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The map label for this gene is ahpC [C]

Identifier: 218708615

GI number: 218708615

Start: 617322

End: 617930

Strand: Reverse

Name: ahpC [C]

Synonym: VS_0593

Alternate gene names: 218708615

Gene position: 617930-617322 (Counterclockwise)

Preceding gene: 218708617

Following gene: 218708614

Centisome position: 18.73

GC content: 45.98

Gene sequence:

>609_bases
ATGGTACTAGTAGGTCGTCAAGCCCCTGACTTTACTGCAGCAGCTGTTCTAGGTAACGGTGAGATCGTTGATAACTTCAA
CTTCGCAGAATTCACTAAAGGTAAGAAAGCTGTAGTTTTCTTCTACCCACTAGACTTCACTTTCGTTTGTCCTTCAGAGC
TAATCGCTTTCGACAACCGTCTAGAAGATTTCCAAGCTAAAGGCGTTGAAGTAATCGGTGTTTCTATCGATTCTCAATTC
TCTCACAACGCATGGCGTAACACAGCTATCGCTGATGGCGGTATCGGTCAAGTTAAATACCCTCTAATTGCTGACGTTAA
GCACGAAATCTGCAAAGCATACGATGTTGAGCACCCAGAAGCAGGCGTTGCTTTCCGTGGTTCTTTCCTAATCGACGCAG
ACGGCCTTGTACGTCACCAAGTAGTTAACGATCTTCCACTAGGTCGTAACATCGACGAAATGCTACGCATGGTAGACGCA
CTAAACTTCCACGAGAAGAACGGTGAAGTATGTCCTGCACAATGGGAAGAAGGTAAATCAGGTATGGACGCATCTCCACA
AGGTGTTGCTGCATTCCTATCTGAGCACGCTGACGACCTAAGCAAGTAA

Upstream 100 bases:

>100_bases
TCGCTTTTTTCTATAGTACCGATTGTACTATAGTTTGTCCCGTAGAAACGGAGCCCAAACAAAGATGTGTTGGGCCAACT
AATTTTTTAGGAGATTCCAA

Downstream 100 bases:

>100_bases
TTACCTCTTAAGCCCGAACTCAACGCGGGTTAATGGTTGGAAGACTCTCTATAAAGAGAAATAAAGCATAAGCTAATAGC
GCAAAGCGCACCGCCAATCA

Product: antioxidant, ahpC/Tsa family

Products: NA

Alternate protein names: Thioredoxin reductase [H]

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MVLVGRQAPDFTAAAVLGNGEIVDNFNFAEFTKGKKAVVFFYPLDFTFVCPSELIAFDNRLEDFQAKGVEVIGVSIDSQF
SHNAWRNTAIADGGIGQVKYPLIADVKHEICKAYDVEHPEAGVAFRGSFLIDADGLVRHQVVNDLPLGRNIDEMLRMVDA
LNFHEKNGEVCPAQWEEGKSGMDASPQGVAAFLSEHADDLSK

Sequences:

>Translated_202_residues
MVLVGRQAPDFTAAAVLGNGEIVDNFNFAEFTKGKKAVVFFYPLDFTFVCPSELIAFDNRLEDFQAKGVEVIGVSIDSQF
SHNAWRNTAIADGGIGQVKYPLIADVKHEICKAYDVEHPEAGVAFRGSFLIDADGLVRHQVVNDLPLGRNIDEMLRMVDA
LNFHEKNGEVCPAQWEEGKSGMDASPQGVAAFLSEHADDLSK
>Mature_202_residues
MVLVGRQAPDFTAAAVLGNGEIVDNFNFAEFTKGKKAVVFFYPLDFTFVCPSELIAFDNRLEDFQAKGVEVIGVSIDSQF
SHNAWRNTAIADGGIGQVKYPLIADVKHEICKAYDVEHPEAGVAFRGSFLIDADGLVRHQVVNDLPLGRNIDEMLRMVDA
LNFHEKNGEVCPAQWEEGKSGMDASPQGVAAFLSEHADDLSK

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=46.6321243523316, Blast_Score=191, Evalue=3e-49,
Organism=Homo sapiens, GI4505591, Length=193, Percent_Identity=45.5958549222798, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI32455266, Length=193, Percent_Identity=45.5958549222798, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI32455264, Length=193, Percent_Identity=45.5958549222798, Blast_Score=186, Evalue=1e-47,
Organism=Homo sapiens, GI5453549, Length=192, Percent_Identity=43.2291666666667, Blast_Score=177, Evalue=5e-45,
Organism=Homo sapiens, GI5802974, Length=183, Percent_Identity=45.3551912568306, Blast_Score=171, Evalue=4e-43,
Organism=Homo sapiens, GI32483377, Length=180, Percent_Identity=46.1111111111111, Blast_Score=171, Evalue=5e-43,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=56.0975609756098, Blast_Score=98, Evalue=6e-21,
Organism=Homo sapiens, GI4758638, Length=190, Percent_Identity=28.4210526315789, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786822, Length=186, Percent_Identity=33.8709677419355, Blast_Score=115, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI193204376, Length=194, Percent_Identity=44.8453608247423, Blast_Score=177, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI32565831, Length=194, Percent_Identity=44.8453608247423, Blast_Score=177, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17554494, Length=170, Percent_Identity=48.2352941176471, Blast_Score=175, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25153706, Length=185, Percent_Identity=26.4864864864865, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=182, Percent_Identity=42.3076923076923, Blast_Score=160, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320661, Length=179, Percent_Identity=40.7821229050279, Blast_Score=152, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6319407, Length=181, Percent_Identity=28.7292817679558, Blast_Score=86, Evalue=5e-18,
Organism=Drosophila melanogaster, GI17738015, Length=201, Percent_Identity=43.2835820895522, Blast_Score=182, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24656348, Length=194, Percent_Identity=43.8144329896907, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17864676, Length=194, Percent_Identity=43.8144329896907, Blast_Score=181, Evalue=3e-46,
Organism=Drosophila melanogaster, GI17157991, Length=186, Percent_Identity=45.6989247311828, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24641739, Length=186, Percent_Identity=45.6989247311828, Blast_Score=171, Evalue=3e-43,
Organism=Drosophila melanogaster, GI21357347, Length=197, Percent_Identity=40.1015228426396, Blast_Score=159, Evalue=9e-40,
Organism=Drosophila melanogaster, GI24581278, Length=185, Percent_Identity=30.2702702702703, Blast_Score=97, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17975518, Length=188, Percent_Identity=28.7234042553192, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652436, Length=188, Percent_Identity=28.7234042553192, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24652434, Length=188, Percent_Identity=28.7234042553192, Blast_Score=79, Evalue=2e-15,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22119; Mature: 22119

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLVGRQAPDFTAAAVLGNGEIVDNFNFAEFTKGKKAVVFFYPLDFTFVCPSELIAFDNR
CEEECCCCCCCEEEEEECCCEEEECCCHHHHCCCCEEEEEEEECCEEEECHHHHHHHHHH
LEDFQAKGVEVIGVSIDSQFSHNAWRNTAIADGGIGQVKYPLIADVKHEICKAYDVEHPE
HHHHHHCCEEEEEEEECCCCCCCCCCCCEECCCCCCCEECHHHHHHHHHHHHHHCCCCCC
AGVAFRGSFLIDADGLVRHQVVNDLPLGRNIDEMLRMVDALNFHEKNGEVCPAQWEEGKS
CCEEECCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GMDASPQGVAAFLSEHADDLSK
CCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLVGRQAPDFTAAAVLGNGEIVDNFNFAEFTKGKKAVVFFYPLDFTFVCPSELIAFDNR
CEEECCCCCCCEEEEEECCCEEEECCCHHHHCCCCEEEEEEEECCEEEECHHHHHHHHHH
LEDFQAKGVEVIGVSIDSQFSHNAWRNTAIADGGIGQVKYPLIADVKHEICKAYDVEHPE
HHHHHHCCEEEEEEEECCCCCCCCCCCCEECCCCCCCEECHHHHHHHHHHHHHHCCCCCC
AGVAFRGSFLIDADGLVRHQVVNDLPLGRNIDEMLRMVDALNFHEKNGEVCPAQWEEGKS
CCEEECCEEEECCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
GMDASPQGVAAFLSEHADDLSK
CCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]