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The map label for this gene is mrdB [H]

Identifier: 218708733

GI number: 218708733

Start: 746829

End: 747950

Strand: Reverse

Name: mrdB [H]

Synonym: VS_0712

Alternate gene names: 218708733

Gene position: 747950-746829 (Counterclockwise)

Preceding gene: 218708734

Following gene: 218708732

Centisome position: 22.67

GC content: 46.08

Gene sequence:

>1122_bases
ATGAAACTTGATCCTTCAACTGGACGAAATAGAGCCCTATTTGAACGGCTGCATATCGACCTGCCGCTATTGCTTGGCAT
TCTGGTTTTAATGGGCTTTGCCCTATTGATTATGTACAGCGCAAGCGGACAGAGCCTTGCGATGATGGATCGCCAAGCGA
TGCGTATGGTGCTGTCTTTAGGTGTGATGATCTTTTTAGCGCAAATCTCGCCTCGTACTTATGAGACCTTGGCTCCACTA
CTGTTTGCGGGCGGCGTTATTCTACTACTCGGAGTGTTGTTCTTTGGCGAGGCCTCTAAAGGTGCACAGCGCTGGTTAAA
CTTCGGCTTTATTCGATTCCAACCCTCTGAACTATTGAAGCTTGCAGTACCTTTGATGCTAGCTCGATTTATTGGTAAGC
GCTCACTGCCACCCACTTTCCAAACCTTGGCTATCTCATTAGTGATGGTGTTTGTACCTACAATCCTTATCGCTAAACAG
CCAGATTTAGGCACATCGATACTCATCGCAGCATCCGGTATCTTCGTGATATTCCTGGCAGGTATTAGTTGGAAGATCAT
TGCCAGTGCCGCGATTGCACTGGGTGGGTTTATTCCAATCTTATGGTTCTTCTTGATGCGTGAATATCAAAAAGTTCGTG
TAAGAACCCTTTTTGACCCTGAATCAGATCCATTAGGTGCAGGCTATCACATCATCCAAAGTAAGATTGCAATTGGCTCT
GGTGGTATATCAGGAAAAGGTTGGCTGCAAGGTACCCAATCTCAACTAGAGTTCATTCCAGAACGCCATACCGACTTTAT
TTTTGCGGTCATCGCCGAAGAGTGGGGCATGATTGGTATTTTGTTTTTGCTCGCTATCTACCTGTTCATTATTGGCCGTG
GCTTAGTGCTTGCAAGCCAAGCTCAAACAGCATTTGGGCGAATGATGGGCGGCAGTATCGTACTGAGTTTCTTCGTCTAT
ATTTTCGTAAACATTGGTATGGTAAGCGGCATTCTACCTGTGGTGGGTGTCCCTCTACCTCTGGTCAGCTATGGCGGCAC
CTCTATGGTTACCCTTATGGCTGGTTTCGGTATTTTAATGTCAATCCATACACACAGAAAAGCATTCTCAAAGGCGACCT
AA

Upstream 100 bases:

>100_bases
AGAATGCCGGTGGTGGTTCATCAAATGGTGGCCCAGTTGTAAGAAGAATTTTAGACCATATTATTCTTGCAGAAGATTAT
GAAAGTGAGCCAATAAAATA

Downstream 100 bases:

>100_bases
TTGATGTCTGTTAAAGTAACTCCTATAAAAACATCTTTGGTTAATGAGCTGCCAATAAAAAAACTAGTGTCTATAGTGAG
CCTAGCCGTTGTTATAAACG

Product: Rod shape-determining protein rodA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 373; Mature: 373

Protein sequence:

>373_residues
MKLDPSTGRNRALFERLHIDLPLLLGILVLMGFALLIMYSASGQSLAMMDRQAMRMVLSLGVMIFLAQISPRTYETLAPL
LFAGGVILLLGVLFFGEASKGAQRWLNFGFIRFQPSELLKLAVPLMLARFIGKRSLPPTFQTLAISLVMVFVPTILIAKQ
PDLGTSILIAASGIFVIFLAGISWKIIASAAIALGGFIPILWFFLMREYQKVRVRTLFDPESDPLGAGYHIIQSKIAIGS
GGISGKGWLQGTQSQLEFIPERHTDFIFAVIAEEWGMIGILFLLAIYLFIIGRGLVLASQAQTAFGRMMGGSIVLSFFVY
IFVNIGMVSGILPVVGVPLPLVSYGGTSMVTLMAGFGILMSIHTHRKAFSKAT

