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The map label for this gene is aspS

Identifier: 218709098

GI number: 218709098

Start: 1167487

End: 1169265

Strand: Direct

Name: aspS

Synonym: VS_1104

Alternate gene names: 218709098

Gene position: 1167487-1169265 (Clockwise)

Preceding gene: 218709090

Following gene: 218709099

Centisome position: 35.39

GC content: 47.39

Gene sequence:

>1779_bases
ATGCGTACCCATTACTGTGGTAACCTGAACAAGTCCCTGGCGGGACAAACTGTAGAATTGTGCGGCTGGGTAAACCGTCG
CCGTGATTTAGGCGGTCTTATCTTTATCGATATGCGAGATCGTGAAGGCGTCGTTCAGGTTGTTGTCGATCCAGATATGA
AAGATATCTTCCCGATCGCTAACCAACTGCGTAATGAATTCTGTATCAAGTTTACTGGTGAAGTACGCGTTCGTCCGGAC
AGCCAAGTAAATAAAGATATGGCGACGGGTGAAGTTGAGCTTTACGCAACTGGCCTAGAGATCATCAACCGTTCAGAAGC
GCTTCCACTAGACTTCAACCAAACGAACTCTGAAGAGCAGCGTCTTAAGTACCGTTACATCGATCTTCGTCGTCCAGAAA
TGAGCGACCGTATCAAGCTTCGTGCGCGTGCTTCTAGCTTCGTTCGTCGTTTCCTAGACGAGAACCTATTCCTAGACATC
GAAACGCCAGTACTAACGAAAGCGACACCTGAAGGCGCTCGTGACTACCTAGTACCAAGCCGTGTTCATAAAGGTAGCTT
CTACGCACTTCCTCAATCTCCTCAGCTGTTCAAGCAACTGCTGATGATGTCTGGTTTTGACCGTTACTACCAAATCGTTA
AATGTTTCCGTGATGAAGATTTACGTGCTGACCGTCAGCCTGAATTTACTCAAATCGATATCGAAACATCTTTCCTGACT
TCTCAAGAAGTGCGTAACGTGACTGAGAAGCTTGTTCATGATATGTGGAAAGAACTTCTAGATGTTGAACTAGGTCAATT
CCCAGTAATGCCTTTCTCTGAAGCGATTCGTCGTTTCGGTTCTGATAAGCCAGATCTACGTAACCCACTAGAGCTAGTGG
ACGTTGCTGACTTGGTTAAAGACGTTGAGTTCAAAGTCTTCTCTGGCCCAGCTAACGACGAAAAAGGTCGCGTAGCGGTT
ATCCGTGTTCCAGGTGGTGCTAAGCTAACTCGTAAGCAAATTGACGGTTACGCTGAACACGTAAACATCTACGGCGCGAA
AGGCCTAGCTTGGATGAAGGTTAACGACCGTGCTGCAGGCATGGAAGGTATTCAATCTCCAGTTGCTAAATTCCTAAGCG
AAGACGTAATCAACGGTATTCTAGATCGCACTCAAGCTGAATCTGGCGATATCATTCTGTTTGGCGCAGACAAAGCGGGC
ATCGTTGCTGAAGCAATGGGTGCACTTCGTCTTAAACTAGGTACTGATCTAGAGCTAACAGACACATCTGCATGGGCTCC
ACTGTGGGTTGTTGACTTCCCAATGTTCGAAGAAGACGGCGAAGGTAACCTACACGCAATGCACCACCCATTCACATCGC
CACTAGGTGTGAACGCGGAAGAGCTAAAAGCGAACCCAGCAGCAGCAAACTCTGATGCATACGACATGGTAATCAACGGC
TACGAAGTAGGCGGTGGTTCGGTACGTATTCATAGCGCAGAAATGCAAACGGCTGTATTCGGTATCCTAGGTATTGAAGC
TAAAGAGCAACAAGAGAAGTTCGGCTTCCTACTTGAAGCACTTAAGTACGGTACGCCACCACACGCAGGTCTAGCATTCG
GTCTTGACCGTCTAGCAATGCTACTTTGTGGTACAGAGAATATCCGTGATGTTATCGCATTCCCGAAAACAACAGCAGCA
GCATGTCTACTAACAGATGCGCCAAGCCTAGCAAACCCAGCATCACTGGAAGAGCTAGCAATCGCTGTTAAATTGGCAGA
GAAGAAAGAGCAAGCGTAA

Upstream 100 bases:

>100_bases
AAGCGAGTTTCCGCGTATAAATGTTCCTTTGCTCTGTTGTGTGGAATGACCACTGACAGCTTGGAAATTAGTAAATAATT
AAGAGATTGGGAAATTCATT

Downstream 100 bases:

>100_bases
GCCTGTTATCTTTCTCGTTGATGAAGAGATCCTAGTTGATAGAGAGCTCTTAATTAATTAGTCAAGATTTGTGAGTAAAT
TAGAAAATGCCCGTTAATTT

Product: aspartyl-tRNA synthetase

Products: NA

Alternate protein names: Aspartate--tRNA ligase; AspRS

Number of amino acids: Translated: 592; Mature: 592

Protein sequence:

>592_residues
MRTHYCGNLNKSLAGQTVELCGWVNRRRDLGGLIFIDMRDREGVVQVVVDPDMKDIFPIANQLRNEFCIKFTGEVRVRPD
SQVNKDMATGEVELYATGLEIINRSEALPLDFNQTNSEEQRLKYRYIDLRRPEMSDRIKLRARASSFVRRFLDENLFLDI
ETPVLTKATPEGARDYLVPSRVHKGSFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIETSFLT
SQEVRNVTEKLVHDMWKELLDVELGQFPVMPFSEAIRRFGSDKPDLRNPLELVDVADLVKDVEFKVFSGPANDEKGRVAV
IRVPGGAKLTRKQIDGYAEHVNIYGAKGLAWMKVNDRAAGMEGIQSPVAKFLSEDVINGILDRTQAESGDIILFGADKAG
IVAEAMGALRLKLGTDLELTDTSAWAPLWVVDFPMFEEDGEGNLHAMHHPFTSPLGVNAEELKANPAAANSDAYDMVING
YEVGGGSVRIHSAEMQTAVFGILGIEAKEQQEKFGFLLEALKYGTPPHAGLAFGLDRLAMLLCGTENIRDVIAFPKTTAA
ACLLTDAPSLANPASLEELAIAVKLAEKKEQA

Sequences:

>Translated_592_residues
MRTHYCGNLNKSLAGQTVELCGWVNRRRDLGGLIFIDMRDREGVVQVVVDPDMKDIFPIANQLRNEFCIKFTGEVRVRPD
SQVNKDMATGEVELYATGLEIINRSEALPLDFNQTNSEEQRLKYRYIDLRRPEMSDRIKLRARASSFVRRFLDENLFLDI
ETPVLTKATPEGARDYLVPSRVHKGSFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIETSFLT
SQEVRNVTEKLVHDMWKELLDVELGQFPVMPFSEAIRRFGSDKPDLRNPLELVDVADLVKDVEFKVFSGPANDEKGRVAV
IRVPGGAKLTRKQIDGYAEHVNIYGAKGLAWMKVNDRAAGMEGIQSPVAKFLSEDVINGILDRTQAESGDIILFGADKAG
IVAEAMGALRLKLGTDLELTDTSAWAPLWVVDFPMFEEDGEGNLHAMHHPFTSPLGVNAEELKANPAAANSDAYDMVING
YEVGGGSVRIHSAEMQTAVFGILGIEAKEQQEKFGFLLEALKYGTPPHAGLAFGLDRLAMLLCGTENIRDVIAFPKTTAA
ACLLTDAPSLANPASLEELAIAVKLAEKKEQA
>Mature_592_residues
MRTHYCGNLNKSLAGQTVELCGWVNRRRDLGGLIFIDMRDREGVVQVVVDPDMKDIFPIANQLRNEFCIKFTGEVRVRPD
SQVNKDMATGEVELYATGLEIINRSEALPLDFNQTNSEEQRLKYRYIDLRRPEMSDRIKLRARASSFVRRFLDENLFLDI
ETPVLTKATPEGARDYLVPSRVHKGSFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIETSFLT
SQEVRNVTEKLVHDMWKELLDVELGQFPVMPFSEAIRRFGSDKPDLRNPLELVDVADLVKDVEFKVFSGPANDEKGRVAV
IRVPGGAKLTRKQIDGYAEHVNIYGAKGLAWMKVNDRAAGMEGIQSPVAKFLSEDVINGILDRTQAESGDIILFGADKAG
IVAEAMGALRLKLGTDLELTDTSAWAPLWVVDFPMFEEDGEGNLHAMHHPFTSPLGVNAEELKANPAAANSDAYDMVING
YEVGGGSVRIHSAEMQTAVFGILGIEAKEQQEKFGFLLEALKYGTPPHAGLAFGLDRLAMLLCGTENIRDVIAFPKTTAA
ACLLTDAPSLANPASLEELAIAVKLAEKKEQA

Specific function: Unknown

COG id: COG0173

COG function: function code J; Aspartyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI40789249, Length=605, Percent_Identity=38.3471074380165, Blast_Score=404, Evalue=1e-112,
Organism=Homo sapiens, GI5031815, Length=255, Percent_Identity=26.2745098039216, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI194272210, Length=255, Percent_Identity=26.2745098039216, Blast_Score=80, Evalue=8e-15,
Organism=Homo sapiens, GI45439306, Length=298, Percent_Identity=26.510067114094, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1788173, Length=583, Percent_Identity=73.0703259005146, Blast_Score=901, Evalue=0.0,
Organism=Escherichia coli, GI1789256, Length=307, Percent_Identity=25.0814332247557, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790571, Length=288, Percent_Identity=24.6527777777778, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32566633, Length=609, Percent_Identity=34.1543513957307, Blast_Score=315, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI71994340, Length=261, Percent_Identity=23.3716475095785, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17535927, Length=261, Percent_Identity=23.3716475095785, Blast_Score=82, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17535925, Length=261, Percent_Identity=23.3716475095785, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17551876, Length=281, Percent_Identity=26.3345195729537, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6325153, Length=640, Percent_Identity=33.4375, Blast_Score=278, Evalue=1e-75,
Organism=Saccharomyces cerevisiae, GI6321807, Length=253, Percent_Identity=28.0632411067194, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323011, Length=279, Percent_Identity=27.5985663082437, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320242, Length=262, Percent_Identity=25.1908396946565, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24584738, Length=598, Percent_Identity=35.4515050167224, Blast_Score=324, Evalue=8e-89,
Organism=Drosophila melanogaster, GI24640849, Length=257, Percent_Identity=26.8482490272374, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI17136276, Length=276, Percent_Identity=26.4492753623188, Blast_Score=77, Evalue=5e-14,
Organism=Drosophila melanogaster, GI24640851, Length=257, Percent_Identity=26.8482490272374, Blast_Score=76, Evalue=7e-14,

Paralogues:

None

Copy number: 1320 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYD_VIBSL (B7VMI0)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416719.1
- GeneID:   7160696
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_1104
- HOGENOM:   HBG396032
- OMA:   AFPKTQQ
- ProtClustDB:   PRK00476
- GO:   GO:0005737
- HAMAP:   MF_00044_B
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR020564
- InterPro:   IPR004524
- InterPro:   IPR018153
- InterPro:   IPR002312
- InterPro:   IPR004115
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:3.30.1360.30
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF5
- PRINTS:   PR01042
- TIGRFAMs:   TIGR00459

Pfam domain/function: PF02938 GAD; PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.12

Molecular weight: Translated: 65982; Mature: 65982

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTHYCGNLNKSLAGQTVELCGWVNRRRDLGGLIFIDMRDREGVVQVVVDPDMKDIFPIA
CCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHH
NQLRNEFCIKFTGEVRVRPDSQVNKDMATGEVELYATGLEIINRSEALPLDFNQTNSEEQ
HHHCCCEEEEEECCEEECCCCHHCCCCCCCEEEEEEECHHHHCCCCCCCCCCCCCCCHHH
RLKYRYIDLRRPEMSDRIKLRARASSFVRRFLDENLFLDIETPVLTKATPEGARDYLVPS
HHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCCCCCCCCC
RVHKGSFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIETSFLT
CCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHC
SQEVRNVTEKLVHDMWKELLDVELGQFPVMPFSEAIRRFGSDKPDLRNPLELVDVADLVK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
DVEFKVFSGPANDEKGRVAVIRVPGGAKLTRKQIDGYAEHVNIYGAKGLAWMKVNDRAAG
HCCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHCCHHHHEEEEECCCEEEEEECCCCCC
MEGIQSPVAKFLSEDVINGILDRTQAESGDIILFGADKAGIVAEAMGALRLKLGTDLELT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHEEEEECCCEEEC
DTSAWAPLWVVDFPMFEEDGEGNLHAMHHPFTSPLGVNAEELKANPAAANSDAYDMVING
CCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHCCCCCCCCCCCEEEEEEE
YEVGGGSVRIHSAEMQTAVFGILGIEAKEQQEKFGFLLEALKYGTPPHAGLAFGLDRLAM
EEECCCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LLCGTENIRDVIAFPKTTAAACLLTDAPSLANPASLEELAIAVKLAEKKEQA
HHHCCCCHHHHHCCCCCHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRTHYCGNLNKSLAGQTVELCGWVNRRRDLGGLIFIDMRDREGVVQVVVDPDMKDIFPIA
CCCCCCCCCCHHHCCCHHHHHHHHHHHCCCCCEEEEEEECCCCEEEEEECCCHHHHHHHH
NQLRNEFCIKFTGEVRVRPDSQVNKDMATGEVELYATGLEIINRSEALPLDFNQTNSEEQ
HHHCCCEEEEEECCEEECCCCHHCCCCCCCEEEEEEECHHHHCCCCCCCCCCCCCCCHHH
RLKYRYIDLRRPEMSDRIKLRARASSFVRRFLDENLFLDIETPVLTKATPEGARDYLVPS
HHEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCCCCCCCCCCC
RVHKGSFYALPQSPQLFKQLLMMSGFDRYYQIVKCFRDEDLRADRQPEFTQIDIETSFLT
CCCCCCEEECCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHC
SQEVRNVTEKLVHDMWKELLDVELGQFPVMPFSEAIRRFGSDKPDLRNPLELVDVADLVK
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
DVEFKVFSGPANDEKGRVAVIRVPGGAKLTRKQIDGYAEHVNIYGAKGLAWMKVNDRAAG
HCCEEEEECCCCCCCCCEEEEECCCCCHHHHHHHCCHHHHEEEEECCCEEEEEECCCCCC
MEGIQSPVAKFLSEDVINGILDRTQAESGDIILFGADKAGIVAEAMGALRLKLGTDLELT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHEEEEECCCEEEC
DTSAWAPLWVVDFPMFEEDGEGNLHAMHHPFTSPLGVNAEELKANPAAANSDAYDMVING
CCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCHHHHCCCCCCCCCCCEEEEEEE
YEVGGGSVRIHSAEMQTAVFGILGIEAKEQQEKFGFLLEALKYGTPPHAGLAFGLDRLAM
EEECCCEEEEEHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
LLCGTENIRDVIAFPKTTAAACLLTDAPSLANPASLEELAIAVKLAEKKEQA
HHHCCCCHHHHHCCCCCHHHEEEEECCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA