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The map label for this gene is elaC

Identifier: 218695871

GI number: 218695871

Start: 2583631

End: 2584548

Strand: Direct

Name: elaC

Synonym: EC55989_2516

Alternate gene names: 218695871

Gene position: 2583631-2584548 (Clockwise)

Preceding gene: 218695861

Following gene: 218695872

Centisome position: 50.12

GC content: 50.65

Gene sequence:

>918_bases
ATGGAATTAATTTTTTTAGGTACTTCGGCCGGTGTGCCAACCCGCACGCGCAATGTCACGGCAATATTGCTTAACCTGCA
ACATCCGACCCAGAGCGGACTTTGGTTGTTTGACTGCGGTGAAGGCACCCAGCATCAGCTACTGCATACCGCCTTTAACC
CTGGAAAACTGGACAAGATTTTTATCAGTCACCTTCATGGCGATCATCTTTTTGGTTTACCCGGCTTGCTGTGCAGTCGT
TCTATGTCAGGCATTATCCAACCCTTAACGATTTATGGTCCGCAAGGTATCCGTGAATTTGTGGAAACCGCGCTGCGGAT
TAGCGGCTCATGGACCGATTATCCGCTGGAAATTGTCGAAATTGGCGCTGGCGAAATTCTCGATGATGGCCTGCGCAAAG
TAACCGCTTATCCGCTGGAACACCCACTGGAATGTTATGGCTATCGTATTGAAGAACATGATAAACCGGGTGCATTAAAT
GCCCAGGCATTAAAAGCTGCTGGCGTGCCGCCTGGTCCACTGTTTCAGGAATTAAAAGCGGGCAAAACAATCACCCTGGA
AGATGGAAGGCAGATTAACGGCGCAGATTACTTAGCTGCTCCAGTGCCAGGTAAAGCGCTCGCTATTTTCGGCGATACCG
GCCCCTGCGATGCCGCACTTGATCTGGCTAAAGGTGTCGATGTCATGGTGCACGAAGCGACGCTGGATATAACCATGGAA
GCCAAAGCCAATAGTCGCGGCCATAGCTCTACACGCCAGGCTGCGACACTGGCCCGTGAGGCTGGAGTCGGTATGCTAAT
CATTACCCACGTCAGCTCGCGCTATGATGACAAAGGTTGTCAGCACCTGTTACGTGAATGCAGGTCAATTTTCCCGGCGA
CTGAACTGGCGAATGATTTCACCGTGTTTAACGTTTAA

Upstream 100 bases:

>100_bases
TAATTCAGAGTGATGCAGATCTTGCCATTCAATCATAATGCTCTCCTTTTAGATGTATGCCTTATACTAGCCGGAATATT
TTTTGAAACGTGATGAACTC

Downstream 100 bases:

>100_bases
CTCTGCTTATTATTAAAAACAGGGCGAAACTTGCCCTGTTATCGCAACCCGCGCTACATATATCCACCCACACGGGCATA
TTGAGCGATTTTTGATATTT

Product: ribonuclease Z

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MELIFLGTSAGVPTRTRNVTAILLNLQHPTQSGLWLFDCGEGTQHQLLHTAFNPGKLDKIFISHLHGDHLFGLPGLLCSR
SMSGIIQPLTIYGPQGIREFVETALRISGSWTDYPLEIVEIGAGEILDDGLRKVTAYPLEHPLECYGYRIEEHDKPGALN
AQALKAAGVPPGPLFQELKAGKTITLEDGRQINGADYLAAPVPGKALAIFGDTGPCDAALDLAKGVDVMVHEATLDITME
AKANSRGHSSTRQAATLAREAGVGMLIITHVSSRYDDKGCQHLLRECRSIFPATELANDFTVFNV

Sequences:

