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The map label for this gene is nuoN [H]

Identifier: 218884284

GI number: 218884284

Start: 918087

End: 919649

Strand: Direct

Name: nuoN [H]

Synonym: DKAM_0973

Alternate gene names: 218884284

Gene position: 918087-919649 (Clockwise)

Preceding gene: 218884283

Following gene: 218884286

Centisome position: 67.25

GC content: 45.17

Gene sequence:

>1563_bases
ATGAGCCCACATGTAATCGGCTTAATACCCTTTATACCTGTATTAGGCGCATTTCTCACACCCCTCGTATACCTGGTTTC
CAGGAGCAGGCTCACGGTATTTGCTCACGGAGTATTATTCACCCTTATCACACTTGCATTATCGATACTGGGGTTTATTC
AAGCATATGAGAGTGATGCACCCCAAGCCTATCTCATGGGCGGGTGGCCTCCACCACTCGGAATAACCTATACGCTTGAT
AAATTAACAGGGATACTGGTGTTAACCACAAGCCTCGTCCTAACCGTGATCATGGTGTATAGCGTGGAATACATAGTGGA
TGACGGGTATCCATGGTATGTAACACTTATGTTAGGGGTTTTCTCAGGCATACTGGGTGTTATAATGACATCGGATGTCT
TCAATTTATTCGTTATGTTGGAGGTCACGGGTGTATCATCCTACGGGCTTGTAATGTATTACAGGCACAGGGCTGGCCCG
ATAGTCTCAGGTATAAAATATGCCTTCGTGGGGGCAATGGGTACAACCCTCTACCTTCTAGCCCTGGCTATAATATATAA
TGTATATGGATCCCTGAACCTCATAGATTTATCGTTGAAGACGCATGGATACCGGGGGAGCTCAATAACGTATATGGGTA
CAGGCTACGATGCCGTGTCAATAGGTTTAATCATGGCTATCTCGTTCTGGACGTTCAGCATTAAAAGCGGTGTATTCCCT
AATCACTTTTGGCTACCTGATGCTCATCCAGCAGCTCCGTCACCTGTTTCAGCAATGCTGAGTGGGTTAGTGGTTAACAC
TGGTGCTGTGGGACTATATAAAATCCTTTACCTGATATATGGTGGAAGCATACTGGATTCATTAACCCCGGCTAGGGACG
CTATATCGTTCCTAATCGTGTTAACTGGGGCTTTCTCAGCGATTATAGGTGCTTTACTAATGAATATCCAGGAAGACGTA
AAGAGAATGATAGCTTACTCCACAGTCATGAATACAGGCTATATATTCATGGGTATAGGGATCTTAAGCCCATTCGGTAT
CCTGGCATTCCTATATTACACTGTGGTACACTCGCTTGCGAAATCCACCCTCTTCCTGAGCACGGGCTTACTGATAAAAT
ACACCGGTAGCCGTAGGATAAATGAGCTAGCCGGGTCATTTAAGACTCATATCATACCCGGAGTAGCCAGCGTTATATCT
CTGCTCACGTTATCCGGGATACCGCCTCTCCCAGGCTTCCTAGGCAAGCTACTCCTATACAACGCGTTATTCAGTTACAA
CCCTGTATTCGCTATAGTTATGCTGATTGCAAGCGCTATAGGTCTACTAGCATATATGAGGTTATTCTTCATACTGGTCT
TCGAGGCACCTACAAGGAAGACTATTGGAAAAAGGTTCCTGCTTTCAGAAGCATCAACCCTGGCCATCGCGTTATTCACA
TCGATCGTGGGGATATTACTCCTGTTTCGCCAAGACTTCTTCGATGCATTATTCATGGAGTCAGTCAACCAGGTTGCAGA
CGTCGTGAAATACATGGAGCAACTAGCATCATCACTAATTTAA

Upstream 100 bases:

>100_bases
GACGTATCAACCAAGGACCCCTTAGAGGCTAGGCGCTCGATAAGCGAGGAGTTCGAGACTTATGCTTCGAAAATACTTGA
TTAAGATAGCAGGTGATTAG

Downstream 100 bases:

>100_bases
CCTGGGAAACCTGGTTTATCCAGGCACAATATATTACGACAGAGGGCTAAAAGCCGGAAAACTTTTAAATTCCATTATAC
ATGTTGTGGATACCTGGGGG

Product: putative monovalent cation/H+ antiporter subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSPHVIGLIPFIPVLGAFLTPLVYLVSRSRLTVFAHGVLFTLITLALSILGFIQAYESDAPQAYLMGGWPPPLGITYTLD
KLTGILVLTTSLVLTVIMVYSVEYIVDDGYPWYVTLMLGVFSGILGVIMTSDVFNLFVMLEVTGVSSYGLVMYYRHRAGP
IVSGIKYAFVGAMGTTLYLLALAIIYNVYGSLNLIDLSLKTHGYRGSSITYMGTGYDAVSIGLIMAISFWTFSIKSGVFP
NHFWLPDAHPAAPSPVSAMLSGLVVNTGAVGLYKILYLIYGGSILDSLTPARDAISFLIVLTGAFSAIIGALLMNIQEDV
KRMIAYSTVMNTGYIFMGIGILSPFGILAFLYYTVVHSLAKSTLFLSTGLLIKYTGSRRINELAGSFKTHIIPGVASVIS
LLTLSGIPPLPGFLGKLLLYNALFSYNPVFAIVMLIASAIGLLAYMRLFFILVFEAPTRKTIGKRFLLSEASTLAIALFT
SIVGILLLFRQDFFDALFMESVNQVADVVKYMEQLASSLI

Sequences:

>Translated_520_residues
MSPHVIGLIPFIPVLGAFLTPLVYLVSRSRLTVFAHGVLFTLITLALSILGFIQAYESDAPQAYLMGGWPPPLGITYTLD
KLTGILVLTTSLVLTVIMVYSVEYIVDDGYPWYVTLMLGVFSGILGVIMTSDVFNLFVMLEVTGVSSYGLVMYYRHRAGP
IVSGIKYAFVGAMGTTLYLLALAIIYNVYGSLNLIDLSLKTHGYRGSSITYMGTGYDAVSIGLIMAISFWTFSIKSGVFP
NHFWLPDAHPAAPSPVSAMLSGLVVNTGAVGLYKILYLIYGGSILDSLTPARDAISFLIVLTGAFSAIIGALLMNIQEDV
KRMIAYSTVMNTGYIFMGIGILSPFGILAFLYYTVVHSLAKSTLFLSTGLLIKYTGSRRINELAGSFKTHIIPGVASVIS
LLTLSGIPPLPGFLGKLLLYNALFSYNPVFAIVMLIASAIGLLAYMRLFFILVFEAPTRKTIGKRFLLSEASTLAIALFT
SIVGILLLFRQDFFDALFMESVNQVADVVKYMEQLASSLI
>Mature_519_residues
SPHVIGLIPFIPVLGAFLTPLVYLVSRSRLTVFAHGVLFTLITLALSILGFIQAYESDAPQAYLMGGWPPPLGITYTLDK
LTGILVLTTSLVLTVIMVYSVEYIVDDGYPWYVTLMLGVFSGILGVIMTSDVFNLFVMLEVTGVSSYGLVMYYRHRAGPI
VSGIKYAFVGAMGTTLYLLALAIIYNVYGSLNLIDLSLKTHGYRGSSITYMGTGYDAVSIGLIMAISFWTFSIKSGVFPN
HFWLPDAHPAAPSPVSAMLSGLVVNTGAVGLYKILYLIYGGSILDSLTPARDAISFLIVLTGAFSAIIGALLMNIQEDVK
RMIAYSTVMNTGYIFMGIGILSPFGILAFLYYTVVHSLAKSTLFLSTGLLIKYTGSRRINELAGSFKTHIIPGVASVISL
LTLSGIPPLPGFLGKLLLYNALFSYNPVFAIVMLIASAIGLLAYMRLFFILVFEAPTRKTIGKRFLLSEASTLAIALFTS
IVGILLLFRQDFFDALFMESVNQVADVVKYMEQLASSLI

