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The map label for this gene is astC

Identifier: 218695306

GI number: 218695306

Start: 1979194

End: 1980414

Strand: Reverse

Name: astC

Synonym: EC55989_1916

Alternate gene names: 218695306

Gene position: 1980414-1979194 (Counterclockwise)

Preceding gene: 218695316

Following gene: 218695305

Centisome position: 38.42

GC content: 55.45

Gene sequence:

>1221_bases
ATGTCTCAGCCAATTACGCGTGAAAACTTTAATGAATGGATGATACCTGTTTACGCTCCGGCACCCTTTATACCGGTACG
TGGCGAAGGTTCGCGCTTGTGGGATCAGCAGGGGAAAGAGTATATCGACTTCGCGGGTGGCATTGCGGTGAACGCGCTGG
GCCATGCGCATCCGGAACTGCGTGAAGCGCTGAACGAACAGGCGAGTAAGTTCTGGCATACCGGCAACGGTTACACCAAC
GAGCCGGTACTGCGACTGGCGAAAAAATTGATCGACGCCACGTTTGCCGATCGCGTCTTCTTTTGTAACTCCGGTGCGGA
AGCCAACGAAGCGGCGCTAAAACTGGCGCGTAAATTCGCTCATGACCGCTACGGCAGCCATAAGAGCGGCATCGTGGCGT
TCAAAAATGCGTTTCATGGTCGCACGCTGTTTACTGTCAGTGCGGGTGGGCAGCCAGCCTATTCACAGGATTTTGCGCCA
CTGCCACCGGATATTCGTCATGCTGCATATAACGATATTAACTCTGCCAGCGCGCTGATTGACGACGCCACCTGTGCGGT
GATTGTCGAACCCATCCAGGGGGAAGGCGGTGTGGTGCCAGCCAGCAACGCATTTTTACAAGATCTGCGTGAATTGTGTG
ACCGCCACAATGCCTTGCTGATTTTTGATGAGGTACAAACCGGCGTCGGGCGCACTGGTGAGCTGTATGCCTATATGCAC
TACGGCGTGACGCCCGATCTGTTAACCACCGCCAAAGCGCTGGGCGGCGGTTTCCCAGTCGGTGCGTTGTTAGCAACCGA
AGAGTGCGCCCGCGTGATGACCGTTGGCACTCATGGCACCACCTATGGCGGCAATCCGCTGGCCTCGGCGGTGGCGGGCA
AAGTGCTGGAGCTCATCAACACACCAGAGATGCTTAATGGCGTTAAGCAGCGTCACGACTGGTTTGTTGAGCGTCTTAAT
ACCCTTAATCACCGCTACGGTTTGTTCAGTGAAGTTCGCGGCTTAGGTCTTTTGATTGGCTGTGTGCTGAATGCGGATTA
CGCCGGGCAAGCGAAACAGATCTCTCAGGAGGCGGCGAAAGCGGGCGTGATGGTGCTGATTGCTGGCGGTAATGTGGTGC
GTTTTGCGCCTGCGCTCAATGTCAGCGAAGAAGAGGTGACGACCGGACTGGATCGCTTTGCAGCTGCTTGCGAACACTTT
GTTAGCCGAGGTTCATCATGA

Upstream 100 bases:

>100_bases
TTTATCACTGGCTGGCACGAACCCTGCAATCTACATTTACAGCGCAAACATTACTTATTGTTAACATATAAATAACGAAT
TATTTACTGTAGAGGTCGCT

Downstream 100 bases:

>100_bases
TGGTCATCCGTCCCGTTGAGCGCTCAGATGTCTCGGCGCTAATGCAACTTGCCAGCAAAACGGGCGGCGGCCTGACGTCG
CTTCCCGCCAATGAAGCCAC

Product: bifunctional succinylornithine transaminase/acetylornithine transaminase

Products: NA

Alternate protein names: Succinylornithine aminotransferase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MSQPITRENFNEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPPDIRHAAYNDINSASALIDDATCAVIVEPIQGEGGVVPASNAFLQDLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLN
TLNHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF
VSRGSS

Sequences:

>Translated_406_residues
MSQPITRENFNEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTN
EPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAP
LPPDIRHAAYNDINSASALIDDATCAVIVEPIQGEGGVVPASNAFLQDLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLN
TLNHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHF
VSRGSS
>Mature_405_residues
SQPITRENFNEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPELREALNEQASKFWHTGNGYTNE
PVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFAHDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPL
PPDIRHAAYNDINSASALIDDATCAVIVEPIQGEGGVVPASNAFLQDLRELCDRHNALLIFDEVQTGVGRTGELYAYMHY
GVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELINTPEMLNGVKQRHDWFVERLNT
LNHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAKAGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFV
SRGSS

Specific function: Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=379, Percent_Identity=34.8284960422164, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI13994255, Length=452, Percent_Identity=28.0973451327434, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI284507298, Length=293, Percent_Identity=35.4948805460751, Blast_Score=169, Evalue=5e-42,
Organism=Homo sapiens, GI37574042, Length=422, Percent_Identity=28.1990521327014, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI226442705, Length=422, Percent_Identity=27.4881516587678, Blast_Score=139, Evalue=5e-33,
Organism=Homo sapiens, GI226442709, Length=387, Percent_Identity=28.4237726098191, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI24119277, Length=412, Percent_Identity=27.4271844660194, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI188536080, Length=433, Percent_Identity=24.0184757505774, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI38679950, Length=433, Percent_Identity=24.0184757505774, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI38679946, Length=433, Percent_Identity=24.0184757505774, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1788044, Length=406, Percent_Identity=98.5221674876847, Blast_Score=828, Evalue=0.0,
Organism=Escherichia coli, GI1789759, Length=397, Percent_Identity=59.4458438287154, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1789016, Length=398, Percent_Identity=34.4221105527638, Blast_Score=211, Evalue=7e-56,
Organism=Escherichia coli, GI145693181, Length=374, Percent_Identity=35.2941176470588, Blast_Score=201, Evalue=5e-53,
Organism=Escherichia coli, GI1787560, Length=390, Percent_Identity=34.8717948717949, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI1786349, Length=312, Percent_Identity=32.6923076923077, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1786991, Length=296, Percent_Identity=32.7702702702703, Blast_Score=127, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=35.5498721227622, Blast_Score=237, Evalue=7e-63,
Organism=Caenorhabditis elegans, GI32564660, Length=435, Percent_Identity=29.8850574712644, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI25144274, Length=287, Percent_Identity=34.1463414634146, Blast_Score=171, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI71992977, Length=433, Percent_Identity=29.3302540415704, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI17541228, Length=308, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI71981843, Length=165, Percent_Identity=34.5454545454545, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6324432, Length=402, Percent_Identity=39.5522388059701, Blast_Score=286, Evalue=6e-78,
Organism=Saccharomyces cerevisiae, GI6323470, Length=417, Percent_Identity=33.0935251798561, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6324386, Length=325, Percent_Identity=28.6153846153846, Blast_Score=112, Evalue=9e-26,
Organism=Saccharomyces cerevisiae, GI6321456, Length=425, Percent_Identity=25.1764705882353, Blast_Score=96, Evalue=7e-21,
Organism=Drosophila melanogaster, GI21357415, Length=379, Percent_Identity=36.1477572559367, Blast_Score=233, Evalue=2e-61,
Organism=Drosophila melanogaster, GI161085790, Length=452, Percent_Identity=29.4247787610619, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI28574759, Length=445, Percent_Identity=29.438202247191, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI21356575, Length=361, Percent_Identity=29.6398891966759, Blast_Score=136, Evalue=2e-32,
Organism=Drosophila melanogaster, GI281366494, Length=429, Percent_Identity=24.7086247086247, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24667139, Length=429, Percent_Identity=24.7086247086247, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24667143, Length=429, Percent_Identity=24.7086247086247, Blast_Score=92, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR017652 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.81 [H]

Molecular weight: Translated: 43734; Mature: 43603

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPITRENFNEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALI
HHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHH
DDATCAVIVEPIQGEGGVVPASNAFLQDLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNTLNHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SQPITRENFNEWMIPVYAPAPFIPVRGEGSRLWDQQGKEYIDFAGGIAVNALGHAHPEL
CCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHCCCHHHHHCCCHHHHHHCCCCHHH
REALNEQASKFWHTGNGYTNEPVLRLAKKLIDATFADRVFFCNSGAEANEAALKLARKFA
HHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCEEEEECCCCCHHHHHHHHHHHHH
HDRYGSHKSGIVAFKNAFHGRTLFTVSAGGQPAYSQDFAPLPPDIRHAAYNDINSASALI
HHHCCCCCCCEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHH
DDATCAVIVEPIQGEGGVVPASNAFLQDLRELCDRHNALLIFDEVQTGVGRTGELYAYMH
CCCCEEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCEEEEEECHHHCCCCCCCEEEEEE
YGVTPDLLTTAKALGGGFPVGALLATEECARVMTVGTHGTTYGGNPLASAVAGKVLELIN
CCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCCCCCHHHHHHHHHHHHHHC
TPEMLNGVKQRHDWFVERLNTLNHRYGLFSEVRGLGLLIGCVLNADYAGQAKQISQEAAK
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
AGVMVLIAGGNVVRFAPALNVSEEEVTTGLDRFAAACEHFVSRGSS
CCEEEEEECCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA