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The map label for this gene is eIF1A

Identifier: 218884397

GI number: 218884397

Start: 1026296

End: 1026646

Strand: Direct

Name: eIF1A

Synonym: DKAM_1086

Alternate gene names: 218884397

Gene position: 1026296-1026646 (Clockwise)

Preceding gene: 218884396

Following gene: 218884398

Centisome position: 75.17

GC content: 45.01

Gene sequence:

>351_bases
GTGAGGTGTCTGAGTAAGAAGCATCAAAAACAGGGAGATGAGCATGGTGGAGAGATACCACTACCCAACCCTGATGAGGG
GACGATAATATGTGGTGTAGTAAGGCATCTAGGCGGAGACTATCTCATAGCTAAGTGCCTCGATGGAGTCGATAGAAAGA
TAAGGATACCTGGTAAACTAAGGAGGAAGGTATGGATAACCGAGGGAGATATTATCCTGGTGGGGCTCTGGGATTTTTCA
TCGGAAAAAGGTGAAGTAGTATATAAGTACGGTAAGAACGAGGTAAACAAACTGGTTGAGAAGGGGGTAGTGCCGAAGGA
GTTCATCGATGCATTAAGTGAACTCATATGA

Upstream 100 bases:

>100_bases
GAGAGGCATCCTTAACCCCAGCTAATTATGGGTTAAAGCCGGGTGATAAAGTTATAATATTGAGTGATGGTGAAAGAGAA
CTAGTAGTAAAAAAGGAGGG

Downstream 100 bases:

>100_bases
GCGACGACATAGATAAATTACTCAGGAAAAAGGAGGAGCCCCGTAGAAAAGATAAAGACCTCTTTGAAACGGTTGAAGAG
GTCTTTGATACAGCCACAGT

Product: translation initiation factor 1A

Products: NA

Alternate protein names: aIF-1A

Number of amino acids: Translated: 116; Mature: 116

Protein sequence:

>116_residues
MRCLSKKHQKQGDEHGGEIPLPNPDEGTIICGVVRHLGGDYLIAKCLDGVDRKIRIPGKLRRKVWITEGDIILVGLWDFS
SEKGEVVYKYGKNEVNKLVEKGVVPKEFIDALSELI

Sequences:

>Translated_116_residues
MRCLSKKHQKQGDEHGGEIPLPNPDEGTIICGVVRHLGGDYLIAKCLDGVDRKIRIPGKLRRKVWITEGDIILVGLWDFS
SEKGEVVYKYGKNEVNKLVEKGVVPKEFIDALSELI
>Mature_116_residues
MRCLSKKHQKQGDEHGGEIPLPNPDEGTIICGVVRHLGGDYLIAKCLDGVDRKIRIPGKLRRKVWITEGDIILVGLWDFS
SEKGEVVYKYGKNEVNKLVEKGVVPKEFIDALSELI

Specific function: Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits

COG id: COG0361

COG function: function code J; Translation initiation factor 1 (IF-1)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1-like domain

Homologues:

Organism=Homo sapiens, GI4503499, Length=82, Percent_Identity=43.9024390243902, Blast_Score=69, Evalue=6e-13,
Organism=Homo sapiens, GI33356163, Length=82, Percent_Identity=43.9024390243902, Blast_Score=69, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI17540984, Length=81, Percent_Identity=44.4444444444444, Blast_Score=68, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323916, Length=95, Percent_Identity=38.9473684210526, Blast_Score=70, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45553405, Length=74, Percent_Identity=48.6486486486487, Blast_Score=69, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24647907, Length=74, Percent_Identity=48.6486486486487, Blast_Score=69, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF1A_DESK1 (B8D5N1)

Other databases:

- EMBL:   CP001140
- RefSeq:   YP_002428779.1
- GeneID:   7171187
- GenomeReviews:   CP001140_GR
- KEGG:   dka:DKAM_1086
- HOGENOM:   HBG521228
- OMA:   WITEGDI
- ProtClustDB:   PRK04012
- HAMAP:   MF_00216
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR006196
- InterPro:   IPR001253
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR21668
- ProDom:   PD005579

Pfam domain/function: PF01176 eIF-1a; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 12997; Mature: 12997

Theoretical pI: Translated: 8.06; Mature: 8.06

Prosite motif: PS01262 IF1A; PS50832 S1_IF1_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRCLSKKHQKQGDEHGGEIPLPNPDEGTIICGVVRHLGGDYLIAKCLDGVDRKIRIPGKL
CCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCEEECCCHH
RRKVWITEGDIILVGLWDFSSEKGEVVYKYGKNEVNKLVEKGVVPKEFIDALSELI
CCEEEECCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHCCCCCHHHHHHHHHHC
>Mature Secondary Structure
MRCLSKKHQKQGDEHGGEIPLPNPDEGTIICGVVRHLGGDYLIAKCLDGVDRKIRIPGKL
CCCCCHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHCCCCCEEECCCHH
RRKVWITEGDIILVGLWDFSSEKGEVVYKYGKNEVNKLVEKGVVPKEFIDALSELI
CCEEEECCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHCCCCCHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA