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The map label for this gene is ribB [H]

Identifier: 218710374

GI number: 218710374

Start: 2580245

End: 2581354

Strand: Reverse

Name: ribB [H]

Synonym: VS_2411

Alternate gene names: 218710374

Gene position: 2581354-2580245 (Counterclockwise)

Preceding gene: 218710375

Following gene: 218710373

Centisome position: 78.24

GC content: 47.03

Gene sequence:

>1110_bases
ATGCCAATTAGTACTCCTCAAGAAATTATTGAAGACATTCGCCTAGGGAAAATGGTTATCCTGATGGATGATGAAGATCG
CGAAAATGAAGGCGATCTGATCATGGCAGCTGAACATGTTACGCCAGAAGCGATTAACTTCATGGCGATGTATGGCCGTG
GCTTAATCTGTTTAACACTGACCAAAGAGCGTTCAAACCGCATGGGTTTAGCGCCTATGGTCCAAGACAACAACGCTCAA
TACACTACTAACTTTACGGTTTCGATTGAAGCGGCAGAGGGCGTAACAACGGGTATTTCTGCATCAGACCGCGCTGTTAC
CGTTCAAGCTGCTGTGGCAAAAGACGCAAAAGCGGCTGACTTAGTTCAACCTGGCCATATATTCCCTCTGACTGCTCAAG
AAGGTGGTGTTCTAACGCGCGCAGGCCATACTGAAGCAGGTTGTGACTTAGCTCGGTTAGCAGGCTGTGAGCCAGCGTCT
GTTATCGTTGAGATCCTAAATGACGATGGCACCATGGCACGTCGCCCTGATCTTGAAGTGTTCGCAGAAAAGCATGACAT
CAAGCTAGGCACCATTGCTGACTTGATCGAATACCGTAACAACACAGAAACAACGATTGAGCGCGTTGCACAATGTCATT
TGCCAACAGAGTTTGGTGATTTCGAGCTTGTGACTTACCGTGACACGATTGATAACCAGATCCACTATGCAATGCAAAAA
GGCAGCTTAACCGAAGGTGCTCCTTTGGTGCGTGTTCACCTGCATGACACGTTTACCGATCTGCTTCATTCAGACCGTGG
TACCGAGCGCAGCTGGTCGCTAGAAAAAGCGATGAAGCGCATTGGCGATGAAGGCGGTGTGCTGGTTATTCTTGGCAACG
AAGAGTCGTCTGATTCTTTGATTCATAAAGTGAAGACGTTCGAAGCTCAAGATAAGAATGAGCAACCAACCATGGCTAAG
AAACAAGGTACTTCTCGTCGTGTTGGTGTAGGTTCTCAGATCCTTCAAGACCTAGGTGTTCATGATATGCGTCTGCTTTC
TTCAAGCACTAAGCGTTATCATGCATTGGGTGGTTTTGGCCTTAATGTTGTTGAATACGTTTGCGAGTAA

Upstream 100 bases:

>100_bases
CAAAGCTTGCTAAAGAGTACTTTGTAAAAGCGCAGCAATATCATCAGGTTTAAATAGTGTCGGTTCTAGGAAGCAGAACC
ATTTCAAAGGATATAGAACA

Downstream 100 bases:

>100_bases
GATGACGTCTGTCCGTTTATAGCGACATAATTTACCGATGATTTCAGCGGCTCTTTTAGAGGTTAATTTCGATAAAAGAG
CAAAGTAGCCAAGCCCGATT

Product: 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MPISTPQEIIEDIRLGKMVILMDDEDRENEGDLIMAAEHVTPEAINFMAMYGRGLICLTLTKERSNRMGLAPMVQDNNAQ
YTTNFTVSIEAAEGVTTGISASDRAVTVQAAVAKDAKAADLVQPGHIFPLTAQEGGVLTRAGHTEAGCDLARLAGCEPAS
VIVEILNDDGTMARRPDLEVFAEKHDIKLGTIADLIEYRNNTETTIERVAQCHLPTEFGDFELVTYRDTIDNQIHYAMQK
GSLTEGAPLVRVHLHDTFTDLLHSDRGTERSWSLEKAMKRIGDEGGVLVILGNEESSDSLIHKVKTFEAQDKNEQPTMAK
KQGTSRRVGVGSQILQDLGVHDMRLLSSSTKRYHALGGFGLNVVEYVCE

Sequences:

>Translated_369_residues
MPISTPQEIIEDIRLGKMVILMDDEDRENEGDLIMAAEHVTPEAINFMAMYGRGLICLTLTKERSNRMGLAPMVQDNNAQ
YTTNFTVSIEAAEGVTTGISASDRAVTVQAAVAKDAKAADLVQPGHIFPLTAQEGGVLTRAGHTEAGCDLARLAGCEPAS
VIVEILNDDGTMARRPDLEVFAEKHDIKLGTIADLIEYRNNTETTIERVAQCHLPTEFGDFELVTYRDTIDNQIHYAMQK
GSLTEGAPLVRVHLHDTFTDLLHSDRGTERSWSLEKAMKRIGDEGGVLVILGNEESSDSLIHKVKTFEAQDKNEQPTMAK
KQGTSRRVGVGSQILQDLGVHDMRLLSSSTKRYHALGGFGLNVVEYVCE
>Mature_368_residues
PISTPQEIIEDIRLGKMVILMDDEDRENEGDLIMAAEHVTPEAINFMAMYGRGLICLTLTKERSNRMGLAPMVQDNNAQY
TTNFTVSIEAAEGVTTGISASDRAVTVQAAVAKDAKAADLVQPGHIFPLTAQEGGVLTRAGHTEAGCDLARLAGCEPASV
IVEILNDDGTMARRPDLEVFAEKHDIKLGTIADLIEYRNNTETTIERVAQCHLPTEFGDFELVTYRDTIDNQIHYAMQKG
SLTEGAPLVRVHLHDTFTDLLHSDRGTERSWSLEKAMKRIGDEGGVLVILGNEESSDSLIHKVKTFEAQDKNEQPTMAKK
QGTSRRVGVGSQILQDLGVHDMRLLSSSTKRYHALGGFGLNVVEYVCE

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=205, Percent_Identity=53.1707317073171, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1787533, Length=168, Percent_Identity=30.3571428571429, Blast_Score=72, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=41.6666666666667, Blast_Score=161, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 40481; Mature: 40350

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPISTPQEIIEDIRLGKMVILMDDEDRENEGDLIMAAEHVTPEAINFMAMYGRGLICLTL
CCCCCHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEE
TKERSNRMGLAPMVQDNNAQYTTNFTVSIEAAEGVTTGISASDRAVTVQAAVAKDAKAAD
ECCCCCCCCCCEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCEEEEEEHHHCCCCHHH
LVQPGHIFPLTAQEGGVLTRAGHTEAGCDLARLAGCEPASVIVEILNDDGTMARRPDLEV
CCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCCHHHHHHHEECCCCCCCCCCCHHH
FAEKHDIKLGTIADLIEYRNNTETTIERVAQCHLPTEFGDFELVTYRDTIDNQIHYAMQK
HHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHC
GSLTEGAPLVRVHLHDTFTDLLHSDRGTERSWSLEKAMKRIGDEGGVLVILGNEESSDSL
CCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCHHH
IHKVKTFEAQDKNEQPTMAKKQGTSRRVGVGSQILQDLGVHDMRLLSSSTKRYHALGGFG
HHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHCCHHEEECCCCC
LNVVEYVCE
HHHHHHHCC
>Mature Secondary Structure 
PISTPQEIIEDIRLGKMVILMDDEDRENEGDLIMAAEHVTPEAINFMAMYGRGLICLTL
CCCCHHHHHHHHCCCEEEEEECCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCEEEEEE
TKERSNRMGLAPMVQDNNAQYTTNFTVSIEAAEGVTTGISASDRAVTVQAAVAKDAKAAD
ECCCCCCCCCCEEEECCCCEEEEEEEEEEEECCCCCCCCCCCCCEEEEEEHHHCCCCHHH
LVQPGHIFPLTAQEGGVLTRAGHTEAGCDLARLAGCEPASVIVEILNDDGTMARRPDLEV
CCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCCHHHHHHHEECCCCCCCCCCCHHH
FAEKHDIKLGTIADLIEYRNNTETTIERVAQCHLPTEFGDFELVTYRDTIDNQIHYAMQK
HHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHC
GSLTEGAPLVRVHLHDTFTDLLHSDRGTERSWSLEKAMKRIGDEGGVLVILGNEESSDSL
CCCCCCCCEEEEEEHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCEEEEECCCCCCHHH
IHKVKTFEAQDKNEQPTMAKKQGTSRRVGVGSQILQDLGVHDMRLLSSSTKRYHALGGFG
HHHHHHHCCCCCCCCCCHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHCCHHEEECCCCC
LNVVEYVCE
HHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339274 [H]