Sequences:

>Translated_373_residues
MKLDPSTGRNRALFERLHIDLPLLLGILVLMGFALLIMYSASGQSLAMMDRQAMRMVLSLGVMIFLAQISPRTYETLAPL
LFAGGVILLLGVLFFGEASKGAQRWLNFGFIRFQPSELLKLAVPLMLARFIGKRSLPPTFQTLAISLVMVFVPTILIAKQ
PDLGTSILIAASGIFVIFLAGISWKIIASAAIALGGFIPILWFFLMREYQKVRVRTLFDPESDPLGAGYHIIQSKIAIGS
GGISGKGWLQGTQSQLEFIPERHTDFIFAVIAEEWGMIGILFLLAIYLFIIGRGLVLASQAQTAFGRMMGGSIVLSFFVY
IFVNIGMVSGILPVVGVPLPLVSYGGTSMVTLMAGFGILMSIHTHRKAFSKAT
>Mature_373_residues
MKLDPSTGRNRALFERLHIDLPLLLGILVLMGFALLIMYSASGQSLAMMDRQAMRMVLSLGVMIFLAQISPRTYETLAPL
LFAGGVILLLGVLFFGEASKGAQRWLNFGFIRFQPSELLKLAVPLMLARFIGKRSLPPTFQTLAISLVMVFVPTILIAKQ
PDLGTSILIAASGIFVIFLAGISWKIIASAAIALGGFIPILWFFLMREYQKVRVRTLFDPESDPLGAGYHIIQSKIAIGS
GGISGKGWLQGTQSQLEFIPERHTDFIFAVIAEEWGMIGILFLLAIYLFIIGRGLVLASQAQTAFGRMMGGSIVLSFFVY
IFVNIGMVSGILPVVGVPLPLVSYGGTSMVTLMAGFGILMSIHTHRKAFSKAT

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=365, Percent_Identity=60.8219178082192, Blast_Score=437, Evalue=1e-124,
Organism=Escherichia coli, GI1786277, Length=324, Percent_Identity=30.2469135802469, Blast_Score=159, Evalue=2e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 40641; Mature: 40641

Theoretical pI: Translated: 10.62; Mature: 10.62

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDPSTGRNRALFERLHIDLPLLLGILVLMGFALLIMYSASGQSLAMMDRQAMRMVLSL
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GVMIFLAQISPRTYETLAPLLFAGGVILLLGVLFFGEASKGAQRWLNFGFIRFQPSELLK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEECHHHHHH
LAVPLMLARFIGKRSLPPTFQTLAISLVMVFVPTILIAKQPDLGTSILIAASGIFVIFLA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GISWKIIASAAIALGGFIPILWFFLMREYQKVRVRTLFDPESDPLGAGYHIIQSKIAIGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHCCC
GGISGKGWLQGTQSQLEFIPERHTDFIFAVIAEEWGMIGILFLLAIYLFIIGRGLVLASQ
CCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHEEHH
AQTAFGRMMGGSIVLSFFVYIFVNIGMVSGILPVVGVPLPLVSYGGTSMVTLMAGFGILM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHH
SIHTHRKAFSKAT
HHHHHHHHHHCCC
>Mature Secondary Structure
MKLDPSTGRNRALFERLHIDLPLLLGILVLMGFALLIMYSASGQSLAMMDRQAMRMVLSL
CCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
GVMIFLAQISPRTYETLAPLLFAGGVILLLGVLFFGEASKGAQRWLNFGFIRFQPSELLK
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCEEEECHHHHHH
LAVPLMLARFIGKRSLPPTFQTLAISLVMVFVPTILIAKQPDLGTSILIAASGIFVIFLA
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHH
GISWKIIASAAIALGGFIPILWFFLMREYQKVRVRTLFDPESDPLGAGYHIIQSKIAIGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHCCC
GGISGKGWLQGTQSQLEFIPERHTDFIFAVIAEEWGMIGILFLLAIYLFIIGRGLVLASQ
CCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHEEHH
AQTAFGRMMGGSIVLSFFVYIFVNIGMVSGILPVVGVPLPLVSYGGTSMVTLMAGFGILM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHH
SIHTHRKAFSKAT
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]