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The map label for this gene is hemA

Identifier: 218708754

GI number: 218708754

Start: 771836

End: 773095

Strand: Direct

Name: hemA

Synonym: VS_0751

Alternate gene names: 218708754

Gene position: 771836-773095 (Clockwise)

Preceding gene: 218708746

Following gene: 218708755

Centisome position: 23.39

GC content: 44.6

Gene sequence:

>1260_bases
ATGTCTTTGCTTGCCGTAGGTATCAATCACAATACAGCGTCGGTTGAATTGCGAGAAAAAGTCGCTTTTGGTCCAGATAA
ATTATCTGAGGCACTTAAGCAACTTAACGCAAATGCACACGTAAATGGAAGTGTCATACTTTCTACCTGTAATCGAACTG
AAGTGTATTGTGACGTCAAAGGCGTGGCAAAAAACAAGTTGATCGATTGGCTGTCTGTATTTCATCAAGTTAGCCCTGAA
GAATTAAAACCGAGCATCTACATCCATGAAGAGCAGGCCGCGATTAAGCACTTAATGCGCGTTGCCTGTGGTTTGGACTC
TCTGGTGTTGGGTGAACCACAGATTTTAGGTCAGGTGAAGCAAGCTTATACAGACTCTCGAGATAACAAATCTGTTGATG
CTTCAATGGAAAAACTGTTTCAGAAATCATTTTCTGTCGCTAAGCGTGTTCGAACTGAAACTGAAATTGGCGGAAGCGCG
GTTTCAGTTGCTTACGCAGCTTGCACATTAGCCAAACACATCTTTGAGTCGATTGCTGAATCAACGGTGTTATTGGTAGG
TGCGGGTGAGACGATTGAATTGGTGGCAAAACACCTTTCAGCGAATGGTTGCACCAAGATGATTGTGGCCAACCGAACTC
GTGAGCGTGCTTTAGGGCTAGCTGAAGAGTTTGGTGCTGAAGTGATTAGCCTCAATGAAATCCCCGATCACCTGCATCGA
GCGGATATCGTGATCAGCTCAACCGCTAGTCCACTGCCTATTATTGGGAAGGGAATGGTTGAGACCGCACTTAAGACAAG
AAAACATCAACCGATGTTGTTGGTTGATATTGCTGTTCCCCGAGACGTTGAGTCTCAGGTAGGCGATCTGAATGATGCTT
ACCTATATTCCGTTGATGATCTGCAGTCGATTGTTGATGGCAACATTGAACAACGTAAAGTGGAAGCTATCCAAGCGGAA
GCTATCGTTAGTGAAGAAAGTGCAGCATTCATGAGTTGGATGCGCTCACTGCAAGCGGTAGACAGTATTCGTGACTATCG
CAAATCGGCCAATGAAATCCGAGAAGAATTATTAAGTAAGAGTTTACAATCACTTGCCGCTGGCGGTGACCCTGAAAAAG
TCTTACTTGAGCTAAGTAACAAGCTCACAAACAAATTGATCCATGCTCCAACGCGTGCACTCCAAAGTGCAGCAGAGCAA
GGAGAACCTGCAAAATTAACGGTCATTAGACAGAGTTTGGGCTTAGAAAACCCTCAATAA

Upstream 100 bases:

>100_bases
CGAACTCAGGAAAACAAATCCCGCTTGCTCTTTAAATAGAGCCATGCATCAAGTAAAATTCGCCCCTTGTTTCCATTCCC
TGATCGAGAACTTCTGATAC

Downstream 100 bases:

>100_bases
TATTCGACCTCCAACAGAATAAGACATTATGAAAGCCTCGATTCTAATAAAGCTTGAAACACTTGTTGAACGCTATGAAG
AAGTTCAACATCTACTTGGT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSLLAVGINHNTASVELREKVAFGPDKLSEALKQLNANAHVNGSVILSTCNRTEVYCDVKGVAKNKLIDWLSVFHQVSPE
ELKPSIYIHEEQAAIKHLMRVACGLDSLVLGEPQILGQVKQAYTDSRDNKSVDASMEKLFQKSFSVAKRVRTETEIGGSA
VSVAYAACTLAKHIFESIAESTVLLVGAGETIELVAKHLSANGCTKMIVANRTRERALGLAEEFGAEVISLNEIPDHLHR
ADIVISSTASPLPIIGKGMVETALKTRKHQPMLLVDIAVPRDVESQVGDLNDAYLYSVDDLQSIVDGNIEQRKVEAIQAE
AIVSEESAAFMSWMRSLQAVDSIRDYRKSANEIREELLSKSLQSLAAGGDPEKVLLELSNKLTNKLIHAPTRALQSAAEQ
GEPAKLTVIRQSLGLENPQ

Sequences:

>Translated_419_residues
MSLLAVGINHNTASVELREKVAFGPDKLSEALKQLNANAHVNGSVILSTCNRTEVYCDVKGVAKNKLIDWLSVFHQVSPE
ELKPSIYIHEEQAAIKHLMRVACGLDSLVLGEPQILGQVKQAYTDSRDNKSVDASMEKLFQKSFSVAKRVRTETEIGGSA
VSVAYAACTLAKHIFESIAESTVLLVGAGETIELVAKHLSANGCTKMIVANRTRERALGLAEEFGAEVISLNEIPDHLHR
ADIVISSTASPLPIIGKGMVETALKTRKHQPMLLVDIAVPRDVESQVGDLNDAYLYSVDDLQSIVDGNIEQRKVEAIQAE
AIVSEESAAFMSWMRSLQAVDSIRDYRKSANEIREELLSKSLQSLAAGGDPEKVLLELSNKLTNKLIHAPTRALQSAAEQ
GEPAKLTVIRQSLGLENPQ
>Mature_418_residues
SLLAVGINHNTASVELREKVAFGPDKLSEALKQLNANAHVNGSVILSTCNRTEVYCDVKGVAKNKLIDWLSVFHQVSPEE
LKPSIYIHEEQAAIKHLMRVACGLDSLVLGEPQILGQVKQAYTDSRDNKSVDASMEKLFQKSFSVAKRVRTETEIGGSAV
SVAYAACTLAKHIFESIAESTVLLVGAGETIELVAKHLSANGCTKMIVANRTRERALGLAEEFGAEVISLNEIPDHLHRA
DIVISSTASPLPIIGKGMVETALKTRKHQPMLLVDIAVPRDVESQVGDLNDAYLYSVDDLQSIVDGNIEQRKVEAIQAEA
IVSEESAAFMSWMRSLQAVDSIRDYRKSANEIREELLSKSLQSLAAGGDPEKVLLELSNKLTNKLIHAPTRALQSAAEQG
EPAKLTVIRQSLGLENPQ

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=418, Percent_Identity=60.5263157894737, Blast_Score=503, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_VIBSL (B7VKH2)

Other databases:

- EMBL:   FM954972
- RefSeq:   YP_002416375.1
- ProteinModelPortal:   B7VKH2
- SMR:   B7VKH2
- GeneID:   7160352
- GenomeReviews:   FM954972_GR
- KEGG:   vsp:VS_0751
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 45592; Mature: 45460

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 107-107 BINDING 118-118

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLLAVGINHNTASVELREKVAFGPDKLSEALKQLNANAHVNGSVILSTCNRTEVYCDVK
CCEEEEECCCCCCCEEHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEC
GVAKNKLIDWLSVFHQVSPEELKPSIYIHEEQAAIKHLMRVACGLDSLVLGEPQILGQVK
HHHHHHHHHHHHHHHCCCHHHCCCCEEEEHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHH
QAYTDSRDNKSVDASMEKLFQKSFSVAKRVRTETEIGGSAVSVAYAACTLAKHIFESIAE
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
STVLLVGAGETIELVAKHLSANGCTKMIVANRTRERALGLAEEFGAEVISLNEIPDHLHR
CEEEEEECCCHHHHHHHHHCCCCCHHHHHHCCHHHHHHCCHHHHCCCEEEHHHHHHHHHH
ADIVISSTASPLPIIGKGMVETALKTRKHQPMLLVDIAVPRDVESQVGDLNDAYLYSVDD
HCEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCCCCEEEEHHH
LQSIVDGNIEQRKVEAIQAEAIVSEESAAFMSWMRSLQAVDSIRDYRKSANEIREELLSK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLQSLAAGGDPEKVLLELSNKLTNKLIHAPTRALQSAAEQGEPAKLTVIRQSLGLENPQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCC
>Mature Secondary Structure 
SLLAVGINHNTASVELREKVAFGPDKLSEALKQLNANAHVNGSVILSTCNRTEVYCDVK
CEEEEECCCCCCCEEHHHHHCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEC
GVAKNKLIDWLSVFHQVSPEELKPSIYIHEEQAAIKHLMRVACGLDSLVLGEPQILGQVK
HHHHHHHHHHHHHHHCCCHHHCCCCEEEEHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHH
QAYTDSRDNKSVDASMEKLFQKSFSVAKRVRTETEIGGSAVSVAYAACTLAKHIFESIAE
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
STVLLVGAGETIELVAKHLSANGCTKMIVANRTRERALGLAEEFGAEVISLNEIPDHLHR
CEEEEEECCCHHHHHHHHHCCCCCHHHHHHCCHHHHHHCCHHHHCCCEEEHHHHHHHHHH
ADIVISSTASPLPIIGKGMVETALKTRKHQPMLLVDIAVPRDVESQVGDLNDAYLYSVDD
HCEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCCHHHHHCCCCCCEEEEHHH
LQSIVDGNIEQRKVEAIQAEAIVSEESAAFMSWMRSLQAVDSIRDYRKSANEIREELLSK
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLQSLAAGGDPEKVLLELSNKLTNKLIHAPTRALQSAAEQGEPAKLTVIRQSLGLENPQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA