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The map label for this gene is murQ

Identifier: 218696063

GI number: 218696063

Start: 2775709

End: 2776605

Strand: Direct

Name: murQ

Synonym: EC55989_2717

Alternate gene names: 218696063

Gene position: 2775709-2776605 (Clockwise)

Preceding gene: 218696055

Following gene: 218696064

Centisome position: 53.85

GC content: 53.62

Gene sequence:

>897_bases
ATGCAACTAGAAAAGATGATTACTGAAGGCTCGAACACCGCCTCGGCTGAAATTGACCGCGTATCGACGCTGGAAATGTG
CCGGATTATCAACGATGAAGATAAAACCGTACCGCTTGCCGTTGAGCGCGTCCTGCCGGATATCGCCGCGGCGATCGATG
TTATCCACGCCCAGGTCAGCGGCGGCGGTCGTCTGATTTATCTCGGTGCGGGAACATCCGGTCGTCTGGGGATTCTGGAT
GCCAGCGAATGTCCGCCCACCTACGGCGTGAAACCGGGTCTGGTGGTTGGTTTGATTGCTGGAGGCGAATATGCCATTCA
GCACGCGGTGGAAGGCGCTGAAGATAGCCGGGAAGGTGGTGTTAACGATCTGAAAAATATTAATTTAACGGCACAGGATG
TGGTGGTTGGCATTGCTGCCAGCGGTCGCACGCCGTATGTGATTGCCGGACTGGAATACGCACGCCAGCTCGGCTGCCGC
ACAGTGGGAATTTCCTGTAATCCGGGGAGTGCCGTTTCCACCACCGCCGAGTTTGCCATTACACCGATTGTAGGTGCCGA
AGTGGTCACTGGTTCTTCGCGAATGAAAGCAGGCACAGCGCAGAAACTGGTGCTCAATATGCTTTCCACCGGGCTGATGA
TTAAATCTGGCAAAGTGTTCGGCAACCTGATGGTCGATGTGGTCGCCACCAACGAAAAACTGCATGTGCGCCAGGTCAAT
ATCGTTAAAAACGCCACCGGATGTAATGCCGAACAAGCGGAAGCGGCGTTAATTGCCTGCGAGCGCAACTGTAAAACGGC
CATTGTGATGGTGCTGAAAAATCTCGATGCCGCAGAAGCTAAAAAACGCCTGGATCAACACGGCGGCTTTATTCGTCAGG
TTTTAGACAAGGAATAA

Upstream 100 bases:

>100_bases
TGCGAGTGTAGACTCAATGATTCCTTTAAGTCTGTCAATTCGGGATATATGATTCCATACATCTGCAATTATTTGATCGT
AAATAGTAAGGTCACCACCG

Downstream 100 bases:

>100_bases
CCCATGGCCAAAGAGATCAGCAGTGAACTTCTGAACACCATCCTTACCCGTGTCGGCGGACCGGGAAATATCGCCAGTTG
TGGTAACTGTATGACGCGCC

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MQLEKMITEGSNTASAEIDRVSTLEMCRIINDEDKTVPLAVERVLPDIAAAIDVIHAQVSGGGRLIYLGAGTSGRLGILD
ASECPPTYGVKPGLVVGLIAGGEYAIQHAVEGAEDSREGGVNDLKNINLTAQDVVVGIAASGRTPYVIAGLEYARQLGCR
TVGISCNPGSAVSTTAEFAITPIVGAEVVTGSSRMKAGTAQKLVLNMLSTGLMIKSGKVFGNLMVDVVATNEKLHVRQVN
IVKNATGCNAEQAEAALIACERNCKTAIVMVLKNLDAAEAKKRLDQHGGFIRQVLDKE

Sequences:

>Translated_298_residues
MQLEKMITEGSNTASAEIDRVSTLEMCRIINDEDKTVPLAVERVLPDIAAAIDVIHAQVSGGGRLIYLGAGTSGRLGILD
ASECPPTYGVKPGLVVGLIAGGEYAIQHAVEGAEDSREGGVNDLKNINLTAQDVVVGIAASGRTPYVIAGLEYARQLGCR
TVGISCNPGSAVSTTAEFAITPIVGAEVVTGSSRMKAGTAQKLVLNMLSTGLMIKSGKVFGNLMVDVVATNEKLHVRQVN
IVKNATGCNAEQAEAALIACERNCKTAIVMVLKNLDAAEAKKRLDQHGGFIRQVLDKE
>Mature_298_residues
MQLEKMITEGSNTASAEIDRVSTLEMCRIINDEDKTVPLAVERVLPDIAAAIDVIHAQVSGGGRLIYLGAGTSGRLGILD
ASECPPTYGVKPGLVVGLIAGGEYAIQHAVEGAEDSREGGVNDLKNINLTAQDVVVGIAASGRTPYVIAGLEYARQLGCR
TVGISCNPGSAVSTTAEFAITPIVGAEVVTGSSRMKAGTAQKLVLNMLSTGLMIKSGKVFGNLMVDVVATNEKLHVRQVN
IVKNATGCNAEQAEAALIACERNCKTAIVMVLKNLDAAEAKKRLDQHGGFIRQVLDKE

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=298, Percent_Identity=99.3288590604027, Blast_Score=597, Evalue=1e-172,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_ECO24 (A7ZPM8)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001463757.1
- ProteinModelPortal:   A7ZPM8
- SMR:   A7ZPM8
- STRING:   A7ZPM8
- EnsemblBacteria:   EBESCT00000021589
- GeneID:   5589393
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_2714
- eggNOG:   COG2103
- GeneTree:   EBGT00050000009225
- HOGENOM:   HBG703490
- OMA:   HLLTEQI
- ProtClustDB:   PRK05441
- BioCyc:   ECOL331111:ECE24377A_2714-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 31213; Mature: 31213

Theoretical pI: Translated: 5.75; Mature: 5.75

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 83-83 ACT_SITE 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLEKMITEGSNTASAEIDRVSTLEMCRIINDEDKTVPLAVERVLPDIAAAIDVIHAQVS
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEC
GGGRLIYLGAGTSGRLGILDASECPPTYGVKPGLVVGLIAGGEYAIQHAVEGAEDSREGG
CCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCC
VNDLKNINLTAQDVVVGIAASGRTPYVIAGLEYARQLGCRTVGISCNPGSAVSTTAEFAI
CCHHHCCCCCHHHEEEEEECCCCCCEEEECHHHHHHCCCEEEEEECCCCCCCCCCHHEEE
TPIVGAEVVTGSSRMKAGTAQKLVLNMLSTGLMIKSGKVFGNLMVDVVATNEKLHVRQVN
EEECCCEEEECCCHHCCCHHHHHHHHHHHCCEEEECCCEEEEEEEEEEECCCEEEEEEEE
IVKNATGCNAEQAEAALIACERNCKTAIVMVLKNLDAAEAKKRLDQHGGFIRQVLDKE
EEECCCCCCHHHHHHEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCC
>Mature Secondary Structure
MQLEKMITEGSNTASAEIDRVSTLEMCRIINDEDKTVPLAVERVLPDIAAAIDVIHAQVS
CCHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHEEEC
GGGRLIYLGAGTSGRLGILDASECPPTYGVKPGLVVGLIAGGEYAIQHAVEGAEDSREGG
CCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHCCCCCCCCCC
VNDLKNINLTAQDVVVGIAASGRTPYVIAGLEYARQLGCRTVGISCNPGSAVSTTAEFAI
CCHHHCCCCCHHHEEEEEECCCCCCEEEECHHHHHHCCCEEEEEECCCCCCCCCCHHEEE
TPIVGAEVVTGSSRMKAGTAQKLVLNMLSTGLMIKSGKVFGNLMVDVVATNEKLHVRQVN
EEECCCEEEECCCHHCCCHHHHHHHHHHHCCEEEECCCEEEEEEEEEEECCCEEEEEEEE
IVKNATGCNAEQAEAALIACERNCKTAIVMVLKNLDAAEAKKRLDQHGGFIRQVLDKE
EEECCCCCCHHHHHHEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA