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The map label for this gene is degS [H]

Identifier: 218708462

GI number: 218708462

Start: 436468

End: 437565

Strand: Reverse

Name: degS [H]

Synonym: VS_0425

Alternate gene names: 218708462

Gene position: 437565-436468 (Counterclockwise)

Preceding gene: 218708463

Following gene: 218708455

Centisome position: 13.26

GC content: 47.54

Gene sequence:

>1098_bases
ATGCTTCATACCTTACTTGTTGAAGAGGGAAACATGCTGTCCTTTCTATTTCGTTCTATTTCCCTTGGACTCGTTTCAGC
GGCGCTTATTCTTCTCGCATTCCCGAGTTTAAGGCCGGCGATTGTTGCAGACGTCACGAACCCTCAAGTCGATAATATTG
GCTCTCTTCAGATCTCATTTAACCAAGCGGTGCGACGAGCTGCACCCGCTGTGGTCAATATTTATAGTCGTAAATACGCA
GAAAGCGATCGCAACAAGCTACTAACTCAAGGATTAGGTTCAGGGGTGATTGTTAGTGAGAAAGGCTACATCATTACCAA
CTTCCATGTTGTTGCTCAAGCTGACCAAATAGTCGTGGCACTTCAAGACGGACGAGTAGCGGCCGCACAACTTGTCGGCT
CAGACAAACGCACCGATATTGCGATACTCCGAGTCAGCGGTGACAACTTACCTGTTATTCCACTGAACCCGAATTACAAA
GCAAATGTCGGCGACGTGGTGCTGGCTATCGGTAACCCATACAACCTAGGGCAAACGACAACCTTTGGCATTATCTCTGC
AACAGGTCGTTCTTCGATCAGTGCAGATGGTCACCAAGCCTTTATCCAGACCGATGCTGCAATCAATGAAGGTAACTCTG
GTGGTGCACTGGTTAACTCACAAGGTGAGCTCGTCGGAATCAACACGGCTTCTTTCCAACAAGCTACCGACATGGAAACC
TACGGGATCTCATTTGCAATCCCCTACTCACTTGCTAATAAAATCATGGAGAAGATCATCGCCGATGGTCGTGTCATTCG
TGGTTATATTGGTATCGACGGACAAGACATCAATTCGGTGACATCACGCTTGCTCGGTACTAAGAACATCGGTGGCATTG
TTGTTTTAGGCATTGACCCGAATGGCCCTGCAGCCGATGCCGGCTTTGAAGCACAAGATATCATTATCAGCATCAACAAC
ACCCAAATTAGCGGACGACAGAGCGTAATGGACATAGTTACTGACCTTCGCCCGGGTACTATCATTGATGTTGGTGTATT
GCGAAAAGGTGAAAACAAGACACTCAAGGTCACCATTACCGAAGACACACGCCTGTAG

Upstream 100 bases:

>100_bases
GGCTCAGTAAGTTTGCTTTAAACTTACTCAGTCTCCCTTTTCTTTAGATCAATCAAAATGCTATGCTTCACTGATAATCA
AGTCAGTCATCCATTGACGG

Downstream 100 bases:

>100_bases
TCTTTATTTAGTTTGATTGCTAATAGCGAGTAACTCAAACCGCCAATTACAGAGACAAAAAGTATAGATACAAAAAACCC
AGCTCTTAAGCTGGGTTTTC

Product: protease DegS precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MLHTLLVEEGNMLSFLFRSISLGLVSAALILLAFPSLRPAIVADVTNPQVDNIGSLQISFNQAVRRAAPAVVNIYSRKYA
ESDRNKLLTQGLGSGVIVSEKGYIITNFHVVAQADQIVVALQDGRVAAAQLVGSDKRTDIAILRVSGDNLPVIPLNPNYK
ANVGDVVLAIGNPYNLGQTTTFGIISATGRSSISADGHQAFIQTDAAINEGNSGGALVNSQGELVGINTASFQQATDMET
YGISFAIPYSLANKIMEKIIADGRVIRGYIGIDGQDINSVTSRLLGTKNIGGIVVLGIDPNGPAADAGFEAQDIIISINN
TQISGRQSVMDIVTDLRPGTIIDVGVLRKGENKTLKVTITEDTRL

Sequences:

>Translated_365_residues
MLHTLLVEEGNMLSFLFRSISLGLVSAALILLAFPSLRPAIVADVTNPQVDNIGSLQISFNQAVRRAAPAVVNIYSRKYA
ESDRNKLLTQGLGSGVIVSEKGYIITNFHVVAQADQIVVALQDGRVAAAQLVGSDKRTDIAILRVSGDNLPVIPLNPNYK
ANVGDVVLAIGNPYNLGQTTTFGIISATGRSSISADGHQAFIQTDAAINEGNSGGALVNSQGELVGINTASFQQATDMET
YGISFAIPYSLANKIMEKIIADGRVIRGYIGIDGQDINSVTSRLLGTKNIGGIVVLGIDPNGPAADAGFEAQDIIISINN
TQISGRQSVMDIVTDLRPGTIIDVGVLRKGENKTLKVTITEDTRL
>Mature_365_residues
MLHTLLVEEGNMLSFLFRSISLGLVSAALILLAFPSLRPAIVADVTNPQVDNIGSLQISFNQAVRRAAPAVVNIYSRKYA
ESDRNKLLTQGLGSGVIVSEKGYIITNFHVVAQADQIVVALQDGRVAAAQLVGSDKRTDIAILRVSGDNLPVIPLNPNYK
ANVGDVVLAIGNPYNLGQTTTFGIISATGRSSISADGHQAFIQTDAAINEGNSGGALVNSQGELVGINTASFQQATDMET
YGISFAIPYSLANKIMEKIIADGRVIRGYIGIDGQDINSVTSRLLGTKNIGGIVVLGIDPNGPAADAGFEAQDIIISINN
TQISGRQSVMDIVTDLRPGTIIDVGVLRKGENKTLKVTITEDTRL

Specific function: Senses the OMP signal triggered by the accumulation of unassembled porins in the envelope and then initiates rseA degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by rseP [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=331, Percent_Identity=34.441087613293, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI22129776, Length=294, Percent_Identity=36.0544217687075, Blast_Score=126, Evalue=4e-29,
Organism=Homo sapiens, GI24308541, Length=324, Percent_Identity=31.4814814814815, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI7019477, Length=321, Percent_Identity=32.7102803738318, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1789630, Length=352, Percent_Identity=53.6931818181818, Blast_Score=348, Evalue=3e-97,
Organism=Escherichia coli, GI1786356, Length=275, Percent_Identity=42.1818181818182, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI1789629, Length=275, Percent_Identity=42.1818181818182, Blast_Score=195, Evalue=4e-51,
Organism=Drosophila melanogaster, GI24646839, Length=296, Percent_Identity=31.7567567567568, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011783
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 38570; Mature: 38570

Theoretical pI: Translated: 5.14; Mature: 5.14

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLHTLLVEEGNMLSFLFRSISLGLVSAALILLAFPSLRPAIVADVTNPQVDNIGSLQISF
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEEEH
NQAVRRAAPAVVNIYSRKYAESDRNKLLTQGLGSGVIVSEKGYIITNFHVVAQADQIVVA
HHHHHHHCCHHEEHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEEEEEECCEEEEE
LQDGRVAAAQLVGSDKRTDIAILRVSGDNLPVIPLNPNYKANVGDVVLAIGNPYNLGQTT
EECCCEEEEHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCEE
TFGIISATGRSSISADGHQAFIQTDAAINEGNSGGALVNSQGELVGINTASFQQATDMET
EEEEEEECCCCCCCCCCCEEEEEECCEECCCCCCCEEEECCCCEEEEECCCCCHHCCCHH
YGISFAIPYSLANKIMEKIIADGRVIRGYIGIDGQDINSVTSRLLGTKNIGGIVVLGIDP
CCEEEEECHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEEECC
NGPAADAGFEAQDIIISINNTQISGRQSVMDIVTDLRPGTIIDVGVLRKGENKTLKVTIT
CCCCCCCCCCCEEEEEEEECCEECCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEE
EDTRL
CCCCC
>Mature Secondary Structure
MLHTLLVEEGNMLSFLFRSISLGLVSAALILLAFPSLRPAIVADVTNPQVDNIGSLQISF
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCEEEEEEH
NQAVRRAAPAVVNIYSRKYAESDRNKLLTQGLGSGVIVSEKGYIITNFHVVAQADQIVVA
HHHHHHHCCHHEEHHHHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEEEEEEECCEEEEE
LQDGRVAAAQLVGSDKRTDIAILRVSGDNLPVIPLNPNYKANVGDVVLAIGNPYNLGQTT
EECCCEEEEHHHCCCCCCEEEEEEECCCCEEEEECCCCCCCCCCCEEEEECCCCCCCCEE
TFGIISATGRSSISADGHQAFIQTDAAINEGNSGGALVNSQGELVGINTASFQQATDMET
EEEEEEECCCCCCCCCCCEEEEEECCEECCCCCCCEEEECCCCEEEEECCCCCHHCCCHH
YGISFAIPYSLANKIMEKIIADGRVIRGYIGIDGQDINSVTSRLLGTKNIGGIVVLGIDP
CCEEEEECHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHCCCCCCCCEEEEEECC
NGPAADAGFEAQDIIISINNTQISGRQSVMDIVTDLRPGTIIDVGVLRKGENKTLKVTIT
CCCCCCCCCCCEEEEEEEECCEECCHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEE
EDTRL
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]