>Translated_305_residues
MELIFLGTSAGVPTRTRNVTAILLNLQHPTQSGLWLFDCGEGTQHQLLHTAFNPGKLDKIFISHLHGDHLFGLPGLLCSR
SMSGIIQPLTIYGPQGIREFVETALRISGSWTDYPLEIVEIGAGEILDDGLRKVTAYPLEHPLECYGYRIEEHDKPGALN
AQALKAAGVPPGPLFQELKAGKTITLEDGRQINGADYLAAPVPGKALAIFGDTGPCDAALDLAKGVDVMVHEATLDITME
AKANSRGHSSTRQAATLAREAGVGMLIITHVSSRYDDKGCQHLLRECRSIFPATELANDFTVFNV
>Mature_305_residues
MELIFLGTSAGVPTRTRNVTAILLNLQHPTQSGLWLFDCGEGTQHQLLHTAFNPGKLDKIFISHLHGDHLFGLPGLLCSR
SMSGIIQPLTIYGPQGIREFVETALRISGSWTDYPLEIVEIGAGEILDDGLRKVTAYPLEHPLECYGYRIEEHDKPGALN
AQALKAAGVPPGPLFQELKAGKTITLEDGRQINGADYLAAPVPGKALAIFGDTGPCDAALDLAKGVDVMVHEATLDITME
AKANSRGHSSTRQAATLAREAGVGMLIITHVSSRYDDKGCQHLLRECRSIFPATELANDFTVFNV

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=361, Percent_Identity=34.6260387811634, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI260166619, Length=289, Percent_Identity=26.2975778546713, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI260166622, Length=289, Percent_Identity=26.2975778546713, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI145553959, Length=289, Percent_Identity=26.2975778546713, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI87082078, Length=305, Percent_Identity=99.672131147541, Blast_Score=625, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI71985808, Length=291, Percent_Identity=28.5223367697594, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71985814, Length=291, Percent_Identity=28.5223367697594, Blast_Score=93, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24652403, Length=175, Percent_Identity=29.1428571428571, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_ECO24 (A7ZP87)

Other databases:

- EMBL:   CP000800
- RefSeq:   YP_001463616.1
- ProteinModelPortal:   A7ZP87
- SMR:   A7ZP87
- STRING:   A7ZP87
- EnsemblBacteria:   EBESCT00000021895
- GeneID:   5586937
- GenomeReviews:   CP000800_GR
- KEGG:   ecw:EcE24377A_2565
- NMPDR:   fig|331111.3.peg.301
- eggNOG:   COG1234
- GeneTree:   EBGT00050000010319
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   PRK00055
- BioCyc:   ECOL331111:ECE24377A_2565-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- InterPro:   IPR013469
- SMART:   SM00849
- TIGRFAMs:   TIGR02651
- TIGRFAMs:   TIGR02649

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 32933; Mature: 32933

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELIFLGTSAGVPTRTRNVTAILLNLQHPTQSGLWLFDCGEGTQHQLLHTAFNPGKLDKI
CEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHH
FISHLHGDHLFGLPGLLCSRSMSGIIQPLTIYGPQGIREFVETALRISGSWTDYPLEIVE
HHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEE
IGAGEILDDGLRKVTAYPLEHPLECYGYRIEEHDKPGALNAQALKAAGVPPGPLFQELKA
ECCCHHHHHHHHHHCCCCCCCCHHHHCCEEECCCCCCCCCHHHHHHCCCCCCHHHHHHHC
GKTITLEDGRQINGADYLAAPVPGKALAIFGDTGPCDAALDLAKGVDVMVHEATLDITME
CCEEEECCCCEECCCCEEECCCCCCEEEEECCCCCCHHHHHHHCCCEEEEEEEEEEEEEE
AKANSRGHSSTRQAATLAREAGVGMLIITHVSSRYDDKGCQHLLRECRSIFPATELANDF
ECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHCCCE
TVFNV
EEEEC
>Mature Secondary Structure
MELIFLGTSAGVPTRTRNVTAILLNLQHPTQSGLWLFDCGEGTQHQLLHTAFNPGKLDKI
CEEEEEECCCCCCCCCCCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHCCCCCCHHHH
FISHLHGDHLFGLPGLLCSRSMSGIIQPLTIYGPQGIREFVETALRISGSWTDYPLEIVE
HHHHHCCCCCCCCHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHCCCCCCCCCEEEEE
IGAGEILDDGLRKVTAYPLEHPLECYGYRIEEHDKPGALNAQALKAAGVPPGPLFQELKA
ECCCHHHHHHHHHHCCCCCCCCHHHHCCEEECCCCCCCCCHHHHHHCCCCCCHHHHHHHC
GKTITLEDGRQINGADYLAAPVPGKALAIFGDTGPCDAALDLAKGVDVMVHEATLDITME
CCEEEECCCCEECCCCEEECCCCCCEEEEECCCCCCHHHHHHHCCCEEEEEEEEEEEEEE
AKANSRGHSSTRQAATLAREAGVGMLIITHVSSRYDDKGCQHLLRECRSIFPATELANDF
ECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHCCCE
TVFNV
EEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA