Click here to switch to the map view.

The map label for this gene is luxQ [H]

Identifier: 218709123

GI number: 218709123

Start: 1194499

End: 1196955

Strand: Direct

Name: luxQ [H]

Synonym: VS_1129

Alternate gene names: 218709123

Gene position: 1194499-1196955 (Clockwise)

Preceding gene: 218709121

Following gene: 218709124

Centisome position: 36.2

GC content: 42.86

Gene sequence:

>2457_bases
ATGGTAGCGCTTGGTGTATACCTCGCAATGTTCATTGCTATTGTCGGTAGTGTGACGTATTACGTCGTAGAATCTCCTGT
ACGCGCTAAGTTGCAACAAAACCTCGACTTACGTACACAACTGTTATCGGAATTGATTACAGCACCCCTCGGCAGCTCTC
AAGGTTTTGTTGATAGTTTGGTTGGTTTCGCTCAGGCGCAGCGCAGTGATACTGATGTTATACCGTTATTTATTAAGTCA
ATGTTGGCGGCGAGCGATGACACGATCGTCAGCGCAGGTATTTGGCCAGAACCGCATGCATTGGATTCTGATAAAATCCT
TAACAGTTATTTTTTCAACAAAGCCGACGATGGTGATATTGACCAGATCTTTTCTTATAACAACCCCAAAAATACGCCTT
ATCAAAACGAATATTGGTATACATCTGTATTAAACAAAGCGCAGGGAACCATTGCATGGAGCAATGTGTATATTGACCCA
TATACACATGTTCAAATGATCACAGCATCTTCACCTTACTATTACGATGGAACTTTTGCAGGTGTCGCGACGGTGGATCT
CTCACTCGAAGAGTTACTCGGCTTTATCAAGAACCATGCGGAAGAATACAACCTTGGTATTACTCTAAGAGACAAACTCA
ACCAAGTGTTGGTTTCTCATAACTTCAATCTCGTTGATGGGATTTATATTAGTAGTAACCAATTTGGAGAGTTTGGATGG
CAAGTGGATGTCGTCAACTCAAAATCACGAGTAGCAGACGAAGTGTTTCGTCAGGTAATGAGCGTTGAAGGCGGTATTGT
GCCGCTGTTGTTATTGTGTGTCATGGCCGGTTATTACTTACTGAACCGCTATTTGATAAACCCAATCACAACGATTGCCG
CCCAAGTTGATAGTTCTAAAGCGGGCGAGATCATCGATGTTGACTACTCTAGTGATGATGAAATCGGTCACTTAATCAAA
ACCTTCAATGAAAAAACCATCTATCTCGAAGCTGAGAAGGTTAAAGCTCAAGCGTCAACTAATGCCAAAACGGCCTTTCT
TGCGACTTTGTCACACGAAATTCGTACCCCGATGAATGGTGTATTAGGAACGGCTCAGATCTTACTGAAAACCCCTTTGA
GCACAGAGCAAGAGAAGCATCTTAAGAGCCTGTATGATTCGGGTGATCATATGATGACGTTACTCAATGAAATTTTGGAT
TTCTCAAAGATAGAGCAGGGTCGGTTAGATCTGGATGAAACACGATTCCCGCTTGATTCAATCATAGGAAGTATCAATAG
TGTCTATTACACATTGTCTTCCGAGAAAGGGCTTCAATTCAAAGTGTACTCCGAAGTGCCTTCTGGCCGTTGGTACTTCT
CAGATAAAGCACGCCTTCGCCAAATTTTATTTAACCTCTTAAACAACGCAGTCAAGTTTACCTCTCGAGGCTTTGTCGAG
GTGTACCTTAAAGAAATCGTAGAGCGAGGTGACACCTACCTTAGTATTCGAGTTCGTGACACGGGGATTGGTATATCTAA
AGAAGCACAAAAACGTATTTTTAAACCGTTTGAACAAGCTGAGTCTTCGACTACGAGACGCTTTGGCGGTACTGGTCTCG
GTTTAGCGATTGTGAAGAAAATTGCCCAATTGATGGAAGGCAGTATTAGTGTCACCAGTGAAGAAGGGATAGGCACCAGC
TTCGATGTTCGCTTGAAGATTAAGCCTTGCCAGCCTGGCGAAATAGAGAGCTTGCCACATAAAAAGTTAGATTACTCTGG
CTTGAAGGTACTGATTGTCGAAGATAACCGAACCAATACCGTCATTATTGAAACCTTCATGAGCAGTAAAGGCTTCACTT
GTAAGAGCGTCGAAAATGGTGAACTTGCGATACAAGCCGTGGTGGCTGAGCGCTTTGATTTGGTATTAATGGATAACCAT
ATGCCAGTGATGGACGGCGTTGAATCAACCACTGCAATTCGAGCTTTGATAGGCGAGATATCATCGGTACTGGTGTTTGG
TTGTACGGCTGATGTCTTTAAAGAGACTCGCGAACGTATGCTTGGTGCGGGTGTGGATTATATTATTGCCAAGCCGATTG
ATGAGCGTGAGTTGGATGATGCGTTATTCCGCTATTCAAACAAGCTTTACCAATACCATGAAGTTAAAGCTCATGATCTT
GATAGCCTAGATGTAGAAAAAAACGATTCGCAAAGTAACAGCGAGTCACTACCTAAACCTGATCTACGAAACAAAGATAA
CACCGAAGAGCTACTCGTCACGCTGTACGTTGCGCTCGAAGATAATAACTTAGCGCTGATTAAGTCTGCATTAGAGAGCT
TGCGTGTTCATGCTGAACCTATGAATAATGCAAAGCTCACAGATCACGTCGATAAAGCTTTAGAGCAGGTTTCTCTCGGT
TTCACTCCTGAACAAGAAATCATCAATACCATTACGGTAAATCTTCCTATGGCATAG

Upstream 100 bases:

>100_bases
CTAAAAACGCTTGATGTCATTAGTGATAAACACTAGGTTAAACAGAAAAGAAAATAACAAGATAATTATGCAAATACGCT
CGTCTCTCAAGAAAAAAAGT

Downstream 100 bases:

>100_bases
TTGTTGTTTAATTACGGAAATATAATAACAAATCGCTCGTTATTTGACCTTTGTGGGTTTTATTGGTGGAAGTGACTGCT
TTTAAAGTGGTTTTTGGTTG

Product: Signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 818; Mature: 818

Protein sequence:

>818_residues
MVALGVYLAMFIAIVGSVTYYVVESPVRAKLQQNLDLRTQLLSELITAPLGSSQGFVDSLVGFAQAQRSDTDVIPLFIKS
MLAASDDTIVSAGIWPEPHALDSDKILNSYFFNKADDGDIDQIFSYNNPKNTPYQNEYWYTSVLNKAQGTIAWSNVYIDP
YTHVQMITASSPYYYDGTFAGVATVDLSLEELLGFIKNHAEEYNLGITLRDKLNQVLVSHNFNLVDGIYISSNQFGEFGW
QVDVVNSKSRVADEVFRQVMSVEGGIVPLLLLCVMAGYYLLNRYLINPITTIAAQVDSSKAGEIIDVDYSSDDEIGHLIK
TFNEKTIYLEAEKVKAQASTNAKTAFLATLSHEIRTPMNGVLGTAQILLKTPLSTEQEKHLKSLYDSGDHMMTLLNEILD
FSKIEQGRLDLDETRFPLDSIIGSINSVYYTLSSEKGLQFKVYSEVPSGRWYFSDKARLRQILFNLLNNAVKFTSRGFVE
VYLKEIVERGDTYLSIRVRDTGIGISKEAQKRIFKPFEQAESSTTRRFGGTGLGLAIVKKIAQLMEGSISVTSEEGIGTS
FDVRLKIKPCQPGEIESLPHKKLDYSGLKVLIVEDNRTNTVIIETFMSSKGFTCKSVENGELAIQAVVAERFDLVLMDNH
MPVMDGVESTTAIRALIGEISSVLVFGCTADVFKETRERMLGAGVDYIIAKPIDERELDDALFRYSNKLYQYHEVKAHDL
DSLDVEKNDSQSNSESLPKPDLRNKDNTEELLVTLYVALEDNNLALIKSALESLRVHAEPMNNAKLTDHVDKALEQVSLG
FTPEQEIINTITVNLPMA

