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The map label for this gene is prs [H]

Identifier: 218883851

GI number: 218883851

Start: 506338

End: 507243

Strand: Reverse

Name: prs [H]

Synonym: DKAM_0540

Alternate gene names: 218883851

Gene position: 507243-506338 (Counterclockwise)

Preceding gene: 218883854

Following gene: 218883850

Centisome position: 37.15

GC content: 49.78

Gene sequence:

>906_bases
GTGTTGATTAAGGCTGTTGTAACCGGTAACTACCCTGATGGATTCAATATAGCTAGGGGAGTCAATGCCGAAGTAATCGG
TATCACGGAGAAAGTGTTCCCCGACGGAGAGCAATACGTGAGGCTTGAGGAGCCGGATAAGGTAAGGGATTCCACGATCC
TCGTTATTTCAACCATGTACCCTATGCAGGATCAATCCCTTCTGAAATTATTAATCCTAGCCGACGCCCTGGCAAGGAAC
CAGGCAAGAGAGTTCATCGGGGTAATACCATACCTGGCCTACTCAAGGCAGGACAAGGTATTTATGCCGGGAGAGCCTGT
ATCGGCCTCAACAGTGTTACGGATCCTTAAATCAGCCGGTTATAGCAGGCTCGTAGTTGTGGACTTCCATAGCAATAGCC
TGCTAAGCGATTTCAAGCCGTACCTTGTAAACATCCTTGTCTCAGACCTCCTTGTTAAAGCAGTGGTGGATAAGCTGGAT
AAGCCGGTCATCCTCGCCCCTGATAAAGGTGCCTTGGAGAGAGCCAGGTTTGCGGCTGAAAGCATTGGCTTAGACTACGA
TTACCTGGTTAAATCAAGGGACAGGGTGACCGGGGCCGTGAGCTATGCCCCTAGAGAGGTGAGCGTCGAGGGAAGGGATG
TCGTGATAGTCGATGACATAATAAGCACGGGTGGGACGATCGCCGAGGCATCAAGGATCCTCTTGAAGCAGGGAGCTAGA
AGAATATTTGTCGCTGCATCCCATGGATTGATGATCGGTAATGCGTTATCGAGGATTATGGATGCGGGTGTCCAGAGAAT
AATATTAGCCAACACGCTTAGCACAAGGCTGGAGCACCCGTTAGTAGAGTATGTTGATATATCGTCGAGGATAGCCAGCG
TGTTGAGAGAGTTAATCCAGGCCTAG

Upstream 100 bases:

>100_bases
ATCTGCTTCCCTAACCCATGGTAGGTCGGGGGAGAACTTCAAGCTTCTCATCCTCTTAAATAAAATTGTTTAGACCCGTA
TTATAATATACTGGTGACTC

Downstream 100 bases:

>100_bases
GGTAACCGTGGTCCCGGGTATGAAGGCATTAGTTAACTACTTCCTGCTAAGAGGAGACAACGAGGCCCTTGGACGAGGAG
AGCTTAAAGCATTACTCGAG

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MLIKAVVTGNYPDGFNIARGVNAEVIGITEKVFPDGEQYVRLEEPDKVRDSTILVISTMYPMQDQSLLKLLILADALARN
QAREFIGVIPYLAYSRQDKVFMPGEPVSASTVLRILKSAGYSRLVVVDFHSNSLLSDFKPYLVNILVSDLLVKAVVDKLD
KPVILAPDKGALERARFAAESIGLDYDYLVKSRDRVTGAVSYAPREVSVEGRDVVIVDDIISTGGTIAEASRILLKQGAR
RIFVAASHGLMIGNALSRIMDAGVQRIILANTLSTRLEHPLVEYVDISSRIASVLRELIQA

Sequences:

>Translated_301_residues
MLIKAVVTGNYPDGFNIARGVNAEVIGITEKVFPDGEQYVRLEEPDKVRDSTILVISTMYPMQDQSLLKLLILADALARN
QAREFIGVIPYLAYSRQDKVFMPGEPVSASTVLRILKSAGYSRLVVVDFHSNSLLSDFKPYLVNILVSDLLVKAVVDKLD
KPVILAPDKGALERARFAAESIGLDYDYLVKSRDRVTGAVSYAPREVSVEGRDVVIVDDIISTGGTIAEASRILLKQGAR
RIFVAASHGLMIGNALSRIMDAGVQRIILANTLSTRLEHPLVEYVDISSRIASVLRELIQA
>Mature_301_residues
MLIKAVVTGNYPDGFNIARGVNAEVIGITEKVFPDGEQYVRLEEPDKVRDSTILVISTMYPMQDQSLLKLLILADALARN
QAREFIGVIPYLAYSRQDKVFMPGEPVSASTVLRILKSAGYSRLVVVDFHSNSLLSDFKPYLVNILVSDLLVKAVVDKLD
KPVILAPDKGALERARFAAESIGLDYDYLVKSRDRVTGAVSYAPREVSVEGRDVVIVDDIISTGGTIAEASRILLKQGAR
RIFVAASHGLMIGNALSRIMDAGVQRIILANTLSTRLEHPLVEYVDISSRIASVLRELIQA

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=289, Percent_Identity=26.9896193771626, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI28557709, Length=286, Percent_Identity=26.9230769230769, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI84875539, Length=285, Percent_Identity=26.3157894736842, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4506129, Length=282, Percent_Identity=25.886524822695, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4506133, Length=304, Percent_Identity=25.6578947368421, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI194018537, Length=302, Percent_Identity=27.1523178807947, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787458, Length=273, Percent_Identity=32.967032967033, Blast_Score=135, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI25149168, Length=301, Percent_Identity=26.2458471760797, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI17554702, Length=301, Percent_Identity=26.2458471760797, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71989924, Length=301, Percent_Identity=26.2458471760797, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17554704, Length=294, Percent_Identity=26.1904761904762, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17570245, Length=288, Percent_Identity=21.5277777777778, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320946, Length=283, Percent_Identity=26.5017667844523, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6319403, Length=304, Percent_Identity=26.3157894736842, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6321776, Length=271, Percent_Identity=27.6752767527675, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322667, Length=197, Percent_Identity=25.3807106598985, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355239, Length=275, Percent_Identity=25.0909090909091, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24651458, Length=345, Percent_Identity=25.2173913043478, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24651456, Length=345, Percent_Identity=25.2173913043478, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI45551540, Length=298, Percent_Identity=23.489932885906, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281362873, Length=345, Percent_Identity=25.2173913043478, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24651454, Length=345, Percent_Identity=25.2173913043478, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24651462, Length=186, Percent_Identity=28.494623655914, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24651464, Length=186, Percent_Identity=28.494623655914, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45552010, Length=186, Percent_Identity=28.494623655914, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 33027; Mature: 33027

Theoretical pI: Translated: 6.82; Mature: 6.82

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIKAVVTGNYPDGFNIARGVNAEVIGITEKVFPDGEQYVRLEEPDKVRDSTILVISTMY
CEEEEEEECCCCCCCCHHCCCCCEEEEEHHHHCCCCHHEEEECCCCCCCCCEEEEEEECC
PMQDQSLLKLLILADALARNQAREFIGVIPYLAYSRQDKVFMPGEPVSASTVLRILKSAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHCC
YSRLVVVDFHSNSLLSDFKPYLVNILVSDLLVKAVVDKLDKPVILAPDKGALERARFAAE
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHH
SIGLDYDYLVKSRDRVTGAVSYAPREVSVEGRDVVIVDDIISTGGTIAEASRILLKQGAR
HHCCCHHHHHCCCHHHEEEEEECCCEEECCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCC
RIFVAASHGLMIGNALSRIMDAGVQRIILANTLSTRLEHPLVEYVDISSRIASVLRELIQ
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
A
C
>Mature Secondary Structure
MLIKAVVTGNYPDGFNIARGVNAEVIGITEKVFPDGEQYVRLEEPDKVRDSTILVISTMY
CEEEEEEECCCCCCCCHHCCCCCEEEEEHHHHCCCCHHEEEECCCCCCCCCEEEEEEECC
PMQDQSLLKLLILADALARNQAREFIGVIPYLAYSRQDKVFMPGEPVSASTVLRILKSAG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHCC
YSRLVVVDFHSNSLLSDFKPYLVNILVSDLLVKAVVDKLDKPVILAPDKGALERARFAAE
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHH
SIGLDYDYLVKSRDRVTGAVSYAPREVSVEGRDVVIVDDIISTGGTIAEASRILLKQGAR
HHCCCHHHHHCCCHHHEEEEEECCCEEECCCCCEEEEEHHHHCCCCHHHHHHHHHHCCCC
RIFVAASHGLMIGNALSRIMDAGVQRIILANTLSTRLEHPLVEYVDISSRIASVLRELIQ
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]