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The map label for this gene is xseA [H]

Identifier: 218708649

GI number: 218708649

Start: 649394

End: 650872

Strand: Reverse

Name: xseA [H]

Synonym: VS_0627

Alternate gene names: 218708649

Gene position: 650872-649394 (Counterclockwise)

Preceding gene: 218708655

Following gene: 218708639

Centisome position: 19.73

GC content: 45.98

Gene sequence:

>1479_bases
TTGGCTACACATTTTTATACTTTTAATTTGCATTTACCCCCTTGCTATGTATTATATTGCCGCTATCTTCCATACTCACG
CCCAGTGAGATTCCAAGAGAAAGACCTTCCTTCAAGGATAGATAGCGCTTCTATGACCAATCCAAACATCTTTACTGTTT
CTCGCCTCAATTCAGAGGTTCGTCTCCTATTAGAAAACGAAATGGGAATAGTCTGGCTCGTTGGTGAAATCTCAAATTTC
TCTGCACCTGTCTCTGGTCACTGGTACCTCACGCTTAAAGACTCTCGCGCTCAAGTTAAGTGCGCTATGTTTCGTGGCAA
TAACCGTCGTGTGACTTTTAAGCCTCAGAACGGTAATCAAGTGCTAGTTAAAGCGCGCCTATCTCTTTATGAGCCACGCG
GTGATTATCAACTGATCATCGAAAGCATGCAGCCAGAAGGTGACGGCAAGCTTCAGCAAGAGTTTGAAAAACTTAAGATG
AACTTGGCGGCGGAAGGTTTATTTGCTCAGTCCAGTAAACAAATTCTTCCAGAACATCCTAAATGTGTTGGTGTTATCAC
CTCTAAAACAGGCGCTGCCCTCTTCGATATTCTCGATGTACTGAAAAGGCGCGACCCGTCATTGCCAGTCATCGTATATC
CGACTATGGTACAAGGTGAAGGAGCTTCGATTCAGATCGCTCAAGCGATTGGGCGTGCCAATGAACGCAATGAGTGTGAT
GTATTGATCGTTGGCCGAGGCGGCGGCTCATTAGAGGACTTATGGTGTTTCAATAACGAGATCGTTGCTCGCACCATTGC
AGCAAGTCAGATCCCGATTATCAGCGCCGTTGGACACGAAGTTGATGTCACTATCGCCGATTTCGTCGCAGATATGCGAG
CTCCAACGCCATCAGCAGCCGCTGAATTGGTTAGCCGTGACAACAGTCATAAAGAGCAAGCTTATGCGTCTAAACGTTCT
CGTTTAGTGAGTGCGATTCGTCATGTACTAATAAAACAAGCGCAATCAACTCAAACGTTGAAATACCGCTTAGAGAAACA
ACACCCGAGCTACCAACTGCAAAAGCAGAGTCAGCAGCTTGATGACTTAGACATGCGTTTGCGTCGTGGTATGACTCAAT
ACCTAAAGCAACATGCTCAGCGTGTTGAACGTAAGCAGCACCAACTTCAGCTGAACTCGCCAGTGAAACGCCTTGGTGAA
CAGAAACTGCATCTACAACGTTCAGAGCAAAAGCTATTGGATGCAATGGACAAGACATTACTGACTACTCGCCACCAACT
AGCCATGGCTGCCGAGAAGTTAGAAACAGTAAGTCCATTAGCAACCCTAAAACGTGGCTACAGCATCACCCATTCAGCAT
CGAGTAAAACTGTGTCATCGATTAACGATGTCGAAATCGGTGAAGTGATCACCACCCAAGTTGAAGACGGTGTGATTGAA
TCGCAAGTGACAACAAGAGTCGCTAAGAGCGAGCTCTAG

Upstream 100 bases:

>100_bases
CCAATCTCATCGTTTCGCCTAATGAGGGCAGCCAATTAAGGAAAATCAAACTGCATTTGGATTAGATATTGCGGACGGAT
TATACGGCCAACGAAATCGC

Downstream 100 bases:

>100_bases
GTTCATTAGATACAAAAAAGACCCAACTCTTCGGTATTGAGTCTCTGATATAACATTACAGATAGTCGTTTAAGCGATTC
GGCTTAAGTCTATTCAGCAG

Product: exodeoxyribonuclease VII large subunit

Products: NA

Alternate protein names: Exodeoxyribonuclease VII large subunit; Exonuclease VII large subunit [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MATHFYTFNLHLPPCYVLYCRYLPYSRPVRFQEKDLPSRIDSASMTNPNIFTVSRLNSEVRLLLENEMGIVWLVGEISNF
SAPVSGHWYLTLKDSRAQVKCAMFRGNNRRVTFKPQNGNQVLVKARLSLYEPRGDYQLIIESMQPEGDGKLQQEFEKLKM
NLAAEGLFAQSSKQILPEHPKCVGVITSKTGAALFDILDVLKRRDPSLPVIVYPTMVQGEGASIQIAQAIGRANERNECD
VLIVGRGGGSLEDLWCFNNEIVARTIAASQIPIISAVGHEVDVTIADFVADMRAPTPSAAAELVSRDNSHKEQAYASKRS
RLVSAIRHVLIKQAQSTQTLKYRLEKQHPSYQLQKQSQQLDDLDMRLRRGMTQYLKQHAQRVERKQHQLQLNSPVKRLGE
QKLHLQRSEQKLLDAMDKTLLTTRHQLAMAAEKLETVSPLATLKRGYSITHSASSKTVSSINDVEIGEVITTQVEDGVIE
SQVTTRVAKSEL

Sequences:

>Translated_492_residues
MATHFYTFNLHLPPCYVLYCRYLPYSRPVRFQEKDLPSRIDSASMTNPNIFTVSRLNSEVRLLLENEMGIVWLVGEISNF
SAPVSGHWYLTLKDSRAQVKCAMFRGNNRRVTFKPQNGNQVLVKARLSLYEPRGDYQLIIESMQPEGDGKLQQEFEKLKM
NLAAEGLFAQSSKQILPEHPKCVGVITSKTGAALFDILDVLKRRDPSLPVIVYPTMVQGEGASIQIAQAIGRANERNECD
VLIVGRGGGSLEDLWCFNNEIVARTIAASQIPIISAVGHEVDVTIADFVADMRAPTPSAAAELVSRDNSHKEQAYASKRS
RLVSAIRHVLIKQAQSTQTLKYRLEKQHPSYQLQKQSQQLDDLDMRLRRGMTQYLKQHAQRVERKQHQLQLNSPVKRLGE
QKLHLQRSEQKLLDAMDKTLLTTRHQLAMAAEKLETVSPLATLKRGYSITHSASSKTVSSINDVEIGEVITTQVEDGVIE
SQVTTRVAKSEL
>Mature_491_residues
ATHFYTFNLHLPPCYVLYCRYLPYSRPVRFQEKDLPSRIDSASMTNPNIFTVSRLNSEVRLLLENEMGIVWLVGEISNFS
APVSGHWYLTLKDSRAQVKCAMFRGNNRRVTFKPQNGNQVLVKARLSLYEPRGDYQLIIESMQPEGDGKLQQEFEKLKMN
LAAEGLFAQSSKQILPEHPKCVGVITSKTGAALFDILDVLKRRDPSLPVIVYPTMVQGEGASIQIAQAIGRANERNECDV
LIVGRGGGSLEDLWCFNNEIVARTIAASQIPIISAVGHEVDVTIADFVADMRAPTPSAAAELVSRDNSHKEQAYASKRSR
LVSAIRHVLIKQAQSTQTLKYRLEKQHPSYQLQKQSQQLDDLDMRLRRGMTQYLKQHAQRVERKQHQLQLNSPVKRLGEQ
KLHLQRSEQKLLDAMDKTLLTTRHQLAMAAEKLETVSPLATLKRGYSITHSASSKTVSSINDVEIGEVITTQVEDGVIES
QVTTRVAKSEL

Specific function: Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides [H]

COG id: COG1570

COG function: function code L; Exonuclease VII, large subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xseA family [H]

Homologues:

Organism=Escherichia coli, GI1788856, Length=437, Percent_Identity=55.8352402745995, Blast_Score=487, Evalue=1e-139,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003753
- InterPro:   IPR020579
- InterPro:   IPR004365
- InterPro:   IPR008207 [H]

Pfam domain/function: PF02601 Exonuc_VII_L; PF01336 tRNA_anti [H]

EC number: =3.1.11.6 [H]

Molecular weight: Translated: 55347; Mature: 55216

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHFYTFNLHLPPCYVLYCRYLPYSRPVRFQEKDLPSRIDSASMTNPNIFTVSRLNSEV
CCEEEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEEECCCEE
RLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSRAQVKCAMFRGNNRRVTFKPQNGNQ
EEEEECCCCEEEEEEECCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCEEEEECCCCCE
VLVKARLSLYEPRGDYQLIIESMQPEGDGKLQQEFEKLKMNLAAEGLFAQSSKQILPEHP
EEEEEEEHHCCCCCCCEEHEECCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCC
KCVGVITSKTGAALFDILDVLKRRDPSLPVIVYPTMVQGEGASIQIAQAIGRANERNECD
CEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEHHHHHCCCCCCCCCC
VLIVGRGGGSLEDLWCFNNEIVARTIAASQIPIISAVGHEVDVTIADFVADMRAPTPSAA
EEEEECCCCCCCCEEECCCHHHHHHHHHCCCCEEEECCCEEEEEHHHHHHHHCCCCHHHH
AELVSRDNSHKEQAYASKRSRLVSAIRHVLIKQAQSTQTLKYRLEKQHPSYQLQKQSQQL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHH
DDLDMRLRRGMTQYLKQHAQRVERKQHQLQLNSPVKRLGEQKLHLQRSEQKLLDAMDKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHH
LTTRHQLAMAAEKLETVSPLATLKRGYSITHSASSKTVSSINDVEIGEVITTQVEDGVIE
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHCCCCCCHHHHHHHHHHCCHHH
SQVTTRVAKSEL
HHHHHHHHHCCC
>Mature Secondary Structure 
ATHFYTFNLHLPPCYVLYCRYLPYSRPVRFQEKDLPSRIDSASMTNPNIFTVSRLNSEV
CEEEEEEEEECCHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEEECCCEE
RLLLENEMGIVWLVGEISNFSAPVSGHWYLTLKDSRAQVKCAMFRGNNRRVTFKPQNGNQ
EEEEECCCCEEEEEEECCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCEEEEECCCCCE
VLVKARLSLYEPRGDYQLIIESMQPEGDGKLQQEFEKLKMNLAAEGLFAQSSKQILPEHP
EEEEEEEHHCCCCCCCEEHEECCCCCCCCHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCC
KCVGVITSKTGAALFDILDVLKRRDPSLPVIVYPTMVQGEGASIQIAQAIGRANERNECD
CEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCEEHHHHHCCCCCCCCCC
VLIVGRGGGSLEDLWCFNNEIVARTIAASQIPIISAVGHEVDVTIADFVADMRAPTPSAA
EEEEECCCCCCCCEEECCCHHHHHHHHHCCCCEEEECCCEEEEEHHHHHHHHCCCCHHHH
AELVSRDNSHKEQAYASKRSRLVSAIRHVLIKQAQSTQTLKYRLEKQHPSYQLQKQSQQL
HHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCHHHHHHHHHH
DDLDMRLRRGMTQYLKQHAQRVERKQHQLQLNSPVKRLGEQKLHLQRSEQKLLDAMDKTL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHHHHHHHHHHHHH
LTTRHQLAMAAEKLETVSPLATLKRGYSITHSASSKTVSSINDVEIGEVITTQVEDGVIE
HHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHCCCCCCHHHHHHHHHHCCHHH
SQVTTRVAKSEL
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA