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The map label for this gene is tbp [H]

Identifier: 218883586

GI number: 218883586

Start: 254278

End: 254862

Strand: Reverse

Name: tbp [H]

Synonym: DKAM_0275

Alternate gene names: 218883586

Gene position: 254862-254278 (Counterclockwise)

Preceding gene: 218883587

Following gene: 218883585

Centisome position: 18.67

GC content: 46.5

Gene sequence:

>585_bases
ATGAACACTATCCCTTTTAAAACCAGTTACCGTGTTGAAAACATTGTGGCAACAGTCATCCTTGAGCACGACCTCGACCT
GGAGCTTATTGAGACAAGGATACCCAGCATCACTTATAAACCCGATCAATTCCCTGGGTTAATATTCCGTCTGGATAAAC
CCAGGGCTACAGCACTCGTGTTTAAATCAGGCAAGATGGTTGTAACAGGGACTAAGAGCACTCAGCAACTCGTTGAGGCA
GTCAAGAAAATAATAAAGACGTTCGTGAAGAATGGTGTAAACGTCCATGGAAGGCCCCGTGTCCAGATACAGAATATAGT
TGCAGGCGGTGATATACACGCATACGTGAACCTTGAGAAAGCAGCCTACCACCTTGAGGACAGTATGTACGAGCCCGAGC
AATTCCCCGGGCTGATACATAGGATGAGGGATCCAAGGGTGGTTCTCCTAATATTCAGTAGTGGTAAAATGGTGATTACC
GGTGCTAAGGAAGAGGTTGAGGTCGAGAGAGCTGTGAACAATATTGCTAGACAACTATATAAAGCTGGATGCATAGTGGG
TCCCAGGCTAGGCGAGGAGGAATGA

Upstream 100 bases:

>100_bases
CCGTCTTTAAAATAGCTCATTAAATTATTCGTGCCCCTATTCTTCAATAGTTTATAAAGCCTCTCCTCGATAATTACTAT
AAGCACGAGTGGTGGTCGGC

Downstream 100 bases:

>100_bases
CTTATTTTTAAACCACCTTAAACTATTAATTAGCATAGTGATGACGCGGGCAGCCACTTAGACCACTGGTTTCAATGGGA
TGAAGACCCTTATGCTCAAT

Product: transcription factor

Products: NA

Alternate protein names: Box A-binding protein; BAP; TATA sequence-binding protein; TBP; TATA-box factor [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MNTIPFKTSYRVENIVATVILEHDLDLELIETRIPSITYKPDQFPGLIFRLDKPRATALVFKSGKMVVTGTKSTQQLVEA
VKKIIKTFVKNGVNVHGRPRVQIQNIVAGGDIHAYVNLEKAAYHLEDSMYEPEQFPGLIHRMRDPRVVLLIFSSGKMVIT
GAKEEVEVERAVNNIARQLYKAGCIVGPRLGEEE

Sequences:

>Translated_194_residues
MNTIPFKTSYRVENIVATVILEHDLDLELIETRIPSITYKPDQFPGLIFRLDKPRATALVFKSGKMVVTGTKSTQQLVEA
VKKIIKTFVKNGVNVHGRPRVQIQNIVAGGDIHAYVNLEKAAYHLEDSMYEPEQFPGLIHRMRDPRVVLLIFSSGKMVIT
GAKEEVEVERAVNNIARQLYKAGCIVGPRLGEEE
>Mature_194_residues
MNTIPFKTSYRVENIVATVILEHDLDLELIETRIPSITYKPDQFPGLIFRLDKPRATALVFKSGKMVVTGTKSTQQLVEA
VKKIIKTFVKNGVNVHGRPRVQIQNIVAGGDIHAYVNLEKAAYHLEDSMYEPEQFPGLIHRMRDPRVVLLIFSSGKMVIT
GAKEEVEVERAVNNIARQLYKAGCIVGPRLGEEE

Specific function: General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation [H]

COG id: COG2101

COG function: function code K; TATA-box binding protein (TBP), component of TFIID and TFIIIB

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TBP family [H]

Homologues:

Organism=Homo sapiens, GI39930602, Length=166, Percent_Identity=45.1807228915663, Blast_Score=129, Evalue=2e-30,
Organism=Homo sapiens, GI4507379, Length=166, Percent_Identity=45.1807228915663, Blast_Score=128, Evalue=3e-30,
Organism=Homo sapiens, GI285026520, Length=166, Percent_Identity=45.1807228915663, Blast_Score=128, Evalue=3e-30,
Organism=Caenorhabditis elegans, GI17555358, Length=165, Percent_Identity=43.6363636363636, Blast_Score=120, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6320996, Length=165, Percent_Identity=44.2424242424242, Blast_Score=124, Evalue=1e-29,
Organism=Drosophila melanogaster, GI17136834, Length=167, Percent_Identity=40.1197604790419, Blast_Score=120, Evalue=7e-28,
Organism=Drosophila melanogaster, GI17647997, Length=166, Percent_Identity=43.3734939759036, Blast_Score=118, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012295
- InterPro:   IPR000814
- InterPro:   IPR012294 [H]

Pfam domain/function: PF00352 TBP [H]

EC number: NA

Molecular weight: Translated: 21813; Mature: 21813

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00351 TFIID

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTIPFKTSYRVENIVATVILEHDLDLELIETRIPSITYKPDQFPGLIFRLDKPRATALV
CCCCCCCCCHHHHHHEEEEEEECCCCHHHHHHCCCCEEECCCCCCCEEEEECCCCEEEEE
FKSGKMVVTGTKSTQQLVEAVKKIIKTFVKNGVNVHGRPRVQIQNIVAGGDIHAYVNLEK
EECCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEEEEEEHHH
AAYHLEDSMYEPEQFPGLIHRMRDPRVVLLIFSSGKMVITGAKEEVEVERAVNNIARQLY
HHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHH
KAGCIVGPRLGEEE
HCCCEECCCCCCCC
>Mature Secondary Structure
MNTIPFKTSYRVENIVATVILEHDLDLELIETRIPSITYKPDQFPGLIFRLDKPRATALV
CCCCCCCCCHHHHHHEEEEEEECCCCHHHHHHCCCCEEECCCCCCCEEEEECCCCEEEEE
FKSGKMVVTGTKSTQQLVEAVKKIIKTFVKNGVNVHGRPRVQIQNIVAGGDIHAYVNLEK
EECCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCCEEEEEEHHH
AAYHLEDSMYEPEQFPGLIHRMRDPRVVLLIFSSGKMVITGAKEEVEVERAVNNIARQLY
HHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHHH
KAGCIVGPRLGEEE
HCCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11572479 [H]