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The map label for this gene is mtaP [H]

Identifier: 218884114

GI number: 218884114

Start: 773515

End: 774237

Strand: Direct

Name: mtaP [H]

Synonym: DKAM_0803

Alternate gene names: 218884114

Gene position: 773515-774237 (Clockwise)

Preceding gene: 218884113

Following gene: 218884115

Centisome position: 56.66

GC content: 51.45

Gene sequence:

>723_bases
TTGCCCATACATATTAAGGCTTCCCCAGGCGATATAGCCGAGAACGTTATAGCTGTCGGTGATCCTGGACGCGTAGACAT
ACTCTCCGGGCTACTCAGCAACGTTAAAACCGTTAACATCCACCGGGGATTCAAGATAGTTACCGGCTTATATAACGGTG
AGAAGGTAACCATCGCGACACACGGGGTAGGTGCCCCGAGTGCCAGCATAGTCTTCGAGGAGCTACGTCAGCTAGGGGCC
AAGAGGATAGTCAGGATAGGTACAACCGGTGGTGTGAGAAAAGATACCAGGATAGGTGACGTGATCGTTGCAACTGGTGC
AGCATACACGGTCAACGGCTGTGGACTAGGCCAGTACATGCCTGGAATATGCGGCGCCGCCTCACCGGATCCCGTGTTAA
CTACAAGGATAATCGAGTCTATGGAGGAGCATGGAATAGAATATAAGAAGGGCCCGGTTTTCTCCAGTGATGCATTCTAC
GCTGAAGACCCGTCATTCGCCGAGAGGCTGTCACACTACGGGATTGTTGCAGTGGAAATGGAGGCTGCAGCATTATTCGC
GCTTGGCTGGCTAAGGGGTTTTGAGACCGCCTGTGTTCTAGTGGTTAGCGATGTACTCCATGGCGAGGAAGCTATGAAGA
AATACTTGACTACGGAGGAGCTGGCCGAGGTCTTCTTAAAGGTTGCGAAGCTGGTTCTCGATGTCTTCCACAAGTATTAT
TGA

Upstream 100 bases:

>100_bases
TAGGAGGAAAAAGCCTAAAACCTCAAAAACCAAGAGAAAGAAAAGTAAGACAAGGAAAAAGAAAGGCGGGAAGAGTAAGA
GGAAGTAGGGGTGTGTCGAC

Downstream 100 bases:

>100_bases
AGGATTGGGAGGCATGCTTCCAGCTATAAAAATATATGATACTTTATCCAGGGATTTAAAGGAGCTGCAGCCCATTGAGC
CAGGCATAGTTAAAATGTAT

Product: purine and other phosphorylase, family 1

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 240; Mature: 239

Protein sequence:

>240_residues
MPIHIKASPGDIAENVIAVGDPGRVDILSGLLSNVKTVNIHRGFKIVTGLYNGEKVTIATHGVGAPSASIVFEELRQLGA
KRIVRIGTTGGVRKDTRIGDVIVATGAAYTVNGCGLGQYMPGICGAASPDPVLTTRIIESMEEHGIEYKKGPVFSSDAFY
AEDPSFAERLSHYGIVAVEMEAAALFALGWLRGFETACVLVVSDVLHGEEAMKKYLTTEELAEVFLKVAKLVLDVFHKYY

Sequences:

>Translated_240_residues
MPIHIKASPGDIAENVIAVGDPGRVDILSGLLSNVKTVNIHRGFKIVTGLYNGEKVTIATHGVGAPSASIVFEELRQLGA
KRIVRIGTTGGVRKDTRIGDVIVATGAAYTVNGCGLGQYMPGICGAASPDPVLTTRIIESMEEHGIEYKKGPVFSSDAFY
AEDPSFAERLSHYGIVAVEMEAAALFALGWLRGFETACVLVVSDVLHGEEAMKKYLTTEELAEVFLKVAKLVLDVFHKYY
>Mature_239_residues
PIHIKASPGDIAENVIAVGDPGRVDILSGLLSNVKTVNIHRGFKIVTGLYNGEKVTIATHGVGAPSASIVFEELRQLGAK
RIVRIGTTGGVRKDTRIGDVIVATGAAYTVNGCGLGQYMPGICGAASPDPVLTTRIIESMEEHGIEYKKGPVFSSDAFYA
EDPSFAERLSHYGIVAVEMEAAALFALGWLRGFETACVLVVSDVLHGEEAMKKYLTTEELAEVFLKVAKLVLDVFHKYY

Specific function: Endowed with a broad substrate specificity, being able to phosphorolytically cleave inosine, guanosine, and adenosine with a better efficiency than MTA [H]

COG id: COG2820

COG function: function code F; Uridine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/UDP phosphorylase family [H]

Homologues:

Organism=Escherichia coli, GI1790844, Length=235, Percent_Identity=31.9148936170213, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI1790265, Length=212, Percent_Identity=29.2452830188679, Blast_Score=85, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018017
- InterPro:   IPR018016
- InterPro:   IPR000845 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 25741; Mature: 25610

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS01232 PNP_UDP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIHIKASPGDIAENVIAVGDPGRVDILSGLLSNVKTVNIHRGFKIVTGLYNGEKVTIAT
CCEEEECCCCHHHHCEEEECCCCHHHHHHHHHHCCEEEEEECCEEEEEEEECCCEEEEEE
HGVGAPSASIVFEELRQLGAKRIVRIGTTGGVRKDTRIGDVIVATGAAYTVNGCGLGQYM
CCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEECCCEEEECCCCCCHHC
PGICGAASPDPVLTTRIIESMEEHGIEYKKGPVFSSDAFYAEDPSFAERLSHYGIVAVEM
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEEH
EAAALFALGWLRGFETACVLVVSDVLHGEEAMKKYLTTEELAEVFLKVAKLVLDVFHKYY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PIHIKASPGDIAENVIAVGDPGRVDILSGLLSNVKTVNIHRGFKIVTGLYNGEKVTIAT
CEEEECCCCHHHHCEEEECCCCHHHHHHHHHHCCEEEEEECCEEEEEEEECCCEEEEEE
HGVGAPSASIVFEELRQLGAKRIVRIGTTGGVRKDTRIGDVIVATGAAYTVNGCGLGQYM
CCCCCCHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEECCCEEEECCCCCCHHC
PGICGAASPDPVLTTRIIESMEEHGIEYKKGPVFSSDAFYAEDPSFAERLSHYGIVAVEM
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEEH
EAAALFALGWLRGFETACVLVVSDVLHGEEAMKKYLTTEELAEVFLKVAKLVLDVFHKYY
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11427726; 7929153 [H]