Click here to switch to the map view.

The map label for this gene is thiL [H]

Identifier: 218710371

GI number: 218710371

Start: 2577937

End: 2578914

Strand: Reverse

Name: thiL [H]

Synonym: VS_2408

Alternate gene names: 218710371

Gene position: 2578914-2577937 (Counterclockwise)

Preceding gene: 218710372

Following gene: 218710370

Centisome position: 78.17

GC content: 47.44

Gene sequence:

>978_bases
GTGATGTCTGGCGAATTTAACCTGATTGAAAAATATTTTGTAAATCGACAACCACAACGTAAAGATGTACATCTGGCAGC
GGGCGATGACTGTGCTTTGGTCAAAGCGCCGGGCAATGTTGAGATAGCGATCAGCACGGATACCTTAGTGGCGGGCACTC
ACTTCTTAACAGAGGCGAATCCGGCATGGGTAGCACACAAGGCGTTGGCTTCGAACATTAGCGACCTTGCGGCGATGGGT
GCGACGCCTGCCTGGGTTTCATTTGCGTTAACCATGCCAGAAGTTGATGAAGAATGGCTTGCTCCCTTCTGTGATTCCTT
CTTCAAACTTGCAGACTATTTTGGTATTCAACTTATTGGTGGTGACACGACCAAAGGGCCGCTGAGTTTAACGCTGACTG
TACAGGGCTTTGTGCCAGAAGGCCGAGCACTACGCAGAGATGGCGCGAAAGTGGGGGACTGGATTTACGTAACGGGTAAC
TTAGGTGACAGCAAAGCTGGGCTAGAGGTGATATTAGACCCAGAACAGAACAAAGCTAAGCCTTATGCACTTGAGCTAGA
AGAGAGGCACTACATCAGCTCTCCACGAGTATTGGCGGGTCAGGCGCTCGTGAACCTAGCTTCATCGGCTATTGATATCT
CTGATGGCGTTATTGCTGATTTAAAACATATCCTGAAGCGTTCAGAGGTTGGTGCAAGCATTGATGTGAGTGCGTTGCCT
ATCTCTGCTGAATTACGCCAGTTTTCTTCCGATATCGCTTCTGCACAGCAGTATGCGCTTACCAGTGGTGAAGAGTACGA
ACTGTGCTTTACCGTGCCGGAAGAAAATAAAGGTTCACTGGAAAGTGCTTTGTCACACACTGGCACAAAAGTCACCTGCA
TTGGCCAGATAAGACCTGTAGAATATTTTGAATTACACAATAATGGTGAACCACTAAGCTGGAACTTAACTGGTTACGAT
CACTTTAAGGTTAATTGA

Upstream 100 bases:

>100_bases
TTGAATCTAAAGGTCAGCTTTTATGCTGGCCTTTTTTGTAACTAAATTATCGTAATACCAATAATTACGGTGATTTGTAT
GAAGACTAAAGATAGGGCAT

Downstream 100 bases:

>100_bases
TGACAAATCCACTTTCTCTTATTTCTCTTAAAAATCCTTGGCACTTATTGGCTACGGGTTTTGGCAGTGGCTTATCGCCG
ATTATTCCAGGCACAATGGG

Product: thiamine monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 325; Mature: 325

Protein sequence:

>325_residues
MMSGEFNLIEKYFVNRQPQRKDVHLAAGDDCALVKAPGNVEIAISTDTLVAGTHFLTEANPAWVAHKALASNISDLAAMG
ATPAWVSFALTMPEVDEEWLAPFCDSFFKLADYFGIQLIGGDTTKGPLSLTLTVQGFVPEGRALRRDGAKVGDWIYVTGN
LGDSKAGLEVILDPEQNKAKPYALELEERHYISSPRVLAGQALVNLASSAIDISDGVIADLKHILKRSEVGASIDVSALP
ISAELRQFSSDIASAQQYALTSGEEYELCFTVPEENKGSLESALSHTGTKVTCIGQIRPVEYFELHNNGEPLSWNLTGYD
HFKVN

Sequences:

>Translated_325_residues
MMSGEFNLIEKYFVNRQPQRKDVHLAAGDDCALVKAPGNVEIAISTDTLVAGTHFLTEANPAWVAHKALASNISDLAAMG
ATPAWVSFALTMPEVDEEWLAPFCDSFFKLADYFGIQLIGGDTTKGPLSLTLTVQGFVPEGRALRRDGAKVGDWIYVTGN
LGDSKAGLEVILDPEQNKAKPYALELEERHYISSPRVLAGQALVNLASSAIDISDGVIADLKHILKRSEVGASIDVSALP
ISAELRQFSSDIASAQQYALTSGEEYELCFTVPEENKGSLESALSHTGTKVTCIGQIRPVEYFELHNNGEPLSWNLTGYD
HFKVN
>Mature_325_residues
MMSGEFNLIEKYFVNRQPQRKDVHLAAGDDCALVKAPGNVEIAISTDTLVAGTHFLTEANPAWVAHKALASNISDLAAMG
ATPAWVSFALTMPEVDEEWLAPFCDSFFKLADYFGIQLIGGDTTKGPLSLTLTVQGFVPEGRALRRDGAKVGDWIYVTGN
LGDSKAGLEVILDPEQNKAKPYALELEERHYISSPRVLAGQALVNLASSAIDISDGVIADLKHILKRSEVGASIDVSALP
ISAELRQFSSDIASAQQYALTSGEEYELCFTVPEENKGSLESALSHTGTKVTCIGQIRPVEYFELHNNGEPLSWNLTGYD
HFKVN

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=323, Percent_Identity=55.1083591331269, Blast_Score=348, Evalue=3e-97,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 35232; Mature: 35232

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00079 MULTICOPPER_OXIDASE1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSGEFNLIEKYFVNRQPQRKDVHLAAGDDCALVKAPGNVEIAISTDTLVAGTHFLTEAN
CCCCCHHHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCEEEEEECCEEEECEEEEECCC
PAWVAHKALASNISDLAAMGATPAWVSFALTMPEVDEEWLAPFCDSFFKLADYFGIQLIG
CHHHHHHHHHHCHHHHHHHCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEC
GDTTKGPLSLTLTVQGFVPEGRALRRDGAKVGDWIYVTGNLGDSKAGLEVILDPEQNKAK
CCCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCC
PYALELEERHYISSPRVLAGQALVNLASSAIDISDGVIADLKHILKRSEVGASIDVSALP
CEEEEECCCCCCCCCCEEHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCEEEEEECC
ISAELRQFSSDIASAQQYALTSGEEYELCFTVPEENKGSLESALSHTGTKVTCIGQIRPV
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCE
EYFELHNNGEPLSWNLTGYDHFKVN
EEEEECCCCCCEEEEECCEEEEEEC
>Mature Secondary Structure
MMSGEFNLIEKYFVNRQPQRKDVHLAAGDDCALVKAPGNVEIAISTDTLVAGTHFLTEAN
CCCCCHHHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCEEEEEECCEEEECEEEEECCC
PAWVAHKALASNISDLAAMGATPAWVSFALTMPEVDEEWLAPFCDSFFKLADYFGIQLIG
CHHHHHHHHHHCHHHHHHHCCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHCCEEEEC
GDTTKGPLSLTLTVQGFVPEGRALRRDGAKVGDWIYVTGNLGDSKAGLEVILDPEQNKAK
CCCCCCCEEEEEEEEEECCCCCHHHCCCCCCCCEEEEECCCCCCCCCEEEEECCCCCCCC
PYALELEERHYISSPRVLAGQALVNLASSAIDISDGVIADLKHILKRSEVGASIDVSALP
CEEEEECCCCCCCCCCEEHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHCCCEEEEEECC
ISAELRQFSSDIASAQQYALTSGEEYELCFTVPEENKGSLESALSHTGTKVTCIGQIRPV
CHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHCCCEEEEEECCCCE
EYFELHNNGEPLSWNLTGYDHFKVN
EEEEECCCCCCEEEEECCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]