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The map label for this gene is MCM [H]

Identifier: 218883998

GI number: 218883998

Start: 656706

End: 658808

Strand: Reverse

Name: MCM [H]

Synonym: DKAM_0687

Alternate gene names: 218883998

Gene position: 658808-656706 (Counterclockwise)

Preceding gene: 218883999

Following gene: 218883996

Centisome position: 48.26

GC content: 47.55

Gene sequence:

>2103_bases
TTGGATAGCGAGGCTGATGTACAGGTAAGCCTGAAGGGAGCCGAGCTCACCGAGGCATTCAAGAAGTTCCTGGAAACATA
CCGCTCTAAGGAGGGCCTACGTAAATACATGGAGAGAATAGGCCAGATGATTGTGACAGGGCAGAAGAGCCTGACAGTGG
ACTTCATGGATCTGATAGAATATGATAGAGCCCTGGCAAGCATGGTGCTTGATAAACCTGATGAAGCCATTGAAAGGTTC
AGTGAGGCAGTGAAACTAGTTGTCGAGAAAGAGAACCCGGAGTACGCTAGAAAAATAGTGAAGTTCTACCCGAGGTTTAG
AAACCCGCCTGAGACGCATAGGATAAGAGATATATCGAGTGATTACATCGGCAAGCTCATCGCGATAGAGGGGATAGTTA
CACGAGTGACAAAGATAGATGCTAAAATAGTGAAAGCGACGTATAGGCATAGAGATCCTGAGACAGGTATACATGAATTC
GTATACCCTGATGAAGGCGAGATAGGCGAGAGGTTTGAGAAACCAGCGTACTGCCCTATATGTGGTAAGCCAGGTAGATT
CGAGCTACTCCCGGAGAAGAGTACTTTTATAGACTGGCAGAAAATAGTTGTCCAGGAGAAACCAGAGGAGGTCCCAGGAG
GTCAGATACCTAGGAGTATTGAGGTTATACTCACAGGCGACATAGTCGACGTCGCCAGGCCTGGCGATAGAGTAATCGTT
ATCGGGATACTAAGGGTTGCACCTATCTCCTCTCTAGAGAGGCACAGTCCTAGGGTCTTATTCTCCTTCTACATAGATGC
AAACAATATTGAGGTCCAGGAGAAGGTCCTTGAGGAAATAGAGATAACAGATGAAGACGAGAAAATGATAAGGGAGCTTG
CTAAGGACCCGTGGATAAGGGAGAAAATTATCGCGAGCATTGCGCCAGGTATCTACGGATACTGGGATATCAAGGAGGCC
ATAGCCCTCTTACTCTTAGGTGGTGTGCAAAAGATACTCCAGGACGGTACAAGGATCAGAGGGGATATACATGTCTTACT
TGTTGGGGATCCAGGTACTGCTAAATCACAGCTACTTCAATTCACCTCGAGACTAGCTCCCAGGGGATTATACACGAGTG
GCAAGGGCTCAACAGCCGCAGGATTAACAGCCACCGTCCTACGGGATAAGATGACAGGAGAATACTATTTAGAGGCTGGC
GCGCTAGTAATAGCAGATGGCGGTGTAGCCTGCATCGATGAGATAGATAAGATGAGGGAGGAGGATAGAAGCGCCATACA
TGAAGCCCTCGAGCAGCAGACGGTTAGCATCGCGAAGGCTGGAATAGTTGCAAGGCTTAACGCCAGATCCTCTGTCCTGG
CGGCCGGGAACCCTAAGGATGGAAGATACGATCCCACGAAGCCTGTAAGCAAGAACATAGATTTACCGCCCACAATACTC
TCGAGGTTTGACCTCATATTCACTATCAGGGATGTACCAAACACTGGACAGGATAAAAGGCTTGCACGCCATATACTCGG
GGTACATAGTGAAGTAGATAAGACGCGGTCACTAATAGATCTCACGTTGCTCAAGAAGTATATCAGTTATGCCAGGAGAT
ATGTGCGTCCACAGCTCACGCCTGAGGCAGCTAGGTTAATAGAGGAGTTCTACGTTAGCATGAGGCAGTCATCTATTTCA
AGCGATCCAAGCCAGCCAACCGCGATAGCTATAACGCCGAGGCAGCTTGAAGCAATAATAAGGCTTACAGAAGCACATGC
GCGTCTCTCGCTAAAGAATAGGGCTACAGTTGAAGACGCCGAGGAAGCCATAAGGCTCATGCTTGTTATGCTGAGCAAGA
TAGGTATAGATGTTGAAAGTGGACGTATAGATATAGATGTCATAGAATCAGGTGTATCAGCATCTAAAAGAGAAAAGAAG
AGGAGGTTCAGGGAGTTCGTGTTCAGGCTCCTCGAGGATGTAGGGAAGATAAGTATAAGCGAACTAGTCGCTAAAGCCAG
CGAGAAAGGCTTCGAAAAAGAATTCGCGAAAGAGGAGATAAGGGAGATGCTTAGACGTGGCGAGCTATACGAGCCTGAAA
GCGGTTATGTAGCTAAAGCATAG

Upstream 100 bases:

>100_bases
GACATCGTGGAGAACCTGAGTGAGGAGGAGAAGATACTCTTCAACGCATTGAAGACTATTCTAGATATATACTATAGGAG
GTTCATAGGGGTTGAAACAA

Downstream 100 bases:

>100_bases
CATTAGCTCACTAAGCTTGTTGACCCTGTATTTTCCCCTGTATCCACTTCTTCCTATGCCGCCATAGCGATACAGGTGTC
CAGAGTATCCAGGCTGGTAC

Product: MCM family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 700; Mature: 700

Protein sequence:

>700_residues
MDSEADVQVSLKGAELTEAFKKFLETYRSKEGLRKYMERIGQMIVTGQKSLTVDFMDLIEYDRALASMVLDKPDEAIERF
SEAVKLVVEKENPEYARKIVKFYPRFRNPPETHRIRDISSDYIGKLIAIEGIVTRVTKIDAKIVKATYRHRDPETGIHEF
VYPDEGEIGERFEKPAYCPICGKPGRFELLPEKSTFIDWQKIVVQEKPEEVPGGQIPRSIEVILTGDIVDVARPGDRVIV
IGILRVAPISSLERHSPRVLFSFYIDANNIEVQEKVLEEIEITDEDEKMIRELAKDPWIREKIIASIAPGIYGYWDIKEA
IALLLLGGVQKILQDGTRIRGDIHVLLVGDPGTAKSQLLQFTSRLAPRGLYTSGKGSTAAGLTATVLRDKMTGEYYLEAG
ALVIADGGVACIDEIDKMREEDRSAIHEALEQQTVSIAKAGIVARLNARSSVLAAGNPKDGRYDPTKPVSKNIDLPPTIL
SRFDLIFTIRDVPNTGQDKRLARHILGVHSEVDKTRSLIDLTLLKKYISYARRYVRPQLTPEAARLIEEFYVSMRQSSIS
SDPSQPTAIAITPRQLEAIIRLTEAHARLSLKNRATVEDAEEAIRLMLVMLSKIGIDVESGRIDIDVIESGVSASKREKK
RRFREFVFRLLEDVGKISISELVAKASEKGFEKEFAKEEIREMLRRGELYEPESGYVAKA

Sequences:

>Translated_700_residues
MDSEADVQVSLKGAELTEAFKKFLETYRSKEGLRKYMERIGQMIVTGQKSLTVDFMDLIEYDRALASMVLDKPDEAIERF
SEAVKLVVEKENPEYARKIVKFYPRFRNPPETHRIRDISSDYIGKLIAIEGIVTRVTKIDAKIVKATYRHRDPETGIHEF
VYPDEGEIGERFEKPAYCPICGKPGRFELLPEKSTFIDWQKIVVQEKPEEVPGGQIPRSIEVILTGDIVDVARPGDRVIV
IGILRVAPISSLERHSPRVLFSFYIDANNIEVQEKVLEEIEITDEDEKMIRELAKDPWIREKIIASIAPGIYGYWDIKEA
IALLLLGGVQKILQDGTRIRGDIHVLLVGDPGTAKSQLLQFTSRLAPRGLYTSGKGSTAAGLTATVLRDKMTGEYYLEAG
ALVIADGGVACIDEIDKMREEDRSAIHEALEQQTVSIAKAGIVARLNARSSVLAAGNPKDGRYDPTKPVSKNIDLPPTIL
SRFDLIFTIRDVPNTGQDKRLARHILGVHSEVDKTRSLIDLTLLKKYISYARRYVRPQLTPEAARLIEEFYVSMRQSSIS
SDPSQPTAIAITPRQLEAIIRLTEAHARLSLKNRATVEDAEEAIRLMLVMLSKIGIDVESGRIDIDVIESGVSASKREKK
RRFREFVFRLLEDVGKISISELVAKASEKGFEKEFAKEEIREMLRRGELYEPESGYVAKA
>Mature_700_residues
MDSEADVQVSLKGAELTEAFKKFLETYRSKEGLRKYMERIGQMIVTGQKSLTVDFMDLIEYDRALASMVLDKPDEAIERF
SEAVKLVVEKENPEYARKIVKFYPRFRNPPETHRIRDISSDYIGKLIAIEGIVTRVTKIDAKIVKATYRHRDPETGIHEF
VYPDEGEIGERFEKPAYCPICGKPGRFELLPEKSTFIDWQKIVVQEKPEEVPGGQIPRSIEVILTGDIVDVARPGDRVIV
IGILRVAPISSLERHSPRVLFSFYIDANNIEVQEKVLEEIEITDEDEKMIRELAKDPWIREKIIASIAPGIYGYWDIKEA
IALLLLGGVQKILQDGTRIRGDIHVLLVGDPGTAKSQLLQFTSRLAPRGLYTSGKGSTAAGLTATVLRDKMTGEYYLEAG
ALVIADGGVACIDEIDKMREEDRSAIHEALEQQTVSIAKAGIVARLNARSSVLAAGNPKDGRYDPTKPVSKNIDLPPTIL
SRFDLIFTIRDVPNTGQDKRLARHILGVHSEVDKTRSLIDLTLLKKYISYARRYVRPQLTPEAARLIEEFYVSMRQSSIS
SDPSQPTAIAITPRQLEAIIRLTEAHARLSLKNRATVEDAEEAIRLMLVMLSKIGIDVESGRIDIDVIESGVSASKREKK
RRFREFVFRLLEDVGKISISELVAKASEKGFEKEFAKEEIREMLRRGELYEPESGYVAKA

Specific function: Has ATPase and DNA helicase activities. The latter preferentially melts 5'-tailed oligonucleotides and is stimulated by the SSB protein (single-stranded DNA binding protein) [H]

COG id: COG1241

COG function: function code L; Predicted ATPase involved in replication control, Cdc46/Mcm family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 MCM domain [H]

Homologues:

Organism=Homo sapiens, GI33469919, Length=674, Percent_Identity=37.0919881305638, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI33469917, Length=674, Percent_Identity=37.0919881305638, Blast_Score=417, Evalue=1e-116,
Organism=Homo sapiens, GI33356547, Length=624, Percent_Identity=37.9807692307692, Blast_Score=409, Evalue=1e-114,
Organism=Homo sapiens, GI23510448, Length=717, Percent_Identity=36.1227336122734, Blast_Score=392, Evalue=1e-109,
Organism=Homo sapiens, GI7427519, Length=659, Percent_Identity=35.8118361153263, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI33469968, Length=648, Percent_Identity=37.1913580246914, Blast_Score=357, Evalue=3e-98,
Organism=Homo sapiens, GI19923727, Length=715, Percent_Identity=33.2867132867133, Blast_Score=335, Evalue=1e-91,
Organism=Homo sapiens, GI6631095, Length=666, Percent_Identity=35.5855855855856, Blast_Score=333, Evalue=3e-91,
Organism=Homo sapiens, GI33469922, Length=459, Percent_Identity=43.3551198257081, Blast_Score=323, Evalue=3e-88,
Organism=Homo sapiens, GI33469924, Length=664, Percent_Identity=33.433734939759, Blast_Score=321, Evalue=1e-87,
Organism=Homo sapiens, GI310128402, Length=273, Percent_Identity=39.1941391941392, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI310119838, Length=273, Percent_Identity=39.1941391941392, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI310115110, Length=273, Percent_Identity=39.1941391941392, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI23397546, Length=396, Percent_Identity=30.8080808080808, Blast_Score=153, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17508417, Length=709, Percent_Identity=36.1071932299013, Blast_Score=413, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71997752, Length=618, Percent_Identity=38.1877022653722, Blast_Score=407, Evalue=1e-113,
Organism=Caenorhabditis elegans, GI17554306, Length=643, Percent_Identity=34.9922239502333, Blast_Score=367, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI71997563, Length=648, Percent_Identity=34.1049382716049, Blast_Score=338, Evalue=5e-93,
Organism=Caenorhabditis elegans, GI17562700, Length=663, Percent_Identity=34.0874811463047, Blast_Score=336, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17562702, Length=504, Percent_Identity=39.0873015873016, Blast_Score=334, Evalue=9e-92,
Organism=Caenorhabditis elegans, GI71997571, Length=330, Percent_Identity=45.7575757575758, Blast_Score=266, Evalue=3e-71,
Organism=Saccharomyces cerevisiae, GI6325276, Length=735, Percent_Identity=36.4625850340136, Blast_Score=414, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6323304, Length=671, Percent_Identity=35.9165424739195, Blast_Score=374, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6319448, Length=642, Percent_Identity=34.4236760124611, Blast_Score=362, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319679, Length=569, Percent_Identity=36.7311072056239, Blast_Score=323, Evalue=8e-89,
Organism=Saccharomyces cerevisiae, GI6321237, Length=628, Percent_Identity=33.7579617834395, Blast_Score=319, Evalue=8e-88,
Organism=Saccharomyces cerevisiae, GI6320803, Length=473, Percent_Identity=41.014799154334, Blast_Score=299, Evalue=1e-81,
Organism=Drosophila melanogaster, GI17137132, Length=616, Percent_Identity=37.6623376623377, Blast_Score=407, Evalue=1e-113,
Organism=Drosophila melanogaster, GI24645774, Length=733, Percent_Identity=36.0163710777626, Blast_Score=404, Evalue=1e-112,
Organism=Drosophila melanogaster, GI17137242, Length=641, Percent_Identity=35.8814352574103, Blast_Score=377, Evalue=1e-104,
Organism=Drosophila melanogaster, GI17530827, Length=640, Percent_Identity=35.9375, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24639835, Length=630, Percent_Identity=37.7777777777778, Blast_Score=348, Evalue=1e-95,
Organism=Drosophila melanogaster, GI17647617, Length=708, Percent_Identity=34.6045197740113, Blast_Score=341, Evalue=1e-93,
Organism=Drosophila melanogaster, GI24647251, Length=428, Percent_Identity=27.3364485981308, Blast_Score=131, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001208
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF00493 MCM [H]

EC number: NA

Molecular weight: Translated: 78784; Mature: 78784

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: PS50051 MCM_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDSEADVQVSLKGAELTEAFKKFLETYRSKEGLRKYMERIGQMIVTGQKSLTVDFMDLIE
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
YDRALASMVLDKPDEAIERFSEAVKLVVEKENPEYARKIVKFYPRFRNPPETHRIRDISS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCH
DYIGKLIAIEGIVTRVTKIDAKIVKATYRHRDPETGIHEFVYPDEGEIGERFEKPAYCPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHCCCCCCCC
CGKPGRFELLPEKSTFIDWQKIVVQEKPEEVPGGQIPRSIEVILTGDIVDVARPGDRVIV
CCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEE
IGILRVAPISSLERHSPRVLFSFYIDANNIEVQEKVLEEIEITDEDEKMIRELAKDPWIR
EEEHHHCCHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHH
EKIIASIAPGIYGYWDIKEAIALLLLGGVQKILQDGTRIRGDIHVLLVGDPGTAKSQLLQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECEEEEEEECCCCCHHHHHHH
FTSRLAPRGLYTSGKGSTAAGLTATVLRDKMTGEYYLEAGALVIADGGVACIDEIDKMRE
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCEEEEECCCCHHHHHHHHHHH
EDRSAIHEALEQQTVSIAKAGIVARLNARSSVLAAGNPKDGRYDPTKPVSKNIDLPPTIL
HHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHH
SRFDLIFTIRDVPNTGQDKRLARHILGVHSEVDKTRSLIDLTLLKKYISYARRYVRPQLT
HHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PEAARLIEEFYVSMRQSSISSDPSQPTAIAITPRQLEAIIRLTEAHARLSLKNRATVEDA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHH
EEAIRLMLVMLSKIGIDVESGRIDIDVIESGVSASKREKKRRFREFVFRLLEDVGKISIS
HHHHHHHHHHHHHHCCEECCCEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
ELVAKASEKGFEKEFAKEEIREMLRRGELYEPESGYVAKA
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEECC
>Mature Secondary Structure
MDSEADVQVSLKGAELTEAFKKFLETYRSKEGLRKYMERIGQMIVTGQKSLTVDFMDLIE
CCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
YDRALASMVLDKPDEAIERFSEAVKLVVEKENPEYARKIVKFYPRFRNPPETHRIRDISS
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCH
DYIGKLIAIEGIVTRVTKIDAKIVKATYRHRDPETGIHEFVYPDEGEIGERFEKPAYCPI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCCHHHHHCCCCCCCC
CGKPGRFELLPEKSTFIDWQKIVVQEKPEEVPGGQIPRSIEVILTGDIVDVARPGDRVIV
CCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCEEE
IGILRVAPISSLERHSPRVLFSFYIDANNIEVQEKVLEEIEITDEDEKMIRELAKDPWIR
EEEHHHCCHHHHHHCCCEEEEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHCCCHH
EKIIASIAPGIYGYWDIKEAIALLLLGGVQKILQDGTRIRGDIHVLLVGDPGTAKSQLLQ
HHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECEEEEEEECCCCCHHHHHHH
FTSRLAPRGLYTSGKGSTAAGLTATVLRDKMTGEYYLEAGALVIADGGVACIDEIDKMRE
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEEEECCEEEEECCCCHHHHHHHHHHH
EDRSAIHEALEQQTVSIAKAGIVARLNARSSVLAAGNPKDGRYDPTKPVSKNIDLPPTIL
HHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCCCCCCCCCCCCCCCCCCHHHH
SRFDLIFTIRDVPNTGQDKRLARHILGVHSEVDKTRSLIDLTLLKKYISYARRYVRPQLT
HHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PEAARLIEEFYVSMRQSSISSDPSQPTAIAITPRQLEAIIRLTEAHARLSLKNRATVEDA
HHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCHHHH
EEAIRLMLVMLSKIGIDVESGRIDIDVIESGVSASKREKKRRFREFVFRLLEDVGKISIS
HHHHHHHHHHHHHHCCEECCCEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHH
ELVAKASEKGFEKEFAKEEIREMLRRGELYEPESGYVAKA
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10701121; 11427726 [H]