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The map label for this gene is atoC

Identifier: 218700689

GI number: 218700689

Start: 2433957

End: 2435342

Strand: Direct

Name: atoC

Synonym: ECIAI39_2358

Alternate gene names: 218700689

Gene position: 2433957-2435342 (Clockwise)

Preceding gene: 218700688

Following gene: 218700690

Centisome position: 47.43

GC content: 49.42

Gene sequence:

>1386_bases
ATGACTGCTATTAATCGCATCCTTATTGTGGATGATGAAGATAATGTTCGCCGTATGCTGAGCACCGCTTTTGCACTACA
AGGATTCGAAACACATTGTGCGAACAACGGGCGCACAGCATTACACCTGTTTGCCGATATTCACCCTGACGTGGTGTTGA
TGGATATCCGCATGCCAGAGATGGACGGCATCAAGGCACTCAAGGAGATGCGCAGTAATGAGACCCGGACACCCGTTATT
CTGATGACGGCCTATGCTGAAGTGGAAACCGCCGTCGAAGCGCTACGCTGCGGGGCCTTCGACTATGTTATTAAACCGTT
TGATCTCGATGAGTTGAATTTAATCGTTCAGCGCGCTTTACAACTCCAGTCAATGAAAAAAGAGATCCGTCATCTGCACC
AGGCACTGAGCACCAGCTGGCAATGGGGGCACATTCTCACCAACAGCCCGGCGATGATGGATATCTGCAAAGACACCGCC
AAAATTGCCCTTTCTCAGGCCAGCGTCTTGATTAGTGGTGAAAGCGGCACCGGGAAAGAGTTGATTGCCAGAGCGATTCA
CTACAATTCGCGGCGGGCAAAGGGGCCGTTCATTAAAGTCAACTGCGCGGCGCTGCCGGAATCGTTGCTCGAAAGTGAAC
TGTTTGGTCATGAAAAAGGTGCATTTACTGGTGCACAAACCTTGCGTCAGGGATTATTTGAACGTGCCAACGAAGGTACT
CTGCTCCTCGACGAAATTGGCGAAATGCCGCTCGTACTGCAAGCCAAATTACTACGCATTCTGCAGGAACGGGAATTTGA
ACGGATTGGCGGCCATCAGACCATAAAAGTTGATATCCGCATCATTGCTGCCACCAACCGTGACTTGCAGGCAATGGTAA
AAGAAGGCACCTTCCGTGAAGATCTCTTTTATCGCCTTAACGTTATTCATTTAATACTGCCGCCTCTGCGCGATCGCCGG
GAAGATATTTCCCTGTTAGCTAATCACTTTTTGCAAAAATTCAGTAGTGAGAATCAGCGCGATATTATCGACATCGATCC
GATGGCAATGTCGCTGCTTACCGCCTGGTCATGGCCGGGTAATATTCGAGAGCTTTCCAACGTCATTGAACGCGCCGTCG
TGATGAACTCAGGCCCGATCATTTTCTCTGAGGATCTTCCGCCGCAGATTCGTCAGCCAGTCTGTAATGCTGGTGAGGCA
AAAACAGCCCCTGTCGGTGAGCGTAATTTAAAAGAGGAAATTAAACGCGTCGAAAAACGCATCATTATGGAAGTGCTGGA
ACAACAAGAAGGAAACCGAACCCGCACTGCGTTAATGCTGGGCATCAGTCGCCGTGCATTGATGTATAAACTCCAGGAAT
ACGGTATCGATCCGGCGGATGTATAA

Upstream 100 bases:

>100_bases
TTAATGCCCATCAGGGTGATATTCGCGTCGCCAGTTTGCCGGGCTACGGCGCAACCTTCACGCTTATTTTACCGATCAAC
CCGCAGGGAAATCAGACTGT

Downstream 100 bases:

>100_bases
CGCCAAAACTTGCTATGCAGAAATTTGCACAGTGCGCAATTTTCTGCATAGCCGCTCATTCTCCTTATAAACCCCCATCT
AATTTATCCTTTTCTATTCA

Product: acetoacetate metabolism regulatory protein AtoC

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTAINRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSNETRTPVI
LMTAYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQLQSMKKEIRHLHQALSTSWQWGHILTNSPAMMDICKDTA
KIALSQASVLISGESGTGKELIARAIHYNSRRAKGPFIKVNCAALPESLLESELFGHEKGAFTGAQTLRQGLFERANEGT
LLLDEIGEMPLVLQAKLLRILQEREFERIGGHQTIKVDIRIIAATNRDLQAMVKEGTFREDLFYRLNVIHLILPPLRDRR
EDISLLANHFLQKFSSENQRDIIDIDPMAMSLLTAWSWPGNIRELSNVIERAVVMNSGPIIFSEDLPPQIRQPVCNAGEA
KTAPVGERNLKEEIKRVEKRIIMEVLEQQEGNRTRTALMLGISRRALMYKLQEYGIDPADV

Sequences:

>Translated_461_residues
MTAINRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSNETRTPVI
LMTAYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQLQSMKKEIRHLHQALSTSWQWGHILTNSPAMMDICKDTA
KIALSQASVLISGESGTGKELIARAIHYNSRRAKGPFIKVNCAALPESLLESELFGHEKGAFTGAQTLRQGLFERANEGT
LLLDEIGEMPLVLQAKLLRILQEREFERIGGHQTIKVDIRIIAATNRDLQAMVKEGTFREDLFYRLNVIHLILPPLRDRR
EDISLLANHFLQKFSSENQRDIIDIDPMAMSLLTAWSWPGNIRELSNVIERAVVMNSGPIIFSEDLPPQIRQPVCNAGEA
KTAPVGERNLKEEIKRVEKRIIMEVLEQQEGNRTRTALMLGISRRALMYKLQEYGIDPADV
>Mature_460_residues
TAINRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPEMDGIKALKEMRSNETRTPVIL
MTAYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRALQLQSMKKEIRHLHQALSTSWQWGHILTNSPAMMDICKDTAK
IALSQASVLISGESGTGKELIARAIHYNSRRAKGPFIKVNCAALPESLLESELFGHEKGAFTGAQTLRQGLFERANEGTL
LLDEIGEMPLVLQAKLLRILQEREFERIGGHQTIKVDIRIIAATNRDLQAMVKEGTFREDLFYRLNVIHLILPPLRDRRE
DISLLANHFLQKFSSENQRDIIDIDPMAMSLLTAWSWPGNIRELSNVIERAVVMNSGPIIFSEDLPPQIRQPVCNAGEAK
TAPVGERNLKEEIKRVEKRIIMEVLEQQEGNRTRTALMLGISRRALMYKLQEYGIDPADV

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=461, Percent_Identity=99.5661605206074, Blast_Score=945, Evalue=0.0,
Organism=Escherichia coli, GI1790437, Length=446, Percent_Identity=48.2062780269058, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1790299, Length=468, Percent_Identity=42.9487179487179, Blast_Score=379, Evalue=1e-106,
Organism=Escherichia coli, GI1788905, Length=455, Percent_Identity=40.2197802197802, Blast_Score=314, Evalue=7e-87,
Organism=Escherichia coli, GI87082117, Length=353, Percent_Identity=48.4419263456091, Blast_Score=295, Evalue=6e-81,
Organism=Escherichia coli, GI1789087, Length=322, Percent_Identity=46.2732919254658, Blast_Score=267, Evalue=9e-73,
Organism=Escherichia coli, GI1789233, Length=306, Percent_Identity=48.0392156862745, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI87082152, Length=296, Percent_Identity=45.945945945946, Blast_Score=248, Evalue=8e-67,
Organism=Escherichia coli, GI87081872, Length=318, Percent_Identity=43.0817610062893, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1786524, Length=340, Percent_Identity=43.8235294117647, Blast_Score=235, Evalue=4e-63,
Organism=Escherichia coli, GI1787583, Length=318, Percent_Identity=39.622641509434, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1789828, Length=247, Percent_Identity=38.4615384615385, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI87081858, Length=325, Percent_Identity=31.0769230769231, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=37.5, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1786784, Length=107, Percent_Identity=33.6448598130841, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786911, Length=121, Percent_Identity=33.8842975206612, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1787375, Length=107, Percent_Identity=30.8411214953271, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082012, Length=161, Percent_Identity=26.7080745341615, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1789402, Length=107, Percent_Identity=34.5794392523364, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786599, Length=109, Percent_Identity=36.697247706422, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1788713, Length=126, Percent_Identity=30.952380952381, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI145693157, Length=104, Percent_Identity=36.5384615384615, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790863, Length=212, Percent_Identity=25.9433962264151, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1786838, Length=131, Percent_Identity=32.824427480916, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=29.4117647058824, Blast_Score=62, Evalue=7e-11,
Organism=Escherichia coli, GI1790552, Length=123, Percent_Identity=28.4552845528455, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 52126; Mature: 51995

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAINRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPE
CCCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEEECCCCEEEEEECCCC
MDGIKALKEMRSNETRTPVILMTAYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRAL
CHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHEECCCCCHHHHHHHHHHH
QLQSMKKEIRHLHQALSTSWQWGHILTNSPAMMDICKDTAKIALSQASVLISGESGTGKE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCEEEEECCCCCHHH
LIARAIHYNSRRAKGPFIKVNCAALPESLLESELFGHEKGAFTGAQTLRQGLFERANEGT
HHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
LLLDEIGEMPLVLQAKLLRILQEREFERIGGHQTIKVDIRIIAATNRDLQAMVKEGTFRE
EEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCHHHHHHHHCCCHHH
DLFYRLNVIHLILPPLRDRREDISLLANHFLQKFSSENQRDIIDIDPMAMSLLTAWSWPG
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHCCCCC
NIRELSNVIERAVVMNSGPIIFSEDLPPQIRQPVCNAGEAKTAPVGERNLKEEIKRVEKR
CHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
IIMEVLEQQEGNRTRTALMLGISRRALMYKLQEYGIDPADV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TAINRILIVDDEDNVRRMLSTAFALQGFETHCANNGRTALHLFADIHPDVVLMDIRMPE
CCCCEEEEECCCHHHHHHHHHHHHHCCHHHHHCCCCCEEEEEEEECCCCEEEEEECCCC
MDGIKALKEMRSNETRTPVILMTAYAEVETAVEALRCGAFDYVIKPFDLDELNLIVQRAL
CHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCHHHEECCCCCHHHHHHHHHHH
QLQSMKKEIRHLHQALSTSWQWGHILTNSPAMMDICKDTAKIALSQASVLISGESGTGKE
HHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHHHHHHHHCEEEEECCCCCHHH
LIARAIHYNSRRAKGPFIKVNCAALPESLLESELFGHEKGAFTGAQTLRQGLFERANEGT
HHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCC
LLLDEIGEMPLVLQAKLLRILQEREFERIGGHQTIKVDIRIIAATNRDLQAMVKEGTFRE
EEHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEEEECCHHHHHHHHCCCHHH
DLFYRLNVIHLILPPLRDRREDISLLANHFLQKFSSENQRDIIDIDPMAMSLLTAWSWPG
HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHCCCCC
NIRELSNVIERAVVMNSGPIIFSEDLPPQIRQPVCNAGEAKTAPVGERNLKEEIKRVEKR
CHHHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
IIMEVLEQQEGNRTRTALMLGISRRALMYKLQEYGIDPADV
HHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]