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The map label for this gene is cya [H]

Identifier: 218710391

GI number: 218710391

Start: 2597743

End: 2598906

Strand: Reverse

Name: cya [H]

Synonym: VS_2428

Alternate gene names: 218710391

Gene position: 2598906-2597743 (Counterclockwise)

Preceding gene: 218710392

Following gene: 218710389

Centisome position: 78.77

GC content: 38.75

Gene sequence:

>1164_bases
GTGGCTAATAGGAATTTATCTAGAGTCGATGACATTATGTATAAAGGCGATGCAGCAATAGAGCCATCTGGGATAGTGCC
TCTTCATAAAGATCTAATTATCCAAACTGCATTCCAGAACAATTGCATTATCCTAGTTCGGCCTGTAAATAAATTGTCGA
CTTCGCTTATTGCGGAAGGCTACGCTACAAAAGATTTACATGTGAAAGGAAAATCATCGAACTGGGGACCTCAATCTGGC
TTTATTTGCTGTGACCAAAAATTTAGTAAACTGTTTAAGAAAAGCCCTCAGGAAATTGTAAAATTTAACAGTAAAGTTAA
AGAGTCAATACGGGATAGGTTTGCCAAACCTGTACCACTACTGATATCAAACGAGCGTCTGAATTCTTTAATTAAAGACA
AAATGCTGCATATAGTCTCTAAAGATCGGGGGATTATTCATGTGACTAACCATGGAAAGCCTCACCACGATTTCGTTCTA
TATCCAAATGCAATGATGCCTTTTGGTGACTATCCTATACGGTATCGAAATCATCAAAAGAATTTAATGGTGATGTTCAA
GAATCTTCCGCAATTGAAACATGGCTATTGGGTTATGACAAAAAATGGCGAATCTATTGAGGAGCTCCTTGTTCTAGCTG
AATTTGATAGTTGTGTACCATTAACCGCTGATTATGATTTGTTTGGTGTGCTACCACATTTAAGCAGTTTCTCACACTCA
AAACCTTTAAATCTCAAGTCAGCAGCGCGTGTTGTATCAACTGCTTTAGCCCAAAAAGAAAGGCGTATCAACGATGCTGA
TCTAGGGCGGATTTCTAGCATAACACGCAGAGTTAAAACACAAATCAACCAAAAAATAGGGCTTAGAAAAGTTATCCATC
ATGGATGCGAACTAGATAACCCCGTTACAGAGCTAGATTATCCAATTACCGCTTTTACTCCGTGGAACGAAGTGGTTGGG
GCGGAAAACCAAGGCGAGTTAGAGGCTTTAATCAGAGATACAATAAAGCTGGGCTATGCCTTTTATGCTAATCGACTGTG
GAGTCAGTTAGGGAAAGTTAATACCAATTCAAAACAGTTAGGCTATTTAAGAGATTATCAGTGGGATACGAATATTCCAG
AGAGTTCGTTGTCAAAATTAGAAGTATTAACCCCTAGGGTTTGA

Upstream 100 bases:

>100_bases
ATCTTAACCTTCAACTAACGCATGATGGCTTATTGATATCGTGGCTCGATCTTGTAAGTGTATGCTGAATGTTTCACTCG
TTTTGAAATTAGTATAGATT

Downstream 100 bases:

>100_bases
CAGATTCTAGTCGTTTAAGCTCTCTTTAGGTTGGTGATCCCAATGTGTTCACTAACCTAAATTAACTCGCTATGTACCTT
TATTAACAAGTAACATCAGC

Product: hypothetical protein

Products: NA

Alternate protein names: AC-HLY; ACT; Cyclolysin; ATP pyrophosphate-lyase; Adenylyl cyclase [H]

Number of amino acids: Translated: 387; Mature: 386

Protein sequence:

>387_residues
MANRNLSRVDDIMYKGDAAIEPSGIVPLHKDLIIQTAFQNNCIILVRPVNKLSTSLIAEGYATKDLHVKGKSSNWGPQSG
FICCDQKFSKLFKKSPQEIVKFNSKVKESIRDRFAKPVPLLISNERLNSLIKDKMLHIVSKDRGIIHVTNHGKPHHDFVL
YPNAMMPFGDYPIRYRNHQKNLMVMFKNLPQLKHGYWVMTKNGESIEELLVLAEFDSCVPLTADYDLFGVLPHLSSFSHS
KPLNLKSAARVVSTALAQKERRINDADLGRISSITRRVKTQINQKIGLRKVIHHGCELDNPVTELDYPITAFTPWNEVVG
AENQGELEALIRDTIKLGYAFYANRLWSQLGKVNTNSKQLGYLRDYQWDTNIPESSLSKLEVLTPRV

Sequences:

>Translated_387_residues
MANRNLSRVDDIMYKGDAAIEPSGIVPLHKDLIIQTAFQNNCIILVRPVNKLSTSLIAEGYATKDLHVKGKSSNWGPQSG
FICCDQKFSKLFKKSPQEIVKFNSKVKESIRDRFAKPVPLLISNERLNSLIKDKMLHIVSKDRGIIHVTNHGKPHHDFVL
YPNAMMPFGDYPIRYRNHQKNLMVMFKNLPQLKHGYWVMTKNGESIEELLVLAEFDSCVPLTADYDLFGVLPHLSSFSHS
KPLNLKSAARVVSTALAQKERRINDADLGRISSITRRVKTQINQKIGLRKVIHHGCELDNPVTELDYPITAFTPWNEVVG
AENQGELEALIRDTIKLGYAFYANRLWSQLGKVNTNSKQLGYLRDYQWDTNIPESSLSKLEVLTPRV
>Mature_386_residues
ANRNLSRVDDIMYKGDAAIEPSGIVPLHKDLIIQTAFQNNCIILVRPVNKLSTSLIAEGYATKDLHVKGKSSNWGPQSGF
ICCDQKFSKLFKKSPQEIVKFNSKVKESIRDRFAKPVPLLISNERLNSLIKDKMLHIVSKDRGIIHVTNHGKPHHDFVLY
PNAMMPFGDYPIRYRNHQKNLMVMFKNLPQLKHGYWVMTKNGESIEELLVLAEFDSCVPLTADYDLFGVLPHLSSFSHSK
PLNLKSAARVVSTALAQKERRINDADLGRISSITRRVKTQINQKIGLRKVIHHGCELDNPVTELDYPITAFTPWNEVVGA
ENQGELEALIRDTIKLGYAFYANRLWSQLGKVNTNSKQLGYLRDYQWDTNIPESSLSKLEVLTPRV

Specific function: This adenylate cyclase belongs to a special class of bacterial toxin. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 17 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005165
- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF03497 Anthrax_toxA; PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: =4.6.1.1 [H]

Molecular weight: Translated: 43962; Mature: 43831

Theoretical pI: Translated: 9.83; Mature: 9.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANRNLSRVDDIMYKGDAAIEPSGIVPLHKDLIIQTAFQNNCIILVRPVNKLSTSLIAEG
CCCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEEECCCCCEEEEECHHHHHHHHHHCC
YATKDLHVKGKSSNWGPQSGFICCDQKFSKLFKKSPQEIVKFNSKVKESIRDRFAKPVPL
CCCCEEEEECCCCCCCCCCCEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCE
LISNERLNSLIKDKMLHIVSKDRGIIHVTNHGKPHHDFVLYPNAMMPFGDYPIRYRNHQK
EECCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCEEECCCCC
NLMVMFKNLPQLKHGYWVMTKNGESIEELLVLAEFDSCVPLTADYDLFGVLPHLSSFSHS
HHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCC
KPLNLKSAARVVSTALAQKERRINDADLGRISSITRRVKTQINQKIGLRKVIHHGCELDN
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVTELDYPITAFTPWNEVVGAENQGELEALIRDTIKLGYAFYANRLWSQLGKVNTNSKQL
CHHHCCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHC
GYLRDYQWDTNIPESSLSKLEVLTPRV
CCCCCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure 
ANRNLSRVDDIMYKGDAAIEPSGIVPLHKDLIIQTAFQNNCIILVRPVNKLSTSLIAEG
CCCCHHHHHHHHCCCCCCCCCCCCCCCCHHHHEEEECCCCCEEEEECHHHHHHHHHHCC
YATKDLHVKGKSSNWGPQSGFICCDQKFSKLFKKSPQEIVKFNSKVKESIRDRFAKPVPL
CCCCEEEEECCCCCCCCCCCEEEECHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCE
LISNERLNSLIKDKMLHIVSKDRGIIHVTNHGKPHHDFVLYPNAMMPFGDYPIRYRNHQK
EECCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCEEECCCCC
NLMVMFKNLPQLKHGYWVMTKNGESIEELLVLAEFDSCVPLTADYDLFGVLPHLSSFSHS
HHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCC
KPLNLKSAARVVSTALAQKERRINDADLGRISSITRRVKTQINQKIGLRKVIHHGCELDN
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
PVTELDYPITAFTPWNEVVGAENQGELEALIRDTIKLGYAFYANRLWSQLGKVNTNSKQL
CHHHCCCCEEEECCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHC
GYLRDYQWDTNIPESSLSKLEVLTPRV
CCCCCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557410; 12910271 [H]