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The map label for this gene is allB [H]

Identifier: 218884052

GI number: 218884052

Start: 711479

End: 712828

Strand: Direct

Name: allB [H]

Synonym: DKAM_0741

Alternate gene names: 218884052

Gene position: 711479-712828 (Clockwise)

Preceding gene: 218884041

Following gene: 218884053

Centisome position: 52.11

GC content: 48.74

Gene sequence:

>1350_bases
GTGATAGCTATGAGCCTACTCATTAGAAACGGGCTCCTCATTACTCCTCGGAGAGTATTCAGGGCTGATGTGAAAATAGT
GAACGGGGTTATCACTGAGATAGGGGTTGGACTTAGCACTAGTGGGGTGGATGAGGTCATCGATGCATCAGGCATGCTTG
TACTACCCGGTGTAATAGATGAGCACGTACACATGAGGGAGCCCGGCCTAGAGTACAAGGATGACTTCACTCATGGAACC
AGGGCTGCTTTAAAAGGAGGCGTTACAACAGTTATAGAGCACCCTAATACGCTTCCACCGGTGGAGGACCCAGGTAAATT
AGCCAGTAAGGCGAGACTGCTTGAGTCGAAGGCGTATGTTGACTACGCGCTTCTCGGCGTCCTCCACGATGGGAATATAC
ATTTATTCGAGGACATTATCGCAGCAGGAGCAGTAGGCTTCAAGATATTTATGGGCCCGACGACAGGTAATATCCCGCCG
CCTAGTGATAGCAGTTTATATGAGGCCCTCTCCAAATCAGGCAAGACAGGAGTTACGATGGCCTTCCACGCTGAAGACCA
TTCACTGGTAACATATTTCACCGAGAAGGTGAAGGCAGGAGGCGGAATGGATCCATGGCTCCATATCGAGGCTAGGCCGC
CAATAACTGAGGAATACAGTATTGTTAAAATAGCCACCATCGCGAAGCAAACCCATGGGAGAGTATTGATAGTACATATA
TCATCTATAGAGGCGCTTGAAGCCGTTCGAAAAGCTAGGAGCGAGGGAGTTGAAATATATGGAGAGACATGCCCACACTA
CCTCGTACTTGATAAGGCTGACTACCAGAAACACGGAAGCTTAATCAAGGTTAACCCACCAATAAGGGGAGGCATTCACC
GGGAGAGACTACTTGAAGCCGTGGGGAACGGTCTAATAGACACCCTTGGCTCAGATCACGCCCCCCACACCCAAGAGGAG
AAGAAGAGGGATATATGGAGCGCTGCATCAGGGATGCCCGGGGTTCAAACACTGCTTCCCATAATGCTCGATCTAGCTTT
AAGGAATGTAGTCCCCTTAACCAGGATGCCTATACTACTATCTGAGAACCCAGCTAAGCTATGGGGATTGTGGCCTAGAA
AGGGCTCGATAGATATAGGGTTCGATGGAGACCTAGTTATCGTCGACCCGGGTGGCGAGACGGTTGTAACGGAGGAGTGG
CTTGAATACAAGTATAAGCTCTCTCCATACATAGGGTGGAGGCTTAAGGGTAAGATAAGGTACACTATACTCAGAGGGAT
GGTGATATACCGTGATGGCGTGATCACAGATAAACCTGTTGGAAAATGGATTAGACCAGTTAAATTATAA

Upstream 100 bases:

>100_bases
TCTCCAGGAGGCTGGTTGAATCCACCATAAGTGCACCTCAAGTCAATTTATTGCTATAATAAATAAATATTTTTTATTCA
ATATATCATCGATCCATAAT

Downstream 100 bases:

