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The map label for this gene is kdsA [H]

Identifier: 218708759

GI number: 218708759

Start: 776524

End: 777378

Strand: Direct

Name: kdsA [H]

Synonym: VS_0756

Alternate gene names: 218708759

Gene position: 776524-777378 (Clockwise)

Preceding gene: 218708758

Following gene: 218708760

Centisome position: 23.54

GC content: 45.5

Gene sequence:

>855_bases
ATGATGGAACAGAAAACAGTTCACATTGGCAATATGCCAATTGCTAATGACAAGCCATTTACGCTATTTGCAGGTATGAA
CGTTCTTGAATCTCGCGATCTAGCTATGCAGATCTGTGAGCACTACGTGAAAGTAACAGAGAAGCTGGGTATCCCTTATG
TATTTAAGGCGTCTTTCGACAAAGCAAACCGTAGCTCAGTTCACTCATACCGTGGTCCTGGCATGGAAGAAGGTCTTAAA
ATTTTCCAAGAGCTGAAAGATACCTTTGGCGTGAAGATCATCACTGATATTCACACTGAAGCGCAAGCTCAGCCTGTTGC
TGATGTGGTTGATGTAATCCAGCTTCCAGCGTTCCTTGCTCGTCAAACTGATCTTGTTGAAGCAATGGCTAAGACTGGCG
CGGTTATCAATGTGAAGAAGCCTCAGTTCATGAGCCCAGATCAAGTGGGTAATATCGTTGATAAGTTTGCTGAGTGTGGC
AACGAGAACATCATTCTTTGTGAACGCGGTTCTTGCATGGGTTATGACAACCTAGTAGTTGATATGCTTGGTTTTGGTGT
GATGAAGAAATCATCAAACGGTAGCCCAATCATCTTTGATGTGACTCACGCGCTTCAAATGCGTGATCCATCAGGTGCTG
CATCTGGCGGTCGTCGTGAGCAAACGGTTGAACTAGCTAAAGCGGGTATTGCGACGGGTATTGCTGGTCTATTTCTTGAG
GCTCACCCTAACCCAGATCAAGCACGCTGTGATGGCCCATCGGCGTTACCGCTAGATAAGCTAGAACCGTTCTTGAAGCA
GATGAAAGCACTTGATGACCTTATCAAAGGCTTCGAGCACATCGAAATCAAATAG

Upstream 100 bases:

>100_bases
TGCCCAGATGACCCTGCATCTGAGCTACTAAAATCTCAAGTGAACGTCATGAACGAAAAGACAGTGGTTGTTCACTAATT
AATAATTATTTAGAGAGAAT

Downstream 100 bases:

>100_bases
TTTTATCTGATGTTAAGTCACTAGTATTAACTAGAGAATGTTAACTCGTTATTTGATTGTAATAGACAAACGCCCAACTC
TTAGAGTTGGGCGTTTTTTA

Product: 2-dehydro-3-deoxyphosphooctonate aldolase

Products: NA

Alternate protein names: 3-deoxy-D-manno-octulosonic acid 8-phosphate synthase; KDO-8-phosphate synthase; KDO 8-P synthase; KDOPS; Phospho-2-dehydro-3-deoxyoctonate aldolase [H]

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MMEQKTVHIGNMPIANDKPFTLFAGMNVLESRDLAMQICEHYVKVTEKLGIPYVFKASFDKANRSSVHSYRGPGMEEGLK
IFQELKDTFGVKIITDIHTEAQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFMSPDQVGNIVDKFAECG
NENIILCERGSCMGYDNLVVDMLGFGVMKKSSNGSPIIFDVTHALQMRDPSGAASGGRREQTVELAKAGIATGIAGLFLE
AHPNPDQARCDGPSALPLDKLEPFLKQMKALDDLIKGFEHIEIK

Sequences:

>Translated_284_residues
MMEQKTVHIGNMPIANDKPFTLFAGMNVLESRDLAMQICEHYVKVTEKLGIPYVFKASFDKANRSSVHSYRGPGMEEGLK
IFQELKDTFGVKIITDIHTEAQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFMSPDQVGNIVDKFAECG
NENIILCERGSCMGYDNLVVDMLGFGVMKKSSNGSPIIFDVTHALQMRDPSGAASGGRREQTVELAKAGIATGIAGLFLE
AHPNPDQARCDGPSALPLDKLEPFLKQMKALDDLIKGFEHIEIK
>Mature_284_residues
MMEQKTVHIGNMPIANDKPFTLFAGMNVLESRDLAMQICEHYVKVTEKLGIPYVFKASFDKANRSSVHSYRGPGMEEGLK
IFQELKDTFGVKIITDIHTEAQAQPVADVVDVIQLPAFLARQTDLVEAMAKTGAVINVKKPQFMSPDQVGNIVDKFAECG
NENIILCERGSCMGYDNLVVDMLGFGVMKKSSNGSPIIFDVTHALQMRDPSGAASGGRREQTVELAKAGIATGIAGLFLE
AHPNPDQARCDGPSALPLDKLEPFLKQMKALDDLIKGFEHIEIK

Specific function: Synthesis Of Kdo 8-P Which Is Required For Lipid A Maturation And Cellular Growth. [C]

COG id: COG2877

COG function: function code M; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsA family [H]

Homologues:

Organism=Escherichia coli, GI1787466, Length=281, Percent_Identity=79.3594306049822, Blast_Score=474, Evalue=1e-135,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006218
- InterPro:   IPR006269 [H]

Pfam domain/function: PF00793 DAHP_synth_1 [H]

EC number: =2.5.1.55 [H]

Molecular weight: Translated: 31066; Mature: 31066

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMEQKTVHIGNMPIANDKPFTLFAGMNVLESRDLAMQICEHYVKVTEKLGIPYVFKASFD
CCCCCEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
KANRSSVHSYRGPGMEEGLKIFQELKDTFGVKIITDIHTEAQAQPVADVVDVIQLPAFLA
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEEECCCHHCCCHHHHHHHHHHHHHHHH
RQTDLVEAMAKTGAVINVKKPQFMSPDQVGNIVDKFAECGNENIILCERGSCMGYDNLVV
HHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHH
DMLGFGVMKKSSNGSPIIFDVTHALQMRDPSGAASGGRREQTVELAKAGIATGIAGLFLE
HHHHHHHEECCCCCCEEEEEEHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEE
AHPNPDQARCDGPSALPLDKLEPFLKQMKALDDLIKGFEHIEIK
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHCCCC
>Mature Secondary Structure
MMEQKTVHIGNMPIANDKPFTLFAGMNVLESRDLAMQICEHYVKVTEKLGIPYVFKASFD
CCCCCEEEECCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCC
KANRSSVHSYRGPGMEEGLKIFQELKDTFGVKIITDIHTEAQAQPVADVVDVIQLPAFLA
CCCHHHHHHHCCCCHHHHHHHHHHHHHHHCEEEEEECCCHHCCCHHHHHHHHHHHHHHHH
RQTDLVEAMAKTGAVINVKKPQFMSPDQVGNIVDKFAECGNENIILCERGSCMGYDNLVV
HHHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHH
DMLGFGVMKKSSNGSPIIFDVTHALQMRDPSGAASGGRREQTVELAKAGIATGIAGLFLE
HHHHHHHEECCCCCCEEEEEEHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEE
AHPNPDQARCDGPSALPLDKLEPFLKQMKALDDLIKGFEHIEIK
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA