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The map label for this gene is murP

Identifier: 218696064

GI number: 218696064

Start: 2776609

End: 2778033

Strand: Direct

Name: murP

Synonym: EC55989_2718

Alternate gene names: 218696064

Gene position: 2776609-2778033 (Clockwise)

Preceding gene: 218696063

Following gene: 218696065

Centisome position: 53.86

GC content: 56.28

Gene sequence:

>1425_bases
ATGGCCAAAGAGATCAGCAGTGAACTTCTGAACACCATCCTTACCCGTGTCGGCGGACCGGGAAATATCGCCAGTTGTGG
TAACTGTATGACGCGCCTGCGTCTGGGTGTACATGACAGTTCACTGGTTGATCCCAATATCAAAACGCTGGAAGGCGTGA
AGGGCGTCATTTTGACCAGCGACCAGGTGCAGGTCGTTTTTGGGCCTGGTAAAGCGCATCGTGCCGCAAAAGCGATGAGC
GAGCTGCTGGGCGAGGCACCGGTACAGGATGCCGCAGAAATCGCCGCCCAGAACAAACGTCAGTTAAAAGCCAAACAAAC
CTCCGGCGTGCAACAATTTCTCGCCAAATTCGCCACCATCTTCACGCCGCTGATCCCCGGTTTTATTGCCGCCGGTCTGC
TGCTGGGGATAGCGACGTTAATTGCCACGGTGATGCACGTTCCGGCAGATGCTCAGGGCACGCTACCCGACGCGCTGAAT
TTTATGAAGGTGTTCAGCAAAAGTTTGTTCACTTTCCTGGTGATTCTGGTGGGCTATAACGCCGCCCAGGCATTTGGCGG
CACGGGCGTCAATGGCGCAATTATTGCCGCACTCTTTTTGCTCGGTTATAACCCCGCTGCAACCACCGGTTACTACGCCG
GTTTTCACGATTTCTTTGGTCTGCCCATCGATCCGCGCGGCAATATTATCGGCGTGCTGATTGCCGCGTGGGCCTGCGCC
CGCATTGAAGGCATGGTGCGCCGCTTTATGCCGGACGATCTCGACATGCTGCTGACCTCGTTAATCACCCTGCTGATCAC
CGCTACGCTTGCGTACCTGATCATTATGCCGCTGGGTGGCTGGTTATTCGAAGGTATGTCATGGCTGTTTATGCACCTGA
ACAGTAATCCGTTCGGTTGTGCGGTTTTAGCCGGGCTGTTCCTGATCGCCGTGGTATTTGGCGTGCATCAGGGCTTTATT
CCTGTTTACCTCGCGTTAATGGACAGCCAGGGATTCAACAGCTTATTTCCCATCCTTTCAATGGCAGGCGCGGGCCAGGT
GGGCGCGGCGCTGGCACTCTACTGGCGGGCGCAACCGCACAGTGCATTACGCAGTCAGGTACGCGGGGCGATTATTCCCG
GTCTGCTGGGCGTTGGTGAACCGTTGATTTACGGCGTCACCCTGCCCCGCATGAAACCGTTTATTACCGCCTGTTTAGGC
GGCGCAGCGGGCGGTTTGTTTATCGGCCTGATAGCCTGGTGGGGTCTGCCGATGGGCTTAAACAGCGCCTTTGGGCCGTC
TGGTCTGGTGGCGCTGCCGCTGATGACTTCCGCACAAGGCATCCTTCCGGCAATGTCGGTTTATGCTGGCGGGATTCTGG
TGGCATGGGTTTGCGGGTTTATTTTCACCACGCTCTTTGGCTGCCGTAACGTCAATCTGGACTGA

Upstream 100 bases:

>100_bases
CATTGTGATGGTGCTGAAAAATCTCGATGCCGCAGAAGCTAAAAAACGCCTGGATCAACACGGCGGCTTTATTCGTCAGG
TTTTAGACAAGGAATAACCC

Downstream 100 bases:

>100_bases
TATCATGAAACGGACAATGCTCTATCTTTCTCTGCTGGCTGTTAGTTGTAGCGTCAGCGCCGCAAAATACCCTGTTCTGA
CAGAAAGTTCGCCAGAGAAA

Product: PTS system N-acetylmuramic acid transporter subunits EIIBC

Products: NA

Alternate protein names: EIIBC-MurNAc; N-acetylmuramic acid-specific phosphotransferase enzyme IIB component; PTS system N-acetylmuramic acid-specific EIIB component; N-acetylmuramic acid permease IIC component; PTS system N-acetylmuramic acid-specific EIIC component [H]

Number of amino acids: Translated: 474; Mature: 473

Protein sequence:

>474_residues
MAKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPNIKTLEGVKGVILTSDQVQVVFGPGKAHRAAKAMS
ELLGEAPVQDAAEIAAQNKRQLKAKQTSGVQQFLAKFATIFTPLIPGFIAAGLLLGIATLIATVMHVPADAQGTLPDALN
FMKVFSKSLFTFLVILVGYNAAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACA
RIEGMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPFGCAVLAGLFLIAVVFGVHQGFI
PVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPHSALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFITACLG
GAAGGLFIGLIAWWGLPMGLNSAFGPSGLVALPLMTSAQGILPAMSVYAGGILVAWVCGFIFTTLFGCRNVNLD

Sequences:

>Translated_474_residues
MAKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPNIKTLEGVKGVILTSDQVQVVFGPGKAHRAAKAMS
ELLGEAPVQDAAEIAAQNKRQLKAKQTSGVQQFLAKFATIFTPLIPGFIAAGLLLGIATLIATVMHVPADAQGTLPDALN
FMKVFSKSLFTFLVILVGYNAAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACA
RIEGMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPFGCAVLAGLFLIAVVFGVHQGFI
PVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPHSALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFITACLG
GAAGGLFIGLIAWWGLPMGLNSAFGPSGLVALPLMTSAQGILPAMSVYAGGILVAWVCGFIFTTLFGCRNVNLD
>Mature_473_residues
AKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPNIKTLEGVKGVILTSDQVQVVFGPGKAHRAAKAMSE
LLGEAPVQDAAEIAAQNKRQLKAKQTSGVQQFLAKFATIFTPLIPGFIAAGLLLGIATLIATVMHVPADAQGTLPDALNF
MKVFSKSLFTFLVILVGYNAAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACAR
IEGMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPFGCAVLAGLFLIAVVFGVHQGFIP
VYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPHSALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFITACLGG
AAGGLFIGLIAWWGLPMGLNSAFGPSGLVALPLMTSAQGILPAMSVYAGGILVAWVCGFIFTTLFGCRNVNLD

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788769, Length=474, Percent_Identity=99.3670886075949, Blast_Score=942, Evalue=0.0,
Organism=Escherichia coli, GI1790159, Length=435, Percent_Identity=29.8850574712644, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI2367362, Length=428, Percent_Identity=26.8691588785047, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI48994906, Length=487, Percent_Identity=25.8726899383984, Blast_Score=108, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018113
- InterPro:   IPR001996
- InterPro:   IPR003352
- InterPro:   IPR013013 [H]

Pfam domain/function: PF00367 PTS_EIIB; PF02378 PTS_EIIC [H]

EC number: =2.7.1.69 [H]

Molecular weight: Translated: 49863; Mature: 49732

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00024 HEMOPEXIN ; PS01035 PTS_EIIB_TYPE_1_CYS ; PS51098 PTS_EIIB_TYPE_1 ; PS51103 PTS_EIIC_TYPE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPNIKTLEGVKGVILTS
CCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCEEEEC
DQVQVVFGPGKAHRAAKAMSELLGEAPVQDAAEIAAQNKRQLKAKQTSGVQQFLAKFATI
CCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTPLIPGFIAAGLLLGIATLIATVMHVPADAQGTLPDALNFMKVFSKSLFTFLVILVGYN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACA
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
RIEGMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPFGC
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHH
AVLAGLFLIAVVFGVHQGFIPVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPH
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCH
SALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFITACLGGAAGGLFIGLIAWWGLPMGL
HHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
NSAFGPSGLVALPLMTSAQGILPAMSVYAGGILVAWVCGFIFTTLFGCRNVNLD
CCCCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
AKEISSELLNTILTRVGGPGNIASCGNCMTRLRLGVHDSSLVDPNIKTLEGVKGVILTS
CHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCEEEEC
DQVQVVFGPGKAHRAAKAMSELLGEAPVQDAAEIAAQNKRQLKAKQTSGVQQFLAKFATI
CCEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FTPLIPGFIAAGLLLGIATLIATVMHVPADAQGTLPDALNFMKVFSKSLFTFLVILVGYN
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
AAQAFGGTGVNGAIIAALFLLGYNPAATTGYYAGFHDFFGLPIDPRGNIIGVLIAAWACA
HHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHHHHH
RIEGMVRRFMPDDLDMLLTSLITLLITATLAYLIIMPLGGWLFEGMSWLFMHLNSNPFGC
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCHHH
AVLAGLFLIAVVFGVHQGFIPVYLALMDSQGFNSLFPILSMAGAGQVGAALALYWRAQPH
HHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCH
SALRSQVRGAIIPGLLGVGEPLIYGVTLPRMKPFITACLGGAAGGLFIGLIAWWGLPMGL
HHHHHHHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
NSAFGPSGLVALPLMTSAQGILPAMSVYAGGILVAWVCGFIFTTLFGCRNVNLD
CCCCCCCCCEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]