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The map label for this gene is pyrH [H]

Identifier: 218710316

GI number: 218710316

Start: 2519878

End: 2520609

Strand: Reverse

Name: pyrH [H]

Synonym: VS_2351

Alternate gene names: 218710316

Gene position: 2520609-2519878 (Counterclockwise)

Preceding gene: 218710317

Following gene: 218710315

Centisome position: 76.4

GC content: 45.63

Gene sequence:

>732_bases
ATGACTACGAACCCTAAACCAGCGTATCAACGTATTCTGTTAAAACTTAGCGGTGAAGCGCTACAAGGCGAAGAAGGTTT
TGGTATTGACCCAACGATCCTTGATCGTATGGCTCAAGAAGTAAAAGAATTAGTTGAACTAGGCGTTCAAGTTGGTGTTG
TTATCGGTGGTGGTAACCTTTTCCGTGGCGCAGGCCTAGCAGAAGCGGGTATGAACCGTGTTGTTGGTGACCATATGGGG
ATGCTTGCAACGGTAATGAACGGCCTTGCTATGCGTGACGCACTACACCGTGCTTACGTAAACGCACGTGTAATGTCAGC
AATTCCTCTTAAAGGTGTATGTGACGACTACAACTGGGCAGATGCAATCAGCCAACTACGTCAAGGTCGTGTTGTGATCT
TCTCTGCAGGTACTGGTAACCCATTCTTTACTACAGACTCTGCTGCATGTTTACGCGGTATCGAAATCGAAGCTGACGTA
GTTCTAAAAGCAACAAAAGTAGATGGTGTATTTACTGCTGACCCAGTAGCAAACCCAGACGCAGAGTTGTATGATACGTT
GTCTTACAACACAATTCTTGAGAAAGAATTGAAAGTAATGGACTTGGCCGCATTTACGCTAGCACGTGACCACAAAATGC
CAATCCGTGTATTTAACATGAATAAGCCAGGCGCACTACGTCGCGTGGTTATGGGTGAAACTGAAGGTACATTAATCAGC
GACGCTGACTAA

Upstream 100 bases:

>100_bases
TAATGAATTATTTCCGGCTTTTAGCTGTTATGAATGCAAACTGAGCTCTTCAGTTTTTATCCATGACTGTTAATCATCAA
CTCTTTGGAAGGTAAGCTCC

Downstream 100 bases:

>100_bases
TTTTTCGGGCTTACTGAAGTATAATGCTTCGGTAAGCTTATCCTTATCACTCCAAATAAAAAGCTTTCTTGAAGAAAGAA
CATAATCAAGGTGAAATTGT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 243; Mature: 242

Protein sequence:

>243_residues
MTTNPKPAYQRILLKLSGEALQGEEGFGIDPTILDRMAQEVKELVELGVQVGVVIGGGNLFRGAGLAEAGMNRVVGDHMG
MLATVMNGLAMRDALHRAYVNARVMSAIPLKGVCDDYNWADAISQLRQGRVVIFSAGTGNPFFTTDSAACLRGIEIEADV
VLKATKVDGVFTADPVANPDAELYDTLSYNTILEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGETEGTLIS
DAD

Sequences:

>Translated_243_residues
MTTNPKPAYQRILLKLSGEALQGEEGFGIDPTILDRMAQEVKELVELGVQVGVVIGGGNLFRGAGLAEAGMNRVVGDHMG
MLATVMNGLAMRDALHRAYVNARVMSAIPLKGVCDDYNWADAISQLRQGRVVIFSAGTGNPFFTTDSAACLRGIEIEADV
VLKATKVDGVFTADPVANPDAELYDTLSYNTILEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGETEGTLIS
DAD
>Mature_242_residues
TTNPKPAYQRILLKLSGEALQGEEGFGIDPTILDRMAQEVKELVELGVQVGVVIGGGNLFRGAGLAEAGMNRVVGDHMGM
LATVMNGLAMRDALHRAYVNARVMSAIPLKGVCDDYNWADAISQLRQGRVVIFSAGTGNPFFTTDSAACLRGIEIEADVV
LKATKVDGVFTADPVANPDAELYDTLSYNTILEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGETEGTLISD
AD

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=241, Percent_Identity=85.4771784232365, Blast_Score=431, Evalue=1e-122,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 26188; Mature: 26056

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTNPKPAYQRILLKLSGEALQGEEGFGIDPTILDRMAQEVKELVELGVQVGVVIGGGNL
CCCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCE
FRGAGLAEAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARVMSAIPLKGVCDDYNWA
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
DAISQLRQGRVVIFSAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVFTADPVANPD
HHHHHHHCCCEEEEECCCCCCCEECCHHHHHHCCEEEEEEEEEEEEECCEEECCCCCCCC
AELYDTLSYNTILEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGETEGTLIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHEEECCCCCCEEE
DAD
CCC
>Mature Secondary Structure 
TTNPKPAYQRILLKLSGEALQGEEGFGIDPTILDRMAQEVKELVELGVQVGVVIGGGNL
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCE
FRGAGLAEAGMNRVVGDHMGMLATVMNGLAMRDALHRAYVNARVMSAIPLKGVCDDYNWA
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
DAISQLRQGRVVIFSAGTGNPFFTTDSAACLRGIEIEADVVLKATKVDGVFTADPVANPD
HHHHHHHCCCEEEEECCCCCCCEECCHHHHHHCCEEEEEEEEEEEEECCEEECCCCCCCC
AELYDTLSYNTILEKELKVMDLAAFTLARDHKMPIRVFNMNKPGALRRVVMGETEGTLIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHEEECCCCCCEEE
DAD
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA