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The map label for this gene is serC [H]

Identifier: 218709812

GI number: 218709812

Start: 1963501

End: 1964655

Strand: Reverse

Name: serC [H]

Synonym: VS_1824

Alternate gene names: 218709812

Gene position: 1964655-1963501 (Counterclockwise)

Preceding gene: 218709813

Following gene: 218709811

Centisome position: 59.55

GC content: 45.02

Gene sequence:

>1155_bases
ATGTTGGGTAAAACATGGTATTACTTGCATAGTTATTATTTAGCAGGAGCAATCATCCCCATGGAACTTACATTAGATAA
CGTATTCAACTTCAGTGCTGGCCCAGCTGCACTGCCTAAACCGGTAATGAAACAAGCGCAGGCGGACTTTATTGATTGGA
ATGGTTTAGGGACTTCCGTGATGGAAATCAGCCATCGCAGCAAGGAATTTATTCAAGTTGCTGACGAGTCCGAACAGGAC
CTACGTGATCTTCTGAACATCCCAGACAACTACAAAGTTCTTTTCTGTCAGGGGGGCGCTCGTGCTCAATTCGCTGCTGT
TCCTCTAAACCTTTTAGGTGACGCGACGAAAGCGACTTACATTGATGCGGGTTACTGGGCAGAAAGTGCAGTGACTGAAG
CGAGCAAATATTGCGAAATCGATGTATTCAACGCCAAGACGTCAATTGATGGCAAAGCAGCGGTTGTTCCAGCTAAAGAT
TGGAAAATCGACCCGGAAGCGGCGTATGTACATTTCTGTCCAAATGAGACCATCGATGGTATTGAAATCAGTGAGCTTCC
TCAAACGGATAAGCCAATCGTAGCGGATATGTCATCTAACATTCTGTCTCGTAAGATCGATGTGTCTCAGTACGGTGTTA
TCTACGCTGGCGCTCAAAAGAATATAGGCCCTGCTGGTATTTGCATTGCTATCGTGCGTGATGATCTGCTAGAGCTAGCA
AACGACGTATTGCCGAGCATTCTTAACTACAAAGTACTTGCTGAAAAAGACTCAATGTTCAACACACCGCCAACGTATGC
TTGGTACCTATCAGGCCTCGTATTCAAGTGGTTGAAAGCTCAAGGTGGTGTTGAAGCGATGGAATTAGTGAACAAAGAGA
AAGCTGCGCTGCTTTATAATGCGATTGATAGCTCAGCTTTCTACAGAAACGATGTTCATACGGCAAACCGTTCAAGAATG
AACGTGCCATTCCAATTAGCGAAACCAGAGCTAGATGCTAAGTTTTTAGAGTTGGCTGATGCTGCTGGTCTGAAATCACT
AAAAGGCCACAGAGCGGTAGGTGGGATGCGAGCATCACTTTACAACGCGATGTCTCTGGAAGGCGTGCAAGTATTAGTCA
GCTTCATGAAAGACTTTGAAGAGAAATACGCTTAA

Upstream 100 bases:

>100_bases
GAACAGGCTTGAATACTGATAGGGTGATTTAGCAGGTTCAGCTTAAACATTTTATACGGTACAAAACAAAAGAGGTCTTA
AGACCTCTTTTGTTGTTTTT

Downstream 100 bases:

>100_bases
TTAAGGCGTATTTCACAATAAGAGGAGCGAAAGCTCCTCTTTTTTTACTTGCTGAAAAGGAAGGGTATGAAGAAGTTAGG
TACAGTAAACAGTGTTTTGG

Product: phosphoserine aminotransferase

Products: NA

Alternate protein names: Phosphohydroxythreonine aminotransferase; PSAT [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MLGKTWYYLHSYYLAGAIIPMELTLDNVFNFSAGPAALPKPVMKQAQADFIDWNGLGTSVMEISHRSKEFIQVADESEQD
LRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATKATYIDAGYWAESAVTEASKYCEIDVFNAKTSIDGKAAVVPAKD
WKIDPEAAYVHFCPNETIDGIEISELPQTDKPIVADMSSNILSRKIDVSQYGVIYAGAQKNIGPAGICIAIVRDDLLELA
NDVLPSILNYKVLAEKDSMFNTPPTYAWYLSGLVFKWLKAQGGVEAMELVNKEKAALLYNAIDSSAFYRNDVHTANRSRM
NVPFQLAKPELDAKFLELADAAGLKSLKGHRAVGGMRASLYNAMSLEGVQVLVSFMKDFEEKYA

Sequences:

>Translated_384_residues
MLGKTWYYLHSYYLAGAIIPMELTLDNVFNFSAGPAALPKPVMKQAQADFIDWNGLGTSVMEISHRSKEFIQVADESEQD
LRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATKATYIDAGYWAESAVTEASKYCEIDVFNAKTSIDGKAAVVPAKD
WKIDPEAAYVHFCPNETIDGIEISELPQTDKPIVADMSSNILSRKIDVSQYGVIYAGAQKNIGPAGICIAIVRDDLLELA
NDVLPSILNYKVLAEKDSMFNTPPTYAWYLSGLVFKWLKAQGGVEAMELVNKEKAALLYNAIDSSAFYRNDVHTANRSRM
NVPFQLAKPELDAKFLELADAAGLKSLKGHRAVGGMRASLYNAMSLEGVQVLVSFMKDFEEKYA
>Mature_384_residues
MLGKTWYYLHSYYLAGAIIPMELTLDNVFNFSAGPAALPKPVMKQAQADFIDWNGLGTSVMEISHRSKEFIQVADESEQD
LRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATKATYIDAGYWAESAVTEASKYCEIDVFNAKTSIDGKAAVVPAKD
WKIDPEAAYVHFCPNETIDGIEISELPQTDKPIVADMSSNILSRKIDVSQYGVIYAGAQKNIGPAGICIAIVRDDLLELA
NDVLPSILNYKVLAEKDSMFNTPPTYAWYLSGLVFKWLKAQGGVEAMELVNKEKAALLYNAIDSSAFYRNDVHTANRSRM
NVPFQLAKPELDAKFLELADAAGLKSLKGHRAVGGMRASLYNAMSLEGVQVLVSFMKDFEEKYA

Specific function: Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine [H]

COG id: COG1932

COG function: function code HE; Phosphoserine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily [H]

Homologues:

Organism=Homo sapiens, GI17402893, Length=365, Percent_Identity=45.4794520547945, Blast_Score=330, Evalue=2e-90,
Organism=Homo sapiens, GI10863955, Length=360, Percent_Identity=40.5555555555556, Blast_Score=278, Evalue=5e-75,
Organism=Escherichia coli, GI1787136, Length=359, Percent_Identity=66.5738161559889, Blast_Score=504, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI17506897, Length=360, Percent_Identity=44.1666666666667, Blast_Score=313, Evalue=7e-86,
Organism=Saccharomyces cerevisiae, GI6324758, Length=396, Percent_Identity=43.1818181818182, Blast_Score=289, Evalue=4e-79,
Organism=Drosophila melanogaster, GI21356589, Length=360, Percent_Identity=48.0555555555556, Blast_Score=345, Evalue=3e-95,

Paralogues:

None

Copy number: 2500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR022278
- InterPro:   IPR003248
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.6.1.52 [H]

Molecular weight: Translated: 42300; Mature: 42300

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGKTWYYLHSYYLAGAIIPMELTLDNVFNFSAGPAALPKPVMKQAQADFIDWNGLGTSV
CCCCEEHHHHHHHHHCEEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHCCEEECCCCCHHH
MEISHRSKEFIQVADESEQDLRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATKATY
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCEEEECCHHHHCCCCHHEE
IDAGYWAESAVTEASKYCEIDVFNAKTSIDGKAAVVPAKDWKIDPEAAYVHFCPNETIDG
EECCHHHHHHHHHHHHHEEEEEECCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCC
IEISELPQTDKPIVADMSSNILSRKIDVSQYGVIYAGAQKNIGPAGICIAIVRDDLLELA
CCHHCCCCCCCCEEHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
NDVLPSILNYKVLAEKDSMFNTPPTYAWYLSGLVFKWLKAQGGVEAMELVNKEKAALLYN
HHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHH
AIDSSAFYRNDVHTANRSRMNVPFQLAKPELDAKFLELADAAGLKSLKGHRAVGGMRASL
HHCCCHHHCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCHHHHCCCHHHCCHHHHH
YNAMSLEGVQVLVSFMKDFEEKYA
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLGKTWYYLHSYYLAGAIIPMELTLDNVFNFSAGPAALPKPVMKQAQADFIDWNGLGTSV
CCCCEEHHHHHHHHHCEEEEEEEEHHHHHCCCCCCCCCCHHHHHHHHCCEEECCCCCHHH
MEISHRSKEFIQVADESEQDLRDLLNIPDNYKVLFCQGGARAQFAAVPLNLLGDATKATY
HHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCEEEEEECCCCCEEEECCHHHHCCCCHHEE
IDAGYWAESAVTEASKYCEIDVFNAKTSIDGKAAVVPAKDWKIDPEAAYVHFCPNETIDG
EECCHHHHHHHHHHHHHEEEEEECCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCC
IEISELPQTDKPIVADMSSNILSRKIDVSQYGVIYAGAQKNIGPAGICIAIVRDDLLELA
CCHHCCCCCCCCEEHHHHHHHHHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHH
NDVLPSILNYKVLAEKDSMFNTPPTYAWYLSGLVFKWLKAQGGVEAMELVNKEKAALLYN
HHHHHHHHCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHH
AIDSSAFYRNDVHTANRSRMNVPFQLAKPELDAKFLELADAAGLKSLKGHRAVGGMRASL
HHCCCHHHCCCCCCCCCCCCCCCEEECCCCCCHHHHHHHHHCCHHHHCCCHHHCCHHHHH
YNAMSLEGVQVLVSFMKDFEEKYA
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12620739 [H]