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The map label for this gene is thyX [H]

Identifier: 218884431

GI number: 218884431

Start: 1055150

End: 1056049

Strand: Direct

Name: thyX [H]

Synonym: DKAM_1120

Alternate gene names: 218884431

Gene position: 1055150-1056049 (Clockwise)

Preceding gene: 218884430

Following gene: 218884433

Centisome position: 77.29

GC content: 46.44

Gene sequence:

>900_bases
ATGGAGAAATACCTACCGCGGGCCCTCCTCGTTGCACATTTACCTGATACAAGTAGGATTATAGCATCTGCTTCAAAGCT
CACCCTATCACCAAGAGACTTCACCTCGATTACCGGGGATATGGATTATGTGAAAACCGAGGAGTGGATCAGGGAACTGG
TTAAACGGGGCCATGGCTCTCCACTTGAGCACTCGATATTCATATTCGAAGTGATATGTAGCAGGGTTTGCAGTCATCAA
CTAGTTAGACACAGACATGCCTCGTTCTCACAGCTGTCTCAGAGATACAGTGATAAATCCCTGAGAAACATGGTGACGAA
AATATTCGAGCACACCGGCAGAAATCCACGGGAAGCCGGTTTCAGAGAATACGTTGAGGCTATAGAGGGATTCCTAGATG
CTGATCCAGGTTTCACCGAGTTATTGGAAGTCGTAGCTGAGGCGTTCATAATCCCGCCCAGCACGGTAAGGCTTAAGGAT
AAAGAATCCCTCAGGGCCATTATACAAGGAGTTAAATCCTACTATAAGGCACTCCTCAACGGGATTCCATATGAGGATGC
AAGATACCTACTACCCCAGGCTGTGAAAACCAGGCTACTTGTATCAATGAATGCCAGAGAGCTCATCGAGGTATTTATTC
CACTGAGAACATGTGCCAGGGCACAGTGGGAGATACGCAGCATAGCCTGGCAGATACTAGGTGAGCTGAATAAGGTTGAA
CCATTATTATTCAAGTACGCTGGCCCACGGTGCATCCTACAAGACAATAGAAGTAGGAGTAAGCCATGTACACTTAAAGA
TTACCTTGAGGGAACATGCACACCCACCTTGGAGAGATGCCCGGAACTAGTGCCAAGGGAAAAAATACGGGAATGTATAA
GTACCGCCTTAATAATTTAA

Upstream 100 bases:

>100_bases
GTGATAAATACTGTATGCCCAGCGAGGTAGAACTTGAAGGAGTCGCAGGTGTTTTTAGAAGGCTCGGGTTTAAGACCTTT
ATTAAAGAGGTGCCGAGGTA

Downstream 100 bases:

>100_bases
CATTCATACCCAGTATCGGTGATTATACATCTAGCGGTGGTCCTAGTTTCCAAGACCTATAACGGGCCGTGGAAAGGGGA
CTTCGGGCTTCATAGGGTTT

Product: thymidylate synthase, flavin-dependent

Products: NA

Alternate protein names: TS; TSase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MEKYLPRALLVAHLPDTSRIIASASKLTLSPRDFTSITGDMDYVKTEEWIRELVKRGHGSPLEHSIFIFEVICSRVCSHQ
LVRHRHASFSQLSQRYSDKSLRNMVTKIFEHTGRNPREAGFREYVEAIEGFLDADPGFTELLEVVAEAFIIPPSTVRLKD
KESLRAIIQGVKSYYKALLNGIPYEDARYLLPQAVKTRLLVSMNARELIEVFIPLRTCARAQWEIRSIAWQILGELNKVE
PLLFKYAGPRCILQDNRSRSKPCTLKDYLEGTCTPTLERCPELVPREKIRECISTALII

Sequences:

>Translated_299_residues
MEKYLPRALLVAHLPDTSRIIASASKLTLSPRDFTSITGDMDYVKTEEWIRELVKRGHGSPLEHSIFIFEVICSRVCSHQ
LVRHRHASFSQLSQRYSDKSLRNMVTKIFEHTGRNPREAGFREYVEAIEGFLDADPGFTELLEVVAEAFIIPPSTVRLKD
KESLRAIIQGVKSYYKALLNGIPYEDARYLLPQAVKTRLLVSMNARELIEVFIPLRTCARAQWEIRSIAWQILGELNKVE
PLLFKYAGPRCILQDNRSRSKPCTLKDYLEGTCTPTLERCPELVPREKIRECISTALII
>Mature_299_residues
MEKYLPRALLVAHLPDTSRIIASASKLTLSPRDFTSITGDMDYVKTEEWIRELVKRGHGSPLEHSIFIFEVICSRVCSHQ
LVRHRHASFSQLSQRYSDKSLRNMVTKIFEHTGRNPREAGFREYVEAIEGFLDADPGFTELLEVVAEAFIIPPSTVRLKD
KESLRAIIQGVKSYYKALLNGIPYEDARYLLPQAVKTRLLVSMNARELIEVFIPLRTCARAQWEIRSIAWQILGELNKVE
PLLFKYAGPRCILQDNRSRSKPCTLKDYLEGTCTPTLERCPELVPREKIRECISTALII

Specific function: Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate [H]

COG id: COG1351

COG function: function code F; Predicted alternative thymidylate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thyX (flavin-dependent thymidylate synthase) domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003669 [H]

Pfam domain/function: PF02511 Thy1 [H]

EC number: =2.1.1.148 [H]

Molecular weight: Translated: 34277; Mature: 34277

Theoretical pI: Translated: 8.71; Mature: 8.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKYLPRALLVAHLPDTSRIIASASKLTLSPRDFTSITGDMDYVKTEEWIRELVKRGHGS
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCC
PLEHSIFIFEVICSRVCSHQLVRHRHASFSQLSQRYSDKSLRNMVTKIFEHTGRNPREAG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
FREYVEAIEGFLDADPGFTELLEVVAEAFIIPPSTVRLKDKESLRAIIQGVKSYYKALLN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHC
GIPYEDARYLLPQAVKTRLLVSMNARELIEVFIPLRTCARAQWEIRSIAWQILGELNKVE
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLLFKYAGPRCILQDNRSRSKPCTLKDYLEGTCTPTLERCPELVPREKIRECISTALII
HHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCCCHHHHCHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MEKYLPRALLVAHLPDTSRIIASASKLTLSPRDFTSITGDMDYVKTEEWIRELVKRGHGS
CCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCC
PLEHSIFIFEVICSRVCSHQLVRHRHASFSQLSQRYSDKSLRNMVTKIFEHTGRNPREAG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
FREYVEAIEGFLDADPGFTELLEVVAEAFIIPPSTVRLKDKESLRAIIQGVKSYYKALLN
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCEEECCHHHHHHHHHHHHHHHHHHHC
GIPYEDARYLLPQAVKTRLLVSMNARELIEVFIPLRTCARAQWEIRSIAWQILGELNKVE
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLLFKYAGPRCILQDNRSRSKPCTLKDYLEGTCTPTLERCPELVPREKIRECISTALII
HHHHHHCCCEEEEECCCCCCCCCCHHHHHCCCCCCHHHHCHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10382966 [H]