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=373, Percent_Identity=24.3967828418231, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1788827, Length=395, Percent_Identity=29.3670886075949, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI1788831, Length=304, Percent_Identity=31.25, Blast_Score=120, Evalue=3e-28,
Organism=Escherichia coli, GI1788829, Length=402, Percent_Identity=26.3681592039801, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1788613, Length=459, Percent_Identity=25.7080610021786, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI2367154, Length=341, Percent_Identity=26.3929618768328, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI145693160, Length=381, Percent_Identity=22.8346456692913, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1788614, Length=322, Percent_Identity=24.223602484472, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 56469; Mature: 56338

Theoretical pI: Translated: 8.98; Mature: 8.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPHVIGLIPFIPVLGAFLTPLVYLVSRSRLTVFAHGVLFTLITLALSILGFIQAYESDA
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PQAYLMGGWPPPLGITYTLDKLTGILVLTTSLVLTVIMVYSVEYIVDDGYPWYVTLMLGV
CCEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHH
FSGILGVIMTSDVFNLFVMLEVTGVSSYGLVMYYRHRAGPIVSGIKYAFVGAMGTTLYLL
HHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHHHHH
ALAIIYNVYGSLNLIDLSLKTHGYRGSSITYMGTGYDAVSIGLIMAISFWTFSIKSGVFP
HHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
NHFWLPDAHPAAPSPVSAMLSGLVVNTGAVGLYKILYLIYGGSILDSLTPARDAISFLIV
CCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHH
LTGAFSAIIGALLMNIQEDVKRMIAYSTVMNTGYIFMGIGILSPFGILAFLYYTVVHSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHH
KSTLFLSTGLLIKYTGSRRINELAGSFKTHIIPGVASVISLLTLSGIPPLPGFLGKLLLY
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NALFSYNPVFAIVMLIASAIGLLAYMRLFFILVFEAPTRKTIGKRFLLSEASTLAIALFT
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
SIVGILLLFRQDFFDALFMESVNQVADVVKYMEQLASSLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPHVIGLIPFIPVLGAFLTPLVYLVSRSRLTVFAHGVLFTLITLALSILGFIQAYESDA
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PQAYLMGGWPPPLGITYTLDKLTGILVLTTSLVLTVIMVYSVEYIVDDGYPWYVTLMLGV
CCEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHH
FSGILGVIMTSDVFNLFVMLEVTGVSSYGLVMYYRHRAGPIVSGIKYAFVGAMGTTLYLL
HHHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEEHHCCCHHHHHHHHHHHHHHHHHHHH
ALAIIYNVYGSLNLIDLSLKTHGYRGSSITYMGTGYDAVSIGLIMAISFWTFSIKSGVFP
HHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCC
NHFWLPDAHPAAPSPVSAMLSGLVVNTGAVGLYKILYLIYGGSILDSLTPARDAISFLIV
CCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHCCCHHHHHHHHHH
LTGAFSAIIGALLMNIQEDVKRMIAYSTVMNTGYIFMGIGILSPFGILAFLYYTVVHSLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHHHHHHHHHHHHH
KSTLFLSTGLLIKYTGSRRINELAGSFKTHIIPGVASVISLLTLSGIPPLPGFLGKLLLY
HHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHH
NALFSYNPVFAIVMLIASAIGLLAYMRLFFILVFEAPTRKTIGKRFLLSEASTLAIALFT
HHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
SIVGILLLFRQDFFDALFMESVNQVADVVKYMEQLASSLI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA