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The map label for this gene is galK [H]

Identifier: 218883570

GI number: 218883570

Start: 239581

End: 240903

Strand: Reverse

Name: galK [H]

Synonym: DKAM_0259

Alternate gene names: 218883570

Gene position: 240903-239581 (Counterclockwise)

Preceding gene: 218883573

Following gene: 218883569

Centisome position: 17.65

GC content: 48.9

Gene sequence:

>1323_bases
ATGGGTTTAATAAGAATTACATCAAAGTTTAAAATCCAAGGGGTCTCATCATGGAGGATCTGGGAGGATGATTTCATGAT
TGATAAAATAGGTATAGCATTCAAGGAGTTCTACGGTGAGAAGCCATCGATAGTGGTCTCAGCACCTGGTAGACTGGACT
TCCTGAATACCCACCAGGATTATAAGGGCTTACCGGTCTCAGCTATAGGAGTAAACCTTAGGACATATATTGCATTAGCG
CCCAGCAATAATGGAGTCATGGCTTACTCCGAGAACCTTAACGCTGTGGATGAGTTCCACCCAGAAGAGATAACACTGAG
GGGTGGTAAATGGTTCGGCGACTATATTAGGGCGGTATTCAAGGTCTTCACTGAGGAAGGATACAGGATCAAGGGGTTCA
AGGCATATATTGCAAGCAATATACCCATCGCCTCAGGGCTGGCGAGCAGTGCAGCCCTGGAAGTAGCTGTCGCCTGGGGT
ATAAGCGAGCTCAACGGGCTTGGGCTTAGTAGGAAGGATATAGCTGAGTATGCCTTCAAAGCCGAGAGCAAGGTCATGGG
TATACCCTGCGGGAGACTAGACCAGTATGGTTCAGCCTTCGGCGGTGTAACATTGATACATACAAGGCCCCCGTACAATG
TTGAGGAACTCGGGTTCAGAGAGGGGGTTTGGCTCGTAGTGGACTCCGGGATCAGGCACTCGACAGCCGATATCCATCCA
CGTGTACAGGGTGAGATAGATAGGGCATTAAACGAGTTAATGAGTATTGTTCCCCCGGGCTTGAAGAGCAAGCTGGGGTA
TAGGTACTGGGAGCCGAGGTGGGAGGAGCTCACACTAGACGAGCTCACCCCATACCTTGATAACGTGAATAGGACTGGGG
CTAGGAAGATAGAGTTCACGATTAGAATGCATTCATCCACGATGCTAGCGGTTAAGGCGTTAAAGGGGTTTAAGCCCACG
GTTGGTGAGGTTGTAGAGGTCCTCGGTAGTGAATTAGCGGAGCCTGAAAAGGTGAGGTCTATTCTCTCCAGTAATACATG
GAGACTGGAGCTAATAGGCTTAGTAATGAATCATCAGCATTACTTACTTAGCAAGCTATATGATGTAAGCCTGCCAGAGA
TAGATAGGATAGTTGATGAAATGAATAAGCTTGGAGCACTGGGGGCCAAGCTCTCGGGAGCGGGGCTAGGCGGCTCCGTT
ATAGCTTTATGCAGGGATAGGGATACTGCTGGGAAAGCACTTAAAGGAGTCCTGGATTGCTGCGCACCCCGTGGATGGAT
AGTTGAGATAGATGAGGGAGTTAAAACGCATGGAGACAGGTGA

Upstream 100 bases:

>100_bases
AGGTAGTCGACTAAGTGGCTACCTATGAAGCCCGCTCCTCCTGTGACAACATATCTCATGCTTAATTCCTCTCCTGCATC
ATATAAGCTCATTATTAGGT

Downstream 100 bases:

>100_bases
TCACTAGTGGAGAGAAGGATCCAGGAGCTGAGATGGGACCCTGTCCTCGGAGAGTGGGTCATGGTTTCAAGCATAAGGGA
GGCGAGGCCCTGGCAACCCG

Product: GHMP kinase

Products: NA

Alternate protein names: Galactose kinase [H]

Number of amino acids: Translated: 440; Mature: 439

Protein sequence:

>440_residues
MGLIRITSKFKIQGVSSWRIWEDDFMIDKIGIAFKEFYGEKPSIVVSAPGRLDFLNTHQDYKGLPVSAIGVNLRTYIALA
PSNNGVMAYSENLNAVDEFHPEEITLRGGKWFGDYIRAVFKVFTEEGYRIKGFKAYIASNIPIASGLASSAALEVAVAWG
ISELNGLGLSRKDIAEYAFKAESKVMGIPCGRLDQYGSAFGGVTLIHTRPPYNVEELGFREGVWLVVDSGIRHSTADIHP
RVQGEIDRALNELMSIVPPGLKSKLGYRYWEPRWEELTLDELTPYLDNVNRTGARKIEFTIRMHSSTMLAVKALKGFKPT
VGEVVEVLGSELAEPEKVRSILSSNTWRLELIGLVMNHQHYLLSKLYDVSLPEIDRIVDEMNKLGALGAKLSGAGLGGSV
IALCRDRDTAGKALKGVLDCCAPRGWIVEIDEGVKTHGDR

Sequences:

>Translated_440_residues
MGLIRITSKFKIQGVSSWRIWEDDFMIDKIGIAFKEFYGEKPSIVVSAPGRLDFLNTHQDYKGLPVSAIGVNLRTYIALA
PSNNGVMAYSENLNAVDEFHPEEITLRGGKWFGDYIRAVFKVFTEEGYRIKGFKAYIASNIPIASGLASSAALEVAVAWG
ISELNGLGLSRKDIAEYAFKAESKVMGIPCGRLDQYGSAFGGVTLIHTRPPYNVEELGFREGVWLVVDSGIRHSTADIHP
RVQGEIDRALNELMSIVPPGLKSKLGYRYWEPRWEELTLDELTPYLDNVNRTGARKIEFTIRMHSSTMLAVKALKGFKPT
VGEVVEVLGSELAEPEKVRSILSSNTWRLELIGLVMNHQHYLLSKLYDVSLPEIDRIVDEMNKLGALGAKLSGAGLGGSV
IALCRDRDTAGKALKGVLDCCAPRGWIVEIDEGVKTHGDR
>Mature_439_residues
GLIRITSKFKIQGVSSWRIWEDDFMIDKIGIAFKEFYGEKPSIVVSAPGRLDFLNTHQDYKGLPVSAIGVNLRTYIALAP
SNNGVMAYSENLNAVDEFHPEEITLRGGKWFGDYIRAVFKVFTEEGYRIKGFKAYIASNIPIASGLASSAALEVAVAWGI
SELNGLGLSRKDIAEYAFKAESKVMGIPCGRLDQYGSAFGGVTLIHTRPPYNVEELGFREGVWLVVDSGIRHSTADIHPR
VQGEIDRALNELMSIVPPGLKSKLGYRYWEPRWEELTLDELTPYLDNVNRTGARKIEFTIRMHSSTMLAVKALKGFKPTV
GEVVEVLGSELAEPEKVRSILSSNTWRLELIGLVMNHQHYLLSKLYDVSLPEIDRIVDEMNKLGALGAKLSGAGLGGSVI
ALCRDRDTAGKALKGVLDCCAPRGWIVEIDEGVKTHGDR

Specific function: Galactose metabolism; first step. [C]

COG id: COG0153

COG function: function code G; Galactokinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. GalK subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503895, Length=391, Percent_Identity=25.5754475703325, Blast_Score=105, Evalue=1e-22,
Organism=Escherichia coli, GI1786972, Length=381, Percent_Identity=23.0971128608924, Blast_Score=95, Evalue=8e-21,
Organism=Drosophila melanogaster, GI24661292, Length=429, Percent_Identity=21.6783216783217, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21355577, Length=429, Percent_Identity=21.6783216783217, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24661285, Length=429, Percent_Identity=21.6783216783217, Blast_Score=79, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000705
- InterPro:   IPR022963
- InterPro:   IPR019741
- InterPro:   IPR019539
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR006206
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF10509 GalKase_gal_bdg; PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.6 [H]

Molecular weight: Translated: 48635; Mature: 48504

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLIRITSKFKIQGVSSWRIWEDDFMIDKIGIAFKEFYGEKPSIVVSAPGRLDFLNTHQD
CCEEEEECEEEEEECCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCC
YKGLPVSAIGVNLRTYIALAPSNNGVMAYSENLNAVDEFHPEEITLRGGKWFGDYIRAVF
CCCCCCCEEEEEEEEEEEEECCCCCEEEECCCCCCHHHCCCCEEEEECCCHHHHHHHHHH
KVFTEEGYRIKGFKAYIASNIPIASGLASSAALEVAVAWGISELNGLGLSRKDIAEYAFK
HHHHCCCCEEEEEEEEEECCCCHHHCCCHHHHEEEHEECCHHHHHCCCCCHHHHHHHHHH
AESKVMGIPCGRLDQYGSAFGGVTLIHTRPPYNVEELGFREGVWLVVDSGIRHSTADIHP
CCCCEEECCCCCHHHHCCCCCCEEEEECCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCC
RVQGEIDRALNELMSIVPPGLKSKLGYRYWEPRWEELTLDELTPYLDNVNRTGARKIEFT
CHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEE
IRMHSSTMLAVKALKGFKPTVGEVVEVLGSELAEPEKVRSILSSNTWRLELIGLVMNHQH
EEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEHHCCHH
YLLSKLYDVSLPEIDRIVDEMNKLGALGAKLSGAGLGGSVIALCRDRDTAGKALKGVLDC
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
CAPRGWIVEIDEGVKTHGDR
HCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
GLIRITSKFKIQGVSSWRIWEDDFMIDKIGIAFKEFYGEKPSIVVSAPGRLDFLNTHQD
CEEEEECEEEEEECCCEEEECCCCCHHHHHHHHHHHCCCCCCEEEECCCCEEEECCCCC
YKGLPVSAIGVNLRTYIALAPSNNGVMAYSENLNAVDEFHPEEITLRGGKWFGDYIRAVF
CCCCCCCEEEEEEEEEEEEECCCCCEEEECCCCCCHHHCCCCEEEEECCCHHHHHHHHHH
KVFTEEGYRIKGFKAYIASNIPIASGLASSAALEVAVAWGISELNGLGLSRKDIAEYAFK
HHHHCCCCEEEEEEEEEECCCCHHHCCCHHHHEEEHEECCHHHHHCCCCCHHHHHHHHHH
AESKVMGIPCGRLDQYGSAFGGVTLIHTRPPYNVEELGFREGVWLVVDSGIRHSTADIHP
CCCCEEECCCCCHHHHCCCCCCEEEEECCCCCCHHHCCCCCCEEEEEECCCCCCCCCCCC
RVQGEIDRALNELMSIVPPGLKSKLGYRYWEPRWEELTLDELTPYLDNVNRTGARKIEFT
CHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEE
IRMHSSTMLAVKALKGFKPTVGEVVEVLGSELAEPEKVRSILSSNTWRLELIGLVMNHQH
EEECCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEHHCCHH
YLLSKLYDVSLPEIDRIVDEMNKLGALGAKLSGAGLGGSVIALCRDRDTAGKALKGVLDC
HHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHH
CAPRGWIVEIDEGVKTHGDR
HCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA