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The map label for this gene is fabF [H]

Identifier: 218708772

GI number: 218708772

Start: 794266

End: 795489

Strand: Reverse

Name: fabF [H]

Synonym: VS_0770

Alternate gene names: 218708772

Gene position: 795489-794266 (Counterclockwise)

Preceding gene: 218708773

Following gene: 218708770

Centisome position: 24.11

GC content: 48.61

Gene sequence:

>1224_bases
ATGACCCGCCGCGTTGTTGTAACTGGCATGTCAGGCGTTACCGCTTTTGGCAACGATTGGCAGCACATCGAGCCAAAACT
AAAAGCGTGTGAAAATGCGACCCAGTATATGCCAAGCTTTGAGCAGTACGATGGCCTCAACACAAAGCTTGCCGCACCTA
TTGATGACTTCCAACTACCTAAGCACTATAAGCGTAAACAAGTACGTGGTATGGGCCGTGTGTCTCGCCTAGCAACAGTG
GCGACCGAAAATGCACTAGAGCAAGCAGGACTGATTGGCCACGACGTTTTGACTAATGGCGAAACAGGCATTGCCTATGG
TTCTTCAACCGGCAGTACTGATGCGGTTGGTGCATTTGGCGTGATGCTTAACGAGAAATCGACACGAGCGATCACCGCAA
CGACTTACGTTCAGATGATGCCACACACCGCAGCGGTCAACGTCGGGCTATTCTTTGGCTTACGTGGACGTGTGATTCCC
ACCAGCAGTGCCTGTACTTCAGGTAGCCAAGCGATTGGTTACGCCTATGAAGCGATCAAACACGGCTACCAAACTGTGAT
GGTGGCCGGAGGTGGTGAAGAACTATGCCCAACCGAATCTGCCGTTTTTGATACCCTTTTTGCTACCAGTTTAAAAAACG
ACACGCCAGAAAAATCCCCTAGCCCTTACGACAGTGAGCGCGATGGCCTAGTTATCGGTGAAGGTGCTGGTACGCTTGTT
CTTGAAGAGTATGAACATGCGGTTGCTCGCGGTGCAAAGATCTACGCTGAGATCATCGGTTTTGCCAGCAACTGCGATGC
AGCTCATGTGACTCAACCTCAGATGGAAACCATGCAAATCTGTATGGAGAAAGCGCTGAAAGATGCACAGCTTCCTGCTG
AAAAAATTGGTTATGTTTCGGCGCACGGAACGGCAACAGATAAAGGCGATATTGCAGAAAGTAATGCGACCGCGAACATT
TTTGGTGAAGTGCCAATCAGCTCATTAAAAAGCTACTTTGGTCATACGCTTGGCGCATGTGGTGCCATTGAGGCTTGGTT
GAGCCTAGAAATGATGCATTCCGGCTGGTTCAGCCCAACATTGAACCTTGAAAACATCGACGAACGCTGCGGTAAACTCG
ATTACATTACAGGTTCTGGTCGCGAATTGGATGTTGAGTATGTAATGAGTAATAACTTTGCCTTTGGCGGAATCAACACT
TCCATCATCTTCAAAAAGATTTAA

Upstream 100 bases:

>100_bases
TGGGCGAGCCAGAAGAAGTCGCCGGCCTAGTCAGCTACCTAATGTCGGATATTGCCGGCTACGTAACTCGCCAAGTGATT
TCAGTTAATGGAGGCTTAGT

Downstream 100 bases:

>100_bases
GCCTATTTATTAGCTAAAACTCGAGACAAATAAAAAGGGTCAGTAACCAAGTTACTGACCCTTTTTTGAATCTAGCAAAA
GCTCAATTAAGCATTAGCTT

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTRRVVVTGMSGVTAFGNDWQHIEPKLKACENATQYMPSFEQYDGLNTKLAAPIDDFQLPKHYKRKQVRGMGRVSRLATV
ATENALEQAGLIGHDVLTNGETGIAYGSSTGSTDAVGAFGVMLNEKSTRAITATTYVQMMPHTAAVNVGLFFGLRGRVIP
TSSACTSGSQAIGYAYEAIKHGYQTVMVAGGGEELCPTESAVFDTLFATSLKNDTPEKSPSPYDSERDGLVIGEGAGTLV
LEEYEHAVARGAKIYAEIIGFASNCDAAHVTQPQMETMQICMEKALKDAQLPAEKIGYVSAHGTATDKGDIAESNATANI
FGEVPISSLKSYFGHTLGACGAIEAWLSLEMMHSGWFSPTLNLENIDERCGKLDYITGSGRELDVEYVMSNNFAFGGINT
SIIFKKI

Sequences:

>Translated_407_residues
MTRRVVVTGMSGVTAFGNDWQHIEPKLKACENATQYMPSFEQYDGLNTKLAAPIDDFQLPKHYKRKQVRGMGRVSRLATV
ATENALEQAGLIGHDVLTNGETGIAYGSSTGSTDAVGAFGVMLNEKSTRAITATTYVQMMPHTAAVNVGLFFGLRGRVIP
TSSACTSGSQAIGYAYEAIKHGYQTVMVAGGGEELCPTESAVFDTLFATSLKNDTPEKSPSPYDSERDGLVIGEGAGTLV
LEEYEHAVARGAKIYAEIIGFASNCDAAHVTQPQMETMQICMEKALKDAQLPAEKIGYVSAHGTATDKGDIAESNATANI
FGEVPISSLKSYFGHTLGACGAIEAWLSLEMMHSGWFSPTLNLENIDERCGKLDYITGSGRELDVEYVMSNNFAFGGINT
SIIFKKI
>Mature_406_residues
TRRVVVTGMSGVTAFGNDWQHIEPKLKACENATQYMPSFEQYDGLNTKLAAPIDDFQLPKHYKRKQVRGMGRVSRLATVA
TENALEQAGLIGHDVLTNGETGIAYGSSTGSTDAVGAFGVMLNEKSTRAITATTYVQMMPHTAAVNVGLFFGLRGRVIPT
SSACTSGSQAIGYAYEAIKHGYQTVMVAGGGEELCPTESAVFDTLFATSLKNDTPEKSPSPYDSERDGLVIGEGAGTLVL
EEYEHAVARGAKIYAEIIGFASNCDAAHVTQPQMETMQICMEKALKDAQLPAEKIGYVSAHGTATDKGDIAESNATANIF
GEVPISSLKSYFGHTLGACGAIEAWLSLEMMHSGWFSPTLNLENIDERCGKLDYITGSGRELDVEYVMSNNFAFGGINTS
IIFKKI

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=32.5358851674641, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI223972627, Length=175, Percent_Identity=34.8571428571429, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI41872631, Length=357, Percent_Identity=27.1708683473389, Blast_Score=75, Evalue=8e-14,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=38.8888888888889, Blast_Score=239, Evalue=2e-64,
Organism=Escherichia coli, GI1788663, Length=411, Percent_Identity=35.2798053527981, Blast_Score=225, Evalue=3e-60,
Organism=Caenorhabditis elegans, GI71983541, Length=414, Percent_Identity=30.6763285024155, Blast_Score=178, Evalue=4e-45,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=35.2272727272727, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI212642053, Length=357, Percent_Identity=26.3305322128852, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17550940, Length=268, Percent_Identity=25.3731343283582, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=448, Percent_Identity=30.8035714285714, Blast_Score=175, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24644341, Length=411, Percent_Identity=32.6034063260341, Blast_Score=201, Evalue=9e-52,
Organism=Drosophila melanogaster, GI221330659, Length=364, Percent_Identity=25.5494505494505, Blast_Score=76, Evalue=3e-14,
Organism=Drosophila melanogaster, GI19920632, Length=364, Percent_Identity=25.5494505494505, Blast_Score=76, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43657; Mature: 43526

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRRVVVTGMSGVTAFGNDWQHIEPKLKACENATQYMPSFEQYDGLNTKLAAPIDDFQLP
CCCEEEEECCCCCEECCCCHHHCCHHHHHHHHHHHHCCCHHHHCCCCCEEECCCCCCCCC
KHYKRKQVRGMGRVSRLATVATENALEQAGLIGHDVLTNGETGIAYGSSTGSTDAVGAFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEECCCCCCCCCHHHEE
VMLNEKSTRAITATTYVQMMPHTAAVNVGLFFGLRGRVIPTSSACTSGSQAIGYAYEAIK
EEECCCCCCEEEEEHHEECCCCHHHEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHHHH
HGYQTVMVAGGGEELCPTESAVFDTLFATSLKNDTPEKSPSPYDSERDGLVIGEGAGTLV
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAVARGAKIYAEIIGFASNCDAAHVTQPQMETMQICMEKALKDAQLPAEKIGYVS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCEEE
AHGTATDKGDIAESNATANIFGEVPISSLKSYFGHTLGACGAIEAWLSLEMMHSGWFSPT
ECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LNLENIDERCGKLDYITGSGRELDVEYVMSNNFAFGGINTSIIFKKI
CCCCCHHHHCCCEEEEECCCCEEEEEEEEECCEEECCCCEEEEEEEC
>Mature Secondary Structure 
TRRVVVTGMSGVTAFGNDWQHIEPKLKACENATQYMPSFEQYDGLNTKLAAPIDDFQLP
CCEEEEECCCCCEECCCCHHHCCHHHHHHHHHHHHCCCHHHHCCCCCEEECCCCCCCCC
KHYKRKQVRGMGRVSRLATVATENALEQAGLIGHDVLTNGETGIAYGSSTGSTDAVGAFG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCCCEEECCCCCCCCCHHHEE
VMLNEKSTRAITATTYVQMMPHTAAVNVGLFFGLRGRVIPTSSACTSGSQAIGYAYEAIK
EEECCCCCCEEEEEHHEECCCCHHHEEEEEEECCCCCEEECCCCCCCCCHHHHHHHHHHH
HGYQTVMVAGGGEELCPTESAVFDTLFATSLKNDTPEKSPSPYDSERDGLVIGEGAGTLV
CCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYEHAVARGAKIYAEIIGFASNCDAAHVTQPQMETMQICMEKALKDAQLPAEKIGYVS
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHCCEEE
AHGTATDKGDIAESNATANIFGEVPISSLKSYFGHTLGACGAIEAWLSLEMMHSGWFSPT
ECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
LNLENIDERCGKLDYITGSGRELDVEYVMSNNFAFGGINTSIIFKKI
CCCCCHHHHCCCEEEEECCCCEEEEEEEEECCEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]