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The map label for this gene is ppx [H]

Identifier: 218708605

GI number: 218708605

Start: 604196

End: 605707

Strand: Reverse

Name: ppx [H]

Synonym: VS_0582

Alternate gene names: 218708605

Gene position: 605707-604196 (Counterclockwise)

Preceding gene: 218708606

Following gene: 218708601

Centisome position: 18.36

GC content: 43.85

Gene sequence:

>1512_bases
ATGCCGCTAATTGATAACAAACATTCTCGATGTATTGCCGCTATCGACTTGGGTTCGAACAGTTTTCATATGGTGGTTGC
CCGAGTATTCGAACAACACCTGCAATTAGTCAGCAGACACAAACAGAAAGTGAGATTAGGTGATGGGTTGGATGAGTTTA
ACTTCTTATCCGAAAGTGCTATCGAGCGAGGCTTGGAGTGCCTCAAAGTGTTCGCAGAACGACTAGCGGATTTTGAACTT
GATGATGTAAGAGTTGTTGCGACTCATACCCTAAGAAAAGCCAAAAACGCTCAAGACTTCTTAGAGCAAGCCAAACCACT
GTTTCCTTTTCCAATAGAGATCATTTCAGGTCAAGAAGAAGCTCGAATAATCTATAACGGTGTAGAACACACTCAAACCG
CTTCTGAATCTAAATTGGTTATTGATATCGGTGGAGGGAGTACGGAACTCGTCGCAGGGAAAGGCTTTACGCCCCTAATT
ATGCGCAGTTTACCTATGGGATGCGTCAGCTTCACTCAACACTTCTTTGCTGACGGAGAGCTAACCTCACAACACTTCTC
AGATGCTTATACCGCGGCTACTCGTCTATTGATGCCATTGATTGAAGAATATACAAAGGCGCCTTGGGAAATCGCCTTTG
GCTCATCAGGAACGACTAAGTCAATAAAAGAGGTACTCATTGGTTTAGGCTTTACCGATGGTCTCATTACGCCGCAACGT
CTGTCCTATTTGAAAAATCACTTATGTGAGTTTTCATCATCCAAAACCTTAGACCTTTCAGGTTTAAGTGATGAGAGAAA
GCCGGTGTTTGCTGCTGGCGTCATCATTCTTTCAGCAGCCATGGATACGCTAGACATAAAGGAGTTACATTTTTCTGATG
GCGCCCTGAGAGAAGGCGTTCTTTATGACATGGAGGATAGGTTTAAAGATATTGATGTTCGAACAAGAACTGCCGAAACG
CTCGTCTCTCGATACCATGTTGACGTAGCTCATGGCCAGAGAGTCAAAGAACTCGCCCTTGCATTACTGAAACAAGTGCA
GCCTCAAGTAACGACTATGGTCACTAATGAGCTGTATGATCTAGTTGGTTGGGCTGCACTACTTCATGAGGTAGGGCAAA
GCATCGCATTCCAAGGCTATCACCGCCATTCGGCTTATCTGCTTAAGCACACGACAATGCCCGGTTTCAATACTGAGCAA
CAACGTCTTATCTCGACATTGGTTCGCCACCAAAGAAAAGCGATTAAGCGACAAGACTTGCCGGAACTGTCTCTATTTTC
TCCACAACAAATAACGCTACTAATTCGCATATTAAGACTCGCTATTTTACTCAATCGTCAGAGAAATCAAGCACTAGTCC
CAGACACGACTCTAACGATTGAACAACAGGATAACTGGGGATTGAAAGGATCTAACAGCTATTGGTTGGCCCAAAACCAA
CTGCTTGAATATGAACTCAAAGAAGAACAACAACGTTGGCAAAATGCTGGATGGTCGTTAAAGGTAGAATAA

Upstream 100 bases:

>100_bases
CAAACCCACTCGATTACCCGACGTCACAACTCTCCACTTACCACTATATTAAACGTATGGAGAAACTTGCTCGCAAGAAG
TACAAACAAGAGAAGAAATC

Downstream 100 bases:

>100_bases
CGACCAGTCAAAATAAAAACAGCCTGCGACTTAGCAAGCTGTTCATACGTTCGTTTTCTAAGTTTGTATTAGCCTCAATC
AGAGCCCGACTTTTGCCAAC

Product: exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 503; Mature: 502

Protein sequence:

>503_residues
MPLIDNKHSRCIAAIDLGSNSFHMVVARVFEQHLQLVSRHKQKVRLGDGLDEFNFLSESAIERGLECLKVFAERLADFEL
DDVRVVATHTLRKAKNAQDFLEQAKPLFPFPIEIISGQEEARIIYNGVEHTQTASESKLVIDIGGGSTELVAGKGFTPLI
MRSLPMGCVSFTQHFFADGELTSQHFSDAYTAATRLLMPLIEEYTKAPWEIAFGSSGTTKSIKEVLIGLGFTDGLITPQR
LSYLKNHLCEFSSSKTLDLSGLSDERKPVFAAGVIILSAAMDTLDIKELHFSDGALREGVLYDMEDRFKDIDVRTRTAET
LVSRYHVDVAHGQRVKELALALLKQVQPQVTTMVTNELYDLVGWAALLHEVGQSIAFQGYHRHSAYLLKHTTMPGFNTEQ
QRLISTLVRHQRKAIKRQDLPELSLFSPQQITLLIRILRLAILLNRQRNQALVPDTTLTIEQQDNWGLKGSNSYWLAQNQ
LLEYELKEEQQRWQNAGWSLKVE

Sequences:

>Translated_503_residues
MPLIDNKHSRCIAAIDLGSNSFHMVVARVFEQHLQLVSRHKQKVRLGDGLDEFNFLSESAIERGLECLKVFAERLADFEL
DDVRVVATHTLRKAKNAQDFLEQAKPLFPFPIEIISGQEEARIIYNGVEHTQTASESKLVIDIGGGSTELVAGKGFTPLI
MRSLPMGCVSFTQHFFADGELTSQHFSDAYTAATRLLMPLIEEYTKAPWEIAFGSSGTTKSIKEVLIGLGFTDGLITPQR
LSYLKNHLCEFSSSKTLDLSGLSDERKPVFAAGVIILSAAMDTLDIKELHFSDGALREGVLYDMEDRFKDIDVRTRTAET
LVSRYHVDVAHGQRVKELALALLKQVQPQVTTMVTNELYDLVGWAALLHEVGQSIAFQGYHRHSAYLLKHTTMPGFNTEQ
QRLISTLVRHQRKAIKRQDLPELSLFSPQQITLLIRILRLAILLNRQRNQALVPDTTLTIEQQDNWGLKGSNSYWLAQNQ
LLEYELKEEQQRWQNAGWSLKVE
>Mature_502_residues
PLIDNKHSRCIAAIDLGSNSFHMVVARVFEQHLQLVSRHKQKVRLGDGLDEFNFLSESAIERGLECLKVFAERLADFELD
DVRVVATHTLRKAKNAQDFLEQAKPLFPFPIEIISGQEEARIIYNGVEHTQTASESKLVIDIGGGSTELVAGKGFTPLIM
RSLPMGCVSFTQHFFADGELTSQHFSDAYTAATRLLMPLIEEYTKAPWEIAFGSSGTTKSIKEVLIGLGFTDGLITPQRL
SYLKNHLCEFSSSKTLDLSGLSDERKPVFAAGVIILSAAMDTLDIKELHFSDGALREGVLYDMEDRFKDIDVRTRTAETL
VSRYHVDVAHGQRVKELALALLKQVQPQVTTMVTNELYDLVGWAALLHEVGQSIAFQGYHRHSAYLLKHTTMPGFNTEQQ
RLISTLVRHQRKAIKRQDLPELSLFSPQQITLLIRILRLAILLNRQRNQALVPDTTLTIEQQDNWGLKGSNSYWLAQNQL
LEYELKEEQQRWQNAGWSLKVE

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=505, Percent_Identity=48.5148514851485, Blast_Score=471, Evalue=1e-134,
Organism=Escherichia coli, GI48994966, Length=497, Percent_Identity=38.8329979879276, Blast_Score=331, Evalue=6e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 56802; Mature: 56671

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLIDNKHSRCIAAIDLGSNSFHMVVARVFEQHLQLVSRHKQKVRLGDGLDEFNFLSESA
CCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IERGLECLKVFAERLADFELDDVRVVATHTLRKAKNAQDFLEQAKPLFPFPIEIISGQEE
HHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCHHHHHHHCCCCCCCCHHEECCCCC
ARIIYNGVEHTQTASESKLVIDIGGGSTELVAGKGFTPLIMRSLPMGCVSFTQHFFADGE
CEEEECCCHHCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCC
LTSQHFSDAYTAATRLLMPLIEEYTKAPWEIAFGSSGTTKSIKEVLIGLGFTDGLITPQR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHH
LSYLKNHLCEFSSSKTLDLSGLSDERKPVFAAGVIILSAAMDTLDIKELHFSDGALREGV
HHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
LYDMEDRFKDIDVRTRTAETLVSRYHVDVAHGQRVKELALALLKQVQPQVTTMVTNELYD
EECHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LVGWAALLHEVGQSIAFQGYHRHSAYLLKHTTMPGFNTEQQRLISTLVRHQRKAIKRQDL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
PELSLFSPQQITLLIRILRLAILLNRQRNQALVPDTTLTIEQQDNWGLKGSNSYWLAQNQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEHHH
LLEYELKEEQQRWQNAGWSLKVE
HHHHHHHHHHHHHHCCCCEEEEC
>Mature Secondary Structure 
PLIDNKHSRCIAAIDLGSNSFHMVVARVFEQHLQLVSRHKQKVRLGDGLDEFNFLSESA
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
IERGLECLKVFAERLADFELDDVRVVATHTLRKAKNAQDFLEQAKPLFPFPIEIISGQEE
HHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHCCHHHHHHHCCCCCCCCHHEECCCCC
ARIIYNGVEHTQTASESKLVIDIGGGSTELVAGKGFTPLIMRSLPMGCVSFTQHFFADGE
CEEEECCCHHCCCCCCCEEEEEECCCCEEEEECCCCHHHHHHHCCHHHHHHHHHHHCCCC
LTSQHFSDAYTAATRLLMPLIEEYTKAPWEIAFGSSGTTKSIKEVLIGLGFTDGLITPQR
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCHHH
LSYLKNHLCEFSSSKTLDLSGLSDERKPVFAAGVIILSAAMDTLDIKELHFSDGALREGV
HHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCC
LYDMEDRFKDIDVRTRTAETLVSRYHVDVAHGQRVKELALALLKQVQPQVTTMVTNELYD
EECHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHH
LVGWAALLHEVGQSIAFQGYHRHSAYLLKHTTMPGFNTEQQRLISTLVRHQRKAIKRQDL
HHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHCCC
PELSLFSPQQITLLIRILRLAILLNRQRNQALVPDTTLTIEQQDNWGLKGSNSYWLAQNQ
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEHHH
LLEYELKEEQQRWQNAGWSLKVE
HHHHHHHHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]