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The map label for this gene is moeA [C]

Identifier: 218883813

GI number: 218883813

Start: 473305

End: 474555

Strand: Direct

Name: moeA [C]

Synonym: DKAM_0502

Alternate gene names: 218883813

Gene position: 473305-474555 (Clockwise)

Preceding gene: 218883812

Following gene: 218883816

Centisome position: 34.67

GC content: 48.2

Gene sequence:

>1251_bases
GTGGTGTGGTTGGATAGAAGGCTTACAACACTTATAAGTGTTGATGACGCGGTGGAACTACTTGCCAGGACTCTAAGCGG
GGCAGTAAGCCTGGAACCCGAAGAGGTAAGAGTGCTTGAAGCAGTTGGCAGGATAATAGCTGAACCGGTGGAAGCCGAAA
TAGATATACCTCCATTTAATAGGAGCGCCGTGGATGGATATGCTGTCCAGGCAGGCGATACAGTTAATGCATCAGTGTAT
AACCCGGTTGAGCTAGTATTAAAAGGAGTTCTCACAGCAAGCGATAAGCCTCCAAGCGAATGCGTGGAGCCAGGTGAAGC
AGTAAGAGTTCACACGGGTTCACCTATACCGTGCGGAGCCAACGCGGTGGTTATGGATGAGGATGTAGAGGTTAAGGATG
GTAGCATAGTAGTGTACAAGCCGGTATCGCCTGGTCAAAACATATCAAGGAGAGGTGAGGACTTCGTCAAGGGAGACGTC
ATCATAGCCAGGGGTACCATATTGAACCCGGTGCATATAGGAGTTATCTCAAGCATTGGAGTAGACAGGGTAAAAGTGTA
TAGAAGGCTTAGAATAGGTGTTTTAACATCAGGTAACGAGGTATGCGAGCCTGGGATAGATAGGGACTGCGATACCCTCA
TATATAACTCGTCGGCTAGGCTTATCACGGCCCTCCTCCGTCAGAGCAGGTTTATCGATGTGAAGTATTATGGTGTCTTC
CCGGATGACCCGGAAATACTATCCAATGCTGTAGTGGAGGCATCCATGGAGAATGACCTAGTTGTTACGACAGGGGGCAC
CGGGATCAGTGAAGGCGATGCATTAATCGATGCCATGTTAAATACAGGTAAAATAATCTTTAGAGGAGTCAAGATGAGGC
CTGGTAGGCCTACCACGCTCTCGTTGATAAACAATAAGCCGGCTCTCCATTTATCAGGCTACCCTGTAGCGGCTTGGACA
GGGTATGAAGCCATACTCATCCCAGCTGTCAGGAAGTGGCTTGGGTTAAAAGGATTGGAGAGGCCAGTGGTATATGCAAG
GCTTTCACGTAGAATACCTAACACAGTAGGGTACAGGAGCTACATAAGGGTTATACTGAGAGACGCTGGGGGAGAATATG
TGGCGGAACCCTACATGCTCAGGGGTAGCGGGATATTATCTAGTCTGCTCAAGAGTCACGGCTACATAGTTATACCTGAG
AATGTTGAAGGGGTTGAAAAAGACTCAGTGGTACCTGTCCATCTTTTCTAA

Upstream 100 bases:

>100_bases
GCTGGGGCAGCGCATCTCATTATATAACCTGGCTACCGGCTTATTAACAATTGTATCTCTTATAGCTATAATACGTGGTT
ATAGATAGGGGATTACGGGA

Downstream 100 bases:

>100_bases
ATCTAACATCAGTATTTGGCTAGGCATTCGCAGCAATCATATTGTCCTGGTTAAGGCCTCTACCTCGTAGAGGCTTGAGG
GAGGTTTATTAAGCAATGGA

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MVWLDRRLTTLISVDDAVELLARTLSGAVSLEPEEVRVLEAVGRIIAEPVEAEIDIPPFNRSAVDGYAVQAGDTVNASVY
NPVELVLKGVLTASDKPPSECVEPGEAVRVHTGSPIPCGANAVVMDEDVEVKDGSIVVYKPVSPGQNISRRGEDFVKGDV
IIARGTILNPVHIGVISSIGVDRVKVYRRLRIGVLTSGNEVCEPGIDRDCDTLIYNSSARLITALLRQSRFIDVKYYGVF
PDDPEILSNAVVEASMENDLVVTTGGTGISEGDALIDAMLNTGKIIFRGVKMRPGRPTTLSLINNKPALHLSGYPVAAWT
GYEAILIPAVRKWLGLKGLERPVVYARLSRRIPNTVGYRSYIRVILRDAGGEYVAEPYMLRGSGILSSLLKSHGYIVIPE
NVEGVEKDSVVPVHLF

Sequences:

>Translated_416_residues
MVWLDRRLTTLISVDDAVELLARTLSGAVSLEPEEVRVLEAVGRIIAEPVEAEIDIPPFNRSAVDGYAVQAGDTVNASVY
NPVELVLKGVLTASDKPPSECVEPGEAVRVHTGSPIPCGANAVVMDEDVEVKDGSIVVYKPVSPGQNISRRGEDFVKGDV
IIARGTILNPVHIGVISSIGVDRVKVYRRLRIGVLTSGNEVCEPGIDRDCDTLIYNSSARLITALLRQSRFIDVKYYGVF
PDDPEILSNAVVEASMENDLVVTTGGTGISEGDALIDAMLNTGKIIFRGVKMRPGRPTTLSLINNKPALHLSGYPVAAWT
GYEAILIPAVRKWLGLKGLERPVVYARLSRRIPNTVGYRSYIRVILRDAGGEYVAEPYMLRGSGILSSLLKSHGYIVIPE
NVEGVEKDSVVPVHLF
>Mature_416_residues
MVWLDRRLTTLISVDDAVELLARTLSGAVSLEPEEVRVLEAVGRIIAEPVEAEIDIPPFNRSAVDGYAVQAGDTVNASVY
NPVELVLKGVLTASDKPPSECVEPGEAVRVHTGSPIPCGANAVVMDEDVEVKDGSIVVYKPVSPGQNISRRGEDFVKGDV
IIARGTILNPVHIGVISSIGVDRVKVYRRLRIGVLTSGNEVCEPGIDRDCDTLIYNSSARLITALLRQSRFIDVKYYGVF
PDDPEILSNAVVEASMENDLVVTTGGTGISEGDALIDAMLNTGKIIFRGVKMRPGRPTTLSLINNKPALHLSGYPVAAWT
GYEAILIPAVRKWLGLKGLERPVVYARLSRRIPNTVGYRSYIRVILRDAGGEYVAEPYMLRGSGILSSLLKSHGYIVIPE
NVEGVEKDSVVPVHLF

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=381, Percent_Identity=31.2335958005249, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI66932975, Length=381, Percent_Identity=31.2335958005249, Blast_Score=155, Evalue=9e-38,
Organism=Escherichia coli, GI1787049, Length=393, Percent_Identity=31.0432569974555, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25147659, Length=352, Percent_Identity=29.8295454545455, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17562606, Length=343, Percent_Identity=25.9475218658892, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17136978, Length=302, Percent_Identity=25.1655629139073, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24638841, Length=302, Percent_Identity=25.1655629139073, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45063; Mature: 45063

Theoretical pI: Translated: 5.20; Mature: 5.20

Prosite motif: PS01078 MOCF_BIOSYNTHESIS_1 ; PS00214 FABP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVWLDRRLTTLISVDDAVELLARTLSGAVSLEPEEVRVLEAVGRIIAEPVEAEIDIPPFN
CEEECCHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHCCCCCCEECCCCCC
RSAVDGYAVQAGDTVNASVYNPVELVLKGVLTASDKPPSECVEPGEAVRVHTGSPIPCGA
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCEEEEECCCCCCCCC
NAVVMDEDVEVKDGSIVVYKPVSPGQNISRRGEDFVKGDVIIARGTILNPVHIGVISSIG
CEEEECCCCEECCCCEEEEECCCCCCCHHHCCCCHHCCCEEEECCCEECCEEEEHHHHCC
VDRVKVYRRLRIGVLTSGNEVCEPGIDRDCDTLIYNSSARLITALLRQSRFIDVKYYGVF
HHHHHHHHHHEEEEEECCCHHCCCCCCCCCCEEEECCCHHHHHHHHHHCCEEEEEEEECC
PDDPEILSNAVVEASMENDLVVTTGGTGISEGDALIDAMLNTGKIIFRGVKMRPGRPTTL
CCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCEE
SLINNKPALHLSGYPVAAWTGYEAILIPAVRKWLGLKGLERPVVYARLSRRIPNTVGYRS
EEECCCCEEEECCCCEEEECCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHH
YIRVILRDAGGEYVAEPYMLRGSGILSSLLKSHGYIVIPENVEGVEKDSVVPVHLF
HHHHHHHHCCCCEECCCEEEECCHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEEC
>Mature Secondary Structure
MVWLDRRLTTLISVDDAVELLARTLSGAVSLEPEEVRVLEAVGRIIAEPVEAEIDIPPFN
CEEECCHHHHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHHHCCCCCCEECCCCCC
RSAVDGYAVQAGDTVNASVYNPVELVLKGVLTASDKPPSECVEPGEAVRVHTGSPIPCGA
CCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCHHHHCCCCCEEEEECCCCCCCCC
NAVVMDEDVEVKDGSIVVYKPVSPGQNISRRGEDFVKGDVIIARGTILNPVHIGVISSIG
CEEEECCCCEECCCCEEEEECCCCCCCHHHCCCCHHCCCEEEECCCEECCEEEEHHHHCC
VDRVKVYRRLRIGVLTSGNEVCEPGIDRDCDTLIYNSSARLITALLRQSRFIDVKYYGVF
HHHHHHHHHHEEEEEECCCHHCCCCCCCCCCEEEECCCHHHHHHHHHHCCEEEEEEEECC
PDDPEILSNAVVEASMENDLVVTTGGTGISEGDALIDAMLNTGKIIFRGVKMRPGRPTTL
CCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCEE
SLINNKPALHLSGYPVAAWTGYEAILIPAVRKWLGLKGLERPVVYARLSRRIPNTVGYRS
EEECCCCEEEECCCCEEEECCCCEEHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHH
YIRVILRDAGGEYVAEPYMLRGSGILSSLLKSHGYIVIPENVEGVEKDSVVPVHLF
HHHHHHHHCCCCEECCCEEEECCHHHHHHHHHCCEEEECCCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]