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The map label for this gene is fimB [H]

Identifier: 218700831

GI number: 218700831

Start: 2597520

End: 2598089

Strand: Direct

Name: fimB [H]

Synonym: ECIAI39_2506

Alternate gene names: 218700831

Gene position: 2597520-2598089 (Clockwise)

Preceding gene: 218700828

Following gene: 218700833

Centisome position: 50.61

GC content: 32.98

Gene sequence:

>570_bases
ATGCGCAAATTTATTACTCATAGTGAATGGTTGTTATTTTTTGAAGCCATCAACGGTTCAAAAAATGAAATTAGAGATAA
AGCCATGTTACAAATGGCATATGTACATGGTCTTAGGGTAAGCGAGCTTATTGCACTAAAGATTAGCGACATTGACTTTT
CAGAGTCAGCAATATATATCAAGCGTTTAAAAAATGGATTATCCACAGTACATCCCCTGCAAAAAGAAACTGTTCTGTTA
TTAAAAAAATGGCTAGCACTACGTGATAACATAGTAAAAAAACCTTTTGAAGACTCTTTATTTCTTTCTTGTCAAGGAAA
TAAAATCTCGAGACAATATGTGTATAAGATGTGTAAGAAATATAGTCACAATATGAATATTAATATTCATCCTCACATGC
TTAGGCATGGTTGTGGGTATGCTTTAGCTAATCAAGGGTTAGACACCAGACTAATACAAGATTATTTAGGGCACAGAAAT
ATACATCATACGGTATTATATACAGCCAGTAATGCAGCAAGATTTAAACGAGTATGGGAGGGTGATGTGTTAGATATAAA
GAAGATATAA

Upstream 100 bases:

>100_bases
AAACCCCAGCTCATTATTTGCTTATAAAAAACAAGCAATAATACCAGGCTCTGGTATTTATAGTTTATTTTTTAACTTAA
TTAGTATAACCGATAATATT

Downstream 100 bases:

>100_bases
CCCCTGTTCTAAAGGCCTCAATTCATTGAGGCTTTTAGCCCCTCATTTTTATGACATACAACTGATAATCATAATAGATC
CTCAATATTAATCAAAATGA

Product: Type 1 fimbriae regulatory protein fimB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MRKFITHSEWLLFFEAINGSKNEIRDKAMLQMAYVHGLRVSELIALKISDIDFSESAIYIKRLKNGLSTVHPLQKETVLL
LKKWLALRDNIVKKPFEDSLFLSCQGNKISRQYVYKMCKKYSHNMNINIHPHMLRHGCGYALANQGLDTRLIQDYLGHRN
IHHTVLYTASNAARFKRVWEGDVLDIKKI

Sequences:

>Translated_189_residues
MRKFITHSEWLLFFEAINGSKNEIRDKAMLQMAYVHGLRVSELIALKISDIDFSESAIYIKRLKNGLSTVHPLQKETVLL
LKKWLALRDNIVKKPFEDSLFLSCQGNKISRQYVYKMCKKYSHNMNINIHPHMLRHGCGYALANQGLDTRLIQDYLGHRN
IHHTVLYTASNAARFKRVWEGDVLDIKKI
>Mature_189_residues
MRKFITHSEWLLFFEAINGSKNEIRDKAMLQMAYVHGLRVSELIALKISDIDFSESAIYIKRLKNGLSTVHPLQKETVLL
LKKWLALRDNIVKKPFEDSLFLSCQGNKISRQYVYKMCKKYSHNMNINIHPHMLRHGCGYALANQGLDTRLIQDYLGHRN
IHHTVLYTASNAARFKRVWEGDVLDIKKI

Specific function: FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790767, Length=183, Percent_Identity=49.7267759562842, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1790768, Length=181, Percent_Identity=45.8563535911602, Blast_Score=171, Evalue=3e-44,
Organism=Escherichia coli, GI1790244, Length=147, Percent_Identity=34.0136054421769, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1789261, Length=160, Percent_Identity=34.375, Blast_Score=84, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 22042; Mature: 22042

Theoretical pI: Translated: 10.20; Mature: 10.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKFITHSEWLLFFEAINGSKNEIRDKAMLQMAYVHGLRVSELIALKISDIDFSESAIYI
CCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCHHHHH
KRLKNGLSTVHPLQKETVLLLKKWLALRDNIVKKPFEDSLFLSCQGNKISRQYVYKMCKK
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHH
YSHNMNINIHPHMLRHGCGYALANQGLDTRLIQDYLGHRNIHHTVLYTASNAARFKRVWE
HCCCCCEEECHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHC
GDVLDIKKI
CCCEEEECC
>Mature Secondary Structure
MRKFITHSEWLLFFEAINGSKNEIRDKAMLQMAYVHGLRVSELIALKISDIDFSESAIYI
CCCCCCCHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCHHHHH
KRLKNGLSTVHPLQKETVLLLKKWLALRDNIVKKPFEDSLFLSCQGNKISRQYVYKMCKK
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHH
YSHNMNINIHPHMLRHGCGYALANQGLDTRLIQDYLGHRNIHHTVLYTASNAARFKRVWE
HCCCCCEEECHHHHHHCCCHHHHCCCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHC
GDVLDIKKI
CCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]