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The map label for this gene is fliI

Identifier: 218695546

GI number: 218695546

Start: 2202593

End: 2203966

Strand: Direct

Name: fliI

Synonym: EC55989_2161

Alternate gene names: 218695546

Gene position: 2202593-2203966 (Clockwise)

Preceding gene: 218695545

Following gene: 218695547

Centisome position: 42.73

GC content: 58.59

Gene sequence:

>1374_bases
ATGACCACGCGCCTGACTCGCTGGCTAACCACGCTGGATAACTTTGAAGCCAAAATGGCGCAGTTGCCTGCGGTACGTCG
CTATGGGCGATTAACCCGCGCTACCGGGCTGGTGCTGGAAGCCACCGGATTACAATTGCCGCTCGGCGCAACCTGTGTCA
TTGAACGCCAGAACGGCAGCGAAACGCACGAAGTAGAAAGCGAAGTCGTTGGCTTTAACGGTCAACGGCTGTTTTTAATG
CCGCTGGAGGAAGTGGAAGGTGTCCTGCCCGGCGCGCGGGTTTATGCCAAAAACATTTCGGCTGAAGGACTGCAAAGCGG
CAAGCAGTTGCCGCTCGGTCCGGCGTTATTAGGTCGCGTTCTGGACGGCAGCGGTAAGCCGCTCGATGGCCTGCCCTCCC
CCGATACGACGGAAACCGGTGCGCTGATTACCCCGCCATTTAACCCGTTGCAACGTACACCGATTGAACATGTGCTGGAC
ACCGGCGTGCGCCCAATCAATGCCCTGCTTACCGTTGGGCGCGGGCAGCGTATGGGGCTGTTTGCCGGGTCCGGCGTTGG
TAAAAGTGTGCTGCTGGGGATGATGGCACGTTACACCCGCGCCGATGTCATTGTCGTGGGTTTGATTGGTGAACGTGGGC
GCGAAGTAAAAGATTTTATTGAGAATATCCTCGGTGCCGAAGGGCGTGCACGCTCCGTGGTGATTGCCGCTCCGGCGGAT
GTCTCTCCGCTTCTGCGAATGCAAGGTGCCGCCTATGCCACGCGCATTGCCGAAGATTTTCGCGATCGTGGTCAGCATGT
GTTGCTGATTATGGACTCCCTCACCCGCTACGCGATGGCCCAGCGTGAAATTGCGCTGGCGATTGGCGAACCACCCGCCA
CCAAAGGTTATCCCCCGTCGGTGTTTGCCAAATTACCGGCACTGGTCGAGCGTGCCGGAAATGGCATTAGCGGCGGCGGA
TCGATTACCGCGTTTTATACCGTGCTCACCGAGGGCGATGACCAGCAGGACCCCATTGCCGACTCCGCGCGGGCAATCCT
CGACGGTCACATTGTGCTGTCTCGCCGACTGGCGGAAGCCGGGCACTATCCGGCTATCGATATTGAAGCGTCGATCAGCC
GCGCAATGACGGCGTTGATCAGCGAGCAACATTACGCGCGAGTGCGCACCTTCAAACAGCTGTTGTCGAGTTTTCAGCGT
AACCGAGATCTGGTTAGCGTCGGCGCGTATGCCAAAGGCAGCGATCCGATGCTCGATAAAGCCATCGCCCTGTGGCCGCA
GCTGGAGGGCTATTTGCAACAAGGCATTTTTGAACGCGCGGACTGGGAAGCGTCTCTCCAGGGGCTGGAGCGTATTTTCC
CGACAGTGTCATAA

Upstream 100 bases:

>100_bases
CTGGCGGCTGTAAAGTCTCCGCCGATGAAGGCGATCTCGACGCCAGTGTCGCCACTCGCTGGCAAGAACTCTGCCGTCTG
GCAGCACCAGGAGTGGTGTA

Downstream 100 bases:

>100_bases
CCCAGGAGATAACGGCAGATGGCAGAACATGGTGCGCTGGCGACCCTGAAAGATCTGGCAGAAAAAGAGGTAGAGGATGC
CGCGCGCCTGCTGGGTGAAA

Product: flagellum-specific ATP synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 456

Protein sequence:

>457_residues
MTTRLTRWLTTLDNFEAKMAQLPAVRRYGRLTRATGLVLEATGLQLPLGATCVIERQNGSETHEVESEVVGFNGQRLFLM
PLEEVEGVLPGARVYAKNISAEGLQSGKQLPLGPALLGRVLDGSGKPLDGLPSPDTTETGALITPPFNPLQRTPIEHVLD
TGVRPINALLTVGRGQRMGLFAGSGVGKSVLLGMMARYTRADVIVVGLIGERGREVKDFIENILGAEGRARSVVIAAPAD
VSPLLRMQGAAYATRIAEDFRDRGQHVLLIMDSLTRYAMAQREIALAIGEPPATKGYPPSVFAKLPALVERAGNGISGGG
SITAFYTVLTEGDDQQDPIADSARAILDGHIVLSRRLAEAGHYPAIDIEASISRAMTALISEQHYARVRTFKQLLSSFQR
NRDLVSVGAYAKGSDPMLDKAIALWPQLEGYLQQGIFERADWEASLQGLERIFPTVS

Sequences:

>Translated_457_residues
MTTRLTRWLTTLDNFEAKMAQLPAVRRYGRLTRATGLVLEATGLQLPLGATCVIERQNGSETHEVESEVVGFNGQRLFLM
PLEEVEGVLPGARVYAKNISAEGLQSGKQLPLGPALLGRVLDGSGKPLDGLPSPDTTETGALITPPFNPLQRTPIEHVLD
TGVRPINALLTVGRGQRMGLFAGSGVGKSVLLGMMARYTRADVIVVGLIGERGREVKDFIENILGAEGRARSVVIAAPAD
VSPLLRMQGAAYATRIAEDFRDRGQHVLLIMDSLTRYAMAQREIALAIGEPPATKGYPPSVFAKLPALVERAGNGISGGG
SITAFYTVLTEGDDQQDPIADSARAILDGHIVLSRRLAEAGHYPAIDIEASISRAMTALISEQHYARVRTFKQLLSSFQR
NRDLVSVGAYAKGSDPMLDKAIALWPQLEGYLQQGIFERADWEASLQGLERIFPTVS
>Mature_456_residues
TTRLTRWLTTLDNFEAKMAQLPAVRRYGRLTRATGLVLEATGLQLPLGATCVIERQNGSETHEVESEVVGFNGQRLFLMP
LEEVEGVLPGARVYAKNISAEGLQSGKQLPLGPALLGRVLDGSGKPLDGLPSPDTTETGALITPPFNPLQRTPIEHVLDT
GVRPINALLTVGRGQRMGLFAGSGVGKSVLLGMMARYTRADVIVVGLIGERGREVKDFIENILGAEGRARSVVIAAPADV
SPLLRMQGAAYATRIAEDFRDRGQHVLLIMDSLTRYAMAQREIALAIGEPPATKGYPPSVFAKLPALVERAGNGISGGGS
ITAFYTVLTEGDDQQDPIADSARAILDGHIVLSRRLAEAGHYPAIDIEASISRAMTALISEQHYARVRTFKQLLSSFQRN
RDLVSVGAYAKGSDPMLDKAIALWPQLEGYLQQGIFERADWEASLQGLERIFPTVS

Specific function: Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. May be involved in a specialized protein export pathway that proceeds without signal peptide cleavage

COG id: COG1157

COG function: function code NU; Flagellar biosynthesis/type III secretory pathway ATPase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI32189394, Length=347, Percent_Identity=28.8184438040346, Blast_Score=132, Evalue=5e-31,
Organism=Homo sapiens, GI50345984, Length=349, Percent_Identity=28.3667621776504, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI4757810, Length=349, Percent_Identity=28.3667621776504, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI19913426, Length=380, Percent_Identity=27.8947368421053, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI19913428, Length=402, Percent_Identity=27.6119402985075, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI19913424, Length=251, Percent_Identity=30.6772908366534, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1788251, Length=457, Percent_Identity=100, Blast_Score=918, Evalue=0.0,
Organism=Escherichia coli, GI1790170, Length=348, Percent_Identity=29.0229885057471, Blast_Score=145, Evalue=5e-36,
Organism=Escherichia coli, GI1790172, Length=345, Percent_Identity=25.2173913043478, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1790217, Length=241, Percent_Identity=26.1410788381743, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI25144756, Length=313, Percent_Identity=29.3929712460064, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71988080, Length=426, Percent_Identity=27.2300469483568, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71988063, Length=428, Percent_Identity=28.0373831775701, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17570191, Length=413, Percent_Identity=27.6029055690073, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17510931, Length=369, Percent_Identity=26.0162601626016, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17565854, Length=241, Percent_Identity=31.9502074688797, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71988074, Length=372, Percent_Identity=27.4193548387097, Blast_Score=105, Evalue=6e-23,
Organism=Saccharomyces cerevisiae, GI6322581, Length=310, Percent_Identity=30.6451612903226, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6319370, Length=345, Percent_Identity=28.695652173913, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6319603, Length=426, Percent_Identity=27.4647887323944, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320016, Length=268, Percent_Identity=28.3582089552239, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24638766, Length=310, Percent_Identity=29.6774193548387, Blast_Score=134, Evalue=9e-32,
Organism=Drosophila melanogaster, GI28574560, Length=331, Percent_Identity=30.2114803625378, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24658560, Length=346, Percent_Identity=27.4566473988439, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI281361666, Length=398, Percent_Identity=27.1356783919598, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24646341, Length=398, Percent_Identity=27.1356783919598, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI17136796, Length=398, Percent_Identity=27.1356783919598, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24583992, Length=251, Percent_Identity=30.2788844621514, Blast_Score=108, Evalue=7e-24,
Organism=Drosophila melanogaster, GI24583988, Length=243, Percent_Identity=30.8641975308642, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583986, Length=243, Percent_Identity=30.8641975308642, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583984, Length=243, Percent_Identity=30.8641975308642, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI20129479, Length=242, Percent_Identity=29.7520661157025, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: 10-20 (rich media) [C]

Swissprot (AC and ID): FLII_ECOLI (P52612)

Other databases:

- EMBL:   L49147
- EMBL:   U00096
- EMBL:   AP009048
- PIR:   B64958
- RefSeq:   AP_002553.1
- RefSeq:   NP_416451.1
- ProteinModelPortal:   P52612
- SMR:   P52612
- DIP:   DIP-9655N
- IntAct:   P52612
- STRING:   P52612
- EnsemblBacteria:   EBESCT00000000118
- EnsemblBacteria:   EBESCT00000000119
- EnsemblBacteria:   EBESCT00000015972
- GeneID:   946457
- GenomeReviews:   AP009048_GR
- GenomeReviews:   U00096_GR
- KEGG:   ecj:JW1925
- KEGG:   eco:b1941
- EchoBASE:   EB4163
- EcoGene:   EG20266
- eggNOG:   COG1157
- GeneTree:   EBGT00050000009593
- HOGENOM:   HBG565875
- OMA:   INDDSYH
- ProtClustDB:   PRK07960
- BioCyc:   EcoCyc:G377-MONOMER
- Genevestigator:   P52612
- GO:   GO:0005737
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR003593
- InterPro:   IPR005714
- InterPro:   IPR020005
- SMART:   SM00382
- TIGRFAMs:   TIGR03496
- TIGRFAMs:   TIGR01026

Pfam domain/function: PF00006 ATP-synt_ab

EC number: =3.6.3.14

Molecular weight: Translated: 49316; Mature: 49185

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTRLTRWLTTLDNFEAKMAQLPAVRRYGRLTRATGLVLEATGLQLPLGATCVIERQNGS
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCC
ETHEVESEVVGFNGQRLFLMPLEEVEGVLPGARVYAKNISAEGLQSGKQLPLGPALLGRV
CHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCHHHHHHCCCHHHHHCCCCCCCCHHHHHHH
LDGSGKPLDGLPSPDTTETGALITPPFNPLQRTPIEHVLDTGVRPINALLTVGRGQRMGL
HCCCCCCCCCCCCCCCCCCCEEECCCCCCHHCCCHHHHHHCCCHHHHHHHCCCCCCEEEE
FAGSGVGKSVLLGMMARYTRADVIVVGLIGERGREVKDFIENILGAEGRARSVVIAAPAD
EECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCC
VSPLLRMQGAAYATRIAEDFRDRGQHVLLIMDSLTRYAMAQREIALAIGEPPATKGYPPS
CHHHHHHCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHEEEEECCCCCCCCCCHH
VFAKLPALVERAGNGISGGGSITAFYTVLTEGDDQQDPIADSARAILDGHIVLSRRLAEA
HHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GHYPAIDIEASISRAMTALISEQHYARVRTFKQLLSSFQRNRDLVSVGAYAKGSDPMLDK
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHH
AIALWPQLEGYLQQGIFERADWEASLQGLERIFPTVS
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTRLTRWLTTLDNFEAKMAQLPAVRRYGRLTRATGLVLEATGLQLPLGATCVIERQNGS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEEECCCCC
ETHEVESEVVGFNGQRLFLMPLEEVEGVLPGARVYAKNISAEGLQSGKQLPLGPALLGRV
CHHHHHHHHCCCCCCEEEEEEHHHHCCCCCCHHHHHHCCCHHHHHCCCCCCCCHHHHHHH
LDGSGKPLDGLPSPDTTETGALITPPFNPLQRTPIEHVLDTGVRPINALLTVGRGQRMGL
HCCCCCCCCCCCCCCCCCCCEEECCCCCCHHCCCHHHHHHCCCHHHHHHHCCCCCCEEEE
FAGSGVGKSVLLGMMARYTRADVIVVGLIGERGREVKDFIENILGAEGRARSVVIAAPAD
EECCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCCEEEEECCCC
VSPLLRMQGAAYATRIAEDFRDRGQHVLLIMDSLTRYAMAQREIALAIGEPPATKGYPPS
CHHHHHHCCHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHHHEEEEECCCCCCCCCCHH
VFAKLPALVERAGNGISGGGSITAFYTVLTEGDDQQDPIADSARAILDGHIVLSRRLAEA
HHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHC
GHYPAIDIEASISRAMTALISEQHYARVRTFKQLLSSFQRNRDLVSVGAYAKGSDPMLDK
CCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHH
AIALWPQLEGYLQQGIFERADWEASLQGLERIFPTVS
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503