Sequences:

>Translated_818_residues
MVALGVYLAMFIAIVGSVTYYVVESPVRAKLQQNLDLRTQLLSELITAPLGSSQGFVDSLVGFAQAQRSDTDVIPLFIKS
MLAASDDTIVSAGIWPEPHALDSDKILNSYFFNKADDGDIDQIFSYNNPKNTPYQNEYWYTSVLNKAQGTIAWSNVYIDP
YTHVQMITASSPYYYDGTFAGVATVDLSLEELLGFIKNHAEEYNLGITLRDKLNQVLVSHNFNLVDGIYISSNQFGEFGW
QVDVVNSKSRVADEVFRQVMSVEGGIVPLLLLCVMAGYYLLNRYLINPITTIAAQVDSSKAGEIIDVDYSSDDEIGHLIK
TFNEKTIYLEAEKVKAQASTNAKTAFLATLSHEIRTPMNGVLGTAQILLKTPLSTEQEKHLKSLYDSGDHMMTLLNEILD
FSKIEQGRLDLDETRFPLDSIIGSINSVYYTLSSEKGLQFKVYSEVPSGRWYFSDKARLRQILFNLLNNAVKFTSRGFVE
VYLKEIVERGDTYLSIRVRDTGIGISKEAQKRIFKPFEQAESSTTRRFGGTGLGLAIVKKIAQLMEGSISVTSEEGIGTS
FDVRLKIKPCQPGEIESLPHKKLDYSGLKVLIVEDNRTNTVIIETFMSSKGFTCKSVENGELAIQAVVAERFDLVLMDNH
MPVMDGVESTTAIRALIGEISSVLVFGCTADVFKETRERMLGAGVDYIIAKPIDERELDDALFRYSNKLYQYHEVKAHDL
DSLDVEKNDSQSNSESLPKPDLRNKDNTEELLVTLYVALEDNNLALIKSALESLRVHAEPMNNAKLTDHVDKALEQVSLG
FTPEQEIINTITVNLPMA
>Mature_818_residues
MVALGVYLAMFIAIVGSVTYYVVESPVRAKLQQNLDLRTQLLSELITAPLGSSQGFVDSLVGFAQAQRSDTDVIPLFIKS
MLAASDDTIVSAGIWPEPHALDSDKILNSYFFNKADDGDIDQIFSYNNPKNTPYQNEYWYTSVLNKAQGTIAWSNVYIDP
YTHVQMITASSPYYYDGTFAGVATVDLSLEELLGFIKNHAEEYNLGITLRDKLNQVLVSHNFNLVDGIYISSNQFGEFGW
QVDVVNSKSRVADEVFRQVMSVEGGIVPLLLLCVMAGYYLLNRYLINPITTIAAQVDSSKAGEIIDVDYSSDDEIGHLIK
TFNEKTIYLEAEKVKAQASTNAKTAFLATLSHEIRTPMNGVLGTAQILLKTPLSTEQEKHLKSLYDSGDHMMTLLNEILD
FSKIEQGRLDLDETRFPLDSIIGSINSVYYTLSSEKGLQFKVYSEVPSGRWYFSDKARLRQILFNLLNNAVKFTSRGFVE
VYLKEIVERGDTYLSIRVRDTGIGISKEAQKRIFKPFEQAESSTTRRFGGTGLGLAIVKKIAQLMEGSISVTSEEGIGTS
FDVRLKIKPCQPGEIESLPHKKLDYSGLKVLIVEDNRTNTVIIETFMSSKGFTCKSVENGELAIQAVVAERFDLVLMDNH
MPVMDGVESTTAIRALIGEISSVLVFGCTADVFKETRERMLGAGVDYIIAKPIDERELDDALFRYSNKLYQYHEVKAHDL
DSLDVEKNDSQSNSESLPKPDLRNKDNTEELLVTLYVALEDNNLALIKSALESLRVHAEPMNNAKLTDHVDKALEQVSLG
FTPEQEIINTITVNLPMA

Specific function: At low cell density, in absence of AI-2 (autoinducer 2), luxQ has a kinase activity and autophosphorylates on a histidine residue. The phosphoryl group is then transferred to an aspartate residue in the response regulator domain. The phosphoryl group is t

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=358, Percent_Identity=32.122905027933, Blast_Score=197, Evalue=2e-51,
Organism=Escherichia coli, GI1788713, Length=472, Percent_Identity=29.4491525423729, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1789149, Length=288, Percent_Identity=35.0694444444444, Blast_Score=185, Evalue=1e-47,
Organism=Escherichia coli, GI87081816, Length=415, Percent_Identity=31.0843373493976, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI145693157, Length=288, Percent_Identity=34.7222222222222, Blast_Score=167, Evalue=3e-42,
Organism=Escherichia coli, GI1788549, Length=260, Percent_Identity=28.0769230769231, Blast_Score=90, Evalue=6e-19,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=29.1479820627803, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1786783, Length=306, Percent_Identity=26.1437908496732, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1786912, Length=227, Percent_Identity=29.0748898678414, Blast_Score=83, Evalue=7e-17,
Organism=Escherichia coli, GI1788393, Length=287, Percent_Identity=24.7386759581882, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=305, Percent_Identity=23.2786885245902, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1787894, Length=224, Percent_Identity=28.5714285714286, Blast_Score=74, Evalue=5e-14,
Organism=Escherichia coli, GI1788279, Length=209, Percent_Identity=28.2296650717703, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1790436, Length=224, Percent_Identity=28.5714285714286, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1790861, Length=237, Percent_Identity=24.8945147679325, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1790346, Length=214, Percent_Identity=26.6355140186916, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1790551, Length=331, Percent_Identity=24.4712990936556, Blast_Score=66, Evalue=8e-12,
Organism=Escherichia coli, GI1789808, Length=302, Percent_Identity=22.8476821192053, Blast_Score=63, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=86, Percent_Identity=38.3720930232558, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR015387
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789
- ProDom:   PD142495 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09308 LuxQ-periplasm; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 91203; Mature: 91203

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVALGVYLAMFIAIVGSVTYYVVESPVRAKLQQNLDLRTQLLSELITAPLGSSQGFVDSL
CCHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHH
VGFAQAQRSDTDVIPLFIKSMLAASDDTIVSAGIWPEPHALDSDKILNSYFFNKADDGDI
HHHHHHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCH
DQIFSYNNPKNTPYQNEYWYTSVLNKAQGTIAWSNVYIDPYTHVQMITASSPYYYDGTFA
HHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEEECCCCEEEEEEECCCEEECCEEC
GVATVDLSLEELLGFIKNHAEEYNLGITLRDKLNQVLVSHNFNLVDGIYISSNQFGEFGW
CEEEECCCHHHHHHHHHHCHHHHCCCEEEHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
QVDVVNSKSRVADEVFRQVMSVEGGIVPLLLLCVMAGYYLLNRYLINPITTIAAQVDSSK
EEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGEIIDVDYSSDDEIGHLIKTFNEKTIYLEAEKVKAQASTNAKTAFLATLSHEIRTPMNG
CCCEEEECCCCCCHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHCCCHHH
VLGTAQILLKTPLSTEQEKHLKSLYDSGDHMMTLLNEILDFSKIEQGRLDLDETRFPLDS
HHHHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHH
IIGSINSVYYTLSSEKGLQFKVYSEVPSGRWYFSDKARLRQILFNLLNNAVKFTSRGFVE
HHHCHHHEEEEEECCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHH
VYLKEIVERGDTYLSIRVRDTGIGISKEAQKRIFKPFEQAESSTTRRFGGTGLGLAIVKK
HHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHH
IAQLMEGSISVTSEEGIGTSFDVRLKIKPCQPGEIESLPHKKLDYSGLKVLIVEDNRTNT
HHHHHCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCE
VIIETFMSSKGFTCKSVENGELAIQAVVAERFDLVLMDNHMPVMDGVESTTAIRALIGEI
EEEEEECCCCCCEEECCCCCCEEHEEEHHHHCCEEEECCCCCHHCCCHHHHHHHHHHHHH
SSVLVFGCTADVFKETRERMLGAGVDYIIAKPIDERELDDALFRYSNKLYQYHEVKAHDL
HHHHEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
DSLDVEKNDSQSNSESLPKPDLRNKDNTEELLVTLYVALEDNNLALIKSALESLRVHAEP
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEEEEECCCHHHHHHHHHHHEEECCC
MNNAKLTDHVDKALEQVSLGFTPEQEIINTITVNLPMA
CCCCCHHHHHHHHHHHHHCCCCCHHHHHEEEEEEECCC
>Mature Secondary Structure
MVALGVYLAMFIAIVGSVTYYVVESPVRAKLQQNLDLRTQLLSELITAPLGSSQGFVDSL
CCHHHHHHHHHHHHHHHHHEEEECCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHH
VGFAQAQRSDTDVIPLFIKSMLAASDDTIVSAGIWPEPHALDSDKILNSYFFNKADDGDI
HHHHHHHCCCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCCCHHHHHHHHHCCCCCCCCH
DQIFSYNNPKNTPYQNEYWYTSVLNKAQGTIAWSNVYIDPYTHVQMITASSPYYYDGTFA
HHHHCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEEEECCCCEEEEEEECCCEEECCEEC
GVATVDLSLEELLGFIKNHAEEYNLGITLRDKLNQVLVSHNFNLVDGIYISSNQFGEFGW
CEEEECCCHHHHHHHHHHCHHHHCCCEEEHHHHHHHHHHCCCCEEEEEEECCCCCCCCCC
QVDVVNSKSRVADEVFRQVMSVEGGIVPLLLLCVMAGYYLLNRYLINPITTIAAQVDSSK
EEEEECCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
AGEIIDVDYSSDDEIGHLIKTFNEKTIYLEAEKVKAQASTNAKTAFLATLSHEIRTPMNG
CCCEEEECCCCCCHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCHHHHHHHHHHHCCCHHH
VLGTAQILLKTPLSTEQEKHLKSLYDSGDHMMTLLNEILDFSKIEQGRLDLDETRFPLDS
HHHHHHHHEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCHHCCCHHH
IIGSINSVYYTLSSEKGLQFKVYSEVPSGRWYFSDKARLRQILFNLLNNAVKFTSRGFVE
HHHCHHHEEEEEECCCCCEEEEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHCCCHHH
VYLKEIVERGDTYLSIRVRDTGIGISKEAQKRIFKPFEQAESSTTRRFGGTGLGLAIVKK
HHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHH
IAQLMEGSISVTSEEGIGTSFDVRLKIKPCQPGEIESLPHKKLDYSGLKVLIVEDNRTNT
HHHHHCCCEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCEEEEEEECCCCCE
VIIETFMSSKGFTCKSVENGELAIQAVVAERFDLVLMDNHMPVMDGVESTTAIRALIGEI
EEEEEECCCCCCEEECCCCCCEEHEEEHHHHCCEEEECCCCCHHCCCHHHHHHHHHHHHH
SSVLVFGCTADVFKETRERMLGAGVDYIIAKPIDERELDDALFRYSNKLYQYHEVKAHDL
HHHHEECCCHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
DSLDVEKNDSQSNSESLPKPDLRNKDNTEELLVTLYVALEDNNLALIKSALESLRVHAEP
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHEEEEEEEEEECCCHHHHHHHHHHHEEECCC
MNNAKLTDHVDKALEQVSLGFTPEQEIINTITVNLPMA
CCCCCHHHHHHHHHHHHHCCCCCHHHHHEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301; 12176318 [H]