Click here to switch to the map view.

The map label for this gene is uppS [H]

Identifier: 218710314

GI number: 218710314

Start: 2518371

End: 2519138

Strand: Reverse

Name: uppS [H]

Synonym: VS_2349

Alternate gene names: 218710314

Gene position: 2519138-2518371 (Counterclockwise)

Preceding gene: 218710315

Following gene: 218710313

Centisome position: 76.35

GC content: 41.15

Gene sequence:

>768_bases
TTGATTCACTCTTTTATGCATAATTCTCAAGCGTTCACAGACTCTCTTCCTAAACACATTGCTATCATTATGGATGGTAA
TGGTCGCTGGGCAAAAGCTCAGGGTAAGCCTCGTGTCTTTGGTCATAAAAATGGCGTTCAAGCTGTTCGAAAAACCATAT
CTTCAGCAGCCAGACTTGGCATTAAAGCCGTAACTCTTTTTGCTTTTAGTAGTGAAAATTGGCGTCGTCCTGAAGAAGAA
GTGGGTCTCTTGATGGAACTGTTTATTTCAGTGCTATCGAGTGAAGTAAAAAAGCTTCATAAAAATAATCTACAACTTCG
TGTTATTGGTGATAAAAGTCGTTTTAATGAGCGACTACAAAAGAAAATAGAAGAAGCGGAAGCTTTGACTAGCACCAATA
CGGGTATGGTTATTAATATTGCGGCTAACTACGGCGGTAAGTGGGATATCCAGCAAGCGATGACTTCGATTGCTCAACAG
GTTAAGTCTGGCGATATTAATGTAGAAGACATTGATGAAGCTATGATTACACAGCACCTGACGATGGCAGATATTCCAGA
AGTCGATCTACTTATCCGCACTAGTGGCGAGTGCCGCATTAGTAACTTTATGCTTTGGCAATTAGCTTACGCCGAAATGT
ATTTCACTGAACAATTCTGGCCAGACTTTAATGAAGACAGCTTAGTAGAAGCTGTGACTTGGTTTGTAAACCGCGAGCGT
CGTTTTGGATGCACCGGTGAGCAAATTAAAGCTCTGATGGACAGTTAA

Upstream 100 bases:

>100_bases
AGTTGATGGAAGTTTAATTTTCCATATTCTTTTCTTTCAGGAAAAACGCTGTACTCACGGTGCAGCGTTTTTTTATGCTA
TTCTGTTCGACTATTAGAAT

Downstream 100 bases:

>100_bases
TAAGGATTTTTTTGGTTTGAAACAACGAATTATTACGGCGTTGATTTTAGCTCCCCTAGTTATTCTAGGTATTTTCGAGT
TATCACTTCCCACGTTTATT

Product: undecaprenyl pyrophosphate synthetase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 255; Mature: 255

Protein sequence:

>255_residues
MIHSFMHNSQAFTDSLPKHIAIIMDGNGRWAKAQGKPRVFGHKNGVQAVRKTISSAARLGIKAVTLFAFSSENWRRPEEE
VGLLMELFISVLSSEVKKLHKNNLQLRVIGDKSRFNERLQKKIEEAEALTSTNTGMVINIAANYGGKWDIQQAMTSIAQQ
VKSGDINVEDIDEAMITQHLTMADIPEVDLLIRTSGECRISNFMLWQLAYAEMYFTEQFWPDFNEDSLVEAVTWFVNRER
RFGCTGEQIKALMDS

Sequences:

>Translated_255_residues
MIHSFMHNSQAFTDSLPKHIAIIMDGNGRWAKAQGKPRVFGHKNGVQAVRKTISSAARLGIKAVTLFAFSSENWRRPEEE
VGLLMELFISVLSSEVKKLHKNNLQLRVIGDKSRFNERLQKKIEEAEALTSTNTGMVINIAANYGGKWDIQQAMTSIAQQ
VKSGDINVEDIDEAMITQHLTMADIPEVDLLIRTSGECRISNFMLWQLAYAEMYFTEQFWPDFNEDSLVEAVTWFVNRER
RFGCTGEQIKALMDS
>Mature_255_residues
MIHSFMHNSQAFTDSLPKHIAIIMDGNGRWAKAQGKPRVFGHKNGVQAVRKTISSAARLGIKAVTLFAFSSENWRRPEEE
VGLLMELFISVLSSEVKKLHKNNLQLRVIGDKSRFNERLQKKIEEAEALTSTNTGMVINIAANYGGKWDIQQAMTSIAQQ
VKSGDINVEDIDEAMITQHLTMADIPEVDLLIRTSGECRISNFMLWQLAYAEMYFTEQFWPDFNEDSLVEAVTWFVNRER
RFGCTGEQIKALMDS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=223, Percent_Identity=36.7713004484305, Blast_Score=143, Evalue=1e-34,
Organism=Homo sapiens, GI45580742, Length=223, Percent_Identity=36.7713004484305, Blast_Score=143, Evalue=1e-34,
Organism=Escherichia coli, GI1786371, Length=241, Percent_Identity=57.6763485477178, Blast_Score=305, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71993029, Length=222, Percent_Identity=35.5855855855856, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323748, Length=218, Percent_Identity=33.4862385321101, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6319474, Length=216, Percent_Identity=31.9444444444444, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18857969, Length=209, Percent_Identity=35.4066985645933, Blast_Score=137, Evalue=7e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28962; Mature: 28962

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHSFMHNSQAFTDSLPKHIAIIMDGNGRWAKAQGKPRVFGHKNGVQAVRKTISSAARLG
CCCCHHCCCHHHHHCCCCEEEEEECCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
IKAVTLFAFSSENWRRPEEEVGLLMELFISVLSSEVKKLHKNNLQLRVIGDKSRFNERLQ
HHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHH
KKIEEAEALTSTNTGMVINIAANYGGKWDIQQAMTSIAQQVKSGDINVEDIDEAMITQHL
HHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
TMADIPEVDLLIRTSGECRISNFMLWQLAYAEMYFTEQFWPDFNEDSLVEAVTWFVNRER
HHCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
RFGCTGEQIKALMDS
CCCCCHHHHHHHHCC
>Mature Secondary Structure
MIHSFMHNSQAFTDSLPKHIAIIMDGNGRWAKAQGKPRVFGHKNGVQAVRKTISSAARLG
CCCCHHCCCHHHHHCCCCEEEEEECCCCCEEECCCCCCCCCCCCHHHHHHHHHHHHHHHC
IKAVTLFAFSSENWRRPEEEVGLLMELFISVLSSEVKKLHKNNLQLRVIGDKSRFNERLQ
HHEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHH
KKIEEAEALTSTNTGMVINIAANYGGKWDIQQAMTSIAQQVKSGDINVEDIDEAMITQHL
HHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHC
TMADIPEVDLLIRTSGECRISNFMLWQLAYAEMYFTEQFWPDFNEDSLVEAVTWFVNRER
HHCCCCCEEEEEECCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCC
RFGCTGEQIKALMDS
CCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]