDGFEVMPMSEAAEIGDIFITATGNKAVIRREHFEKMKNGAILANAGH
EECCHHHHHHHHHCCCEEEECHHCCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEECCE
FNVEVWIPDLEELARSKRHVLPYVTEYELRDGRKIYLLAEGRLVNLVAAEGHPSEVMDMS
EEEEEECCCHHHHHHCCCCCCCCEEEEEECCCCEEEEEECCCEEEEEECCCCCHHHHHHH
FANQFLASLYLMDNKGKLPLRVMNPPLELDEMVASLKLESMSVRIDSMTREQEEYVKSWR
HHHHHHHHEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHC
HGT
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]