>100_bases
CGGGGGCTCACCATAAAGTAGTTGTGGTGTACCCCATGTACAAGGGAATGGATGTTATATCAGCCCTCCAGTTCTCCAGG
AGCGATGTGGAGAAATTAAT

Product: putative allantoinase

Products: NA

Alternate protein names: Allantoin-utilizing enzyme [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MIAMSLLIRNGLLITPRRVFRADVKIVNGVITEIGVGLSTSGVDEVIDASGMLVLPGVIDEHVHMREPGLEYKDDFTHGT
RAALKGGVTTVIEHPNTLPPVEDPGKLASKARLLESKAYVDYALLGVLHDGNIHLFEDIIAAGAVGFKIFMGPTTGNIPP
PSDSSLYEALSKSGKTGVTMAFHAEDHSLVTYFTEKVKAGGGMDPWLHIEARPPITEEYSIVKIATIAKQTHGRVLIVHI
SSIEALEAVRKARSEGVEIYGETCPHYLVLDKADYQKHGSLIKVNPPIRGGIHRERLLEAVGNGLIDTLGSDHAPHTQEE
KKRDIWSAASGMPGVQTLLPIMLDLALRNVVPLTRMPILLSENPAKLWGLWPRKGSIDIGFDGDLVIVDPGGETVVTEEW
LEYKYKLSPYIGWRLKGKIRYTILRGMVIYRDGVITDKPVGKWIRPVKL

Sequences:

>Translated_449_residues
MIAMSLLIRNGLLITPRRVFRADVKIVNGVITEIGVGLSTSGVDEVIDASGMLVLPGVIDEHVHMREPGLEYKDDFTHGT
RAALKGGVTTVIEHPNTLPPVEDPGKLASKARLLESKAYVDYALLGVLHDGNIHLFEDIIAAGAVGFKIFMGPTTGNIPP
PSDSSLYEALSKSGKTGVTMAFHAEDHSLVTYFTEKVKAGGGMDPWLHIEARPPITEEYSIVKIATIAKQTHGRVLIVHI
SSIEALEAVRKARSEGVEIYGETCPHYLVLDKADYQKHGSLIKVNPPIRGGIHRERLLEAVGNGLIDTLGSDHAPHTQEE
KKRDIWSAASGMPGVQTLLPIMLDLALRNVVPLTRMPILLSENPAKLWGLWPRKGSIDIGFDGDLVIVDPGGETVVTEEW
LEYKYKLSPYIGWRLKGKIRYTILRGMVIYRDGVITDKPVGKWIRPVKL
>Mature_449_residues
MIAMSLLIRNGLLITPRRVFRADVKIVNGVITEIGVGLSTSGVDEVIDASGMLVLPGVIDEHVHMREPGLEYKDDFTHGT
RAALKGGVTTVIEHPNTLPPVEDPGKLASKARLLESKAYVDYALLGVLHDGNIHLFEDIIAAGAVGFKIFMGPTTGNIPP
PSDSSLYEALSKSGKTGVTMAFHAEDHSLVTYFTEKVKAGGGMDPWLHIEARPPITEEYSIVKIATIAKQTHGRVLIVHI
SSIEALEAVRKARSEGVEIYGETCPHYLVLDKADYQKHGSLIKVNPPIRGGIHRERLLEAVGNGLIDTLGSDHAPHTQEE
KKRDIWSAASGMPGVQTLLPIMLDLALRNVVPLTRMPILLSENPAKLWGLWPRKGSIDIGFDGDLVIVDPGGETVVTEEW
LEYKYKLSPYIGWRLKGKIRYTILRGMVIYRDGVITDKPVGKWIRPVKL

Specific function: Catalyzes the conversion of allantoin (5- ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring [H]

COG id: COG0044

COG function: function code F; Dihydroorotase and related cyclic amidohydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Allantoinase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19923821, Length=457, Percent_Identity=30.6345733041575, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI4503375, Length=454, Percent_Identity=29.7356828193833, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI4503379, Length=443, Percent_Identity=26.86230248307, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI4503051, Length=460, Percent_Identity=28.0434782608696, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI62422571, Length=460, Percent_Identity=28.0434782608696, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI18105007, Length=412, Percent_Identity=29.126213592233, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI190194363, Length=461, Percent_Identity=27.114967462039, Blast_Score=147, Evalue=3e-35,
Organism=Homo sapiens, GI4503377, Length=445, Percent_Identity=26.2921348314607, Blast_Score=145, Evalue=7e-35,
Organism=Escherichia coli, GI1786722, Length=436, Percent_Identity=35.0917431192661, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87082175, Length=460, Percent_Identity=29.1304347826087, Blast_Score=192, Evalue=4e-50,
Organism=Caenorhabditis elegans, GI71989490, Length=461, Percent_Identity=27.114967462039, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17539558, Length=449, Percent_Identity=26.0579064587973, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI193204318, Length=405, Percent_Identity=26.9135802469136, Blast_Score=139, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI86575075, Length=450, Percent_Identity=24, Blast_Score=120, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322218, Length=404, Percent_Identity=30.9405940594059, Blast_Score=176, Evalue=5e-45,
Organism=Drosophila melanogaster, GI24642586, Length=407, Percent_Identity=28.7469287469287, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI18859883, Length=466, Percent_Identity=30.2575107296137, Blast_Score=155, Evalue=7e-38,
Organism=Drosophila melanogaster, GI17137462, Length=447, Percent_Identity=26.3982102908277, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI221377917, Length=452, Percent_Identity=27.212389380531, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24644287, Length=301, Percent_Identity=29.9003322259136, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI24644289, Length=236, Percent_Identity=30.0847457627119, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017593
- InterPro:   IPR006680
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.5 [H]

Molecular weight: Translated: 49232; Mature: 49232

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAMSLLIRNGLLITPRRVFRADVKIVNGVITEIGVGLSTSGVDEVIDASGMLVLPGVID
CCEEEEHHHCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEECCHHC
EHVHMREPGLEYKDDFTHGTRAALKGGVTTVIEHPNTLPPVEDPGKLASKARLLESKAYV
CCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
DYALLGVLHDGNIHLFEDIIAAGAVGFKIFMGPTTGNIPPPSDSSLYEALSKSGKTGVTM
EEEEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEE
AFHAEDHSLVTYFTEKVKAGGGMDPWLHIEARPPITEEYSIVKIATIAKQTHGRVLIVHI
EEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEHHHHCCCCEEEEEE
SSIEALEAVRKARSEGVEIYGETCPHYLVLDKADYQKHGSLIKVNPPIRGGIHRERLLEA
CCHHHHHHHHHHHHCCEEEEECCCCCEEEEECCCHHHCCCEEEECCCCCCCCCHHHHHHH
VGNGLIDTLGSDHAPHTQEEKKRDIWSAASGMPGVQTLLPIMLDLALRNVVPLTRMPILL
HCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHCCEEE
SENPAKLWGLWPRKGSIDIGFDGDLVIVDPGGETVVTEEWLEYKYKLSPYIGWRLKGKIR
CCCCHHHEEECCCCCCEEECCCCCEEEECCCCCEEEEHHHHHEEEEECCEECEEEECEEE
YTILRGMVIYRDGVITDKPVGKWIRPVKL
EEEECCEEEEECCCCCCCCHHHCCCCCCC
>Mature Secondary Structure
MIAMSLLIRNGLLITPRRVFRADVKIVNGVITEIGVGLSTSGVDEVIDASGMLVLPGVID
CCEEEEHHHCCEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCCCEEECCHHC
EHVHMREPGLEYKDDFTHGTRAALKGGVTTVIEHPNTLPPVEDPGKLASKARLLESKAYV
CCCCCCCCCCCCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHH
DYALLGVLHDGNIHLFEDIIAAGAVGFKIFMGPTTGNIPPPSDSSLYEALSKSGKTGVTM
EEEEEEEEECCCCHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCEEE
AFHAEDHSLVTYFTEKVKAGGGMDPWLHIEARPPITEEYSIVKIATIAKQTHGRVLIVHI
EEECCCCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEEEEEHHHHCCCCEEEEEE
SSIEALEAVRKARSEGVEIYGETCPHYLVLDKADYQKHGSLIKVNPPIRGGIHRERLLEA
CCHHHHHHHHHHHHCCEEEEECCCCCEEEEECCCHHHCCCEEEECCCCCCCCCHHHHHHH
VGNGLIDTLGSDHAPHTQEEKKRDIWSAASGMPGVQTLLPIMLDLALRNVVPLTRMPILL
HCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHCCEEE
SENPAKLWGLWPRKGSIDIGFDGDLVIVDPGGETVVTEEWLEYKYKLSPYIGWRLKGKIR
CCCCHHHEEECCCCCCEEECCCCCEEEECCCCCEEEEHHHHHEEEEECCEECEEEECEEE
YTILRGMVIYRDGVITDKPVGKWIRPVKL
EEEECCEEEEECCCCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]