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The map label for this gene is gatD

Identifier: 218695710

GI number: 218695710

Start: 2400740

End: 2401780

Strand: Reverse

Name: gatD

Synonym: EC55989_2345

Alternate gene names: 218695710

Gene position: 2401780-2400740 (Counterclockwise)

Preceding gene: 218695711

Following gene: 218695709

Centisome position: 46.59

GC content: 48.32

Gene sequence:

>1041_bases
ATGAAATCAGTGGTGAATGATACTGATGGTATCGTGCGCGTTGCAGAAAGCGTCATTCCTGAAATTAAACATCAGGATGA
GGTGCGGGTAAAAATTGCCAGCTCGGGCTTATGTGGTTCCGATTTATCCAGGATATTTAAAAATGGTGCACATTATTATC
CAATAACGTTAGGCCATGAATTTAGCGGCTATATTGATGCGGTGGGATCCGGTGTTGATGATTTACACCCTGACGATGCG
GTTGCCTGTGTGCCGTTATTACCCTGTTTTACTTGTCCAGAGTGTCTGAAAGGGTTTTATTCCCAGTGCGCAAAATATGA
TTTTATTGGCTCGCGGCGTGATGGTGGATTTGCTGAATATATTGTCGTTAAGCGAAAAAATGTCTTTGCTCTACCCACGG
ATATGCCTATTGAGGATGGGGCTTTTATTGAGCCGATTACCGTTGGTCTGCATGCTTTTCATTTAGCGCAAGGTTGTGAG
AATAAAAACGTTATTATTATTGGTGCCGGAACCATTGGCCTGCTGGCTATTCAGTGCGCTGTCGCGCTGGGAGCAAAGAG
TGTGACGGCTATCGACATTAGCTCAGAAAAACTGGCACTGGCAAAATCTTTCGGTGCGATGCAAACATTTAACAGTAGCG
AAATGGGCGCGCCGCAAATGCAGAGCGTTTTACGCGAACTGCGTTTTAATCAGCTTATCCTCGAGACGGCTGGCGTACCG
CAAACTGTCGAACTGGCGGTAGAGATTGCCGGTCCTCATGCCCAACTGGCGCTGGTGGGCACGTTGCATCAGGATCTGCA
TTTAACATCGGCAACGTTTGGCAAAATATTGCGTAAAGAGCTGACGGTTATCGGCAGTTGGATGAACTATTCCAGCCCTT
GGCCGGGGCAGGAGTGGGAAACGGCGAGCCGGTTGCTGACAGAACGTAAGTTAAGCCTGGAGCCATTAATCGCTCACCGT
GGAAGCTTTGAAAGCTTCACCCAGGCGGTGCGTGACATCGCTCGTAATGCCATGCCGGGCAAAGTGTTGCTCATTCCATG
A

Upstream 100 bases:

>100_bases
GGCGTAGAGCGCGTGGCTTTATTAAACAAGAGAAAGTCGTTCTCGCAGAATAATTTTTACCTGAGGGGGAGGTTATCCCC
CTTAACAATCAGGAGTTTTT

Downstream 100 bases:

>100_bases
AACCGCGGGCCAGCGTGATGCTGGCCCGGTATTGTGCAAAACAGATCATTCACCAATGGTCCCCCTTCGTTTACACTAGC
CACAATTGAATATGGGTAAA

Product: galactitol-1-phosphate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLSRIFKNGAHYYPITLGHEFSGYIDAVGSGVDDLHPDDA
VACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTDMPIEDGAFIEPITVGLHAFHLAQGCE
NKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMGAPQMQSVLRELRFNQLILETAGVP
QTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWETASRLLTERKLSLEPLIAHR
GSFESFTQAVRDIARNAMPGKVLLIP

Sequences:

>Translated_346_residues
MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLSRIFKNGAHYYPITLGHEFSGYIDAVGSGVDDLHPDDA
VACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTDMPIEDGAFIEPITVGLHAFHLAQGCE
NKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMGAPQMQSVLRELRFNQLILETAGVP
QTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWETASRLLTERKLSLEPLIAHR
GSFESFTQAVRDIARNAMPGKVLLIP
>Mature_346_residues
MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLSRIFKNGAHYYPITLGHEFSGYIDAVGSGVDDLHPDDA
VACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEYIVVKRKNVFALPTDMPIEDGAFIEPITVGLHAFHLAQGCE
NKNVIIIGAGTIGLLAIQCAVALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMGAPQMQSVLRELRFNQLILETAGVP
QTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWETASRLLTERKLSLEPLIAHR
GSFESFTQAVRDIARNAMPGKVLLIP

Specific function: Converts galactitol 1-phosphate to tagatose 6-phosphate [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=351, Percent_Identity=26.7806267806268, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI4501929, Length=224, Percent_Identity=29.0178571428571, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI4501939, Length=338, Percent_Identity=24.5562130177515, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI156523966, Length=338, Percent_Identity=24.5562130177515, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI34577061, Length=226, Percent_Identity=29.2035398230088, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4501933, Length=226, Percent_Identity=29.2035398230088, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI71565154, Length=338, Percent_Identity=24.2603550295858, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI262073058, Length=234, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI71743840, Length=234, Percent_Identity=25.6410256410256, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1788407, Length=346, Percent_Identity=98.8439306358381, Blast_Score=705, Evalue=0.0,
Organism=Escherichia coli, GI1788073, Length=335, Percent_Identity=29.2537313432836, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1787863, Length=333, Percent_Identity=31.2312312312312, Blast_Score=135, Evalue=3e-33,
Organism=Escherichia coli, GI1790045, Length=344, Percent_Identity=26.453488372093, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI226510992, Length=318, Percent_Identity=29.2452830188679, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI87082125, Length=337, Percent_Identity=28.486646884273, Blast_Score=115, Evalue=6e-27,
Organism=Escherichia coli, GI1790718, Length=336, Percent_Identity=28.2738095238095, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788075, Length=312, Percent_Identity=25, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1786825, Length=316, Percent_Identity=25, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786518, Length=272, Percent_Identity=28.3088235294118, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17562876, Length=325, Percent_Identity=28.9230769230769, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17562878, Length=229, Percent_Identity=31.8777292576419, Blast_Score=116, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=341, Percent_Identity=24.633431085044, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17565904, Length=323, Percent_Identity=24.7678018575851, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=354, Percent_Identity=28.8135593220339, Blast_Score=145, Evalue=1e-35,
Organism=Saccharomyces cerevisiae, GI6319955, Length=338, Percent_Identity=29.8816568047337, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6322619, Length=338, Percent_Identity=29.8816568047337, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6319258, Length=237, Percent_Identity=30.379746835443, Blast_Score=103, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6319257, Length=236, Percent_Identity=27.9661016949153, Blast_Score=93, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6320033, Length=353, Percent_Identity=23.2294617563739, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=290, Percent_Identity=26.8965517241379, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137530, Length=204, Percent_Identity=33.8235294117647, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI17737897, Length=204, Percent_Identity=34.3137254901961, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221457811, Length=238, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45551930, Length=238, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI45550770, Length=238, Percent_Identity=26.4705882352941, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17737895, Length=228, Percent_Identity=27.6315789473684, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.251 [H]

Molecular weight: Translated: 37439; Mature: 37439

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLSRIFKNGAHYYPITLGHE
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCC
FSGYIDAVGSGVDDLHPDDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEY
CHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEE
IVVKRKNVFALPTDMPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCA
EEEECCCEEECCCCCCCCCCCEECHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHH
VALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMGAPQMQSVLRELRFNQLILETAGVP
HHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
QTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWE
CEEEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
TASRLLTERKLSLEPLIAHRGSFESFTQAVRDIARNAMPGKVLLIP
HHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEC
>Mature Secondary Structure
MKSVVNDTDGIVRVAESVIPEIKHQDEVRVKIASSGLCGSDLSRIFKNGAHYYPITLGHE
CCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCC
FSGYIDAVGSGVDDLHPDDAVACVPLLPCFTCPECLKGFYSQCAKYDFIGSRRDGGFAEY
CHHHHHHHCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEE
IVVKRKNVFALPTDMPIEDGAFIEPITVGLHAFHLAQGCENKNVIIIGAGTIGLLAIQCA
EEEECCCEEECCCCCCCCCCCEECHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHH
VALGAKSVTAIDISSEKLALAKSFGAMQTFNSSEMGAPQMQSVLRELRFNQLILETAGVP
HHHCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
QTVELAVEIAGPHAQLALVGTLHQDLHLTSATFGKILRKELTVIGSWMNYSSPWPGQEWE
CEEEEEEEECCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
TASRLLTERKLSLEPLIAHRGSFESFTQAVRDIARNAMPGKVLLIP
HHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]