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The map label for this gene is treA [H]

Identifier: 218710341

GI number: 218710341

Start: 2544668

End: 2546362

Strand: Reverse

Name: treA [H]

Synonym: VS_2377

Alternate gene names: 218710341

Gene position: 2546362-2544668 (Counterclockwise)

Preceding gene: 218710342

Following gene: 218710337

Centisome position: 77.18

GC content: 45.55

Gene sequence:

>1695_bases
GTGTTAGAGATGGCGATGACTGAGCATGATGAAAGTTGGTGGAAAACCGCAACCATCTATCAAATCTACCCAAAGAGTTT
TTGTGACAGTGGCAGTAAAGGTACTGGCGATATCAAAGGGATCATTTCGAAACTGGATTACCTTAAACATTTGAGCGTGG
ATGCGATTTGGCTAACCCCAGTTTACGCGTCACCCATGATCGACAACGGTTATGATATCTCAGACTACTACGCGATTAAC
CCTCAATTCGGCACTATGGAAGACTTCGACTTATTATTGTCTGAAGCGCACCAACGTGGCATTCGCATCGTGATGGATAT
TGTGGTCAACCATACTTCAACAGAGCATGCATGGTTTCAGTCTGCATTGGGTGACAAAAACAGCCCATACCGCGATTACT
ACATCTGGAAAGACCCTGTGAACGGCCAAGCACCAACCAACTGGCAGTCTAAATTCGGTGGTAATGCATGGGAAATGGAT
AAGGCCACTGGGCAATACTTCCTGCATTTATTTGCGAAAGAACAGGCCGACCTTAACTGGGAGAATCCGGTTGTACGTGA
AGAAGTAAAAGATGTCATCAGCTTCTGGGCTGAGAAGGGCGTCGATGGTTTTCGCTTGGACGTAATCAACCTGATTTCAA
AGCAGCAAGATTTCCCACATGATGATATCGGTGATGGTCGCCGTTTCTATACCGATGGCCCACGAGTGCACGAATACCTG
AAAGAGATCAGCGAAGCGGTATTCCAAAAATACGGTAGCGTAACCGTAGGTGAGATGTCTTCAACCACGTTGGAACATTG
TCAGCAATACTCAAACGTTGATAACAGCGAGCTATCAATGGTGTTTAACTTCCACCACCTCAAGGTTGATTACACTAATG
GTGAAAAGTGGACCAATGCGCCGTTTGATTTCTTACAGCTCAAATCGATCTTCAATCATTGGCAAACTGGCTTAAACGGA
AAAGGGTGGGGCGCACTATTCTGGTGTAACCATGACCAACCACGAGTGGTGAGCCGCTTAGGTAACGATCAACAATATCG
CGTTGAATCAGCCAAGATGCTTGCCGCCTCGGTTCACATGATGCAAGGCACACCTTATATCTATCAAGGTGAAGAGATTG
GCATGACCAACCCGGGTTACACCGAGATCAGCCAGTATCGTGATGTAGAGAGCACCAACATGTACGATATCATGGTGAAC
CGTGATGGTGTGGCTCATCAAGATATGATGGCGATCTTAGCGCAGAAATCTCGTGATAACTCTCGTACGCCAATGCAGTG
GAACAGTGAGCCTTACGCCGGATTCTCACAAGCTCAACCATGGCTTGATGTGGCGAATAACTACACTGAAATCAACGCCG
AGCAAGCGTTGGAAGATAAAGACTCTGTATTTTACTTTTACAAGGCTTTGATTGAGTTACGTAAACAGCTACCGGTGATT
ACGGATGGCAGCTATCAAGATCTATTGCCTGAGCATTCATCTGTATTTGCGTATGTTCGTGAGAGTGAAGGGCAAACTCT
GCTGTGTATTAATAACTATTATGGCGAAGAAACAGAGTGCGTTTTACCTGAGCGTTTTGAGATGGCGAAGGCTAAGAGCT
TGTTGTTTAATTATCAAGTGAGCGAGAGTTTAGTGGCGTCTCATCACCAAGTACTACGACCTTACGAGACTCGTATTCTC
TTGATTGAAGATTAG

Upstream 100 bases:

>100_bases
CATCGCTTTTTCCCTTAGTTATAGCTTTTTCTTTTAGTTATAACGGCTATTCGACCATGATTCACATGGTGATTTTTTAT
TTATATTTTCTGGTAAGTGA

Downstream 100 bases:

>100_bases
CCTTGTTTCTATTTCTATAAGCCTAATTCTATTCCCCTTAAGAATTAGGCCTCTACAAAGGCTTTGGAGTGCTTCCCAAA
GCCTTTTTACATTGAGTCTG

Product: trehalose-6-phosphate hydrolase

Products: NA

Alternate protein names: Alpha,alpha-phosphotrehalase [H]

Number of amino acids: Translated: 564; Mature: 564

Protein sequence:

>564_residues
MLEMAMTEHDESWWKTATIYQIYPKSFCDSGSKGTGDIKGIISKLDYLKHLSVDAIWLTPVYASPMIDNGYDISDYYAIN
PQFGTMEDFDLLLSEAHQRGIRIVMDIVVNHTSTEHAWFQSALGDKNSPYRDYYIWKDPVNGQAPTNWQSKFGGNAWEMD
KATGQYFLHLFAKEQADLNWENPVVREEVKDVISFWAEKGVDGFRLDVINLISKQQDFPHDDIGDGRRFYTDGPRVHEYL
KEISEAVFQKYGSVTVGEMSSTTLEHCQQYSNVDNSELSMVFNFHHLKVDYTNGEKWTNAPFDFLQLKSIFNHWQTGLNG
KGWGALFWCNHDQPRVVSRLGNDQQYRVESAKMLAASVHMMQGTPYIYQGEEIGMTNPGYTEISQYRDVESTNMYDIMVN
RDGVAHQDMMAILAQKSRDNSRTPMQWNSEPYAGFSQAQPWLDVANNYTEINAEQALEDKDSVFYFYKALIELRKQLPVI
TDGSYQDLLPEHSSVFAYVRESEGQTLLCINNYYGEETECVLPERFEMAKAKSLLFNYQVSESLVASHHQVLRPYETRIL
LIED

Sequences:

>Translated_564_residues
MLEMAMTEHDESWWKTATIYQIYPKSFCDSGSKGTGDIKGIISKLDYLKHLSVDAIWLTPVYASPMIDNGYDISDYYAIN
PQFGTMEDFDLLLSEAHQRGIRIVMDIVVNHTSTEHAWFQSALGDKNSPYRDYYIWKDPVNGQAPTNWQSKFGGNAWEMD
KATGQYFLHLFAKEQADLNWENPVVREEVKDVISFWAEKGVDGFRLDVINLISKQQDFPHDDIGDGRRFYTDGPRVHEYL
KEISEAVFQKYGSVTVGEMSSTTLEHCQQYSNVDNSELSMVFNFHHLKVDYTNGEKWTNAPFDFLQLKSIFNHWQTGLNG
KGWGALFWCNHDQPRVVSRLGNDQQYRVESAKMLAASVHMMQGTPYIYQGEEIGMTNPGYTEISQYRDVESTNMYDIMVN
RDGVAHQDMMAILAQKSRDNSRTPMQWNSEPYAGFSQAQPWLDVANNYTEINAEQALEDKDSVFYFYKALIELRKQLPVI
TDGSYQDLLPEHSSVFAYVRESEGQTLLCINNYYGEETECVLPERFEMAKAKSLLFNYQVSESLVASHHQVLRPYETRIL
LIED
>Mature_564_residues
MLEMAMTEHDESWWKTATIYQIYPKSFCDSGSKGTGDIKGIISKLDYLKHLSVDAIWLTPVYASPMIDNGYDISDYYAIN
PQFGTMEDFDLLLSEAHQRGIRIVMDIVVNHTSTEHAWFQSALGDKNSPYRDYYIWKDPVNGQAPTNWQSKFGGNAWEMD
KATGQYFLHLFAKEQADLNWENPVVREEVKDVISFWAEKGVDGFRLDVINLISKQQDFPHDDIGDGRRFYTDGPRVHEYL
KEISEAVFQKYGSVTVGEMSSTTLEHCQQYSNVDNSELSMVFNFHHLKVDYTNGEKWTNAPFDFLQLKSIFNHWQTGLNG
KGWGALFWCNHDQPRVVSRLGNDQQYRVESAKMLAASVHMMQGTPYIYQGEEIGMTNPGYTEISQYRDVESTNMYDIMVN
RDGVAHQDMMAILAQKSRDNSRTPMQWNSEPYAGFSQAQPWLDVANNYTEINAEQALEDKDSVFYFYKALIELRKQLPVI
TDGSYQDLLPEHSSVFAYVRESEGQTLLCINNYYGEETECVLPERFEMAKAKSLLFNYQVSESLVASHHQVLRPYETRIL
LIED

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=534, Percent_Identity=30.1498127340824, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI61744481, Length=111, Percent_Identity=32.4324324324324, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI61744479, Length=111, Percent_Identity=32.4324324324324, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI65506891, Length=111, Percent_Identity=32.4324324324324, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI61744483, Length=111, Percent_Identity=32.4324324324324, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI61744475, Length=112, Percent_Identity=33.0357142857143, Blast_Score=71, Evalue=3e-12,
Organism=Homo sapiens, GI61744477, Length=112, Percent_Identity=33.0357142857143, Blast_Score=71, Evalue=3e-12,
Organism=Escherichia coli, GI1790687, Length=549, Percent_Identity=57.1948998178506, Blast_Score=656, Evalue=0.0,
Organism=Escherichia coli, GI1786604, Length=502, Percent_Identity=23.7051792828685, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789995, Length=150, Percent_Identity=29.3333333333333, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25147709, Length=488, Percent_Identity=24.7950819672131, Blast_Score=106, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI32565753, Length=203, Percent_Identity=30.0492610837438, Blast_Score=100, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6322245, Length=583, Percent_Identity=37.3927958833619, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6321726, Length=593, Percent_Identity=35.9190556492412, Blast_Score=367, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321731, Length=592, Percent_Identity=37.3310810810811, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324416, Length=593, Percent_Identity=36.7622259696459, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322241, Length=593, Percent_Identity=36.7622259696459, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6322021, Length=593, Percent_Identity=36.7622259696459, Blast_Score=365, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319776, Length=592, Percent_Identity=37.1621621621622, Blast_Score=364, Evalue=1e-101,
Organism=Drosophila melanogaster, GI221330053, Length=509, Percent_Identity=37.328094302554, Blast_Score=291, Evalue=7e-79,
Organism=Drosophila melanogaster, GI24583745, Length=551, Percent_Identity=34.6642468239564, Blast_Score=278, Evalue=5e-75,
Organism=Drosophila melanogaster, GI24586599, Length=566, Percent_Identity=33.5689045936396, Blast_Score=276, Evalue=4e-74,
Organism=Drosophila melanogaster, GI24586597, Length=505, Percent_Identity=34.8514851485148, Blast_Score=275, Evalue=8e-74,
Organism=Drosophila melanogaster, GI24583749, Length=559, Percent_Identity=34.3470483005367, Blast_Score=270, Evalue=2e-72,
Organism=Drosophila melanogaster, GI24586593, Length=542, Percent_Identity=34.3173431734317, Blast_Score=270, Evalue=3e-72,
Organism=Drosophila melanogaster, GI24583747, Length=559, Percent_Identity=34.3470483005367, Blast_Score=270, Evalue=3e-72,
Organism=Drosophila melanogaster, GI45549022, Length=579, Percent_Identity=31.0880829015544, Blast_Score=265, Evalue=9e-71,
Organism=Drosophila melanogaster, GI24586591, Length=496, Percent_Identity=36.491935483871, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24586589, Length=536, Percent_Identity=34.8880597014925, Blast_Score=254, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24586587, Length=584, Percent_Identity=31.6780821917808, Blast_Score=249, Evalue=4e-66,
Organism=Drosophila melanogaster, GI281360393, Length=486, Percent_Identity=31.6872427983539, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781
- InterPro:   IPR012769 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.93 [H]

Molecular weight: Translated: 65047; Mature: 65047

Theoretical pI: Translated: 4.64; Mature: 4.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEMAMTEHDESWWKTATIYQIYPKSFCDSGSKGTGDIKGIISKLDYLKHLSVDAIWLTP
CCCCCCCCCCCCHHEEEEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECC
VYASPMIDNGYDISDYYAINPQFGTMEDFDLLLSEAHQRGIRIVMDIVVNHTSTEHAWFQ
CCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHEEEEHHHCCCCCHHHHHH
SALGDKNSPYRDYYIWKDPVNGQAPTNWQSKFGGNAWEMDKATGQYFLHLFAKEQADLNW
HHHCCCCCCCCCEEEECCCCCCCCCCCHHHHCCCCCEECCHHHHHHHHHHHHHHCCCCCC
ENPVVREEVKDVISFWAEKGVDGFRLDVINLISKQQDFPHDDIGDGRRFYTDGPRVHEYL
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHH
KEISEAVFQKYGSVTVGEMSSTTLEHCQQYSNVDNSELSMVFNFHHLKVDYTNGEKWTNA
HHHHHHHHHHHCCEEECCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEECCCCCCCCC
PFDFLQLKSIFNHWQTGLNGKGWGALFWCNHDQPRVVSRLGNDQQYRVESAKMLAASVHM
CHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHH
MQGTPYIYQGEEIGMTNPGYTEISQYRDVESTNMYDIMVNRDGVAHQDMMAILAQKSRDN
HCCCCEEEECCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCC
SRTPMQWNSEPYAGFSQAQPWLDVANNYTEINAEQALEDKDSVFYFYKALIELRKQLPVI
CCCCCCCCCCCCCCHHHCCCHHHHCCCCEECCHHHHHCCCCHHHHHHHHHHHHHHHCCEE
TDGSYQDLLPEHSSVFAYVRESEGQTLLCINNYYGEETECVLPERFEMAKAKSLLFNYQV
ECCCHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHH
SESLVASHHQVLRPYETRILLIED
HHHHHHHHHHHHCCCCCEEEEEEC
>Mature Secondary Structure
MLEMAMTEHDESWWKTATIYQIYPKSFCDSGSKGTGDIKGIISKLDYLKHLSVDAIWLTP
CCCCCCCCCCCCHHEEEEEEEECCHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEECC
VYASPMIDNGYDISDYYAINPQFGTMEDFDLLLSEAHQRGIRIVMDIVVNHTSTEHAWFQ
CCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHCCHHEEEEHHHCCCCCHHHHHH
SALGDKNSPYRDYYIWKDPVNGQAPTNWQSKFGGNAWEMDKATGQYFLHLFAKEQADLNW
HHHCCCCCCCCCEEEECCCCCCCCCCCHHHHCCCCCEECCHHHHHHHHHHHHHHCCCCCC
ENPVVREEVKDVISFWAEKGVDGFRLDVINLISKQQDFPHDDIGDGRRFYTDGPRVHEYL
CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHH
KEISEAVFQKYGSVTVGEMSSTTLEHCQQYSNVDNSELSMVFNFHHLKVDYTNGEKWTNA
HHHHHHHHHHHCCEEECCCHHHHHHHHHHHCCCCCCCEEEEEEEEEEEEEECCCCCCCCC
PFDFLQLKSIFNHWQTGLNGKGWGALFWCNHDQPRVVSRLGNDQQYRVESAKMLAASVHM
CHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHCCCCCHHHHHHHHHHHHHHHH
MQGTPYIYQGEEIGMTNPGYTEISQYRDVESTNMYDIMVNRDGVAHQDMMAILAQKSRDN
HCCCCEEEECCCCCCCCCCHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCC
SRTPMQWNSEPYAGFSQAQPWLDVANNYTEINAEQALEDKDSVFYFYKALIELRKQLPVI
CCCCCCCCCCCCCCHHHCCCHHHHCCCCEECCHHHHHCCCCHHHHHHHHHHHHHHHCCEE
TDGSYQDLLPEHSSVFAYVRESEGQTLLCINNYYGEETECVLPERFEMAKAKSLLFNYQV
ECCCHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCCEECCHHHHHHHHHHHHHHHHH
SESLVASHHQVLRPYETRILLIED
HHHHHHHHHHHHCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7651129; 8969503; 9384377; 7751281 [H]