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The map label for this gene is degQ [H]

Identifier: 218708463

GI number: 218708463

Start: 437691

End: 439049

Strand: Reverse

Name: degQ [H]

Synonym: VS_0426

Alternate gene names: 218708463

Gene position: 439049-437691 (Counterclockwise)

Preceding gene: 218708464

Following gene: 218708462

Centisome position: 13.31

GC content: 46.06

Gene sequence:

>1359_bases
ATGATGAAAAAACCTTTGCTTGCTTTATCAGTACTGACTTTAAGCTTAAGTTCAATCATCACCCCCATTCAAGCTACAGC
CGCACTTCCATTAAGTGTGGGTAATGAACAATTACCAAGCCTTGCTCCTATGCTTGAACAAGTAACCCCCGCTGTGGTTA
GTATTGCCGTAGAAGGCAAACAGGTACAACGTCAGCAAATCCCTGAACAATTTCAATTCTTTTTTGGTCCAGAACAAACA
CGAGAACGCCCATTCCGCGGGCTAGGCTCTGGTGTCATCATTGATGCCAAGAAAGGCCATATTGTCACCAATTACCATGT
CATCAATGGTGCCGACGATATCAAAGTAAAACTGCATGATGGTCGAGAGTACGATGCAGAGCTCATCGGCGGCGACCAGA
TGTCTGATATCGCGCTATTAAAACTCGAAACAGCCAAAAACCTTACCCAGATAAAAGTCGCAGATTCCGACAAATTGAGA
GTCGGCGATTTCAGTGTGGCTATCGGCAACCCATTTGGGCTTGGTCAAACCGTAACATCCGGTATCGTTTCAGCGTTAGG
ACGTAGCGGTCTCAATCTAGAGAACTTCGAAAACTTCATTCAAACCGATGCCGCGATTAACAGTGGTAACTCTGGAGGTG
CGTTAGTGAATCTTAACGGTGAACTGATTGGTATCAACACGGCCATCCTAGGACCTAACGGAGGCAATGTCGGTATCGGC
TTTGCCATTCCATCCAATATGATGACAAACCTGACTGAACAGATTCTCGATTTCGGTGAAGTAAAACGTGGCATGCTTGG
TGTCCAAGGTGGAGAGGTCACCTCGGAATTGGCTGAAGCGCTTGGTTATGAGTCCAGCAAAGGTGCTTTTGTTAGCCAAA
TTGTACCCGACAGTGCTGCAGACAAAGCCGGATTGAAAGCGGGCGATGTCATTATCTCCATTAACGGTAAGCGTATTGAT
ACTTTTAGTGAGTTAAGAGCCAAAGTAGCCACCCTAGGTGCAGGTAAACAGATCGAGTTAGGCGTGGTTCGTGACGGTAA
GAATAAGACCTTTGACGTCACGCTGGGTGAATCCACAAATAGTAAGACACAAGCTGAAAAGCTCCATGAAGGACTTGCCG
GTGCAGAGCTCACCAACACAACCGACAGCGATTCAGCGACAGGCGTCAAGGTATCAAGTGTCGCTCAAGGTTCGCCAGCA
GAAGCTTATCAGCTTCTTAAAGATGACATCATCATCGGGGTAAACCGACAACCAGTTAAGAACCTTGCTGAATTTAGAAA
GATTCTTGAAAAACAACCTGGCGTATTGGCACTTAATATCCAGCGAGACGATAGGACTATCTATCTAGTTATTCGATAG

Upstream 100 bases:

>100_bases
TACAAAGGTTTTTGAGTCATAACTTTCACTCAGGTCATTTGAAACTTCTCATACTTATTAAACGTATAAGAGGGTTAAGA
CCTTAACTAGAGAGGAGTTT

Downstream 100 bases:

>100_bases
CCATACGTCAGCGTAATTACAGGGGGGCTCAGTAAGTTTGCTTTAAACTTACTCAGTCTCCCTTTTCTTTAGATCAATCA
AAATGCTATGCTTCACTGAT

Product: protease DegQ precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MMKKPLLALSVLTLSLSSIITPIQATAALPLSVGNEQLPSLAPMLEQVTPAVVSIAVEGKQVQRQQIPEQFQFFFGPEQT
RERPFRGLGSGVIIDAKKGHIVTNYHVINGADDIKVKLHDGREYDAELIGGDQMSDIALLKLETAKNLTQIKVADSDKLR
VGDFSVAIGNPFGLGQTVTSGIVSALGRSGLNLENFENFIQTDAAINSGNSGGALVNLNGELIGINTAILGPNGGNVGIG
FAIPSNMMTNLTEQILDFGEVKRGMLGVQGGEVTSELAEALGYESSKGAFVSQIVPDSAADKAGLKAGDVIISINGKRID
TFSELRAKVATLGAGKQIELGVVRDGKNKTFDVTLGESTNSKTQAEKLHEGLAGAELTNTTDSDSATGVKVSSVAQGSPA
EAYQLLKDDIIIGVNRQPVKNLAEFRKILEKQPGVLALNIQRDDRTIYLVIR

Sequences:

>Translated_452_residues
MMKKPLLALSVLTLSLSSIITPIQATAALPLSVGNEQLPSLAPMLEQVTPAVVSIAVEGKQVQRQQIPEQFQFFFGPEQT
RERPFRGLGSGVIIDAKKGHIVTNYHVINGADDIKVKLHDGREYDAELIGGDQMSDIALLKLETAKNLTQIKVADSDKLR
VGDFSVAIGNPFGLGQTVTSGIVSALGRSGLNLENFENFIQTDAAINSGNSGGALVNLNGELIGINTAILGPNGGNVGIG
FAIPSNMMTNLTEQILDFGEVKRGMLGVQGGEVTSELAEALGYESSKGAFVSQIVPDSAADKAGLKAGDVIISINGKRID
TFSELRAKVATLGAGKQIELGVVRDGKNKTFDVTLGESTNSKTQAEKLHEGLAGAELTNTTDSDSATGVKVSSVAQGSPA
EAYQLLKDDIIIGVNRQPVKNLAEFRKILEKQPGVLALNIQRDDRTIYLVIR
>Mature_452_residues
MMKKPLLALSVLTLSLSSIITPIQATAALPLSVGNEQLPSLAPMLEQVTPAVVSIAVEGKQVQRQQIPEQFQFFFGPEQT
RERPFRGLGSGVIIDAKKGHIVTNYHVINGADDIKVKLHDGREYDAELIGGDQMSDIALLKLETAKNLTQIKVADSDKLR
VGDFSVAIGNPFGLGQTVTSGIVSALGRSGLNLENFENFIQTDAAINSGNSGGALVNLNGELIGINTAILGPNGGNVGIG
FAIPSNMMTNLTEQILDFGEVKRGMLGVQGGEVTSELAEALGYESSKGAFVSQIVPDSAADKAGLKAGDVIISINGKRID
TFSELRAKVATLGAGKQIELGVVRDGKNKTFDVTLGESTNSKTQAEKLHEGLAGAELTNTTDSDSATGVKVSSVAQGSPA
EAYQLLKDDIIIGVNRQPVKNLAEFRKILEKQPGVLALNIQRDDRTIYLVIR

Specific function: Protease with a shared specificity with degP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=353, Percent_Identity=36.5439093484419, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI4506141, Length=293, Percent_Identity=39.9317406143345, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI24308541, Length=299, Percent_Identity=33.1103678929766, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI7019477, Length=334, Percent_Identity=34.7305389221557, Blast_Score=138, Evalue=1e-32,
Organism=Escherichia coli, GI1789629, Length=456, Percent_Identity=56.578947368421, Blast_Score=496, Evalue=1e-142,
Organism=Escherichia coli, GI1786356, Length=457, Percent_Identity=55.7986870897155, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1789630, Length=276, Percent_Identity=44.5652173913043, Blast_Score=212, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24646839, Length=284, Percent_Identity=34.1549295774648, Blast_Score=128, Evalue=8e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 47842; Mature: 47842

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKPLLALSVLTLSLSSIITPIQATAALPLSVGNEQLPSLAPMLEQVTPAVVSIAVEGK
CCCCHHHHHHHHHHHHHHHHCHHHHHHCCEECCCCCCCCHHHHHHHHHCCEEEEEEECCH
QVQRQQIPEQFQFFFGPEQTRERPFRGLGSGVIIDAKKGHIVTNYHVINGADDIKVKLHD
HHHHHHCCHHHHEECCCCHHHCCCHHCCCCCEEEECCCCEEEEEEEEECCCCEEEEEEEC
GREYDAELIGGDQMSDIALLKLETAKNLTQIKVADSDKLRVGDFSVAIGNPFGLGQTVTS
CCCCCCEEECCCCCCCEEEEEEECCCCCEEEEECCCCCEEECEEEEEECCCCCCCHHHHH
GIVSALGRSGLNLENFENFIQTDAAINSGNSGGALVNLNGELIGINTAILGPNGGNVGIG
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCEEEEEEEEEECCCCCCEEEE
FAIPSNMMTNLTEQILDFGEVKRGMLGVQGGEVTSELAEALGYESSKGAFVSQIVPDSAA
EECCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCC
DKAGLKAGDVIISINGKRIDTFSELRAKVATLGAGKQIELGVVRDGKNKTFDVTLGESTN
CCCCCCCCCEEEEECCCEECHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCCC
SKTQAEKLHEGLAGAELTNTTDSDSATGVKVSSVAQGSPAEAYQLLKDDIIIGVNRQPVK
CHHHHHHHHCCCCCCEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCEEEECCCCHHH
NLAEFRKILEKQPGVLALNIQRDDRTIYLVIR
HHHHHHHHHHCCCCEEEEEEEECCCEEEEEEC
>Mature Secondary Structure
MMKKPLLALSVLTLSLSSIITPIQATAALPLSVGNEQLPSLAPMLEQVTPAVVSIAVEGK
CCCCHHHHHHHHHHHHHHHHCHHHHHHCCEECCCCCCCCHHHHHHHHHCCEEEEEEECCH
QVQRQQIPEQFQFFFGPEQTRERPFRGLGSGVIIDAKKGHIVTNYHVINGADDIKVKLHD
HHHHHHCCHHHHEECCCCHHHCCCHHCCCCCEEEECCCCEEEEEEEEECCCCEEEEEEEC
GREYDAELIGGDQMSDIALLKLETAKNLTQIKVADSDKLRVGDFSVAIGNPFGLGQTVTS
CCCCCCEEECCCCCCCEEEEEEECCCCCEEEEECCCCCEEECEEEEEECCCCCCCHHHHH
GIVSALGRSGLNLENFENFIQTDAAINSGNSGGALVNLNGELIGINTAILGPNGGNVGIG
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCEEEEEEEEEECCCCCCEEEE
FAIPSNMMTNLTEQILDFGEVKRGMLGVQGGEVTSELAEALGYESSKGAFVSQIVPDSAA
EECCHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHCCCCCCCCCHHHHCCCCCC
DKAGLKAGDVIISINGKRIDTFSELRAKVATLGAGKQIELGVVRDGKNKTFDVTLGESTN
CCCCCCCCCEEEEECCCEECHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEECCCCC
SKTQAEKLHEGLAGAELTNTTDSDSATGVKVSSVAQGSPAEAYQLLKDDIIIGVNRQPVK
CHHHHHHHHCCCCCCEECCCCCCCCCCCEEEECCCCCCHHHHHHHHHCCEEEECCCCHHH
NLAEFRKILEKQPGVLALNIQRDDRTIYLVIR
HHHHHHHHHHCCCCEEEEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8576051; 9278503 [H]